Clinical trials: End Stage Disease
End Stage Renal Disease on Dialysis
Compare Elbow mNT-BBAVF With Wrist RCAVF for Hemodialysis Access
Investigator plan to conduct a multicenter, open-labelled, randomized study to compare the primary patency and safety of elbow mNT-BBAVF and wrist RCAVF in hemodialysis patients.
- Trial name
- NCT03701243
- Testing
- mNT-BBAVF, RCAVF
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shanghai 10th People's Hospital
Infections, Bacterial
Pharmacokinetic Study of Gepotidacin in Subjects With Varying Degrees of Renal Impairment and in Subjects With Normal Renal Function
This study will be conducted to determine if altered renal function affects the plasma pharmacokinetics of gepotidacin, which will inform if dosing recommendations based upon renal impairment are required.
- Trial name
- NCT02729038
- Testing
- Gepotidacin
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
End Stage Renal Disease (ESRD)
Product Evaluation for the Effectiveness of the ClearGuard™ HD End Cap
To assess positive blood cultures (PBCs) in hemodialysis central venous catheter (CVC) patients using two FDA cleared devices: ClearGuard HD end caps compared to conventional end caps.
- Trial name
- NCT02604264
- Testing
- ClearGuard HD end cap
- Where
- United States
- Volunteers
- 2,912 people
- Sponsor
- Pursuit Vascular, Inc.
End Stage Renal Disease on Dialysis
Colchicine and Inflammation in Hemodialysis Patients
Chronic, low-grade inflammation is regarded as a common comorbid condition in chronic dialysis patients. Increased inflammatory markers in chronic dialysis patients are associated with adverse clinical outcomes .
- Trial name
- CICI-HP (NCT05677555)
- Testing
- Colchicine 0.5 MG
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
Kidney Failure, Chronic, Heart Failure
Empagliflozin in ESKD - A Feasibility Study
The aim of this study is to learn about the safety of empagliflozin in dialysis patients as a preparation for a future large clinical trial.
- Trial name
- NCT05687058
- Testing
- Empagliflozin 25 mg thrice-weekly post-hemodialysis dosing, Empagliflozin 10 mg daily dosing
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of Mississippi Medical Center
End Stage Renal Disease
The 2-minute Walk Test in Hemodialysis Patients
Walking tests are widely used to assess functional capacity in different populations because of their ease of administration, interpretability and representativeness of activities of daily living.The aim of our study was to…
- Trial name
- NCT06650215
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
End Stage Liver Disease, Liver Diseases
Normothermic Liver Preservation Trial
This trial is to assess the safety and efficacy of normothermic machine perfusion (NMP) as an organ preservation method prior to transplantation using the OrganOx metra™ device.
- Trial name
- NCT03089840
- Testing
- OrganOx metra
- Where
- Canada
- Volunteers
- 106 people
- Sponsor
- University of Alberta
End Stage Renal Disease (ESRD), Kidney Disease
RaDIANT Health Systems Intervention
The overarching goal of the proposed study is to determine whether the addition of structural interventions at the health system level targeting upstream barriers in the transplant process will improve access to transplant…
- Trial name
- NCT07033117
- Testing
- Performance Feedback Reports on Referral and Evaluation Closures, Dialysis Facility Awareness Campaign, Patient Contact via Preferred Method
- Where
- 5 sites in United States
- Volunteers
- 14,000 people, healthy volunteers welcome
- Sponsor
- Indiana University
End Stage Renal Disease on Dialysis
AQP-1 Polymorphism on Fluid Status in Hemodialysis Patients
It is a cross sectional observational study. It is to investigate whether AQP-1 polymorphism has any impact on fluid status in hemodialysis patients.
- Trial name
- NCT05275387
- Testing
- observational study, no intervention
- Where
- China
- Volunteers
- 250 people
- Sponsor
- RenJi Hospital
End Stage Renal Disease, Kidney Failure
Using Shared Decision Making to Improve Kidney Transplantation Rates
The goal of this clinical trial is to increase shared decision-making between dialysis providers and patients in order to increase patients' probability of transplantation and to reduce socioeconomic/racial disparities in access…
- Trial name
- NCT06141499
- Testing
- Provider educational materials, Patient letters
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Columbia University
End Stage Renal Disease, End Stage Renal Disease on Dialysis
First Evaluation of the Moda-Flx Hemodialysis System™ in Real World Clinical Settings
This is a non-significant risk study utilizing a device cleared for use by the FDA under its 510(k) clearance. Consented patients will complete their usual dialysis treatment under professional care in an ICHD (In-Center…
- Conditions
- End Stage Renal Disease, End Stage Renal Disease on Dialysis, End Stage Kidney Disease
- Trial name
- NCT06581393
- Testing
- Moda-flx Hemodialysis System
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Diality Inc.
Left Ventricular Dysfunction
Use of Adult Autologous Stem Cells in Treating People Who Have Had a Heart Attack (The TIME Study)
Heart attacks are a leading cause of death for both men and women in the United States. A heart attack occurs when blood flow to the heart is restricted, commonly due to a blood clot that has formed in one of the coronary…
- Trial name
- NCT00684021
- Testing
- Adult stem cells
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- The University of Texas Health Science Center, Houston
End Stage Kidney Disease (ESKD)
Acupuncture for Symptom Burden and Quality of Life in Patients With End-Stage Kidney Disease
Patients with end-stage kidney disease (ESKD) undergoing hemodialysis or peritoneal dialysis experience a high burden of symptoms, including fatigue, pain, pruritus, muscle cramps, and sleep disturbances, which substantially…
- Trial name
- Acup-ESKD (NCT07887607)
- Testing
- Acupuncture
- Where
- Greece
- Volunteers
- 160 people
- Sponsor
- University General Hospital of Heraklion
Anemia, Renal Insufficiency, Chronic
A Prospective Interventional Study Assessing the Clinical and Operational Effectiveness of Transitioning From Mircera to Daprodustat for the Treatment of Anemia in End Stage Kidney Disease
Investigator-initiated, interventional, prospective study to assess the clinical and operational effectiveness of daprodustat in adult patients receiving in center hemodialysis or peritoneal home dialysis who are transitioning…
- Conditions
- Anemia, Renal Insufficiency, Chronic, Renal Anemia
- Trial name
- ROQ-IT (NCT05951192)
- Testing
- Daprodustat
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- USRC Kidney Research
Hemodialysis Complication, Anticoagulants
Variability in Micro-CT Imaging Results to Quantify Dialyzer Clotting
Different cross-over studies have been performed investigating dialyzer fiber patency in different dialysis setups. Herewith, post dialysis micro computed tomography (CT) images of the dialyzer were compared.
- Trial name
- ClotVar (NCT06140563)
- Testing
- anticoagulation dosing
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- University Hospital, Ghent
End-Stage Renal Disease, Renal Dialysis
Effects of Horticultural Therapy on Acute Stress and Salivary Cortisol Levels in Hemodialysis Patients
The purpose of this study is to evaluate the acute psychological and physiological effects of a single-session structured horticultural therapy program on patients undergoing routine hemodialysis.
- Conditions
- End-Stage Renal Disease, Renal Dialysis, Acute Stress
- Trial name
- NCT07845214
- Testing
- Horticultural Therapy
- Volunteers
- 80 people
- Sponsor
- Ataturk University
Diabetic Kidney Disease (DKD)
YiqiJiangzhuoHuoxueTongluo Method to Delay the Occurrence of End-stage Renal Disease in Diabetic Kidney Disease--Study1
In order to reduce the clinical demand for kidney dialysis rate of Diabetic Kidney Disease（DKD） patients, a bidirectional cohort study of 4472 patients with DKD (Qi deficiency and collateral stasis syndrome) was carried out based…
- Trial name
- NCT07032116
- Where
- 5 sites in China
- Volunteers
- 4,472 people
- Sponsor
- Liu Hongfang
End Stage Renal Disease, Hemodialysis
The Effects of Intradialytic Exercise in Hemodiafiltration Patients
Low physical activity is associated with in hemodialysis and hemodiafiltration (HDF) patients. Previous studies showed the benefits of intradialytic exercise for improvement of physical fitness and hemodialysis adequacy.
- Conditions
- End Stage Renal Disease, Hemodialysis, Sedentary Lifestyle
- Trial name
- NCT03353844
- Testing
- Intradialytic exercise
- Where
- Thailand
- Volunteers
- 12 people
- Sponsor
- Chulalongkorn University
Chronic Kidney Failure, HIV Infection
Kidney Transplant for HIV-Infected Patients in Renal Failure
This study will examine the safety and effectiveness of renal (kidney) transplantation for HIV-infected patients with end-stage renal disease (kidney failure).
- Trial name
- NCT00009009
- Testing
- immunosuppressive regimen designed to complement HAART
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Gastric Cancer, Complication,Postoperative
The Model for End-Stage Liver Disease Sodium (MELD-Na) Score in Non-cirrhotic Patients With Gastric Cancer
Gastric cancer is the fifth most common cancer worldwide. Gastrectomy with lymphadenectomy is still the most effective treatment modality, depending on the stage and location.
- Conditions
- Gastric Cancer, Complication,Postoperative, Complications; Gastrointestinal, Postoperative, Morality
- Trial name
- NCT04791293
- Testing
- MELD-Na score
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people
- Sponsor
- Istanbul Training and Research Hospital
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