Clinical trials: End Stage Disease
End Stage Renal Failure on Dialysis, Actual Impaired Fluid Volume
Blood Volume Analysis and Renal Outcomes in Hemodialysis
The objective of the proposed study is to demonstrate that serial blood volume analysis (BVA) using RI-BVA (BVA-100, Daxor, NY) can be used to guide changes in prescription of dry weight for hemodialysis patients.
- Conditions
- End Stage Renal Failure on Dialysis, Actual Impaired Fluid Volume, Kidney Failure
- Trial name
- NCT02717533
- Testing
- dry weight adjustment
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- VA New York Harbor Healthcare System
End Stage Renal Disease
Reducing Arrhythmia in Dialysis by Adjusting the Rx Electrolytes/Ultrafiltration, Study A
The primary purpose of this study is to test the feasibility of trials which change the dialysate (dialysis bath prescription) of potassium and bicarbonate according to a standardized algorithm and according to the results of…
- Trial name
- RADAR-A (NCT03519347)
- Testing
- Potassium Removal Maximization, Potassium Gradient Minimization, Alkalosis Avoidance
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- NYU Langone Health
End Stage Renal Disease, Pruritus
Evaluating the Effect of Senna in Uremic Pruritus
Uremic pruritus remains one of the most frustrating and potentially disabling symptoms in patients with end stage renal disease. It affect up to 90 percent of patients with end stage renal disease.
- Trial name
- NCT02008864
- Testing
- Senna
- Volunteers
- 60 people
- Sponsor
- Shiraz University of Medical Sciences
Kidney Diseases
Promoting Increases in Living Donation Via Tele-navigation (PILOT)
We hypothesize that expansion of the Living Donor Navigator (LDN) program to include tele-health delivery will overcome geographic disparities in access and facilitate sustained increases in living donation.
- Trial name
- PILOT (NCT05468463)
- Testing
- Living Donor Navigator Program
- Where
- United States
- Volunteers
- 347 people
- Sponsor
- University of Alabama at Birmingham
End Stage Renal Disease on Dialysis
VR Study Virtual Reality for Patients During Arteriovenous Fistula Surgery
Patients undergoing arterio-venous fistula commonly experience pain and anxiety due to their pre-operative circumstances and the fact that they remain conscious throughout the surgery.
- Trial name
- VR (NCT07538687)
- Testing
- Virtual Reality
- Volunteers
- 64 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Terminal Illness
Open-Label Treatment Extension of Protocol MNTX 301
This study is an open-label extension allowing patients who have completed Protocol MNTX 301 to continue to receive SC MNTX.
- Trial name
- NCT01367600
- Testing
- SC Methylnaltrexone (MNTX)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Bausch Health Americas, Inc.
End Stage Renal Disease on Dialysis
Coated Aldehyde Oxystarch for Protein-Bound Uremic Toxin Reduction in End-Stage Renal Disease
The goal of this clinical trial is to learn if Coated Aldehyde Oxystarch (Xiqing) works to reduce protein-bound uremic toxins (PBUTs) in adults with end-stage renal disease (ESRD).
- Trial name
- NCT07653711
- Testing
- Coated Aldehyde Oxystarch
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University People's Hospital
Chronic Periodontitis, End Stage Renal Disease
Novel PAradigm to Improve Inflammatory Burden in ESRD (rePAIR): A Pilot and Feasibility Randomized Controlled Trial
The goal of this project is to assess repeated and ongoing oral care and the way it may affect inflammation and quality of life in hemodialysis patients.
- Trial name
- rePAIR (NCT03241511)
- Testing
- Test
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- UConn Health
End-Stage Renal Disease
L-Carnitine in Peritoneal Dialysis
The development of glucose-sparing strategies able to provide an efficacious ultrafiltration profile represents one of the modern goals of peritoneal dialysis therapy.
- Trial name
- NCT00922701
- Testing
- L-carnitine
- Where
- Italy
- Volunteers
- 4 people
- Sponsor
- Iperboreal Pharma Srl
Kidney Failure, Chronic, Exercise
The Effect of Physical ACtivity Enhancement Scheme (PACES) in Hemodialysis Patients
Hemodialysis is the most commonly used renal replacement therapy for end-stage renal disease (ESRD) patients. At present, more than 553,000 ESRD patients in China are receiving hemodialysis treatment, but the long-term survival…
- Conditions
- Kidney Failure, Chronic, Exercise, Physical Activity, Renal Dialysis
- Trial name
- NCT05718765
- Testing
- PACES intervention
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xi'an Jiaotong University
Diabetes Mellitus, Type 2, End-Stage Kidney Disease
Sitagliptin Versus Glipizide in Participants With Type 2 Diabetes Mellitus and End-Stage Renal Disease (MK-0431-073 AM1)
The purpose of the study is to compare sitagliptin and glipizide in lowering blood sugar in participants with type-2 diabetes mellitus (T2DM) and end-stage renal disease on dialysis who do not have adequate glycemic control.
- Trial name
- NCT00509236
- Testing
- Sitagliptin, Glipizide
- Volunteers
- 129 people
- Sponsor
- Merck Sharp & Dohme LLC
End-stage Renal Disease
Effect of Acupressure on Fatigue in Hemodialysis Patients
OBJECTIVE: To investigate the effect of acupressure on fatigue in patients with end-stage renal disease (ESRD) undergoing hemodialysis (HD) as well as assess sleep quality and psychological status HYPOTHESIS TO BE TESTED: Upon…
- Trial name
- NCT05571007
- Testing
- True acupressure
- Where
- Indonesia
- Volunteers
- 116 people
- Sponsor
- Woung-Ru Tang
Knee Osteoarthritis, Sarcopenia
The Effects of Pulsed Electromagnetic Field Therapy on Patients With End-stage of Knee Osteoarthritis
A double-blinded, randomizepd controlled trial to investigate the treatment effects of pulsed electromagnetic field (PEMF) on end stage of knee osteoarthritis patients with sarcopenia will be carried out.
- Trial name
- NCT05550428
- Testing
- home-based-exercise, active pulsed electromagnetic field（PEMF）therapy
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
End-stage Renal Failure, Graft Rejection
Standard Versus Prolonged-release Tacrolimus Monotherapy After Alemtuzumab Induction in Kidney Transplantation
The current anti-rejection drug regime for kidney transplant recipients in use at the West London Renal \& Transplant Centre (WLRaTC) consists of induction therapy with the very potent monoclonal antibody Campath 1-H…
- Trial name
- TAESR (NCT00807144)
- Testing
- Tacrolimus (Kidney transplant maintenance immunosuppression), Kidney transplant maintenance immunosuppression
- Where
- United Kingdom
- Volunteers
- 102 people
- Sponsor
- Imperial College Healthcare NHS Trust
Kidney Diseases, Chronic Kidney Diseases
Pathways Project: Kidney Supportive Care
The Pathways Collaborative is the first attempt to implement supportive (palliative) kidney care at multiple sites in the United States.
- Conditions
- Kidney Diseases, Chronic Kidney Diseases, End Stage Renal Disease, End Stage Renal Disease on Dialysis
- Trial name
- NCT04125537
- Testing
- IHI Breakthrough Collaborative Model
- Where
- 13 sites in United States
- Volunteers
- 476 people
- Sponsor
- George Washington University
End Stage Renal Disease, Hemodiafiltration
To Assess the Effect of HDF Versus High Flux Dialysis on Free Light Chains and Cumulative Albumin Loss, in End Stage Renal Disease Patients.
Removal of uremic toxins is the main goal of HD, It was improved by using high volume convective technique with high flux (HF) dialyzer.
- Conditions
- End Stage Renal Disease, Hemodiafiltration, Hemodialysis
- Trial name
- NCT04747067
- Testing
- BIOPURE 260HF dialyzer
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Ain Shams University
End Stage Liver Diseases
Analysis of Respiratory System Mechanics and Inflammatory Response During Orthotopic Liver Transplantation (SPPLIT Trial)
During orthotopic liver transplantation (OLT), respiratory system function may be severely impaired for several reasons including anaesthesia effects, hyperdynamic volume state with fluid overload and ischemia reperfusion injury.
- Trial name
- SPPLIT (NCT02119585)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Turin, Italy
Heart Failure, Systolic, Renal Disease, End Stage
Interleukin-1 Blockade for the Treatment of Heart Failure in Patients With Advanced Chronic Kidney Disease
Interleukin-1 blockade for the treatment of heart failure in patients with advanced chronic kidney disease (End-stage renal disease and Heart fAilure - Anakinra Remodeling Trial) is a Phase 2, single-arm trial designed to…
- Conditions
- Heart Failure, Systolic, Renal Disease, End Stage, Chronic Kidney Diseases
- Trial name
- E-HART (NCT03062176)
- Testing
- Anakinra
- Sponsor
- Virginia Commonwealth University
Colorectal Neoplasms
Clinical Study of Apatinib and XELOX Combination Regimen to Treat Colorectal Cancer Patients
This study makes an observation over the objective response rate of Apatinib and XELOX combination regimen in the first-line treatment of metastatic colorectal cancer.
- Trial name
- NCT02829385
- Testing
- Apatinib and XELOX combined treatment group
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Shoucheng Ma
Hyperphosphatemia, End-stage Renal Disease
Study of Individualized Therapy on Hyperphosphatemia in Maintenance Hemodialysis Patients
This study is designed to study and compare the efficacy and cost-effectiveness of individualized phosphate-lowering therapy in comparison with regular guideline-recommended therapy.
- Trial name
- NCT02684643
- Testing
- enhanced individualised therapy, non-enhanced individualised therapy, regular intervention
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Huashan Hospital