Clinical trials: Enamel Hypomineralization
Tooth Demineralization, Tooth Sensitivity
Graphene-Reinforced CAD/CAM Restorations for MIH-Affected Molars in Adolescents: A Prospective Clinical Study
This study evaluates the clinical performance, marginal integrity, surface wear, color stability, and postoperative sensitivity of graphene-reinforced CAD/CAM indirect restorations (inlays, onlays, overlays) in molars affected by…
- Conditions
- Tooth Demineralization, Tooth Sensitivity, Enamel Mineralization Disorders, Tooth Sensitivity After Composite Restorations
- Trial name
- NCT07329244
- Testing
- Graphene-reinforced CAD/CAM polymer (G-CAM®)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universitat Internacional de Catalunya
Dental Enamel, Dental Enamel Hypomineralization
Retention of Pits and Fissure Sealants on Non Carious vs Initial Carious Enamel Lesions in Posterior Teeth
This clinical study is planned to be conducted to compare retention rates of pits and fissure sealants on non carious (ICDAS score 0) vs Initial carious enamel lesions (ICDAS Score 1,2) in posterior permeant teeth at 3 months, 6…
- Conditions
- Dental Enamel, Dental Enamel Hypomineralization, Dental Enamel Hypoplasia
- Trial name
- NCT07330089
- Where
- Pakistan
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
Molar Incisor Hypomineralization, Hypersensitivity
Intraosseous vs Infiltration Anesthesia in Molar-Incisor Hypomineralization (MIH) Children
This study aims to compare the effectiveness of intraosseous and infiltration anesthesia techniques administered using a computer-assisted anesthesia device (SleeperOne® 5; Dental HiTec, France) during restorative treatments of…
- Trial name
- MIH (NCT07352813)
- Testing
- Intraosseous anaesthesia using a computerized system, Infiltration anaesthesia using a computerized system
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Molar Incisor Hypomineralization
Clinical Evaluation of Resin Infiltration Treatment of MIH-affected Teeth in Pediatric Patients
The goal of this clinical trial is to examine the clinical success of different pre-treatments in resin infiltration therapy applied to the incisors of pediatric patients with Molar Incisor Hypomineralization (MIH) and to…
- Trial name
- NCT07469124
- Testing
- Resin Infiltration, Microabrasion Followed by Resin Infiltration, Air Abrasion Followed by Resin Infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Inonu University
Molar Incisor Hypomineralisation, Irreversible Pulpitis
Pain Assessment Governing Partial or Full Pulpotomy of Immature Molars With Irreversible Pulpitis in Molar Incisor Hypomineralization
This randomized controlled clinical trial aims to evaluate and compare pain levels associated with partial pulpotomy (PP) and full pulpotomy (FP) in immature permanent first molars diagnosed with irreversible pulpitis.
- Conditions
- Molar Incisor Hypomineralisation, Irreversible Pulpitis, Immature Molars
- Trial name
- NCT07850986
- Testing
- pulpotomy for MIH affected immature PFMs, partial pulpotomy for MIH affected immature PFMs, pulpotomy for non-MIH affected immature PFMs
- Where
- Egypt
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Alaa Khafagy
Dental Enamel Hypoplasia, Dental Caries
Evaluation Direct and Indirect Composite Restoration in Hypomineralization Molars.
The aim of this study is to evaluate the effectiveness of direct and Indirect Composite Restoration in Children With Molar Incisor Hypomineralization Patients (MIH) and following up after 3 , 6 , 12 months (Clinically): Group A …
- Trial name
- NCT05299489
- Testing
- Direct restoration, Indirect restoration
- Where
- Syria
- Volunteers
- 20 people
- Sponsor
- Damascus University
Molar Incisor Hypomineralization
Comparing CAD/CAM vs Composite for Carious Hypomineralized Molars Evaluating Clinical Outcomes of Both Treatments.
Molar Incisor Hypomineralization (MIH) is enamel hypomineralization defined as qualitative defects caused by disruptions in either the calcification or maturation phases of amelogenesis affecting one or more first permanent…
- Trial name
- NCT07049016
- Testing
- restoring the MIH affected young permanent molars using Direct nanohybrid flowable composite, restoring the MIH affected young permanent molars using IPS e.max CAD
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- October University for Modern Sciences and Arts
Molar Incisor Hypomineralization
Effect of Low-intensity Laser and Photodynamic Therapy on Infected Dentin of Permanent Teeth With MIH
The objective of this research was to evaluate the clinical effect of photodynamic therapy on dentin infected by caries lesion in permanent teeth with Molar Incisor Hypomineralization (MIH).
- Trial name
- NCT03826810
- Testing
- aPDT, ART
- Where
- Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Dental Caries Extending to Pulp, Molar Incisor Hypomineralization
Vital Pulp Therapy in Carious Teeth With Hypomineralization
Vital pulp therapy (VPT) is a general term for multiple procedures (indirect pulp cap, direct pulp cap and pulpotomy) all directed toward preserving pulp vitality and enable complete root development in immature teeth.
- Trial name
- NCT03735069
- Testing
- IPT (Indirect pulp treatment), Cvek/partial pulpotomy, Cervical pulpotomy
- Where
- Jordan
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Molar Incisor Hypomineralization
Salivary Cortisol Levels in Children With Molar Incisor Hypomineralization
Molar incisor hypomineralization (MIH) is a developmental condition that affects the enamel of permanent molars and incisors in children and may cause tooth sensitivity, discomfort, and difficulties during dental treatment.
- Trial name
- NCT07389148
- Where
- Turkey (Türkiye)
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Lokman Hekim University
Molar Incisor Hypomineralization
Resin Infiltration Treatment Versus a Combined Treatment With Microabrasion for the Management of MIH Affected Incisors
The prevalence of molar incisor hypomineralization is relatively high. It has been reported that MIH-affected children experience a wide range of negative impacts because of having visible enamel opacities on their incisors…
- Trial name
- NCT04471571
- Testing
- Resin infiltration and microabrasion for MIH-affected incisors, Resin infiltration for MIH-affected incisors
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Molar Incisor Hypomineralization
Comparative Evaluation of Giomer Varnish vs Fluoride Varnish as Desensitizing Agents in Teeth With MIH
this clinical trial's aim is to compare two desensitizing agents available in the market to prove which one is more efficient in children with molar incisor hypomineralization complaining from hypersensitivity
- Trial name
- NCT05542667
- Testing
- Giomer varnish, Fluoride varnish
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Molar Incisor Hypomineralization
Aesthetic Masking and Resin Infiltration Time in MIH-affected Incisors
Background: Resin infiltration often shows unpredictable outcomes in teeth affected by molar incisor hypomineralisation (MIH) due to variable enamel porosities, hypermineralised surface layers, and elevated protein content.
- Trial name
- NCT07753070
- Testing
- macroabrasion followed by oxidative pretreatment, macroabrasion alone
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Molar Incisor Hypomineralization
Three Approaches of Resin Infiltration for MIH Incisor Opacities
Molar incisor hypomineralization (MIH) is a condition which involves enamel hypomineralization of one to four first permanent molars with or without permanent incisors.
- Trial name
- NCT07715370
- Testing
- Resin infiltration, microabrasion, Etch-bleach
- Where
- Egypt
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Dental Fluorosis
Presence of Enamel Fluorosis in Libyan Children
Fluorosis is caused by hypomineralization in the enamel due to increased fluoride ingestion during early childhood (Cawson.1, Wong et al. 2, and Sudhir 3).
- Trial name
- NCT03746990
- Volunteers
- 1,935 people, healthy volunteers welcome
- Sponsor
- Ajman University
MIH, Molar-Incisor Hypomineralization
Effects of Silver Diamine Fluoride and Intraoral Cryotherapy on Local Anesthesia in MIH-Affected Molars
Molar-incisor hypomineralization (MIH) is a developmental enamel defect of unclear etiology that affects permanent first molars and often permanent incisors, leading to increased porosity, hypersensitivity, and poor prognosis.
- Conditions
- MIH, Molar-Incisor Hypomineralization, Caries Assessment
- Trial name
- NCT07326241
- Testing
- Standard Local Anesthesia, Intraoral Cryotherapy, Silver Diamine Fluoride (SDF)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Molar Incisor Hypomineralization
Effects of Different Remineralization Agents on Molar Incisor Hypomineralization Defects: a Randomized Clinical Study
The aim of this study was to present a comparative evaluation of the long-term efficacy of fluoride varnish( Flúor protector), Clinpro™ White Varnish and pastes containing CPP-ACP in the remineralization of creamy-white and…
- Trial name
- NCT06362681
- Testing
- Fluoride
- Where
- Mexico
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Mexico
Molar Hypomineralization, Incisor
Orofacial Functions in Individuals With and Without Molar Incisor Hypomineralization
Molar incisor hypomineralization (MIH) is a qualitative developmental defect of the enamel with a complex, multifactorial nature and a significant genetic component that predominantly affects the permanent first molars and…
- Trial name
- NCT06692257
- Testing
- Observation
- Where
- Brazil
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Enamel Hypomineralization
Clinical Performance of Orthodontic Bands in the Restorative Treatment of Hypomineralised Primary Second Molars
This randomised clinical trial will compare the clinical performance and acceptability of orthodontic bands and preformed stainless steel crowns for the restorative management of hypomineralised second primary molars.
- Trial name
- NCT07814716
- Testing
- Orthodontic band restorative treatment, Hall Technique with preformed stainless steel crown
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
Molar Incisor Hypomineralisation
Effect of Nano Hydroxy Apatite Varnish and Potassium Nitrate Gel on the MIH-affected Permanent Teeth
This clinical study main goal is to investigate the effectiveness of nano hydroxy apatite crystal varnish and potassium nitrate gel as a non invasive approach in managing MIH-affected teeth.
- Trial name
- NCT06896565
- Testing
- nano hydroxy apatite varnish, Potassium Nitrate Gel, Varnishes, Fluoride
- Volunteers
- 48 people
- Sponsor
- Cairo University