Clinical trials: Emergency Treatment
Sepsis
Assessment of Disease Severity, Progression and Treatment in Infected Patients Presenting to the Emergency Department
The results of the SIDED study (doi: 10.1186 / s13054-019-2329-5) showed that MR-proADM can be a good biomarker to establish the prognosis of patients attended in the emergency department (ED) due to suspected infection.
- Trial name
- ADAPTED (NCT03992794)
- Testing
- Measurement of MR-proADM
- Where
- 3 sites in Spain
- Volunteers
- 684 people
- Sponsor
- Juan González-del Castillo
Pain
An Efficacy and Safety of Proprietary Formulations of Oral Ketamine + Aspirin in Treatment of Acute Headache
Headaches affect over 50% of patients annually, with close to 4% of ED visits for headache. Most headaches managed in the ED are benign, with 90% of these headaches classified as tension, migraine, or cluster.
- Trial name
- NCT04860713
- Testing
- aspirin and ketamine, Nurtec (Rimegepant)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Antonios Likourezos
Chronic Back Pain, Degenerative Disc Disease Lumbar
CELZ-201-DDT for the Treatment of Chronic Lower Back Pain
CELZ-201-DDT is an investigational (experimental) cell therapy currently being studied for people with degenerative disc disease who have chronic lower back pain.
- Trial name
- ADAPT (NCT07137559)
- Testing
- CELZ-201-DDT
- Sponsor
- Creative Medical Technology Holdings Inc
Cocaine Intoxication
An Open-Label, Randomized Pilot Study Comparing the Safety of a Single Dose of TNX-1300 to Usual Care (UC) Alone for the Treatment of Signs and Symptoms of Acute Cocaine Intoxication in Male Emergency Department (ED) Subjects
An Open-Label, Randomized Pilot Study Comparing the Safety of a Single Dose of TNX-1300 to Usual Care (UC) Alone for the Treatment of Signs and Symptoms of Acute Cocaine Intoxication in Male Emergency Department (ED) Subjects
- Trial name
- NCT04996056
- Testing
- TNX-1300, Usual Care
- Where
- 2 sites in United States
- Sponsor
- Tonix Pharmaceuticals, Inc.
Covid19
World Health Organization (WHO) COVID-19 Solidarity Trial for COVID-19 Treatments
In early 2020 there were no approved anti-viral treatments for COVID19 Infection. The SOLIDARITY trial is a multicentre adaptive international randomised trial sponsored by Word Health Organization to determine the efficacy of…
- Trial name
- SOLIDARITY (NCT04647669)
- Testing
- Remdesivir, Acalabrutinib, Interferon beta-1a
- Where
- Jamaica
- Volunteers
- 100 people
- Sponsor
- The University of The West Indies
Stroke
The Effect of Implementing Hyper-acute Stroke Guidelines on Decision-Making for or Against Thrombolytic Therapy for Stroke in the Emergency Department
The objective of this study is to determine if the implementation of guidelines utilizing immediate CT Perfusion and CT Angiography in addition to non-contrast CT alters (reduces or increases) the time to decision-making for or…
- Trial name
- NCT01050049
- Where
- United States
- Sponsor
- Temple University
Myocardial Infarction
Feedback Intervention and Treatment Times in ST- Elevation Myocardial Infarction
Part I (Pilot Phase): The purpose of this study is to examine if formalized data assessment and systematic feedback improves treatment times (i.e.
- Trial name
- FITT-STEMI (NCT00794001)
- Testing
- Data analysis and Feedback
- Where
- Germany
- Volunteers
- 50,000 people
- Sponsor
- Karl Heinrich Scholz
Traumatic Brain Injury
Role of Combined Therapy of Propranolol and Gabapentin in Paroxysmal Sympathetic Hyperactivity in Traumatic Brain Injury
Paroxysmal sympathetic hyperactivity (PSH) is a syndrome that comprises a series of signs and symptoms reflecting exacerbated sympathetic activity, including arterial hypertension, fever, tachycardia, generalized perspiration…
- Trial name
- NCT05427474
- Testing
- Propranolol , gabapentin
- Where
- 2 sites in Egypt
- Volunteers
- 90 people
- Sponsor
- Zagazig University
End-of-life Care, Palliative Care
Prehospital Care of End-of-Life Patients by the Strasbourg Mobile Emergency and Resuscitation Service: A Qualitative Study of Healthcare Professionals' Experiences and Use of a Comfort Care Booklet
Prehospital end-of-life care presents complex clinical, ethical, relational, and organizational challenges for healthcare professionals working in the Strasbourg Mobile Emergency and Resuscitation Service (SMUR).
- Conditions
- End-of-life Care, Palliative Care, Prehospital Emergency Care, Healthcare Professionals' Experiences and Perceptions
- Trial name
- PALLI-SMUR1 (NCT07895940)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Acute Coronary Syndrome, Factor X
Comparison of Anti-Xa Activity of ENOXA ® Versus LOVENOX ® in Acute Coronary Syndrome
This study is a clinical trial monocentric, open, randomized ENOXA ® versus LOVENOX ®, conducted on two parallel groups of patients admitted in emergency for acute coronary syndrome.
- Trial name
- AXA (NCT01687491)
- Testing
- ENOXA®, LOVENOX®
- Where
- Tunisia
- Volunteers
- 179 people
- Sponsor
- Les Laboratoires des Médicaments Stériles
Supraventricular Tachycardia
Double-syringe vs Single-syringe Technique of Adenosine for Termination of Regular Narrow Complex Tachycardia
Adenosine has been discovered since 1929 and used in the acute treatment of arrhythmias. It uses as a therapeutic diagnosis in patients with regular narrow QRS complex tachyarrhythmias.
- Trial name
- NCT05022290
- Testing
- Single-syringe diluted with normal saline technique
- Where
- Thailand
- Volunteers
- 300 people
- Sponsor
- Khon Kaen University
Chronic Kidney Disease, Cardiovascular Diseases
SEDentary Lifestyle, Mortality and Major Adverse Clinical Outcomes in Chronic KIDney Disease
The goal of this study is to learn if a simple home exercise program can benefit patients with advanced chronic kidney disease. There is also an observational part of the study without an exercise program.
- Conditions
- Chronic Kidney Disease, Cardiovascular Diseases, Frailty
- Trial name
- SEDKID (NCT06935786)
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- 3 sites in Finland
- Volunteers
- 400 people
- Sponsor
- Turku University Hospital
Sepsis, Severe Sepsis
Protocolized Care for Early Septic Shock
The ProCESS study is large, 5-year, multicenter study of alternative resuscitation strategies for septic shock. The study hypothesizes that there are "golden hours" in the initial management of septic shock where prompt…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- ProCESS (NCT00510835)
- Testing
- Early Goal Directed Therapy (EGDT), Protocolized Standard Care (PSC), Usual Care (UC)
- Where
- 31 sites in United States
- Volunteers
- 1,351 people
- Sponsor
- University of Pittsburgh
Hypotension
Efficacy Study of a Facemask Device to Treat Hypotension
The purpose of this study is to determine if the impedance threshold device (ITD) attached to a facemask can increase blood pressure in patients who present to the emergency department with hypotension secondary to hypovolemia.
- Trial name
- NCT00256724
- Testing
- Impedance Threshold Device
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Advanced Circulatory Systems
Advance Care Planning
Evaluating the Integration of the Recommended Summary Plan for Emergency Care Treatment (ReSPECT) Into Primary Care
When a person becomes seriously ill health professionals treating them need to make decisions quickly. They may have limited information about the person's medical history or about their wishes about treatment.
- Trial name
- NCT05046197
- Where
- United Kingdom
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- University of Warwick
Suicidal Ideation, Emergency Psychiatric
Treatment of Suicidal Ideation in the Emergency Department Using Nitrous Oxide
Suicide prevention is a major public health concern, with nearly 9,000 suicides and over 200,000 suicide attempts reported each year in France.
- Conditions
- Suicidal Ideation, Emergency Psychiatric, Nitrous Oxide
- Trial name
- PROTORISC (NCT06430489)
- Testing
- Nitrous oxide, Medical air
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Tours
Asthma
Breath-Actuated Nebulizer Versus Conventional Continuous-Output Nebulizer in Pediatric Asthma Patients
A Breath-Actuated Nebulizer is a newer type of nebulizer device that creates aerosol only when a patient is inhaling, rather than creating aerosol continuously.
- Trial name
- NCT01045174
- Testing
- Nebulizer (breath-actuated versus conventional continuous-output)
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University Hospitals Cleveland Medical Center