Clinical trials: Emergencies
COVID-19
Strategies and Treatments for Respiratory Infections &Amp; Viral Emergencies (STRIVE): Immune Modulation Strategy Trial
COVID-19 can trigger a dysregulated immune response, and previous studies have shown that immune modulation can improve outcomes in hospitalized patients.
- Trial name
- NCT05822583
- Testing
- abatacept infusion
- Where
- 127 sites in United States, Australia and 17 more
- Volunteers
- 285 people
- Sponsor
- University of Minnesota
Acute Pain
Ketamine for Pain in the Emergency Department
This study will prospectively compare the mean Numerical Rating Scale (NRS) pain score reduction amongst three recommended dosing strategies of intravenous ketamine (0.1 mg/kg, 0.2 mg/kg, and 0.3mg/kg) for acute pain in the…
- Trial name
- NCT03896230
- Testing
- Ketamine Injectable Product
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Hackensack Meridian Health
Atrial Fibrillation and Flutter
Oral vs Intravenous Diltiazem for Rapid Atrial Fibrillation/Flutter Trial
The primary objective of this study is to compare the incidence of rate control (defined as: HR <110 beats/min or conversion to sinus rhythm) at 2 hours after medication administration between oral immediate release diltiazem and…
- Trial name
- OVID RAF (NCT03472495)
- Testing
- Diltiazem Oral Product, Diltiazem Injectable Product
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Virginia Commonwealth University
Headache, Migraine
Efficacy of Haloperidol vs. Metoclopramide for Treatment of Acute Headaches and Migraines in the Emergency Department
Metoclopramide (Reglan) is a common agent used for relief of headaches in the emergency department (ED).In this study the investigators seek to explore another option for treatment of headaches in the ED, one that may be more…
- Trial name
- NCT02972502
- Testing
- Metoclopramide, Haloperidol, Normal Saline
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- OhioHealth
Moderate-to-severe Acute Pain
Open-Label Safety and Efficacy of the Sufentanil Sublingual Tablet 30 mcg for Acute Pain
To evaluate the safety and efficacy of sufentanil tablet (ST) 30 mcg in the management of moderate-to-severe acute pain in patients in an emergency room (ER) setting.
- Trial name
- NCT02447848
- Testing
- sufentanil sublingual 30 mcg tablet
- Where
- 3 sites in United States
- Volunteers
- 76 people
- Sponsor
- Talphera, Inc
Headache, Pregnancy Related
Acute Headache Treatment in Pregnancy: Occipital Nerve Block vs PO Acetaminophen With Caffeine
This is an open label randomized controlled trial evaluating response to bupivacaine occipital nerve block compared to Tylenol/Caffeine cocktail in treatment of pregnant patients seeking care of headache.
- Conditions
- Headache, Pregnancy Related, Occipital Nerve Block
- Trial name
- NCT03951649
- Testing
- Occipital Nerve Block
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Hip Fractures, Analgesia
Comparison of the Efficiency of Femur Nerve Block and Intravenous Analgesia Treatment in Hip Fracture Patients
It is well-established that hip fractures impose a significant medical, socioeconomic, and financial burden. In the elderly population, the associated mortality and morbidity are particularly pronounced: within one year following…
- Conditions
- Hip Fractures, Analgesia, Femoral Nerve
- Trial name
- NCT06862154
- Testing
- IV Analgesia- Fentanyl, Femoral Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Marmara University
Lipid Disorder
EMERALD (Emergency Medicine Cardiovascular Risk Assessment for Lipid Disorders)
The EMERALD intervention involves 1) ordering an Emergency Department (ED) lipid panel, 2) calculating 10-year Atherosclerotic cardiovascular disease (ASCVD) risk using the Pooled Cohort Equations, 3) prescribing a moderate- or…
- Trial name
- EMERALD (NCT05742841)
- Testing
- moderate- or high-intensity statin/ rosuvastatin
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Wake Forest University Health Sciences
Pain
Hypertonic Saline as Therapy for Pediatric Concussion
This single center, blinded, randomized controlled trial evaluated the use of hypertonic saline versus normal saline as therapy for the symptoms of pediatric concussion post head injury.
- Trial name
- NCT01612494
- Testing
- Hypertonic Saline, Normal Saline
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Asthma
Coordinated Healthcare Interventions for Childhood Asthma Gaps in Outcomes
Chicago is an epicenter for asthma health disparities in the U.S., with African-American children 5-11 yrs bearing a disproportionate share of the burden.
- Trial name
- CHICAGO (NCT02319967)
- Testing
- CAPE, CHW home visits
- Where
- 6 sites in United States
- Volunteers
- 373 people
- Sponsor
- University of Illinois Chicago
Depression, Anxiety
Epidemiology of Depression, Anxiety, and Cognitive Impairment
Many older adults have undetected health problems and lack basic prevention measures. Failure to identify and treat these conditions can lead to unnecessary morbidity and mortality and a decreased quality of life.
- Conditions
- Depression, Anxiety, Cognitive Impairment
- Trial name
- NCT00717041
- Where
- United States
- Volunteers
- 1,206 people
- Sponsor
- University of Rochester
Pain
Effectiveness and Feasibility of Patient Controlled Analgesia in the ED
Background: Inadequate pain management is common in the Emergency Department (ED). Optimal treatment of pain necessitates titration to effective dose due to the large inter-individual variability in opioid requirement.
- Trial name
- NCT01775371
- Testing
- Patient controlled analgesia (PCA), Usual Care
- Where
- 3 sites in United States
- Volunteers
- 636 people
- Sponsor
- Albert Einstein College of Medicine
Pain
Vapocoolant (Pain Ease Medium Stream) for Intravenous Lines in Emergency Department Patients
To determine the efficacy and safety of vapocoolant stream (Pain Ease Medium Stream ) in decreasing the pain of intravenous cannulation. To compare vapocoolant stream (Pain Ease medium Stream) with control (e.g.
- Trial name
- NCT01670487
- Testing
- Vapocoolant, Sterile water
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- The Cleveland Clinic
Suicide
Ottawa Suicide Prevention in Men Pilot Study
To refine a novel intervention using a combination of a smart phone application with best practice psychotherapy for men who have presented to hospital with intentional self-harm.
- Trial name
- OSSUPilot (NCT02718248)
- Testing
- CHESS Mobile Health smart phone application, Problem solving therapy
- Where
- 2 sites in Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Melena, Gastrointestinal Hemorrhage
Comparing Early Capsule Deployment to Current Standard of Care for Management of Gastrointestinal Bleeding
The objectives of this study are to test whether there are statistically significant differences between the standard of care workup workup of non-hematemesis gastrointestinal bleeding by endoscopy [upper, lower and other tests]…
- Trial name
- EDCAP (NCT02442830)
- Testing
- Early Video Capsule Endoscopy
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Massachusetts, Worcester
Migraine Headache
Low-dose Propofol for the Treatment of Severe Refractory Migraine Headache in the Emergency Department
Migraine headache is a frequent Emergency Department complaint. While first-line Emergency Department treatment for this condition is well-established, optimal second-line treatment options are not well-defined.
- Trial name
- NCT02492295
- Testing
- Propofol
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Albert Einstein Healthcare Network
Migraine Headaches
Prochlorperazine Versus Acetaminophen, Aspirin, and Caffeine for the Treatment of Acute Migraine
The objective of this randomized, double blind study is to demonstrate that one dose oral "excedrin migraine" (acetaminophen, aspirin and caffeine) is not inferior when compared to one dose of intravenous prochlorperazine for the…
- Trial name
- Migraine (NCT01629329)
- Testing
- Aspirin, Acetaminophen, Caffeine pills, Prochlorperazine 10mg
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Albert Einstein Healthcare Network
Acute Coronary Syndrome, Chest Pain
Cost Comparison of Cardiac Magnetic Resonance Imaging (MRI) Use in Emergency Department (ED) Patients With Chest Pain
The purpose of this study is to investigate the best way to evaluate patients with chest pain in the emergency department. It compares receiving treatment in an observation unit with admission to the hospital.
- Trial name
- NCT00678639
- Testing
- Observation unit care, coupled with cardiac MRI
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Wake Forest University Health Sciences
Hip Fracture
Ultrasound Guided Pain Control Versus Standard Treatment in Emergency Department HIP Fracture Patients
Hip Fracture (HFx) is a painful injury that is often treated in the Emergency Department (ED) with intravenous opiates. However, this class of medications may cause deleterious side effects.
- Trial name
- NCT01904071
- Testing
- UFNB (Ultrasound guided femoral nerve block), UFIB (Ultrasound Guided Fascia Iliaca Compartment Block), IVMS (IV Morphine)
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Antonios Likourezos
Emergency Contraception
A Study of Use of Ella®, an Emergency Contraceptive, Under Simulated OTC Conditions
This study is designed to assess whether consumers select and use ella® (ulipristal acetate 30mg), an emergency contraceptive, in a manner consistent with the OTC package directions in an OTC-like setting.
- Trial name
- LIBRella (NCT03208985)
- Testing
- Use Phase (Ulipristal Acetate, 30 mg)
- Where
- 34 sites in United States
- Volunteers
- 1,270 people, healthy volunteers welcome
- Sponsor
- HRA Pharma