Clinical trials: Emergence From Anesthesia
Neuromuscular Blockade, Anesthesia
Sugammadex Dosing: Anaesthesiologist Clinical Perception Versus Quantitative Monitoring
Many clinicians continue to rely on subjective evaluation in making decisions about the adequacy of neuromuscular function before tracheal extubation rather than using quantitative monitoring.
- Conditions
- Neuromuscular Blockade, Anesthesia, TOF, Curarization, Postoperative Residual
- Trial name
- NCT04762420
- Testing
- Dose of sugammadex according to SSD and QSD
- Where
- Portugal
- Volunteers
- 66 people
- Sponsor
- Hospital do Divino Espírito Santo de Ponta Delgada
Delayed Recovery From Anesthesia
Automated Control of End-tidal Volatile Anesthetic Concentration
The new MIRUS system as well as the established AnaConDa system uses a reflector to conserve volatile anaesthetics (VA). Both systems act with commercially available ICU ventilators.
- Trial name
- MIRCONTROL (NCT02342509)
- Testing
- Desflurane, Sevoflurane, Isoflurane
- Volunteers
- 63 people
- Sponsor
- Ruhr University of Bochum
Neuromuscular Blockade, Residual, Postoperative Complications
Does Electromyography Improve Precision and Reliability of Neuromuscular Monitoring in Paediatric Patients
Neuromuscular monitoring is used as a standard surveillance method of neuromuscular function to ensure full recovery at the end of anaesthesia.
- Trial name
- ETCETERA (NCT06062290)
- Testing
- Electromyography (EMG), Kinemyography (KMG)
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- University Hospital Ulm
Anesthesia
A Study to Determine if Caffeine Accelerates Emergence From Anesthesia
At present clinicians have no way to reverse anesthesia. Patients wake when their bodies clear the anesthetic. Most people wake quickly, but some do not.
- Trial name
- NCT02567968
- Testing
- Caffeine
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Residual Neuromuscular Blockade
Electromyographic Assessment of Onset and Recovery of Neuromuscular Blockade
Residual neuromuscular blockade (weakness) is a common occurrence in the postanesthesia care unit when muscle relaxant drugs have been used in the operating room.
- Trial name
- NCT01678625
- Testing
- Train-of-four ratio calculation (T4-EMG)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Endeavor Health
Neuromuscular Blockade, Residual Curarisation, Postoperative
Provider Variability in the Use of Neuromuscular Blocking Drugs and Reversal
The use of neuromuscular blocking agents during surgery is associated with postoperative respiratory complications and increased risk of readmission to the hospital following ambulatory surgery.
- Conditions
- Neuromuscular Blockade, Residual Curarisation, Postoperative, Surgery Under General Anaesthesia
- Trial name
- NCT03585348
- Testing
- Neuromuscular blocking agents
- Where
- 2 sites in United States
- Volunteers
- 265,537 people
- Sponsor
- Beth Israel Deaconess Medical Center
Postoperative Complications, Delayed Emergence From Anesthesia
EEG-based Depth of Anesthesia-monitoring, Effects on Dosage and Cognition
Depth of anesthesia-monitoring based on EEG changes demands knowledge about the effects of the different anesthetic medications on EEG waveforms.
- Conditions
- Postoperative Complications, Delayed Emergence From Anesthesia, Cognitive Dysfunction
- Trial name
- NCT04529304
- Testing
- Bilateral Bispectral Index and EEG
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Oslo University Hospital
Curarization, Postoperative Residual, Postoperative Pain Of Laparoscopic Surgery
Role of Curarization During Anesthesia for Laparoscopic Hysterectomy
The primary outcome of this study is to investigate whether deep NMB reversed with Sugammadex is superior to moderate NMB reversed with Neostigmine, in terms of overall pain in the first 48 hrs after laparoscopic hysterectomy…
- Conditions
- Curarization, Postoperative Residual, Postoperative Pain Of Laparoscopic Surgery, PONV
- Trial name
- NCT03519633
- Testing
- Sugammadex, Neostigmine
- Where
- Italy
- Volunteers
- 238 people
- Sponsor
- Campus Bio-Medico University
Thyroid Neoplasm
Comparison Between Remifentanil Target-controlled Infusion and Dexmedetomidine Bolus Administration for Smooth Emergence From General Sevoflurane Anesthesia
Remifentanil target-controlled infusion and dexmedetomidine single-dose administration are known to reduce airway response and haemodynamic stimulation during anaesthetic recovery.
- Trial name
- NCT01617694
- Testing
- dexmedetomidine, Normal Saline
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Yonsei University
Cough, General Anesthesia, Extubation, Lidocaine, Sore Throat
Nebulized Lidocaine to Prevent Cough at Emergence From Anesthesia
our study aimed to evaluate the effect of nebulized lidocaine to decrease the incidence of cough and sore throat after extubation after surgeries requiring endotracheal intubation.
- Trial name
- NCT04000633
- Testing
- Lidocaine 2%, Normal saline
- Where
- Tunisia
- Volunteers
- 80 people
- Sponsor
- Mongi Slim Hospital
Delayed Emergence From Anesthesia
General Anesthesia Emergence Induced by Methylphenidate
The purpose of this study is to assess whether methylphenidate affects time of emergence from isoflurane general anesthesia. Time to emergence was defined as the time from termination of isoflurane to extubation.
- Trial name
- MPOrtho (NCT02327195)
- Testing
- Methylphenidate HCl
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Nicoleta Stoicea
Emergence From Anesthesia, Mechanical Ventilation
Controlled Ventilation During Anesthetic Emergence
Absolutely - for a ClinicalTrials.gov-style Brief Summary, I'd keep it simple and patient-friendly like your example: The goal of this clinical trial is to learn whether maintaining controlled mechanical ventilation during…
- Trial name
- NCT07853547
- Testing
- Controlled/Full-Support Mechanical Ventilation During Emergence
- Where
- Saudi Arabia
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz Medical City
Residual Neuromuscular Blockade
Residual Neuromuscular Blockade in Pediatric Anesthesia
Residual neuromuscular blockade (RNB) is frequent and it is associated with postoperative morbidity and mortality. The incidence of the RNB in pediatric anesthesia is currently not known.
- Trial name
- REPEB (NCT02939911)
- Testing
- Residual neuromuscular blockade measurement
- Where
- Czechia
- Volunteers
- 291 people
- Sponsor
- Brno University Hospital
Residual Neuromuscular Blockade
Residual Neuromuscular Blockade in Cardiac Surgery Patients
The purpose of this project is to determine if reversal of neuromuscular blockade in cardiac surgery patients expedites time to extubation in fast track patients.
- Trial name
- NCT03574337
- Testing
- Sugammadex, neostigmine/glycopyrolate
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Neuromuscular Block
Sugammadex and Neostigmine at Shallow Neuromuscular Blockade
This study is designed to compare recovery times after reversal of a residual neuromuscular block (TOF-ratio 0.5) with different doses of either neostigmine or sugammadex.
- Trial name
- SUNDRO (NCT00895609)
- Testing
- Sugammadex, Neostigmine, Saline
- Where
- Germany
- Volunteers
- 99 people
- Sponsor
- Technical University of Munich
Neuromuscular Blockade, Neuromuscular Blockade, Residual
A Comparison of Rocuronium 0.3 mg/kg, and 0.9 mg/kg for Induction of Anesthesia in Elderly Patients.
The number of elderly patients above 80 years is increasing and a large proportion of these patients will require surgery and anesthesia.
- Conditions
- Neuromuscular Blockade, Neuromuscular Blockade, Residual, Anesthesia, Intubation Complication
- Trial name
- NCT04512313
- Testing
- Rocuronium 0,3mg/kg, Rocuronium 0,9mg/kg
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Anesthesia
Arousal Pathways and Emergence From Sedation
Emergence from sedation involves an increase in both the level of consciousness and arousal. Some insight to the neural core of consciousness was gained in the recent past.
- Trial name
- NCT02253758
- Testing
- Propofol
- Where
- 2 sites in Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Respiratory Complication
Optimal Effect-site Concentration of Remifentanil for Inhibiting Response to Laryngeal Mask Airway (LMA) Removal
This study was designed to determine the optimal dose of remifentanil that can prevent the complications associated with the removal of LMA without delaying emergence.
- Trial name
- NCT01915108
- Testing
- Remifentanil
- Volunteers
- 128 people
- Sponsor
- Sangjin Park
Airway Response
Optimal Dose of Alfentanil for Removal of Supreme Laryngeal Mask Airway During Emergence From Desflurane Anaesthesia
This study aims to determine the optimal dose of alfentanil in suppressing the airway reflexes during supreme LMA removal in anaesthetized adult.
- Trial name
- NCT01371968
- Testing
- alfentanil
- Where
- Malaysia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Extubation, Respiratory Depression
Effect of Percutaneous Electrical Acupoint Stimulation on the Improvement of Incidence of Adverse Respiratory Events
The goal of this study is to investigate the effect of combined acupoint electrical stimulation at Taiyuan (LU9) and Hegu (LI4) on improving the incidence of respiratory adverse events after extubation in patients during the…
- Conditions
- Extubation, Respiratory Depression, Acupuncture Points, Hypoxia
- Trial name
- NCT06772961
- Testing
- Transcutaneous electrical acupoint stimulation, Conventional care plan
- Where
- 2 sites in China
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University