Clinical trials: Emotional Depression
Depression, Anxiety
Study of a PST-Trained Voice-Enabled Artificial Intelligence Counselor (SPEAC) for Adults With Emotional Distress (Phase 1)
In the phase 1 of the SPEAC project the specific aims are to: (1) establish the functionality, usability, and treatment fidelity of Lumen using iterative, user-centered design, development, and formative evaluation; and (2)…
- Trial name
- SPEAC (NCT04524104)
- Testing
- Lumen Treatment
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- University of Illinois at Chicago
Depression
Fevarin® Effectiveness in Treatment of Depression in Patients With Neurological Disorder
Prospective, multicenter, non-comparative, observational program to describe prevalence of depressive symptoms in a variety of neurological disorders and effects of Fevarin® on the severity of anxiety and depression, sleep state…
- Trial name
- FRIENDS (NCT02043197)
- Where
- 29 sites in Russia
- Volunteers
- 300 people
- Sponsor
- Abbott
Depressive Symptoms
A Systems-Level Intervention for Rural Adults With Depression
This study aims to test the effectiveness of a computer-assisted cognitive behavioral therapy for depression among rural adults.
- Trial name
- NCT04502186
- Testing
- Raising Our Spirits Together, Enhanced Control Condition
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- University of Michigan
PTSD, Depression
Synchronized Transcranial Magnetic Stimulation for PTSD
The investigators propose a small, two-site, sham-controlled pilot study of synchronized Transcranial Magnetic Stimulation (sTMS) in patients with comorbid post-traumatic stress disorder (PTSD) and depression.
- Trial name
- sTMS (NCT02981381)
- Testing
- NEST-1, NEST-2
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Providence VA Medical Center
Stress, Psychological Stress
Examine the Effects of Meditation on Daily Psychological Stress Responses in Woman With a History of Child Adversity
The aim of the Everyday Moments of Mindfulness (EMMI) study is to test whether brief mindfulness-based practices will improve daily psychological stress responses in women (age 30-60) who report a history of early life adversity.
- Conditions
- Stress, Psychological Stress, Child Maltreatment, Depressive Symptoms
- Trial name
- EMMI (NCT04606199)
- Testing
- Mindfulness-based intervention, up to 5 minutes 0-3 times/day
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Respiratory Insufficiency, Depression
Behavioral Activation-Rehabilitation to Improve Depressive Symptoms & Physical Function After Acute Respiratory Failure
More and more people are surviving after receiving life support for respiratory failure in the intensive care unit, but these patients often experience problems with depression and physical functioning that lead to reduced…
- Conditions
- Respiratory Insufficiency, Depression, Rehabilitation, Critical Care
- Trial name
- BEHAB (NCT03431493)
- Testing
- Behavioral Activation - Rehabilitation
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Johns Hopkins University
Spinal Cord Injury
Treatment of Mild to Moderate Depression Symptoms in Patients With Spinal Cord Injury
This study was initially designed to test the efficacy of Venlafaxine HCl in reducing incidence of the onset of major depression after a new spinal cord injury (SCI).
- Trial name
- NCT00735670
- Testing
- Venlafaxine HCl
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Michigan
Anxiety, Depressive Symptoms
Stepped-Care Telehealth for Distress in Cancer Survivors
Mental health issues in post-treatment adult cancer survivors are associated with multiple adverse outcomes and may represent a cancer health disparity for rural survivors.
- Conditions
- Anxiety, Depressive Symptoms, Sleep Disturbance, Recurrent Disease
- Trial name
- Telehealth (NCT03060096)
- Testing
- Severe Anxiety/depression: High Intensity Stepped Care, Moderate Anxiety/depression: Low Intensity Stepped care, Enhanced Usual Care Control
- Where
- 166 sites in United States
- Volunteers
- 68 people
- Sponsor
- Wake Forest University Health Sciences
Chronic Obstructive Pulmonary Disease, Depression
The Effect on Depressive Symptoms in ECF Residents With COPD
The purpose of this study is to assess the effect of treatment with Advair Diskus on depression using the Cornell depression scale in COPD patients in the nursing home.
- Trial name
- DISK-02 (NCT00974246)
- Testing
- Advair diskus
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Valley Medical Research
Burnout, Caregiver, Burnout, Professional
Frontline Clinician Psilocybin Study
This study aims to investigate the effects of a single dose of psilocybin, delivered in the contextof pre- and post-dose psychotherapy, on symptoms of depression and burnout suffered by healthcare clinicians as a result of…
- Conditions
- Burnout, Caregiver, Burnout, Professional, COVID-19, Depression
- Trial name
- NCT05163496
- Testing
- Psilocybin (Usona Institute)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Washington
Depression, Anxiety
Community Study of Outcome Monitoring for Emotional Disorders in Teens
This study is being done to compare three types of talk therapies for youth who struggle with emotional and behavioral problems (e.g., anxiety, sadness, worries) in Community Mental Health Clinics in Connecticut (CT) and Florida…
- Trial name
- COMET (NCT02567266)
- Testing
- Unified Protocol for Adolescents (UP-A), Youth Outcomes Questionnaire, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 196 people
- Sponsor
- University of Miami
Depressive Symptoms, Aging
ABSORB (Amount of Blueberries So Older Adults Reap Benefits)
This randomized, cross-over, pilot study aims to compare preliminary impact of a standard dose of blueberry powder (24 g) vs a higher dose (48 g) on the bioavailability of flavonoids and inflammatory biomarkers in older adults…
- Trial name
- NCT05937165
- Testing
- Freeze-dried Blueberry Powder
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Hebrew SeniorLife
Depressive Disorder, Major
A Study in People With Depression to Test the Effects of BI 1358894 on Parts of the Brain That Are Involved in Emotions
To assess the effect of a single dose of BI 1358894 compared to placebo on BOLD responses in modulating brain processing of emotional and cognitive stimuli on the amygdala and related brain structure using fMRI in in unmedicated…
- Trial name
- NCT03854578
- Testing
- BI 1358894, Citalopram
- Where
- Germany
- Volunteers
- 73 people
- Sponsor
- Boehringer Ingelheim
Insomnia, Rumination
Reduce Emotional Symptoms of Insomnia With SleepTreatment
The purpose of this research is to test whether Mindfulness-Based Therapy for Insomnia (MBTI) significantly reduces symptoms of insomnia and cognitive arousal in patients with treatment-resistant insomnia.
- Trial name
- RESIST (NCT03724305)
- Testing
- Mindfulness-Based Therapy for Insomnia
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Henry Ford Health System
Depression, Depressive Disorder
Study to Evaluate TNX-601 ER Monotherapy Versus Placebo in Patients With Major Depressive Disorder (MDD)
This is a Phase 2, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy, safety, and tolerability of TNX-601 ER monotherapy versus placebo in patients with Major Depressive Disorder (MDD).
- Conditions
- Depression, Depressive Disorder, Depressive Symptoms, Depressive Disorder, Major
- Trial name
- UPLIFT (NCT05686408)
- Testing
- TNX-601 ER
- Where
- 27 sites in United States
- Volunteers
- 132 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Diabetes, Depression
HOPE Pilot for Veterans With Complex Diabetes
The purpose of this study is to determine if behavioral health coaching for rural veterans with diabetes and depression will improve self-management behaviors and lead to improvement in diabetes care outcomes (e.g., HA1C) and…
- Trial name
- HOPE (NCT01274715)
- Testing
- Behavioral Health Coaching
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Michael E. DeBakey VA Medical Center
Parkinson Disease
Survey on PD Patients With Depressive Symptoms
The primary objective of this investigation is to conduct a 12-week prospective survey in PD patients with depressive symptoms treated with BI Sifrol Tablets (hereinafter referred to as this drug) in the routine clinical settings…
- Trial name
- NCT00614575
- Where
- 238 sites in Japan
- Volunteers
- 1,089 people
- Sponsor
- Boehringer Ingelheim
Major Depression
Study of Brain Response to Emotional Pictures Using a fMRI While on Duloxetine
The purpose of this study is to find out what parts of the brain have increased or decreased activity when people are depressed and how antidepressant medicine changes this activity in depressed patients.
- Trial name
- NCT00532480
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Indiana University
Dementia, Depression
Testing the Feasibility of the Individualized Positive Psychosocial Intervention (IPPI)
The goal of this clinical trial is to test the feasibility of the Individualized Positive Psychosocial Interaction (IPPI) with 108 nursing home residents living with dementia and distress or depressive symptoms.
- Conditions
- Dementia, Depression, Behavior
- Trial name
- IPPI (NCT05980299)
- Testing
- Individualized Positive Psychosocial Interaction
- Where
- 7 sites in United States
- Volunteers
- 200 people
- Sponsor
- Miami University
Cardiovascular Diseases, Acute Coronary Syndrome
MBCT Via Group Videoconferencing for Acute Coronary Syndrome Patients With Depressive Symptoms: A Pilot RCT
The aim of this study is to establish, in a pilot RCT (approx. N=50 participants) with a time- and attention-matched health enhancement control, (a) the feasibility of the recruitment procedures (screening, eligibility…
- Conditions
- Cardiovascular Diseases, Acute Coronary Syndrome, Depression
- Trial name
- NCT04799899
- Testing
- Adapted MBCT, Cardiac Health Enhancement
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Massachusetts General Hospital