Clinical trials: End Stage Disease
Acute Lung Injury, End Stage Lung Disease
Voxelotor for Improving Oxygen Saturation in Adults
The purpose of the study is to evaluate the efficacy of voxelotor for increasing oxygen saturation in 20 patients with hypoxemia.
- Trial name
- Voxelotor (NCT05289570)
- Testing
- Voxelotor
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Duke University
Insomnia, End Stage Renal Disease
Short and Long-Term Effectiveness of Existing Insomnia Therapies for Patients Undergoing Hemodialysis
Insomnia is a common and distressing symptom for patients on hemodialysis (HD), and there is evidence for a much larger impact on the health of patients.
- Trial name
- Sleep-HD (NCT03534284)
- Testing
- Cognitive Behavioral Therapy for Insomnia, Trazodone
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- University of Washington
Kidney Failure, Chronic, Catheter-Related Infections
Study Assessing Safety & Effectiveness of a Catheter Lock Solution in Dialysis Patients to Prevent Bloodstream Infection
The purpose of this study is determine safety and effectiveness of Neutrolin, a catheter lock solution, for prevention of central venous catheter associated bloodstream infection in hemodialysis patients.
- Trial name
- NCT02651428
- Testing
- Neutrolin, Heparin
- Where
- 5 sites in United States
- Volunteers
- 806 people
- Sponsor
- CorMedix Therapeutics
End Stage Renal Failure on Dialysis, Periodontitis
Effect of Non-Surgical Periodontal Therapy on Serum Albumin Levels of Patients on Maintenance Hemodialysis Therapy,
Periodontitis is a destructive chronic infection of the gums, ligaments, and bone, predominantly caused by Gram-negative bacteria. Individuals with periodontal disease are at increased risk of systemic diseases.
- Trial name
- NCT01641757
- Testing
- non-surgical periodontal therapy
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- University of the Punjab
End Stage Renal Disease
Effects of Extended Haemodialysis Treatment Duration in Patients With End-stage Renal Disease
Design: Prospective randomised cross-over study. Fifty-two eligible patients will be randomised to a treatment time of either 6 hours or 4 hours for a period of 24 weeks and following a washout period of 4 weeks, switch to the…
- Trial name
- NCT01721421
- Testing
- extended treatment time, Standard treatment time
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- Imperial College London
End Stage Liver Disease
Splenectomy During Whole Liver Transplantation
Indications for splenectomy during whole liver transplantation remain controversial and splenectomy is often avoided because of common complications.
- Trial name
- NCT03609411
- Testing
- Splenectomy
- Where
- France
- Volunteers
- 141 people
- Sponsor
- Hospices Civils de Lyon
Chronic Liver Failure
Aerobic Capacity Muscle Strength and Health Related Quality of Life in Children With Chronic Liver Disease
Physical therapy program for children with chronic liver disease consist of gait training, strengthening ex for UL\&ll, stretching exercise to improve physical fitness and quality of life
- Trial name
- NCT06240832
- Testing
- Physical therapy exercise
- Where
- Egypt
- Volunteers
- 18 people
- Sponsor
- Cairo University
Participants Must be Women Aged 25 Years or Older, Participants Should Have no Self-reported History of Heart Disease or Stroke
RCT of HeartBot in Women
The goal of this clinical trial is to find out whether an app-based program called HeartBot II, which uses an artificial intelligence (AI) chatbot, can help improve women's awareness and knowledge of heart attacks in women.
- Conditions
- Participants Must be Women Aged 25 Years or Older, Participants Should Have no Self-reported History of Heart Disease or Stroke, Participants Should Have no Terminal Illness or Diagnosed Cognitive Impairment, Including Alzheimer's Disease, Participants Should Not be a Healthcare Professionals or Healthcare Trainees
- Trial name
- HeartBot II (NCT07416734)
- Testing
- HeartBot II Program, Waitlist Control
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Chronic Kidney Diseases
Chronic Kidney Disease: Determinants of Progression and Cardiovascular Risk
Chronic kidney disease has become an important Public Health issue in most developed and developing countries, with increasing incidence and prevalence rates.
- Trial name
- PROGREDIR (NCT03393663)
- Testing
- CKD-related outcomes
- Volunteers
- 454 people
- Sponsor
- University of Sao Paulo
Kidney Disease
Inspiratory Muscle Training in Patients With End-stage Renal Disease
Background: Patients with chronic kidney disease on hemodialysis may have reduced diffusion capacity, lung function and gas exchange due to mechanical and hemodynamic changes in the respiratory system, and decreased respiratory…
- Trial name
- NCT02599987
- Testing
- POWERbreathe® Classic Light
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Universidade Federal de Pernambuco
Liver Disease, Liver Neoplasms
Orthotopic Liver Transplantation Using a Living Donor
The purpose of this study is to: determine the safety of donor right hepatic lobectomy as a procedure to provide a liver graft for living donor liver transplantation.
- Trial name
- NCT00152607
- Testing
- donor right hepatic lobectomy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
End Stage Renal Disease
Study to Evaluate the Safety of Chronic Administration of Simulect to Subjects Receiving a First Kidney Transplant
The study is undertaken to explore the safety of using Simulect at monthly dose intervals to reduce the need of high dose/level CNI's such as Prograf.
- Trial name
- Simulect (NCT00928811)
- Testing
- basiliximab
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Drexel University College of Medicine
Chronic Kidney Disease, Stage 4 (Severe), Chronic Kidney Disease, Stage 5
Impact of PREMs in the Shared Decision Process for Renal Replacement Treatment Methods.
The French "my health 2022" plan is the first bundled payment initiative for stage 4 and 5 chronic kidney disease (CKD) pathway with the aim to improve the quality of care and promote a multi professional collaboration for a more…
- Trial name
- PEACE (NCT06819345)
- Testing
- Survey form
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Hospices Civils de Lyon
Cardiac Disease
DEF-315 Better Accuracy in Ejection Fraction (EF) Assessment With DEFINITY
This is a Phase 3, prospective, open-label, multicenter study to evaluate Left Ventricular Ejection Fraction (LVEF) measurement accuracy and reproducibility of DEFINITY® contrast-enhanced and unenhanced echocardiography as…
- Trial name
- BENEFIT2 (NCT03719612)
- Testing
- DEFINITY®
- Where
- 15 sites in United States
- Volunteers
- 160 people
- Sponsor
- Lantheus Medical Imaging
Sevoflurane, Kidney Diseases
Comparing Sevoflurane With Propofol Sedation in ESRF Patients
End-stage renal failure (ESRF) cohorts undergo brachiocephalic fistula(BCF) transposition with supraclavicular block. However, this is inadequate because the incision may extend to the axillary region which requires…
- Conditions
- Sevoflurane, Kidney Diseases, Procedural Hypotension
- Trial name
- NCT04839536
- Testing
- Sevoflurane inhalant product
- Volunteers
- 36 people
- Sponsor
- University of Malaya
End Stage Renal Disease, Pruritus
Evaluating the Effect of Senna in Uremic Pruritus
Uremic pruritus remains one of the most frustrating and potentially disabling symptoms in patients with end stage renal disease. It affect up to 90 percent of patients with end stage renal disease.
- Trial name
- NCT02008864
- Testing
- Senna
- Volunteers
- 60 people
- Sponsor
- Shiraz University of Medical Sciences
End Stage Renal Disease, Kidney Transplantation
Efficacy of Sirolimus-Based, Steroid Avoidance Immunosuppression African Americans
African Americans receiving a kidney transplant are considered at high risk for early rejection of their transplanted kidney and require more immunosuppression to maintain their kidney transplant function.
- Trial name
- NCT00189202
- Testing
- Sirolimus
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Michigan
End-stage Kidney Disease
Symptom Management in Patients on Dialysis
This is a parallel arm, pilot study used to examine the feasibility of electronic patient reported outcome measures (ePROMs) for symptom assessment and monitoring as well as a linked self-management support and decision support…
- Trial name
- NCT05515991
- Testing
- SUPPORT-DIALYSIS with Access to Output Report and Information Hub, SUPPORT-DIALYSIS Only
- Where
- 2 sites in Canada
- Volunteers
- 36 people
- Sponsor
- University Health Network, Toronto
End Stage Renal Disease
Investigating the Effectiveness of Intradialytic Massage on Cramping in Dialysis Patients
Primary Aim. The primary aim is to determine the effectiveness of intradialytic massage on the frequency and severity of cramping among hemodialysis patients prone to lower extremity cramping during treatment.
- Trial name
- NCT01944280
- Testing
- massage
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Catherine Sullivan
End Stage Kidney Disease
Moda-flx Hemodialysis System™ Under Professional Care Settings by Trained Individuals and At Home by Participants
The purpose of this study is to evaluate the safety and efficacy of the Moda-flx Hemodialysis System™ when used Under Professional Care Settings by trained individuals and At Home by trained Participants and Care Partners
- Trial name
- NCT06613568
- Testing
- Moda-flx Hemodialysis System™
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- Diality Inc.
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