Clinical trials: Empyema
Pleural Effusion Associated With Pulmonary Infection, Bacterial Pleural Effusion Other Than Tuberculosis
Efficacy and Safety of Activase (Ateplase) vs Placebo in Complicated Pleural Effusions (CPE)/Empyemas
The purpose of this study is to document the efficacy and safety of intrapleural instillation of Activase vs Placebo in the management of complicated pleural effusions and empyemas
- Trial name
- CPE (NCT00468104)
- Testing
- Alteplase
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Midwest Pulmonary and Critical Care
Pneumonia, Necrotizing, Lung Abscess
Complicated Pneumonia (CP) in Children in South-East Europe
This retrospective observational study aims to evaluate clinical course of complicated community acquired pneumonia in children, particularly focusing on necrotizing pneumonia cases, as well as determination of etiological agents…
- Conditions
- Pneumonia, Necrotizing, Lung Abscess, Empyema, Pleural
- Trial name
- CP (NCT06657898)
- Where
- Serbia
- Volunteers
- 300 people
- Sponsor
- Aleksandar Sovtic
Pleural Empyema
Dornase Alfa and Urokinase for Kids With Pleural Empyema
The purpose of this study is to determine whether intrapleural treatment with Dornase alfa plus Urokinase improves clinical outcome compared to Urokinase alone in children with complicated parapneumonic effusions
- Trial name
- DUKE (NCT00502632)
- Testing
- Urokinase and Dornase alfa, Urokinase
- Where
- 3 sites in Italy
- Volunteers
- 94 people
- Sponsor
- Azienda Ospedaliera di Padova
Mesothelioma, Lung Neoplasms
Chest Wall Motion Analysis in Disease
Breathing movements, called chest wall motion, are very complex. The investigators are studying how movement of the abdomen, ribs and diaphragm contribute to breathing and how this differs with different diseases in the chest.
- Conditions
- Mesothelioma, Lung Neoplasms, Surgery, Cystic Fibrosis
- Trial name
- CWM (NCT02958683)
- Testing
- Chest wall motion analysis
- Where
- United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Heart of England NHS Trust
Complicated Pleural Effusion/ Empyema
Effectiveness and Safety of Sodium Bicarbonate Pleural Lavage in the Treatment of Complex Pleural Effusion
The goal of this clinical trial is to evaluate the safety and efficacy of sodium bicarbonate pleural lavage in treating complex pleural effusion in adult.
- Trial name
- SAPLIC (NCT06734481)
- Testing
- Sodium bicarbonate pleural lavage, Saline pleural lavage
- Where
- China
- Volunteers
- 260 people
- Sponsor
- First Affiliated Hospital of Ningbo University
Empyema
Thoracoscopy Versus Fibrinolysis in Children With Empyema
The null hypothesis is that patients receiving either thoracoscopy or fibrinolysis for empyema recover in the same amount of time.
- Trial name
- NCT00323531
- Testing
- Chest tube with tPA infusion for 3 days, VATS decortication
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Children's Mercy Hospital Kansas City
Pleural Empyema, Tuberculosis (TB)
The Role of Decortication in Complex Empyema Cases: Multidrug Resistance and Tuberculosis at the Forefront
Empyema is a problem that thoracic surgeons deal in everyday practice. The main goal of treatment is evacuating the pus and fibrin deposits in the thoracic cavity for complete lung expansion.
- Conditions
- Pleural Empyema, Tuberculosis (TB), Bacterial Sepsis
- Trial name
- NCT07167823
- Testing
- Decortication
- Where
- Pakistan
- Volunteers
- 350 people
- Sponsor
- University of Health Sciences Lahore
Pleural Effusion, Pneumothorax
Suturing With U-Technique Versus Un-Reapproximated Wound Edges During Removal of Closed Thoracostomy Tube Drain
The study will be carried out by the principal investigator and his team at the Division of Cardiovascular and Thoracic Surgery of the Department of Surgery, College of Medicine, University of Ibadan and the University College…
- Conditions
- Pleural Effusion, Pneumothorax, Chest Trauma, Video-assisted Thoracoscopic Surgery
- Trial name
- SUTURE (NCT04193241)
- Testing
- Closure of chest tube wound
- Where
- Nigeria
- Volunteers
- 142 people
- Sponsor
- University of Ibadan
Acute Cholecystitis, Empyema of Gallbladder
Effects of Drainage in Laparoscopic Cholecystectomy
During laparoscopic surgery for an acutely inflamed gallbladder, most surgeons routinely insert a drain. However, no consensus has been reached regarding the need for drainage in these cases, and the use of a drain remains…
- Conditions
- Acute Cholecystitis, Empyema of Gallbladder, Abscess of Gallbladder
- Trial name
- NCT02027402
- Testing
- Laparoscopic cholecystectomy with drain insertion
- Where
- South Korea
- Volunteers
- 198 people
- Sponsor
- Seoul St. Mary's Hospital
Second Stage Empyema
Comparative Study Between Outcome of ICT Drainage and VATS in Management of Second Stage Empyema
The goal of this clinical trial is to compare between outcome of inter-costal tube drainage and video assisted thoracoscopic surgery in management of patients with second stage empyema.
- Trial name
- ICT and VATS (NCT06680024)
- Testing
- Intercostal tube, Video assisted thoracoscope
- Volunteers
- 40 people
- Sponsor
- Sohag University
Complicated Parapneumonic Effusion, Empyema, Pleural
Flush, Lyse, Operate
The goal of this observational study is to learn if saline results in improvement for patients with infection of their plerual space.
- Trial name
- FLO (NCT07592520)
- Testing
- Intrapleural Saline with possible escalation to intraplerual alteplase and dornase.
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Pleural Neoplasms, Aspiration, Respiratory
Local Anesthesia Versus Combined Local Anesthesia With Single Dose Analgesia on Pain Control During Thoracic Ultrasound Guided Procedures
This study aims to evaluate the efficacy of single dose analgesia in combination with local anesthesia to control pain during Trans Ultrasound guided procedures.
- Conditions
- Pleural Neoplasms, Aspiration, Respiratory, Pleural Effusion, Lung Neoplasms
- Trial name
- NCT05121233
- Testing
- Diclofenac
- Volunteers
- 100 people
- Sponsor
- Assiut University
Empyema
Medical Thoracoscopy Versus Tube Thoracostomy in Management of Empyema .
Pleural empyema : is a collection of pus in the pleural cavity caused by microorganisms, usually bacteria.[1] Medical thoracoscopy has played a marginal role in the treatment of empyema for a long time, but has become more and…
- Trial name
- NCT03859206
- Testing
- Medical thoracoscopy
- Volunteers
- 60 people
- Sponsor
- Assiut University
Pyothorax, Fungal Infection Lungs
Fungal Empyema Thoracis
Background: Fungal empyema thoracis is a rare but life-threatening pleural infection caused by fungal organisms such as Aspergillus and Candida species.
- Conditions
- Pyothorax, Fungal Infection Lungs, Pleural Empyema
- Trial name
- NCT07337993
- Testing
- pleural lavage followed by surgery, Decortication, Conservative Arm
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- University of Health Sciences Lahore
Hemothorax, Hemopneumothorax; Traumatic
Prospective Evaluation of 14F Thal Tube vs 28 French Chest Tube for Hemothorax and Use of Maximum Barrier Precautions
Traumatic hemothorax and hemopneumothorax are common diagnoses which are typically treated by placement of a chest tube. 28-32 Fr chest tubes have previously been shown equivalent to 36-40 Fr chest tubes for the non-emergent…
- Conditions
- Hemothorax, Hemopneumothorax; Traumatic, Empyema, Chest Tube Size
- Trial name
- NCT03167723
- Testing
- Chest tube placement
- Where
- United States
- Volunteers
- 193 people
- Sponsor
- Wake Forest University Health Sciences
Empyema, Pleural
Comparison of Intrapleural Urokinase and Video-Assisted Thorascopic Surgery in the Treatment of Parapneumonic Pleural Effusion in Children
Despite the improvement in the technology available for diagnosing and treating empyema, the management of empyema in children remains controversial.
- Trial name
- UROVATS (NCT02165891)
- Testing
- insertion of a chest drain with urokinase instillation, primary video-assisted thorascopic surgery
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Queen Fabiola Children's University Hospital
Empyema, Pleural, Pleural Effusion
Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and Empyema
1. Objectives: Main objective: To evaluate the efficacy and safety of intrapleural alteplase vs urokinase in patients with complex complicated parapneumonic pleural effusion and empyema.
- Conditions
- Empyema, Pleural, Pleural Effusion, Pleural Diseases
- Trial name
- NCT01246453
- Testing
- Intrapleurally Alteplase vs Intrapleurally Urokinase
- Where
- 2 sites in Spain
- Volunteers
- 204 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Pleural Infection
Diagnostic Utility of Pleural Infection-specific Multiplex PCR Panel
Pleural effusion is a common cause of hospitalization. Pleural infection ranked third among the pleural effusions requiring hospitalization in the United States.
- Trial name
- PRISM (NCT07077096)
- Testing
- PRISM PCR panel, Conventional bacterial culture
- Where
- Hong Kong
- Volunteers
- 800 people
- Sponsor
- Chinese University of Hong Kong
Empyema, Pleural
VATS Decortication Versus IR Guided Chest Tube Insertion With Fibrinolytics for the Management of Empyema
The American Association of Thoracic Surgery defines empyema as pus in the pleural space. It is a common thoracic surgery presentation with an estimated 65,000 cases occurring annually in the United States.
- Trial name
- DICE (NCT03584113)
- Testing
- Video assisted thorascopic decortication, Interventional radiology guided chest tube insertion with MIST2 trial fibrinolytics
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Dr. Wiley Chung
Empyema
Urokinase Versus Primary Video-Assisted Thorascopic Surgery for Empyema
This study will compare VATS versus chest drain insertion and urokinase in the treatment of childhood empema by a randomised prospective study.
- Trial name
- NCT00144950
- Testing
- insertion of a chest drain with urokinase instillation, primary video-assisted thorascopic surgery
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Institute of Child Health