Clinical trials: End Stage Disease
CLL / SLL
Zanubrutinib Induction Followed by Delayed Fixed-Duration Combination With Sonrotoclax for CLL/SLL：Stop Trial 2.0
The goal of this clinical trial is to learn if zanubrutinib induction followed by delayed fixed-duration combination with sonrotoclax works to treat previously untreated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic…
- Trial name
- ZS (NCT07682415)
- Testing
- 12 cycles of zanubrutinib followed by 12 cycles of zanubrutinib in combination with sonrotoclax, zanubrutinib maintenance until disease progression
- Where
- 7 sites in China
- Volunteers
- 60 people
- Sponsor
- Yi Shuhua
Parkinson Disease
Striatal and Extra-Striatal Cholinergic Terminal Density in LRRK2-PD Mutation
This study explores how a specific genetic mutation of leucine-rich repeat kinase 2 (LRRK2) affects individuals with Parkinson's disease (PD), comparing those with the mutation to others with Parkinson's disease and without the…
- Trial name
- LRRK2 (NCT07642908)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Hospice, Psilocybin
Pilot Study of Psilocybin-Assisted Therapy for Demoralization in Patients Receiving Hospice Care
The overall objective of this study is to develop and pilot test a novel regimen of psilocybin-assisted psychotherapy for demoralization in patients receiving hospice care.
- Conditions
- Hospice, Psilocybin, Demoralization, Terminal Illness
- Trial name
- PATH (NCT04950608)
- Testing
- Psilocybin, Psychotherapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Yvan Beaussant, MD, MSci
Dilated Cardiomyopathy (DCM), Heart Failure
Safety and Efficacy of FAP iCDC in End-stage Dilated Cardiomyopathy
To study the safety and efficacy of fibroblast activation protein (FAP)-targeted immunosuppressive chimeric antigen receptor-dendritic cell (CAR-DC) in the treatment of end-stage dilated cardiomyopathy and provide a new method…
- Trial name
- NCT06902896
- Testing
- FAP immunosuppressive CAR-DC
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
End Stage Renal Disease
A Comparison of Physical Activity Levels With and Without Feedback Via Fitbit® Flex™ in Hemodialysis Patients
This is a pilot study intended to gather data in order to inform future studies about the role of feedback as an incentive for increasing levels of physical activity which could improve health in hemodialysis patients.
- Trial name
- IAM (NCT02320513)
- Testing
- Wearing activty monitoring device (Fitbit Flex), Fitbit Flex
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Renal Research Institute
Cancer, End Stage Renal Disease
The Singapore Chinese Health Study
The "Singapore Chinese Health Study" is a cohort study established by the Department of Epidemiology and Public Health in National University of Singapore, together with collaborators from several universities in the United…
- Conditions
- Cancer, End Stage Renal Disease, Diabetes, Cardiovascular Diseases
- Trial name
- SCHS (NCT03356340)
- Volunteers
- 63,257 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Knee Osteoarthritis, Pain, Joint
Pain Function and QOL Undergoing Whole-Body Vibration and Exercise in End-Stage Knee Osteoarthritis
Knee osteoarthritis (KOA) is a chronic progressive disease that imparts substantial socioeconomic burden to society and healthcare systems.
- Trial name
- NCT06183177
- Testing
- Whole-Body Vibration, Exercise
- Where
- Hong Kong
- Volunteers
- 517 people
- Sponsor
- Chinese University of Hong Kong
End-Stage Renal Disease, End-Stage Kidney Disease
Global Study of MK-2060 (Anti-Factor XI Monoclonal Antibody) in Participants With End Stage Renal Disease Receiving Hemodialysis (FXI Hemodialysis Study) (MK-2060-007)
The purpose of this study is to evaluate the efficacy and safety of two different doses of MK-2060 (a monoclonal antibody against Factor XI) in end stage renal disease (ESRD) participants receiving hemodialysis via an…
- Conditions
- End-Stage Renal Disease, End-Stage Kidney Disease, Kidney Failure, Chronic
- Trial name
- NCT05027074
- Testing
- MK-2060
- Where
- 120 sites in United States, Argentina and 13 more
- Volunteers
- 506 people
- Sponsor
- Merck Sharp & Dohme LLC
End Stage Renal Disease, End Stage Renal Failure on Dialysis
First-in-Human (FIH) Study of the Xeltis Hemodialysis Access Graft
A feasibility study is to assess the preliminary safety and performance of the Xeltis hemodialysis access (aXess) graft.
- Trial name
- aXess-FIH (NCT04898153)
- Testing
- aXess
- Where
- 6 sites in Belgium, Italy and 2 more
- Volunteers
- 20 people
- Sponsor
- Xeltis
Anemia Associated With End Stage Renal Disease
Study of Roxadustat Conversion in Participants Receiving Stable ESA or as Initial Anemia Treatment in Hemodialysis Participants
The purpose of this study is to assess the safety and effectiveness of roxadustat dosing regimens among hemodialysis participants converted from erythropoiesis stimulating agent (ESA) therapy or who are ESA-naïve.
- Trial name
- ASPEN (NCT04484857)
- Testing
- Roxadustat
- Where
- 26 sites in United States
- Volunteers
- 283 people
- Sponsor
- Kyntra Bio
End-Stage Liver DIsease
Effect of Different Frequencies of Umbilical Cord-mesenchymal Stem Cells Through Peripheral Vein in Patients With ESLD
Stem cells are non-terminal cells that can self renew and replicate through symmetric or asymmetric division, with the potential to differentiate into different types of cells and tissues.
- Trial name
- NCT06242405
- Testing
- umbilical cord-mesenchymal stem cells
- Where
- China
- Volunteers
- 92 people
- Sponsor
- General Hospital of Shenyang Military Region
Kidney Failure, Chronic
Observational Study to Evaluate the Time to Achieving the Maintenance Dose of Zemplar® (Paricalcitol Injection) in the Treatment of Patients Suffering From End-stage Renal Disease and Severe Over-reactivity of the Parathyroid Glands
This observational study will evaluate the clinical benefit of Zemplar (paricalcitol injection) in daily routine practice in end-stage renal disease patients with severe over-reactivity of parathyroid glands.
- Trial name
- NCT01273597
- Where
- 11 sites in Hungary
- Volunteers
- 60 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Chronic Kidney Disease Requiring Chronic Dialysis, Cardiovascular Calcification
The Intravenous Amino Acid Therapy for Vascular Rigidity in End Stage Renal Disease
The goal of this study is to learn if giving amino acids through the dialysis machine can help protect the blood vessels and heart in people with kidney failure.
- Trial name
- NASCAR (NCT07392697)
- Testing
- Amino Acid Supplementation, Sterile Saline Arm
- Where
- Norway
- Volunteers
- 120 people
- Sponsor
- Haukeland University Hospital
Cardiogenic Shock, End-stage Heart Failure
ECLS Versus IMPELLA™ as Bridge to LVAD (ECI-BLAD)
In this retrospective observational multicenter study the authors tested the hypothesis that the use of IMPELLA™ pump as bridge to bridge, by giving the opportunity of active rehabilitation, should improve patient's outcomes…
- Trial name
- ECI-BLAD (NCT04480151)
- Testing
- standard of care
- Where
- 5 sites in France
- Volunteers
- 92 people
- Sponsor
- University Hospital, Bordeaux
Airway Disease
Nitrate Supplementation During Final Examination Stress
The purpose of the present study is to explore the effects of a dietary nitrate supplement on immunity, mood, cardiovascular activity, and lung function during and following final exam stress in both healthy and asthmatic…
- Trial name
- NCT03159273
- Testing
- Beetroot Juice Group
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Southern Methodist University
Postprandial Hypoglycemia, End-stage Renal Disease (ESRD)
Anakinra for the Treatment of Postprandial Hypoglycemia in a Patient With Total Gastrectomy and End-Stage Renal Disease
Post-meal low blood sugar (postprandial hypoglycemia) is a common problem after certain stomach surgeries like gastric bypass or stomach removal.
- Conditions
- Postprandial Hypoglycemia, End-stage Renal Disease (ESRD), Gastrectomy, Glucose Metabolism Disorders
- Trial name
- AnPHy-ReD (NCT07580079)
- Testing
- Anakinra (interleukin-1 receptor antagonist)
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- Marc Donath
Anemia
Evaluation of the Conversion From Peginesatide to Epoetin Alfa in Patients Receiving Hemodialysis
The purpose of this study is to evaluate whether hemodialysis patients on peginesatide can be converted to epoetin alfa by using a predefined conversion table while achieving a stable hemoglobin.
- Trial name
- NCT01737879
- Testing
- Peginesatide, Epoetin alfa
- Where
- 23 sites in United States
- Volunteers
- 41 people
- Sponsor
- Amgen
End Stage Renal Disease
Ultrafiltration Profiling and Outcomes Among Individuals on Maintenance Hemodialysis
The rate of fluid removal (ultrafiltration, UF) during hemodialysis (HD) may contribute to cardiovascular morbidity and mortality among individuals receiving maintenance HD.
- Trial name
- NCT03301740
- Testing
- UF profiling during HD, Conventional HD
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of North Carolina, Chapel Hill
Critical Illness, Chronic Disease
Improving Communication About Serious Illness
The purpose of this study is to improve care delivered to patients with serious illness by enhancing communication among patients, families, and clinicians in the outpatient setting.
- Conditions
- Critical Illness, Chronic Disease, Terminal Care, Palliative Care
- Trial name
- ICSI (NCT01933789)
- Testing
- Communication Feedback Form for Patients with Serious Illness
- Where
- 6 sites in United States
- Volunteers
- 817 people
- Sponsor
- University of Washington
HIV Infections
Assessment of Asymptomatic Heart Disease in Children With HIV
The purpose of this study is to perform cardiac evaluation in HIV-1 (predominantly clade C)infected children by history, physical examination, echocardiogram and plasma N-terminal pro-B-type natriuretic peptide (N-BNP)measurement…
- Trial name
- NCT00426374
- Testing
- echocardiography and blood test
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
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