Clinical trials: End Stage Disease
Renal Failure, End Stage
The ONE Study ATDC Trial
To collect evidence of the safety of administering autologous tolerogenic dendritic cells (ATDC) preparations to living-donor renal transplant recipients in the context of an international European Union funded consortium aimed…
- Trial name
- ONEatDC (NCT02252055)
- Testing
- ATDC_Nantes
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Nantes University Hospital
Vitamin D Deficiency, Vascular Calcification
Effects of Cholecalciferol on Osteoprotegerin Levels in Patients on Peritoneal Dialysis
Aim: To investigate whether cholecalciferol (4800 U/daily) or placebo for 16 weeks reduces proteins levels associated with vascular calcification (osteoprotegerin, osteopontin, osteocalcin) in patients treated with peritoneal…
- Conditions
- Vitamin D Deficiency, Vascular Calcification, Renal Insufficiency, End Stage Renal Failure on Dialysis
- Trial name
- NCT02598635
- Testing
- Cholecalciferol
- Where
- Mexico
- Volunteers
- 58 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Renal Impairment
Pharmacokinetics, Safety and Tolerability of AGO178C in Subjects With Renal Deficiencies Compared With Healthy Subjects
This study will assess the pharmacokinetics, safety and tolerability of a single dose of AGO178C in subjects with mild, moderate, severe renal impairment and end-stage renal disease with that in healthy matched control subjects.
- Trial name
- NCT01459250
- Testing
- AGO178C
- Where
- 4 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Critical Illness
Family-Participatory Early Rehabilitation in Critically Ill Patients
This prospective, randomized controlled trial aims to evaluate the efficacy of an Internet-Based, Family-Participatory Early Rehabilitation (IFPER) model compared to standard care for critically ill patients in the Intensive Care…
- Trial name
- NCT07278713
- Testing
- Internet-Based, Family-Participatory Early Rehabilitation (IFPER), Standard ICU Care
- Where
- China
- Volunteers
- 204 people
- Sponsor
- The First Hospital of Hebei Medical University
Malnutrition, End Stage Renal Disease
Oral Nutritional Supplement on Nutritional and Functional Status, and Biomarkers in Malnourished Hemodialysis Patients.
Malnutrition in hemodialysis patients is frequent and it is associated with a reduction in muscular mass, strength, functional capacity and quality of life, with an increment in inflammatory and oxidative markers, and with a…
- Trial name
- RENACARE (NCT03924089)
- Testing
- Oral nutritional supplement with probiotics, Oral nutritional supplement without probiotics, Dietary recommendations
- Where
- 3 sites in Spain
- Volunteers
- 54 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Anemia
Efficacy and Safety of Spironolactone in Pediatric Hemodialysis Patients With Anemia.
The goal of this clinical trial is to learn if Spironolactone drug works to treat anemia in hemodialysis pediatric patients. It will also learn about the safety of Spironolactone drug.
- Trial name
- NCT07715318
- Testing
- Spironolactone (drug), Iron Supplement, Erythropoietin stimulating agent
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Kidney Failure, Chronic
A Study to Evaluate the Pharmacokinetics and Safety of Golcadomide in Participants With Severe Renal Impairment and End-Stage Renal Disease Compared With Participants With Normal Renal Function
The purpose of this study is to assess the pharmacokinetics and safety of golcadomide (BMS-986369) in matched healthy participants with normal renal function, adult participants with severe renal impairment, and participants with…
- Trial name
- NCT07763418
- Testing
- Golcadomide
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
End Stage Renal Disease
Panel Reactive Antibody (PRA) Reduction in Sensitized Patients Awaiting Renal Transplantation
The purpose of this study is to offer Panel Reactive Antibodies [PRA] reduction treatment to high responder renal transplant patients who otherwise may never be compatible with a potential organ donor.
- Trial name
- NCT00784979
- Testing
- CMVIG
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Tampa General Hospital
Cirrhosis, Liver, End Stage Liver DIsease
Testing LiverWatch, a Home-Based Remote-Monitoring Intervention for Advanced Liver Disease
Remote healthcare monitoring for cirrhosis has shown promise in overcoming barriers to accessing specialty care, improving healthcare quality, and reducing mortality.
- Conditions
- Cirrhosis, Liver, End Stage Liver DIsease, Symptoms and Signs, Physical Inactivity
- Trial name
- NCT06136221
- Testing
- LiverWatch Intervention
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Pennsylvania
End-Stage Kidney Disease (ESKD), Maintenance Hemodialysis (MHD)
Health Coaching for Self-Management in Maintenance Hemodialysis Patients
This study is a quasi-experimental study designed to evaluate the effects of a health coaching intervention on self-management ability in patients undergoing maintenance hemodialysis.
- Trial name
- NCT07685626
- Testing
- Health Coaching, Routine Care
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Anhui Medical University
Stenosis of Vascular Prosthetic Devices, Implants and Grafts
Post-Approval Study for the FLAIR Endovascular Stent Graft
The purpose of this study is to confirm the long-term safety and effectiveness of the FLAIR Endovascular Stent Graft for treatment of stenoses at the venous anastomosis of ePTFE or other synthetic arteriovenous (AV) access grafts.
- Trial name
- RENOVA (NCT00677235)
- Testing
- FLAIR Endovascular Stent Graft, PTA
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- C. R. Bard
FSGS
Use of Acthar in Patients With FSGS That Will be Undergoing Renal Transplantation
This study will evaluate the use of Acthar in patients to undergo renal transplantation and will measure the rate of FSGS recurrence.
- Trial name
- NCT02683889
- Testing
- Acthar
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Colorado, Denver
Dyspnea; Uremic, End Stage Renal Disease
Dyspnea Assessment in Hemodialysis Patients
Shortness of breath is very common among patients on dialysis for kidney failure; however, its causes are often not understood. This study will explore the lungs and the heart of these patients to determine the causes of…
- Conditions
- Dyspnea; Uremic, End Stage Renal Disease, Chronic Lung Disease, Chronic Heart Disease
- Trial name
- NCT03773991
- Testing
- Lung MRI, Sodium MRI, Chest CT
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
End Stage Liver Disease
Functional Assessment in Liver Transplantation
This will be a prospective cohort study of patients with liver disease. Subjects will undergo geriatric assessments of frailty, functional status, and disability using functional status measures at baseline and at every clinic…
- Trial name
- FrAILT (NCT03228290)
- Where
- 12 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- University of California, San Francisco
End Stage Renal Disease
Initial Safety Study of the TRUE AVC in Hemodialysis Access (TRUE AVC I Study)
Prospective, nonrandomized, single-arm, single-center, open-label, initial safety study in subjects requiring hemodialysis. Subjects will be followed with physical evaluation and ultrasound vessel imaging at days 15, 29, 57 and…
- Trial name
- NCT05567757
- Testing
- Arteriovenous conduit implant
- Where
- Panama
- Volunteers
- 11 people
- Sponsor
- Vascudyne, Inc.
End-stage Renal Disease
Changes in Renal Perfusion During Hemodialysis in Patients with End-stage Renal Disease
Residual renal function (RRF) characteristically declines after patients with end-stage renal disease (ESRD) initiate dialysis. Although RRF preservation correlates with improved patient\'s quality of life and survival…
- Trial name
- HD-RPC (NCT06587997)
- Volunteers
- 20 people
- Sponsor
- Yuanjun Yang
End Stage Renal Disease, Sars-CoV2
The Impact of COVID-19 on Dialysis Users
To understand the impact of COVID-19 restrictions on the wellbeing, quality of life and physical activity of people with end-stage renal disease, currently dialysing in-centre versus at home in the UK and their experience of…
- Trial name
- NCT04422873
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Portsmouth
Atrial Fibrillation, Atrial Flutter
Strategies for the Management of Atrial Fibrillation in patiEnts Receiving Dialysis 2 (SAFE-D2)
People receiving dialysis are more likely to develop atrial fibrillation (AF), an irregular heartbeat that increases the risk of stroke.
- Conditions
- Atrial Fibrillation, Atrial Flutter, End Stage Kidney Disease (ESRD), Dialysis Patients
- Trial name
- SAFE-D2 (NCT07779746)
- Testing
- Eliquis, No oral anticoagulation
- Volunteers
- 848 people
- Sponsor
- Unity Health Toronto
Hypertension
Effect of Renal Denervation in End Staged Renal Disease With Resistant Hypertension
A. Hypertension is a major cardiovascular risk factor and numerous treatment strategies have been developed to treat hypertension properly and reduce cardiovascular risk. B.
- Trial name
- NCT02346045
- Testing
- Renal sympathetic denervation
- Where
- 4 sites in South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul St. Mary's Hospital
Presence of Periodontal Disease, Knowledge of Periodontal Disease
Knowledge of Periodontitis and Its Relation to Periodontal Health
This study aims to evaluate the level of knowledge regarding periodontal disease and its association with periodontal health status among health sciences students.
- Trial name
- NCT07405541
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
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