Clinical trials: Emergency Department
ED Patients With Chronic Medical Illnesses
An Emergency Department-To-Home Intervention to Improve Quality of Life and Reduce Hospital Use
The purpose of this study is to determine if assigning older, chronically ill patients a healthcare coach after they leave the Emergency Department (ED) improves their quality of life and reduces the need for hospital-based care.
- Trial name
- NCT02079987
- Testing
- ED-to-home care transition intervention, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 1,101 people
- Sponsor
- University of Florida
Angina, Unstable, Cardiovascular Diseases
IMMEDIATE Trial - Out of Hospital Administration of Glucose, Insulin and Potassium.
The purpose of this study is to test the impact of pharmacological myocardial metabolic support, in the form of intravenous (IV) glucose, insulin and potassium (GIK), for the treatment of patients with threatened or established…
- Conditions
- Angina, Unstable, Cardiovascular Diseases, Heart Diseases, Coronary Disease
- Trial name
- IMMEDIATE (NCT00091507)
- Testing
- GIK
- Where
- 13 sites in United States
- Volunteers
- 911 people
- Sponsor
- Tufts Medical Center
Abscess
Management of Skin and Soft Tissue Abscesses in Pediatric Patients After Incision and Drainage
The purpose of the study is to compare rates of cure of abscesses with and without antibiotic treatment after incision and drainage.
- Trial name
- NCT00691600
- Testing
- oral trimethoprim/sulfamethoxazole
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Baylor College of Medicine
Acute Respiratory Failure
DirEct Versus VIdeo LaryngosCopE Trial
Clinicians perform rapid sequence induction, laryngoscopy, and tracheal intubation for more than 5 million critically ill adults as a part of clinical care each year in the United States.
- Trial name
- DEVICE (NCT05239195)
- Testing
- Video Laryngoscope, Direct Laryngoscope
- Where
- 12 sites in United States
- Volunteers
- 1,420 people
- Sponsor
- Vanderbilt University Medical Center
Head Injury
Shared Decision Making in Parents of Children With Head Trauma: Head CT Choice
The investigators will test the impact of a decision aid, Head CT Choice, to determine if its use improves parents' knowledge and engagement in decision making and safely decreases healthcare utilization in children presenting to…
- Trial name
- NCT02063087
- Testing
- Head CT Decision Aid
- Where
- 7 sites in United States
- Volunteers
- 971 people
- Sponsor
- Mayo Clinic
Bronchiolitis
Heliox-Driven Racemic Epinephrine in Treatment of Bronchiolitis in Pediatric ED Patients
The purpose of this study is to assess whether children with moderate to severe bronchiolitis treated with standard racemic epinephrine therapy via 70:30 helium-oxygen (heliox) driven nebulization will have improvements in…
- Trial name
- NCT00116584
- Testing
- heliox, oxygen
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Acute Pain
Protocolized vs Nonprotocolized Treatment of Adult ED Patients With Acute Severe Pain
Patients treated with protocolized pain management (1 mg of IV hydromorphone followed by an additional 1 mg IV hydromorphone if the patient wants more) will have better pain relief and no more adverse events than patients…
- Trial name
- NCT00627367
- Testing
- Hydromorphone, Nonprotocolized
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
HIV/AIDS, PrEP
Pre-Exposure Prophylaxis in the Emergency Department
Despite an increasing armamentarium of behavioral and biomedical HIV prevention methods, since 2010 rates of new infection have remained around 40,000 annually.
- Trial name
- PrEPPED (NCT04429971)
- Testing
- PrEP screening program, PrEP starter pack
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Anxiety
Improving Sedation of Children Undergoing Procedures in the Emergency Department
Lacerations (deep cuts) are a frequent cause of visits to emergency departments and laceration repair is one of the most common procedures performed in that setting.
- Trial name
- NCT00675909
- Testing
- Aerosolized Intranasal midazolam, Aerosolized Buccal Midazolam, Oral midazolam
- Volunteers
- 180 people
- Sponsor
- Seattle Children's Hospital
Uncertainty, Communication Research
Trial of Simulation-based Mastery Learning to Communicate Diagnostic Uncertainty
The goal of this study is to teach emergency medicine resident physicians to communicate more effectively with patients at the time of emergency department discharge in the setting of diagnostic uncertainty (i.e.
- Conditions
- Uncertainty, Communication Research, Emergency Medicine
- Trial name
- NCT04021771
- Testing
- Educational Curriculum Intervention
- Where
- 2 sites in United States
- Volunteers
- 109 people
- Sponsor
- Thomas Jefferson University
Emergency Contraception
Safety and Efficacy of CDB-2914 for Emergency Contraception
The purpose of this study is to assess the safety and efficacy of CDB-2914 for preventing pregnancy when taken 3 to 5 days after unprotected sexual intercourse.
- Trial name
- NCT00411684
- Testing
- CDB-2914
- Where
- 17 sites in United States
- Volunteers
- 1,623 people
- Sponsor
- HRA Pharma
Contraception
Safety and Efficacy of CDB-2914 in Comparison to Levonorgestrel for Emergency Contraception
The purpose of this study is to assess the safety and efficacy of CDB-2914 in comparison to levonorgestrel for preventing pregnancy up to 5 days after unprotected sexual intercourse.
- Trial name
- NCT00551616
- Testing
- CDB-2914, Levonorgestrel
- Where
- 33 sites in United States, Ireland and 1 more
- Volunteers
- 2,221 people
- Sponsor
- HRA Pharma
Severe Sepsis, Septic Shock
Minimally-Invasive Cardiovascular Hemodynamic Optimization (MiCHO) Versus Early Goal-Directed Therapy (EGDT) in the Management of Septic Shock
Early intervention in the treatment of septic shock, including early goal-directed therapy (EGDT) in the first 6 hours of disease presentation, has been shown to significantly decrease mortality.
- Trial name
- MiCHO (NCT00535821)
- Testing
- Esophageal Doppler monitoring - CardioQ, Deltex Inc, Central line with CVP and continuous ScvO2 monitoring
- Where
- 4 sites in United States
- Volunteers
- 5 people
- Sponsor
- Loma Linda University
HIV Infections
HIV Screening in the Emergency Department Setting
Late diagnosis of HIV infection is believed to be responsible for high rates of HIV transmission. The purpose of this study is to determine whether targeted screening versus routine screening will identify a greater number of HIV…
- Trial name
- NCT00667186
- Testing
- Targeted Screening, Routine Screening
- Where
- United States
- Volunteers
- 9,572 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Asthma
Use of Dexamethasone in Pediatric Asthma Exacerbations
The purpose of this study is to compare the efficacy of a single dose of dexamethasone vs. two doses of dexamethasone in mild and moderate asthma exacerbations pediatric patients.
- Trial name
- NCT02192827
- Testing
- Dexamethasone Sodium Phosphate Injection
- Where
- United States
- Volunteers
- 318 people
- Sponsor
- University at Buffalo
Hemorrhage
CU Programme of Idarucizumab for Japanese Patients
The objective is to collect the safety data of idarucizumab for patients treated with dabigatran who require rapid reversal of the anticoagulant effects of dabigatran in cases of uncontrolled or life-threatening bleeding or when…
- Trial name
- NCT02831660
- Testing
- idarucizumab
- Where
- Japan
- Volunteers
- 1 people
- Sponsor
- Boehringer Ingelheim
Pyelonephritis Acute
Patient-Directed Antimicrobial Duration in Acute Uncomplicated Pyelonephritis
This pilot study will randomize 40 female patients with acute uncomplicated pyelonephritis to receive standard duration of therapy versus patient-directed antimicrobial duration (PDAD).
- Trial name
- NCT06127160
- Testing
- Cephalexin
- Where
- 2 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Brett A Faine
Lacerations
Study to Show Equivalence of DERMABOND PROTAPE to DERMABOND HVD for Wound Closure
This is a multicenter, prospective, randomized controlled study for the purpose of comparing DERMABOND PROTAPE to DERMABOND HVD for closure of wounds in the Emergency Department.
- Trial name
- NCT00547638
- Testing
- cyanoacrylate with pressure sensitive mesh, cyanoacrylate
- Where
- 9 sites in United States
- Volunteers
- 216 people
- Sponsor
- Ethicon, Inc.
Acute Pain, Fractures
Comparing Ketamine and Morphine in the Treatment of Acute Fracture Pain
Opioid pain medications such as morphine and dilaudid are commonly used in emergency departments to treat pain in patients. Physicians are familiar with the side effects of these medications; the most concerning of which is…
- Trial name
- NCT02430818
- Testing
- ketamine, morphine
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Pain, Acute
Adult Oral Ibuprofen Study for ED Pain Patients
Ibuprofen is one of the most widely used non-steroidal anti-inflammatory drug (NSAID) for management of mild -to moderate pain in the ED (acute musculo-skeletal pain, headache, dental pain).
- Trial name
- NCT03441269
- Testing
- Oral Ibuprofen
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Antonios Likourezos