Clinical trials: Emotional Distress
Malignant Hepatobiliary Neoplasm
Acceptance and Commitment Therapy for the Improvement of Cancer Distress in Patients With Incurable Cancers, ACT-C Trial
This clinical trial studies whether Acceptance and Commitment Therapy can be used to help improve cancer distress for patients with hepatobiliary or breast cancers for which no treatment is currently available (incurable).
- Trial name
- NCT07124546
- Testing
- Acceptance and Commitment Therapy, Questionnaire Administration, Telemedicine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Malignant Melanoma
Quality of Life and Psychological Well-being in Patients With Malignant Melanoma
The purpose of this study is to analyse the physical and psychological side-effects in the course of treatment with IFN-alpha. The effectiveness of a specific intervention for the management of these side-effects is evaluated.
- Trial name
- NCT00963261
- Testing
- psycho-oncological intervention
- Where
- 2 sites in Germany
- Volunteers
- 600 people
- Sponsor
- University Hospital Freiburg
Psychological Distress
Ensemble Programme an Early Intervention for Informal Caregivers of Psychiatric Patients
This study focuses on the difficulties of maintaining optimal psychological health and quality of life for caregivers in adult psychiatry while they play an important role in helping patients with severe psychiatric disorders.
- Trial name
- Ensemble (NCT04020497)
- Testing
- Ensemble programme, SAU
- Where
- Switzerland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Institut et Haute Ecole de la Santé la Source
Post Traumatic Stress Disorder (PTSD), Depression
Type I Hybrid Effectiveness-Implementation Trial of Primary Care Brief Mindfulness Training for Veterans
The VA wants to understand what type of integrative and whole health approaches are helpful for Veterans. The study is comparing two primary care based mental health treatments, a mindfulness class that teaches mindfulness…
- Conditions
- Post Traumatic Stress Disorder (PTSD), Depression, Anxiety
- Trial name
- NCT06162741
- Testing
- Primary Care Brief Mindfulness Training (PCBMT), Moving Forward (MF)
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- VA Office of Research and Development
Suicide and Depression, Psychological Distress
Preventing Psychological Distress and Suicidal Behaviours: a Web-based and Mobile Suicide Prevention Intervention in the General Population
An interventional research study will be undertaken to assess the effectiveness of the promotion at the local level of an e-health tool for suicide and psychological distress prevention (the StopBlues application and website).
- Conditions
- Suicide and Depression, Psychological Distress, Anxiety Disorders, Local Authorities Promotion
- Trial name
- PRINTEMPS (NCT03565562)
- Testing
- Promotion of the e-health tool by local authorities, Promotion of the e-health tool by local authorities and GPs
- Where
- France
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Respiratory Insufficiency
Pathophysiology of Gas Exchange and Time Course Changes in Spontaneously Breathing Patients With Acute Respiratory Failure Due to COVID-19. A Multicenter Prospective Study.
The pathophysiology of SARS-COV-2 related respiratory disease is still poorly understood, especially in its most severe form called acute respiratory distress syndrome (ARDS).
- Trial name
- COVAQ (NCT05392062)
- Testing
- Pathophysiology of gas exchange
- Where
- France
- Volunteers
- 59 people
- Sponsor
- CHU de Reims
Moral Injury, Moral Distress
A Study of Moral Distress, Moral Injury and Post-Traumatic Stress for Nurses
The goal of this descriptive study is to examine levels of moral distress (MD), moral injury (MI), \& post-traumatic stress (PTS) levels among nursing staff at Mayo Clinic. The main questions this study aims to answer are: 1.
- Conditions
- Moral Injury, Moral Distress, Post-Traumatic Stress, Nurse Well-being
- Trial name
- MDMIPTS (NCT07455370)
- Testing
- Surveys
- Where
- 3 sites in United States
- Volunteers
- 21,300 people
- Sponsor
- Mayo Clinic
Intensive Care Neurological Disorder
Patient and Caregiver Psychological Functioning Following Neuro-ICU Admission: A Prospective Investigation
The current study has the following objectives: 1. To determine predictors of time 2 and 3 (3 and 6 months post-ICU admission) depression, PTSD, satisfaction with life and quality of life in both patients and caregivers, after…
- Trial name
- NCT02435641
- Testing
- Questionnaires
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Psychological Distress
Practice-Based Evidence in Psychotherapy in Ecuador
This is a naturalistic study implementing a routine outcome monitoring system to track clients' change and outcomes at the Centro de Psicología Aplicada (CPA) of the Universidad de Las Américas in Quito, Ecuador
- Trial name
- NCT05343741
- Testing
- Psychological Intervention
- Where
- Ecuador
- Volunteers
- 340 people
- Sponsor
- Universidad de las Americas - Quito
Acute Respiratory Distress Syndrome (ARDS)
Pirfenidone to Prevent Fibrosis in Ards.
Acute respiratory distress syndrome (ARDS) is a severe form of acute lung injury and a major cause of Intensive Care Unit (ICU) admission worldwide.
- Trial name
- PIONEER (NCT05075161)
- Testing
- Pirfenidone
- Where
- 17 sites in Italy, Kazakhstan
- Volunteers
- 130 people
- Sponsor
- Università Vita-Salute San Raffaele
Cancer, Distress, Emotional
Cognitive Trance, Hypnosis and Meditation in Oncology
Patients with cancer often suffer from a symptom cluster, including pain, fatigue, sleep difficulties, emotional distress and cognitive impairments.
- Conditions
- Cancer, Distress, Emotional, Pain, Fatigue
- Trial name
- NCT04873661
- Testing
- Hypnosis group intervention, Cognitive trance group intervention, Meditation group intervention
- Where
- Belgium
- Volunteers
- 160 people
- Sponsor
- University of Liege
Acute Respiratory Distress Syndrome, Barotrauma
Laboratory Biomarkers and Pulmonary Interstitial Emphysema in ARDS (PIE-ARDS)
Barotrauma (pneumothorax, pneumomediastinum) is a well-described complication of Acute Respiratory Distress Syndrome (ARDS), especially in patients with coronavirus disease 2019 (COVID-19) (16.1% in COVID-19, and about 6% in…
- Trial name
- PIE-ARDS (NCT06001645)
- Testing
- Blood and bronchoalveolar fluid collection and analysis, Chest CT scan
- Where
- 4 sites in Italy
- Volunteers
- 110 people
- Sponsor
- Università Vita-Salute San Raffaele
Frailty, Distress, Emotional
Digital Voice Analysis as a Measure of Frailty and Distress
This study evaluates if it is possible to identify quantitative parameters from audio signals to describe the changes in patient's state in relation to frailty and distress.
- Trial name
- DIVAN (NCT05783401)
- Testing
- Data acquisition: Speech acquisition, Data acquisition: G8 Screening tool, Data acquisition: Distress Thermometer
- Where
- 2 sites in Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Basel, Switzerland
Depression, Psychological Distress
A Pilot Study of the Effect of Personalized Depression Risk Communication
Depression is a highly prevalent and disabling mental health problem. It is associated with significant morbidity and mortality and it has a significant economic impact.
- Trial name
- NCT04519892
- Testing
- PDRC, Coach guidance
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Right Heart Failure, Mechanical Ventilation
Effect of APRV vs. LTV on Right Heart Function in ARDS Patients: a Single-center Randomized Controlled Study
Acute Respiratory Distress Syndrome (ARDS) is often complicated by Right Ventricular Dysfunction (RVD), and the incidence can be as high as 64%.
- Conditions
- Right Heart Failure, Mechanical Ventilation, Acute Respiratory Distress Syndrome
- Trial name
- NCT05922631
- Testing
- Airway pressure release ventilation, low tidal volume
- Where
- China
- Volunteers
- 60 people
- Sponsor
- XiaoJing Zou,MD
Endometrial Cancer, Cancer
Anxiety and Distress Levels in Women With Suspected Endometrial Cancer
Patients attending the rapid access gynaecology clinic with a suspicion of endometrial cancer are understandably nervous. Few studies have quantified anxiety and distress of patients in this group.
- Conditions
- Endometrial Cancer, Cancer, Uterine Cancer, Anxiety
- Trial name
- NCT03813719
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Imperial College London
Infertility/Sterility, Psychological Distress
Fertility Life Counselling Aid- FeLiCiA
Research Objectives: 1. To test the FeLiCiA, a 6 week intervention developed for the management of psychological morbidities associated with infertility, using external randomised control trial methods, on patients showing…
- Conditions
- Infertility/Sterility, Psychological Distress, Psychological Stress, Anxiety Disorders
- Trial name
- FeLiCiA (NCT03348865)
- Testing
- Fertility Life Counselling Aid (FeLiCiA)
- Where
- Nigeria
- Volunteers
- 16 people
- Sponsor
- Andrew Weeks MD MRCOG
Cancer Metastatic to Brain, Brain Metastases, Adult
Managing Distress in Malignant Brain Cancer
To identify potential adaptations of the managing cancer and living meaningfully (CALM) intervention that will be required for service members, Veterans, their beneficiaries, and civilian cancer metastasis to the brain (bMET)…
- Trial name
- NCT05087095
- Testing
- CALM Intervention
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Virginia Commonwealth University
Carotid Artery Diseases, Regional Anesthesia
Stress Reduction Using Video Googles on Patients Undergoing Vascular Surgery
One treatment option of internal carotid artery stenosis is open surgical endarterectomy. The operation is frequently carried out under regional plexus anesthesia, allowing the patient to remain awake during the procedure.
- Conditions
- Carotid Artery Diseases, Regional Anesthesia, Distress, Procedural
- Trial name
- MEP-VASC (NCT06704230)
- Testing
- video googles
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital Augsburg
Ventilation Therapy; Complications, Ventilator-Induced Lung Injury
Clinical Decision Support Tool in PARDS Pilot Study
Previous clinical trials in adults with acute respiratory distress syndrome (ARDS) have demonstrated that ventilator management choices can improve Intensive Care Unit (ICU) mortality and shorten time on mechanical ventilation.
- Conditions
- Ventilation Therapy; Complications, Ventilator-Induced Lung Injury, Ards
- Trial name
- NCT04068012
- Testing
- Ventilator protocol
- Where
- 8 sites in United States, Canada and 1 more
- Volunteers
- 180 people
- Sponsor
- Children's Hospital Los Angeles