Clinical trials: End Stage Disease
Knee Osteoarthritis
Pulsed Electromagnetic Field Therapy on Muscle Strength and Function in Patients With End-stage of Knee Osteoarthritis
End-stage OA knee is one of the most common musculoskeletal complaints, with over 34,000 patients waiting for joint replacement in Hong Kong and is expected to increase as the population continues to age constantly.
- Trial name
- NCT06196567
- Testing
- PEMF, exercise
- Where
- Hong Kong
- Volunteers
- 43 people
- Sponsor
- Chinese University of Hong Kong
Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis
Steroid Impregnated Tape in the Treatment of Over-granulating Peritoneal Dialysis Exit Sites
Kidney failure is a devastating illness requiring treatment with dialysis or transplantation to preserve life. Individuals unable to have transplants are managed by peritoneal dialysis (PD)or haemodialysis (HD).
- Conditions
- Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, End Stage Renal Failure, Chronic Renal Failure
- Trial name
- STOP (NCT01996930)
- Testing
- Haelan tape (steroid impregnated tape), Silver Nitrate
- Where
- 8 sites in United Kingdom
- Volunteers
- 32 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Hyperphosphatemia, End-stage Renal Disease
A Safety and Tolerability Study of Zerenex (Ferric Citrate) in Patients With End-Stage Renal Disease (ESRD)
This study is to evaluates the safety and tolerability of Zerenex™ (ferric citrate) as a treatment for hyperphosphatemia in patients with End-Stage Renal Disease.
- Trial name
- NCT00648167
- Testing
- ferric citrate
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Keryx Biopharmaceuticals
Kidney Disease, Chronic, End Stage Renal Disease
Development and Test of a Communication Skills Training for Transplant Providers - Aims 2 & 3
The goal of this clinical trial is to understand the communication occurring between Black and Caucasian patients and their transplant providers during transplant evaluation consultations and assess relationships between these…
- Conditions
- Kidney Disease, Chronic, End Stage Renal Disease, Kidney Replacement
- Trial name
- EPPComm (NCT06182475)
- Testing
- EPPComm Provider Training
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Temple University
End-Stage Renal Disease
Gum Arabic as Antioxidant and Anti-inflammatory in Hemodialysis Patients
Oxidative processes increased in patients with renal failure and especially patients with end stage renal failure on dialysis. Oxidative stress plays a role in renal damage and also on cardiovascular disease, atherosclerosis…
- Trial name
- GA&CRF (NCT03214692)
- Testing
- Gum Arabic
- Where
- Sudan
- Volunteers
- 50 people
- Sponsor
- Lamis Kaddam
End Stage Renal Disease (ESRD), Arteriovenous Fistula Patency
Anesthetic Effect of Ropivacaine on Local Infiltration Anesthesia in Arteriovenous Fistula Surgery
This study compares two local anesthetics, ropivacaine and lidocaine, for patients undergoing arteriovenous fistula surgery. Arteriovenous fistula is the preferred vascular access for end-stage kidney disease patients needing…
- Conditions
- End Stage Renal Disease (ESRD), Arteriovenous Fistula Patency, Chronic Kidney Disease 5D
- Trial name
- NCT07259772
- Testing
- Ropivacaine, Lidocaine
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The First People's Hospital of Lianyungang
Antioxidative Stress, End Stage Renal Disease on Dialysis
A Novel Role of Alpha Lipoic Acid in Comparison With Selenium in Mitochondrial Resuscitation and miRNA-126 Expression in Hemodialysis Patients
An Open labeled, Paralled, Randomized, Prospective, study was conducted on 60 patients who were randomized into 3 groups, 22, 20 and 18 patients in Control, Selenium and, Thiotacid groups respectively.
- Trial name
- NCT05266794
- Testing
- Alpha lipoic acid, Selenium
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Ain Shams University
Acute-On-Chronic Liver Failure, Chronic Liver Failure
Micro-encapsulated Hepatocyte Intraperitoneal Transplantation in Liver Failure Adults
This is a prospective single-center dose escalation study of the administration of the microencapsulated hepatocyte therapy in adult liver failure.
- Trial name
- NCT05727722
- Testing
- a single course of micro-encapsulated hepatocytes intraperitoneal transplantation therapy
- Where
- China
- Volunteers
- 10 people
- Sponsor
- RenJi Hospital
Renal Insufficiency, Chronic, Kidney Failure, Chronic
Effect of Vitamin D Supplementation on Balance in CKD
Patients with end-stage renal disease on dialysis (ESRD5D) are 4-5x more likely to suffer from a fracture. Fractures can occur spontaneously but typically occur after a fall.
- Trial name
- NCT03710161
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Nebraska
End Stage Renal Disease
Pharmacokinetics of Immunosuppressants in Renal Transplant Candidates Who Have Undergone Laparoscopic Sleeve Gastrectomy
The purpose of this study is to evaluate how quickly and to what extent different immunosuppressants are absorbed into the blood (this is called pharmacokinetics) in renal transplant candidates who have undergone a laparoscopic…
- Trial name
- NCT02221583
- Testing
- Astagraf XL, Prograf, Mycophenolate mofetil
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Cincinnati
Chronic Kidney Disease
Evaluation of the Effect of a Daily Dose of Wakame Seaweed on Reducing Circulating Concentrations of Advanced Glycation End Products in Patients With Stage III Chronic Kidney Disease
Persistent glomerular hyperfiltration is a characteristic feature of the early stages of kidney disease and represents a factor in the progression of chronic kidney disease (CKD).
- Trial name
- Ckd-WEED (NCT07729683)
- Testing
- Consumption of wakame
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Groupe Hospitalier de la Rochelle Ré Aunis
Anemia, Kidney Failure, Chronic
Study of the Efficacy of Darbepoetin Alfa in the Treatment of Renal Anemia
Anaemia is a common consequence of chronic renal failure. Darbepoetin alfa is a unique erythropoietic protein that stimulates erythropoiesis by the same mechanism as endogenous erythropietin and conventional recombinant human…
- Conditions
- Anemia, Kidney Failure, Chronic, Peritoneal Dialysis, Continuous Ambulatory
- Trial name
- NCT00563446
- Testing
- Darbepoetin alfa
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Hospital Authority, Hong Kong
End Stage Renal Disease
Evaluation of STARgraft-3 for Hemodialysis
This study is a single site, prospective, single arm evaluation of the safety and effectiveness of the Healionics STARgraft-3 hemodialysis access graft.
- Trial name
- NCT05729620
- Testing
- Implant of STARgraft-3 shunt in the upper arm and subsequent use for hemodialysis access
- Where
- Paraguay
- Volunteers
- 21 people
- Sponsor
- Healionics Corporation
End Stage Renal Failure
Volume,Sodium and Blood Pressure Management in HD
The purpose of this study to conduct a pilot, randomized trial in stable HD patients to evaluate the effect of gradual, step-wise reduction of post-hemodialysis target weight, combined with diligent dietary sodium restriction and…
- Trial name
- VSBP (NCT01766882)
- Testing
- Lower sodium intervention, Progressive Challenge to Post Dialysis Weight
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan
Kidney Failure, Chronic, End Stage Renal Disease, Requiring Dialysis
FREEDOM: Following Rehabilitation, Economics and Everyday-Dialysis Outcome Measurements Study
Purpose The purpose of this study is to compare the economical impact and clinical parameters of short daily hemodialysis using the NxStage® System One hemodialysis device with thrice-weekly conventional in-center dialysis using…
- Trial name
- NCT00288613
- Where
- 41 sites in United States
- Volunteers
- 501 people
- Sponsor
- NxStage Medical
Copd, End Stage Lung Disease
Health Coaching Telemedicine Program for Lung Transplant Candidates With End-stage Lung Disease.
Lung transplantation has become standard of care for selected patients with end stage pulmonary disease. While on the lung transplantation waiting list, patient health, emotional wellbeing and quality of life can deteriorate.
- Trial name
- HCTP (NCT06428513)
- Testing
- HCTP
- Where
- Israel
- Volunteers
- 56 people
- Sponsor
- Sheba Medical Center
Kidney Diseases, End Stage Renal Disease
Non- Clinical Coagulation Activation During Hemodialysis
Every patient included in the study will undergo 1 conventional hemodialysis treatment, ie 1 study visit. During the conventional hemodialysis treatment lasting 4 hours, 2 blood samples will be taken at different time points (5…
- Conditions
- Kidney Diseases, End Stage Renal Disease, Hemodialysis Complication
- Trial name
- NC-Coact (NCT04063423)
- Testing
- blood sample
- Where
- Belgium
- Volunteers
- 32 people
- Sponsor
- Universitair Ziekenhuis Brussel
Renal Disease, End Stage Renal Disease
A Multi-Center, Open-Label Study
This study will be an open-label, single-treatment, single-dose, parallel group study to evaluate the pharmacokinetics (PK) of droxidopa in subjects with mild, moderate, and severe renal dysfunction and End Stage Renal Disease…
- Trial name
- NCT01468259
- Testing
- Droxidopa
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Chelsea Therapeutics
SLE, Lupus Nephritis
Tacrolimus Versus Cyclophosphamide as Treatment for Lupus Nephritis
In this comparative open-label cohort study, the investigators compared the efficacy and safety of tacrolimus (TAC)and cyclophosphamide (CYC) in the treatment of diffuse proliferative and membranous lupus nephritis with severe…
- Conditions
- SLE, Lupus Nephritis, Renal Insufficiency, End-stage Renal Disease
- Trial name
- NCT01207297
- Testing
- Tacrolimus, cyclophosphamide
- Volunteers
- 40 people
- Sponsor
- Zhejiang University
ESRD (End Stage Renal Disease), Dialysis
Laser Acupuncture for Fatigue in Hemodialysis Patients
The goal of this clinical trial is to learn if laser acupuncture (low-level laser therapy) works to treat fatigue and improve quality of life in adults with end-stage renal disease (ESRD) undergoing hemodialysis.
- Conditions
- ESRD (End Stage Renal Disease), Dialysis, Fatigue
- Trial name
- LA-HD-Fatigue (NCT07538310)
- Testing
- Low-Level Laser Acupuncture (LA)
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Taipei City Hospital
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