Clinical trials: Emergency Patients
Hip Fracture
Ultrasound Guided Pain Control Versus Standard Treatment in Emergency Department HIP Fracture Patients
Hip Fracture (HFx) is a painful injury that is often treated in the Emergency Department (ED) with intravenous opiates. However, this class of medications may cause deleterious side effects.
- Trial name
- NCT01904071
- Testing
- UFNB (Ultrasound guided femoral nerve block), UFIB (Ultrasound Guided Fascia Iliaca Compartment Block), IVMS (IV Morphine)
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Antonios Likourezos
Drug Interactions
Emergency Department (ED) Drug Interaction in Emergency Department Patients
This study examines how hepatic cytochrome CYP2D6 drug interactions affects the efficacy of oxycodone, hydrocodone, and ondansetron in Emergency Department (ED) patients.
- Trial name
- NCT01859715
- Testing
- Oxycodone, Hydrocodone, Ondansetron
- Where
- United States
- Volunteers
- 502 people
- Sponsor
- University of Colorado, Denver
Psychiatric Emergency, Aggression
TREC-Lebanon: A Trial for Rapid Tranquilisation for Agitated Patients in the Emergency Setting
This is a randomised controlled trial comparing haloperidol + promethazine versus haloperidol + promethazine + chlorpromazine for agitated patients in the emergency department.
- Conditions
- Psychiatric Emergency, Aggression, Agitation
- Trial name
- TREC (NCT03639558)
- Testing
- Haloperidol + Promethazine + Chlorpromazine, Haloperidol + Promethazine
- Where
- 2 sites in Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Joseph Dib
Advanced Cancer, Hematologic Malignancy
Fatigue in Emergency Center Patients
1. To describe fatigue severity and its related symptom clusters in cancer patients who are seeking emergency care for fever, pain, shortness of breath, or cancer therapy-related gastrointestinal toxicities. 2.
- Conditions
- Advanced Cancer, Hematologic Malignancy, Fatigue
- Trial name
- NCT00504985
- Testing
- Surveys
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- M.D. Anderson Cancer Center
Stroke (CVA) or TIA, Diabetes
Risk Factors, Costs, and Impacts of ED Boarding
The goal of this observational study is to learn about the risk factors, costs, and operational impacts of emergency department boarding (patients admitted to the hospital but remaining in the emergency department awaiting…
- Conditions
- Stroke (CVA) or TIA, Diabetes, Asthma (Diagnosis), COPD (Chronic Obstructive Pulmonary Disease)
- Trial name
- NCT07532564
- Where
- United States
- Volunteers
- 30,486 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Pain
An Efficacy and Safety of Proprietary Formulations of Oral Ketamine + Aspirin in Treatment of Acute Headache
Headaches affect over 50% of patients annually, with close to 4% of ED visits for headache. Most headaches managed in the ED are benign, with 90% of these headaches classified as tension, migraine, or cluster.
- Trial name
- NCT04860713
- Testing
- aspirin and ketamine, Nurtec (Rimegepant)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Antonios Likourezos
Shortness of Breath Episode, Tachycardia
Verification of Prediction Algorithm
Prospective observational clinical study to verify an algorithm used to predict cardiopulmonary events in patients presenting to the emergency department.
- Conditions
- Shortness of Breath Episode, Tachycardia, Bradycardia, Difficulty Breathing
- Trial name
- VPAC (NCT02863666)
- Where
- 3 sites in United States, Belgium
- Volunteers
- 673 people
- Sponsor
- Zoll Medical Corporation
Sickle Cell Disease
Comparing Acute Pain Management Protocols for Patients With Sickle Cell Disease
The goal of this pilot study is to improve emergency department (ED) pain management for adults with sickle cell disease. Sickle cell disease (SCD) is the most common genetic disorder in the United States, and occurs primarily…
- Trial name
- NCT02222246
- Testing
- Hydromorphone (Standardized, weight-based dosing), Morphine Sulfate (Standardized, weight-based dosing), Hydromorphone (Patient Specific dosing)
- Where
- 2 sites in United States
- Volunteers
- 106 people
- Sponsor
- Duke University
Kidney Stone
Effect of Tamsulosin on Stone Expulsion and Pain Resolution in ED Patients With Ureterolithiasis
Tamsulosin (Flowmax)is approved by the FDA for the treatment for enlarged prostate. Several studies regarding the use of Tamsulosin for the treatment of lower kidney stones have been carried out in the non-Emergency Department…
- Trial name
- Flowmax (NCT00762424)
- Testing
- Flowmax
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- WellSpan Health
Opioid-use Disorder
Emergency Department Outcomes for Patients With Opioid Use Disorder
Using mixed methods and triangulating multiples sources of data collected over the course of the parent (CTN-0079 - NCT03544112) and the ancillary studies to evaluate the feasibility, acceptability, sustainability and impact of…
- Trial name
- NCT04289363
- Testing
- Clinical program implementation
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- NYU Langone Health
COVID-19
Hyperbaric Oxygen for COVID-19 Patients
Hyperbaric oxygen therapy (HBOT) treatment will be provided to patients as an adjunct to standard therapy for a cohort of 40 COVID19-positive patients with respiratory distress at NYU Winthrop Hospital.
- Trial name
- NCT04332081
- Testing
- hyperbaric oxygen therapy (HBOT)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- NYU Langone Health
Nervous System Diseases
Open-label Study of Midazolam Hydrochloride Oromucosal Solution (MHOS/SHP615) in Children With Status Epilepticus (Convulsive) in a Healthcare Setting in Japan
The purpose of this study is to assess the efficacy, safety and pharmacokinetics of MHOS/SHP615 administered buccally in children with status epilepticus (convulsive) in a healthcare setting.
- Trial name
- NCT03336645
- Testing
- SHP615
- Where
- 23 sites in Japan
- Volunteers
- 25 people
- Sponsor
- Shire
Diabetes Mellitus
Harnessing mHealth and Social Support to Improve Diabetes Related Health Behavior for Inner-city Patients
In this study, an existing mobile health intervention to improve diabetes self-management will be combined with a social support module and tested for feasibility.
- Trial name
- TExTMEDFANS (NCT01945996)
- Testing
- TExT MED, FANS
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Southern California
Acute Kidney Injury, Pulmonary Embolism
Acute Kidney Injury in Patients Undergoing Contrast Exposure: VQ vs. CT
Both, CT scans and VQ scans, are used by doctors to look for pulmonary embolism. The most common reason to order a VQ scan is to avoid the IV dye.
- Conditions
- Acute Kidney Injury, Pulmonary Embolism, Contrast-induced Nephropathy
- Trial name
- VQ/CT (NCT03116139)
- Testing
- V/Q imaging, Computed tomography scan
- Where
- 5 sites in United States
- Volunteers
- 253 people
- Sponsor
- Indiana University
Presyncope, Arrhythmias, Cardiac
The IPED (Investigation of Palpitations in the ED) Study
Palpitations (noticeable pounding, fluttering or irregular heart beat) and pre-syncope (near blackout) are common ED problems sometimes due to an abnormal cardiac rhythm.
- Conditions
- Presyncope, Arrhythmias, Cardiac, Tachycardia, Supraventricular, Atrial Fibrillation
- Trial name
- IPED (NCT02783898)
- Testing
- AliveCor Heart Monitor
- Where
- 10 sites in United Kingdom
- Volunteers
- 243 people
- Sponsor
- NHS Lothian
Acute Severe Pain
Titration of Intravenous Hydromorphone
This is an exploratory, hypothesis-generating safety and efficacy study for patients who come to the ER in acute (less than 7 days in duration) severe pain. Patients with chronic pain will not be enrolled.
- Trial name
- NCT01892709
- Testing
- Hydromorphone
- Where
- United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Fall Patients, Delirium
Implementation of Multidisciplinary Assessments for Geriatric Patients in an ED Observation Unit
This project will implement a 2 step protocol for multidisciplinary geriatric assessment in the Emergency Department (ED). Candidate: Dr.
- Conditions
- Fall Patients, Delirium, Quality of Life, Functional Status
- Trial name
- IMAGE (NCT04068311)
- Testing
- Geriatric Screening tools
- Where
- United States
- Volunteers
- 373 people
- Sponsor
- Ohio State University
Fentanyl, Platelet Reactivity
Platelet Reactivity With Fentanyl, Morphine, or no Narcotic
The goal is to determine whether fentanyl and morphine have similar effects in reducing aspirin's effect upon platelets in emergency department patients with chest discomfort.
- Trial name
- NCT05367336
- Testing
- Morphine, Fentanyl
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Corewell Health South
Pain, Pain, Acute
Pawsitive Impacts of Therapy Dog Visits
The goal of this unique 18 month study is to better understand the experiences of pain patients in the Royal University Hospital (RUH) Emergency Department (ED), to create excellence in health care.
- Conditions
- Pain, Pain, Acute, Pain, Chronic, Pain, Intractable
- Trial name
- NCT04727749
- Testing
- Therapy Dog Team Visit
- Where
- Canada
- Volunteers
- 211 people
- Sponsor
- University of Saskatchewan
Hypertension, Emergencies
The Effect of Pre-discharge Blood Pressure of Patients With Asymptomatic Severe Hypertension in Emergency Department
The current guideline of asymptomatic severe hypertension (ASH) treatment in emergency department (ED) recommends through low level of evidence that the patients should not be rapidly decreased their BP in ED but instead receive…
- Conditions
- Hypertension, Emergencies, Asymptomatic Conditions
- Trial name
- NCT02534324
- Testing
- Antihypertensive meds
- Where
- Thailand
- Volunteers
- 146 people
- Sponsor
- Chulalongkorn University