Clinical trials: End Stage Chronic Renal Failure
End Stage Renal Disease, Insulin Resistance
Effect of an L-carnitine-containing Peritoneal Dialysis (PD) Solution on Insulin Sensitivity in Patients on Continuous Ambulatory Peritoneal Dialysis (CAPD)
The current study is initiated in order to assess the impact of a PD solution containing L-carnitine on insulin sensitivity measured by a hyperinsulinemic euglycemic clamp.
- Trial name
- NCT00755456
- Testing
- PD solution containing glucose, PD solution containing glucose and L-carnitine
- Where
- 12 sites in Italy
- Volunteers
- 35 people
- Sponsor
- Iperboreal Pharma Srl
End-stage Renal Disease, Renal Failure
Straight Versus Coiled Peritoneal Dialysis Catheter for Peritoneal Dialysis Patients
This study compares the result of straight versus coiled Tenckhoff catheters for peritoneal dialysis patients. Recent meta-analysis of the peritoneal dialysis catheter type was in favor of straight catheters.
- Trial name
- NCT02479295
- Testing
- Tenckhoff catheter
- Where
- 2 sites in Hong Kong
- Volunteers
- 306 people
- Sponsor
- Chinese University of Hong Kong
Non-valvular Atrial Fibrillation (NVAF): Paroxysmal, Persistent, Permanent
Left Atrial Appendage Closure in Patients With Non-valvular Atrial Fibrillation and End-stage Chronic KIDNEY Disease
In the proposed event driven trial, LAA closure devices will be compared in a 1:1 randomization to best medical care in AF patients at high risk of stroke and bleeding with ESKD.
- Trial name
- LAA-KIDNEY (NCT05204212)
- Testing
- Left Atrial Appendage closure
- Where
- Germany
- Volunteers
- 430 people
- Sponsor
- Prof. Dr. med. Ingo Eitel
Myocardial Fibrosis, End Stage Renal Failure on Dialysis
MRI Assessment of Myocardial Fibrosis Associated With Monocyte Phenotype in End Stage Renal Failure
Firstly, this study aims to understand how cardiac fibrosis mediated by inflammatory microvascular disease evolves during advanced chronic kidney disease and end stage renal failure and importantly how this changes with…
- Conditions
- Myocardial Fibrosis, End Stage Renal Failure on Dialysis, Chronic Kidney Disease, Stage IV (Severe), Chronic Kidney Disease Stage V
- Trial name
- CM3 (NCT03857633)
- Testing
- Cardiac MRI 1 - With Gadolinium Contrast, Cardiac MRI 2 - With Gadolinium Contrast, Cardiac MRI 3 - Without Gadolinium Contrast
- Where
- United Kingdom
- Sponsor
- Imperial College London
End Stage Renal Disease and Cognitive Impairment
Blood-Brain Barrier Evaluation In Nephrology (BREIN)
Patients with Chronic Kidney Disease (CKD) have impaired psycho-cognitive functions in parallel with deteriorating kidney function.
- Trial name
- BREIN (NCT04328415)
- Testing
- Cerebral scintigraphy
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
End Stage Renal Disease on Dialysis
Survey and Reduction of Mortality in Peridialysis Uremic Patients Via Intervention of Risk Factors
In patients with non-dialysis-dependent end stage kidney disease (ESKD) the common transition of care to renal replacement therapy is dialysis.
- Trial name
- SURVIVOR (NCT04088526)
- Testing
- intervention group
- Where
- China
- Volunteers
- 2,500 people
- Sponsor
- Shanghai Changzheng Hospital
Renal Failure Chronic Requiring Hemodialysis, Sleep Disorders
Sleep Disturbance in Patients With End-Stage Renal Disease
Sleep disorders are common in patients who have chronic kidney disease (CKD). Insomnia is reported in up to 50% of patients treated with hemodialysis compared to 12% of a control population.
- Trial name
- NCT02583347
- Testing
- Vivia Home Hemodialysis System
- Where
- Ireland
- Volunteers
- 60 people
- Sponsor
- Beaumont Hospital
Chronic Renal Failure
Pharmacodynamics and Non-Clinical Inferiority of Heparin Sodium (Cristália) Compared With the Product Liquemine (Roche) in Chronic Renal Failure
The primary objective of the study was to assess the safety in use of the drug Heparin Sodium, produced by Cristália Laboratory, compared drug Liquemine ®, manufactured by Roche Laboratory, and secondary purpose was to evaluate…
- Trial name
- heparin (NCT00828776)
- Testing
- Heparin sodic - Cristália, heparin - Liquemine (Roche)
- Where
- Brazil
- Volunteers
- 62 people
- Sponsor
- Azidus Brasil
Chronic Renal Failure (CRF), Graft Failure
Renal Transplantation in the Elderly - nEverOld Study
An exploratory study of the efficacy and safety of a regimen consisted of Everolimus plus low tacrolimus for the immunosuppression in renal transplantation in the elderly.
- Conditions
- Chronic Renal Failure (CRF), Graft Failure, Transplant; Failure, Kidney, Renal Transplant Rejection
- Trial name
- NCT01631058
- Testing
- Everolimus
- Where
- 2 sites in Brazil
- Volunteers
- 90 people
- Sponsor
- University of Sao Paulo General Hospital
End Stage Renal Disease, Coronary Artery Disease
Coronary Artery Disease Screening in Kidney Transplant Candidates
Kidney transplant candidates are at very high risk for coronary artery disease (CAD). The optimal strategy to monitor and maintain the cardiac fitness of patients awaiting kidney transplantation is unknown.
- Trial name
- CADScreening (NCT02082483)
- Testing
- Selective Screening
- Where
- 6 sites in Canada
- Volunteers
- 144 people
- Sponsor
- University of British Columbia
Hemodialysis, End Stage Renal Disease
The Effectiveness and the Safety of Acupuncture for Symptomatic Care of Hemodialysis Patients: A Case-series
Purpose: Hemodialysis-dependent patients with an end-stage renal disease (ESRD) suffer from a number of distressing symptoms, such as pain, poor mental health, fatigue, sleep disturbance and pruritus.
- Trial name
- NCT00883831
- Testing
- Individualized manual acupuncture
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Korea Institute of Oriental Medicine
End Stage Renal Disease, Gut Microbiome Dysbiosis
Prebiotics in Peritoneal Dialysis
The Prebiotics in Peritoneal Dialysis trial is a non-randomized, open-label, crossover study of p-inulin for patients with end-stage renal disease treated with peritoneal dialysis.
- Trial name
- NCT03265639
- Testing
- P-inulin
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Ali Ramezani
End Stage Renal Disease (ESRD), Chronic Kidney Disease (CKD)
Advancing Renal TRANSplant eFficacy and Safety Outcomes With an eveRolimus-based regiMen (TRANSFORM)
This is a 2-year, randomized, multicenter, open-label, 2-arm study evaluating the graft function of everolimus and reduced CNI versus MPA and standard CNI in adult de novo renal transplant recipients.
- Conditions
- End Stage Renal Disease (ESRD), Chronic Kidney Disease (CKD), Hemodialysis, Renal Replacement Therapy
- Trial name
- TRANSFORM (NCT01950819)
- Testing
- Induction therapy, Corticosteroids, EVR+rCNI
- Where
- 184 sites in United States, Argentina and 40 more
- Volunteers
- 2,037 people
- Sponsor
- Novartis Pharmaceuticals
End Stage Renal Disease
Alterations in Cognitive Function and Cerebral Blood Flow After Conversion From Calcineurin Inhibitors (CNIs) to Everolimus
The purpose of this study is to learn if changing from Tacrolimus to Everolimus will improve cognitive function by having less effect on brain blood flow.
- Trial name
- NCT03413722
- Testing
- Tacrolimus, Everolimus
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Kansas Medical Center
Children on Chronic Peritoneal Dialysis
Comparing Conventional Continuous Ambulatory Peritoneal Dialysis Prescription (C-CAPD) With Modified-CAPD (M-CAPD) Prescription in Children With End-stage Kidney Disease From Low-resource Settings
This study aims to compare modified CAPD (M-CAPD) and conventional CAPD (C-CAPD) in terms of delivering high-quality, goal-directed PD as well as avoiding resource wastage in prevalent ESKD patients aged 2 to ≤18 years using a…
- Trial name
- NCT07134595
- Testing
- C-CAPD Prescription, M-CAPD Prescription
- Where
- Philippines
- Volunteers
- 44 people
- Sponsor
- National University Health System, Singapore
End Stage Renal Disease, Kidney Transplant; Complications
Study Investigating Whether Robot-assisted Surgery Can Reduce Surgical Complications Following Kidney Transplantation
The purpose of this study is to explore whether robot-assisted surgery can reduce 30-day surgical complications compared to open surgery in kidney transplantation. Participants are adult recipients of kidney transplantation.
- Trial name
- ORAKTx (NCT05730257)
- Testing
- Robot-Assisted Kidney Transplantation, Open Kidney Transplantation
- Where
- 2 sites in Denmark
- Volunteers
- 106 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Medication Adherence, End Stage Renal Failure on Dialysis
Prevalence of Non-adherence to Medication Among Patients on Chronic Hemodialysis
Background: Non-adherence to medication among patients on chronic hemodialysis compromises treatment effects and results in increased morbidity, mortality and extensive costs to the healthcare system.
- Trial name
- NCT03897231
- Testing
- questionnaire
- Where
- Denmark
- Volunteers
- 385 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
End Stage Renal Disease, Venous Stenosis
Sirolimus Use in Angioplasty for Vascular Access Extension
Dialysis patients presenting for angioplasty intervention for graft failure will be randomized to receive either Sirolimus or not receive Sirolimus (standard of care) to assess the time from primary failure or angioplasty…
- Trial name
- SAVE (NCT01595841)
- Testing
- Sirolimus
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Type 2 Diabetes Mellitus
Specified Drug-Use Survey of Trelagliptin Tablets "Survey on Long-term Use in Type 2 Diabetes Mellitus Patients With Severe Renal Impairment or End-stage Renal Disease"
The purpose of this study is to evaluate the long-term safety of trelagliptin tablets in patients with type 2 diabetes mellitus complicated by severe renal impairment or end-stage renal failure in the routine clinical setting.
- Trial name
- NCT04285983
- Testing
- Trelagliptin
- Where
- Japan
- Volunteers
- 89 people
- Sponsor
- Takeda
Kidney Failure, Chronic
Intradialytic Inspiratory Muscle Training at Different Intensities and Functional Capacity
Investigate the effects of Inspiratory Muscle Training (IMT) performed during hemodialysis (HD) procedures in patients with end stage kidney disease (ESKD).
- Trial name
- NCT04660383
- Testing
- Inspiratory Muscle Training
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
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