Clinical trials: End Stage Disease
Peritoneal Dialysis Complication, End Stage Kidney Disease
meChANisms and sAfety of SGLT2 Inhibition in peRitoneal dialYsis
The primary aim of this study is to determine the safety and mechanisms of SGLT2 inhibition in individuals on peritoneal dialysis (PD) with residual kidney function (RKF).
- Conditions
- Peritoneal Dialysis Complication, End Stage Kidney Disease, Sodium-glucose Co-transporter-2 Inhibitors, Kidney Dysfunction
- Trial name
- CANARY (NCT05715814)
- Testing
- Empagliflozin 25 MG
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Hemodialysis Complication, End Stage Renal Disease
Inferior Vena Cava Sonography in Hemodialysis Patients and Quality of Life
Determination of dry weight in patients with end-stage renal disease treated with hemodialysis is an unmet challenge in clinical nephrology.
- Trial name
- NCT03061552
- Testing
- sonographic measurement of inferior vena cava diameter
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
End Stage Liver Disease, Jaundice
SSM Predicts Outcomes of CLD Inpatients With Acute Liver Injury
In this study, a single non-invasive tool, spleen stiffness measurement (SSM), was used to monitor the disease regression of inpatients with chronic liver disease (CLD) and acute liver injury.
- Conditions
- End Stage Liver Disease, Jaundice, Liver Dysfunction, Portal Hypertension
- Trial name
- NCT06173947
- Testing
- FibroScan® Expert 630
- Where
- China
- Volunteers
- 411 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Illness Terminal
The Family Talk Intervention When a Parent With Dependent Children or a Child is Severely Ill
The overall aim of this study is to evaluate the effects and the implementation process of the Family Talk Intervention (FTI) in clinical practice when a child or a parent of dependent children has a…
- Trial name
- NCT05020158
- Testing
- Family Talk Intervention
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Ersta Sköndal University College
Kidney Failure, Chronic, Neuromuscular Blockade
Efficacy and Safety of Sugammadex in Renal Diseased Patients
The purpose of this study is to determine whether sugammadex reverses a profound neuromuscular blockade induced by rocuronium in patients with end-stage renal disease just as effectively and safely as it does in patients with…
- Trial name
- NCT01785758
- Testing
- Sugammadex (4 mg/Kg)
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Chronic Kidney Disease Stage 5 on Dialysis
An Exercise Facilitator to Activate Simple Training Programs in the Dialysis Center
Low physical activity levels and progressive poor functional capacity affect quality of life and clinical outcomes of Chronic Kidney Disease (CKD) patients.
- Trial name
- NCT04282616
- Testing
- Home-based unstructured physical activity program, Home-based structured low-intensity physical activity program, In-hospital structured supervised physical activity program
- Where
- Italy
- Volunteers
- 144 people
- Sponsor
- University Hospital of Ferrara
End-Stage Renal Disease
Intelligent Control Approach to Anemia Management
First clinical evaluation of "Smart Anemia Manager" algorithm.
- Trial name
- NCT00572533
- Testing
- ESA Dose Adjustment per standard Anemia Management Protocol, ESA Dose Adjustment per "Smart Anemia Manager" Algorithm
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Louisville
End Stage Renal Disease on Dialysis
Nutritional Interventions in Peritoneal Dialysis Patients with Hypoalbuminemia
Inadequate dietary protein intake is well-known cause of hypoalbuminemia in dialysis population. Protein loss into dialysate and increased catabolic state due to uremic milieu or inflammation worsened hypoalbuminemia, hence high…
- Trial name
- NCT04546958
- Testing
- Whey protein supplements, Nutritional counseling
- Where
- Taiwan
- Volunteers
- 33 people
- Sponsor
- Far Eastern Memorial Hospital
Vitamin D Deficiency, Hypocalcemia
Effect of Vitamin D Supplement on Disease Activity in SLE
To study the effect of vitamin D supplementation on disease activity of SLE ( SLEDAI-2K ) and IL-6 level
- Conditions
- Vitamin D Deficiency, Hypocalcemia, Hyperparathyroidism, Systemic Lupus Erythematosus (Disorder)
- Trial name
- NCT05260255
- Testing
- vitamin D2 ( calciferol )
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
End-Stage Renal Disease
L-Carnitine as an Osmo-metabolic Agent for Peritoneal Dialysis
A major challenge of peritoneal dialysis (PD) therapy is the development of glucose-sparing strategies able to provide an efficacious ultrafiltration (UF) profile.
- Trial name
- NCT00851838
- Testing
- L-Carnitine
- Where
- Italy
- Volunteers
- 5 people
- Sponsor
- Iperboreal Pharma Srl
Metastatic Breast Cancer
Open Label Dose-Finding Study of TRC105 Plus Capecitabine for Metastatic Breast Cancer
The purpose of this study is to determine the recommended phase 2 dose and overall safety and tolerability of TRC105 when given in combination with capecitabine for the treatment of patients with progressive or recurrent…
- Trial name
- TRC105 (NCT01326481)
- Testing
- TRC105, Capecitabine
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Tracon Pharmaceuticals Inc.
End Stage Renal Disease
Equivalence of Triferic® (Ferric Pyrophosphate Citrate) Administered Via Hemodialysate and Intravenously to Adult CKD-5HD Patients
The main purpose is to establish the equivalence of Triferic iron administered via dialysate into the arterial blood line and into the venous blood line
- Trial name
- NCT03303144
- Testing
- Triferic
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Rockwell Medical Technologies, Inc.
Advanced Glaucoma, Refractory Glaucoma
Safety Study of Conventional Versus Micropulse Transscleral Cyclophotocoagulation in Treating End-Stage Glaucoma
The aim of this study is to compare the safety and efficacy of conventional and micropulse transscleral diode laser in the treatment of end-stage glaucoma.
- Trial name
- NCT00349414
- Testing
- Micropulse Transscleral Cyclophotocoagulation, Conventional Transscleral Cyclophotocoagulation
- Where
- Singapore
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
End Stage Renal Disease, Inflammation
Influence of the Vitamine E Coated Dialyzer on Inflammation and Anemia
Evaluation of the effect of a vitamin E coated high flux polysulfone dialyzer on the inflammatory state of patients' end stage renal disease and its clinical benefits in terms of anemia Objectives : To assess the benefits of a…
- Trial name
- EVIA (NCT03218865)
- Testing
- VIE high flux dialyzer, Leoceed H high flux dialyzer
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hemotech
Endometriosis Related Pain, Overactive Bladder
Study on the Safety of BAY1817080 How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given to Participants With Moderate Renal Impairment and End Stage Renal Disease Requiring Dialysis Compared With Matched Participants With Normal Renal Function
BAY1817080 is currently under clinical development to treat pain related to unexplained chronic cough or chronic cough not affected by a treatment (refractory and/or unexplained chronic cough, RUCC), or a condition where the…
- Conditions
- Endometriosis Related Pain, Overactive Bladder, Diabetic Neuropathic Pain, Refractory or Unexplained Chronic Cough
- Trial name
- NCT04471337
- Testing
- BAY1817080
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bayer
End Stage Kidney Disease
Potassium Containing Salt-Substitute in Hemodialysis-Dependent End Stage Kidney Disease
16 individuals with hemodialysis-dependent end stage kidney disease will receive 16 days of a potassium-containing salt-substitute and 16 days of standard table salt in random order.
- Trial name
- NCT05558267
- Testing
- Standard Table Salt, Salt Substitute
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
End Stage Renal Disease
Safety and Dose Finding Study of Xigris in Hemodialysis Patients
The purpose of the study is to assess the safety of Xigris (Drotrecogin alfa) as an anticoagulant at different dose levels during dialysis treatment in patients with End Stage Renal Disease (ESRD).
- Trial name
- Xigris1003 (NCT01227187)
- Testing
- Drotrecogin alfa activated (Xigris)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- George Washington University
End Stage Renal Disease
Relevance of Flavanols for Cardiovascular Function in End-Stage Renal Disease
In this study, the acute and long-term effects of flavanols on vascular function in patients with ESRD will be investigated.
- Trial name
- ESRD (NCT00835887)
- Testing
- low and high dose flavanoids
- Where
- Germany
- Sponsor
- RWTH Aachen University
End-stage Renal Disease, Chronic Kidney Disease
Acupuncture for Pain Management of Hemodialysis Patients
The purpose of this study is to determine the feasibility, effectiveness and safety of acupuncture for pain management in hemodialysis patients.
- Trial name
- NCT01102816
- Testing
- Individualized acupuncture treatment, Routine care
- Where
- 2 sites in South Korea
- Volunteers
- 1 people
- Sponsor
- Korea Institute of Oriental Medicine
Ventricular Tachycardia, End-stage Heart Failure
Ventricular Tachycardia Ablation in LVAD Patients
The CHANNELED-Registry is a multicenter retrospective study to (1) systematically assess the mechanism and origin of ventricular tachycardia in patients with end-stage heart failure carrying an left ventricular assist device…
- Conditions
- Ventricular Tachycardia, End-stage Heart Failure, Ventricular Arrythmia, LVAD (Left Ventricular Assist Device)
- Trial name
- CHANNELED (NCT06063811)
- Testing
- Ablation
- Volunteers
- 50 people
- Sponsor
- Universitätsklinikum Köln
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