Clinical trials: End Stage Liver Disease
Hepatitis C
Outcomes in Hepatitis C After Living Donor Liver Transplantation in Association With Interleukin 28 B
Hepatitis C is the leading cause of liver transplants in the USA. Given that there is a national organ shortage, living donor liver transplantation has became a viable option for patients with end stage liver disease who are not…
- Trial name
- NCT01429155
- Testing
- Interleukin 28B genotype
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Henry Ford Health System
End Stage Liver Disease
A Comparison of Propofol Based Total Intravenous Anesthesia and Desflurane Based Balanced Anesthesia on Hepatic Protection During Living-donor Liver Transplantation
Renal ischemia/reperfusion (I/R)-induced injury is known to be associated with immediate and long-term hepatic dysfunction after liver transplantation.
- Trial name
- NCT02504138
- Testing
- Desflurane balanced anesthesia, Propofol total intravenous anesthesia
- Where
- South Korea
- Volunteers
- 136 people
- Sponsor
- Yonsei University
End Stage Liver DIsease, Chronic Liver Failure
The Early Strength Training Program in Post-transplant Liver Cases
Liver transplantation (LT) is a current life-saving procedure performed as an open-abdominal surgery for patients with end-stage liver diseases (ESLD).
- Conditions
- End Stage Liver DIsease, Chronic Liver Failure, Liver Transplant Disorder, Muscle Loss
- Trial name
- NCT04546048
- Testing
- Strength Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Memorial Hospital Groups
Acute Kidney Injury, Hyperglycemia
Impact of Glycemic Control After Reperfusion on Acute Kidney Injury in Living Donor Liver Transplantation
This retrospective cohort study of patients classified by the blood glucose level after reperfusion in liver transplantation repicient.
- Conditions
- Acute Kidney Injury, Hyperglycemia, Hypoglycemia, End Stage Liver Disease
- Trial name
- NCT06320730
- Testing
- Observational study, records of blood glucose level after reperfusion
- Where
- South Korea
- Volunteers
- 3,790 people
- Sponsor
- Asan Medical Center
Liver Transplant; Complications
Identifying Perceived Barriers and Facilitators Toward a Liver Transplantation Prehabilitation
The purpose of this study is to formally identify patient and caregiver perceived needs, barriers, and facilitators to inform the development of a home-based multimodal prehabilitation program for potential LT candidates.
- Trial name
- NCT04854564
- Testing
- Prehabilitation intervention, Caregiver intervention
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- University of Alabama at Birmingham
28 Day Mortality
Thromboelastography Guides a Multicentre Cluster Controlled Study of Plasma Exchange for Hepatitis B Associated Acute-on-chronic Liver Failure
In the past ten years, the extracorporeal liver support system has been widely used in clinical practice as a first-line treatment of liver failure.
- Trial name
- NCT04747106
- Testing
- plasma exchange
- Where
- China
- Volunteers
- 390 people
- Sponsor
- Nanfang Hospital, Southern Medical University
End-stage Liver Disease, Liver Cirrhosis
Nutrition and Exercise Prehabilitation in Patients Awaiting Liver Transplantation
This study aims to evaluate the effects of a diet with even protein distribution plus exercise (Group A) versus a diet with skewed protein distribution plus exercise (Group B) versus standard dietary and physical activity advice…
- Conditions
- End-stage Liver Disease, Liver Cirrhosis, Liver Transplantation, Malnutrition
- Trial name
- POWER-LT (NCT07561138)
- Testing
- Diet with even protein distribution plus exercise program, Diet with skewed protein distribution plus exercise program, Standard dietary and physical activity advice
- Where
- 2 sites in Greece
- Volunteers
- 90 people
- Sponsor
- Kalliopi Anna Poulia
Acute-On-Chronic Liver Failure
TAK-242 in Patients With Acute Alcoholic Hepatitis
A phase 2a double-blind, randomized, placebo-controlled, multicenter, proof-of-concept study to evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of TAK-242 in subjects with acute decompensation of…
- Trial name
- NCT04620148
- Testing
- TAK-242
- Where
- 3 sites in United Kingdom
- Volunteers
- 4 people
- Sponsor
- Akaza Bioscience Ltd
End Stage Heart Disease, Hepatitis C
DAA Treatment in Donor HCV-positive to Recipient HCV-negative Heart Transplant
This is a proof of concept, single center study for the donation of HCV-positive hearts to HCV negative recipient patients, with preemptive, interventional treatment with 12 weeks of commercially available DAA therapy to prevent…
- Trial name
- NCT03208244
- Testing
- Clinically prescribed direct acting antiviral
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Liver Failure, Acute on Chronic, Liver Dysfunction
A Validation Cohort for ACLF Diagnosis and Prognosis
Acute on chronic liver failure (ACLF) is a distinct entity encompassing the acute deterioration of liver function, culminating in multiple organs failure and high short-term mortality.
- Trial name
- Ch-CANONIC-Val (NCT03641872)
- Testing
- Standary therapy
- Where
- 12 sites in China
- Volunteers
- 1,370 people
- Sponsor
- Hai Li
End Stage Liver DIsease, Liver Transplant; Complications
Intraoperative Normal Saline Administration and Acute Kidney Injury in Patients Undergoing Liver Transplantation
The investigators attempted to investigate the association of the type of crystalloid administered during liver transplantation with postoperative clinical outcomes.
- Conditions
- End Stage Liver DIsease, Liver Transplant; Complications, Liver Cirrhosis
- Trial name
- NCT05386953
- Testing
- Normal saline, Balanced crystalloid solution
- Where
- South Korea
- Volunteers
- 1,440 people
- Sponsor
- Seoul National University Hospital
Acute Liver Failure, Acute-On-Chronic Liver Failure
Role of Fecal Microbiota in Predicting Graft Rejection and Sepsis Among Recipients of Living Donor Liver Transplant in First Year.
Efficient immunosuppressive therapy and improved surgical techniques have developed liver transplantation as a well-established and life-saving treatment. The 1-year survival rate of approximately 85-90%.
- Conditions
- Acute Liver Failure, Acute-On-Chronic Liver Failure, Liver Cirrhosis
- Trial name
- NCT04621812
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
End Stage Liver Disease, Living Donor
Effect of Intermittent Hepatic Inflow Occlusion During Donor Hepatectomy In Living Donor Liver Transplantation
Intermittent hepatic inflow occlusion (IHIO), also called Pringle maneuver, is a safe and effective procedure for major hepatectomy in patients with liver disease.
- Trial name
- NCT01171742
- Testing
- Intermittent hepatic inflow occlusion (IHIO)
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Samsung Medical Center
Palliative Care, End Stage Liver DIsease
MELD ESAS Evolution: Assessment of the Symptomatic Burden of Patients With Advanced Chronic Liver Disease
The goal of this observational study is to understand if there is a correlation between the evolution of MELD-Na and symptomatic burden of patients with advanced chronic liver disease.
- Trial name
- MELDESAS (NCT06181474)
- Testing
- ESAS
- Where
- Portugal
- Volunteers
- 44 people
- Sponsor
- Unidade Local de Saúde de Matosinhos, EPE
Cirrhosis, End Stage Liver Disease
Screening for Liver Cancer With CT vs. Ultrasound in Patients With Advanced Liver Disease
The purpose of this study is to determine whether ultrasound or CT scanning is more effective at detecting early liver cancer in patients with advanced liver disease.
- Conditions
- Cirrhosis, End Stage Liver Disease, Hepatitis C
- Trial name
- NCT01350167
- Testing
- Screening
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Antiviral Drugs
The Renal Safety of Tenofovir Alafenamide in HBV-related Acute-on-chronic Liver Failure: Real-World Study
Tenofovir alafenamide (TAF) and entecavir (ETV) are the preferred agents in patients with predisposing factors for nephrotoxicity, but few studies to date have directly compared the renal safety of the two antiviral drugs in…
- Trial name
- NCT05453448
- Testing
- tenofovir alafenamide, Entecavir
- Where
- China
- Volunteers
- 272 people
- Sponsor
- Xiangya Hospital of Central South University
End-stage Kidney Disease
Optimizing Kidney Transplant Informed Consent
The objective of this study is to evaluate kidney transplant candidates' comprehension about increased risk donor kidneys necessary for informed consent.
- Trial name
- NCT01859884
- Testing
- Inform Me: web-based education tool
- Where
- 2 sites in United States
- Volunteers
- 288 people
- Sponsor
- Northwestern University
Inpatient With End Stage Liver Disease
Is Access to Liver Transplantation Similar in Alcoholic or Not Patients?
The purpose of this study is to determine whether there are reasons other than medical reasons that could limit access to liver transplantation in alcoholic patients.
- Trial name
- TRANSALC (NCT01820819)
- Where
- France
- Volunteers
- 574 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cirrhosis, Liver, Acute-On-Chronic Liver Failure
20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid in Cirrhosis With Sepsis Induced Hypotension
Patients with cirrhosis patients have a high incidence of sepsis which can trigger decompensation and may result in prolonged hospital stay and increased mortality.
- Conditions
- Cirrhosis, Liver, Acute-On-Chronic Liver Failure, Shock, Septic, Shock Hypovolemic
- Trial name
- NCT05441878
- Testing
- 20% albumin, Balanced salt solution
- Where
- India
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Hepatic Encephalopathy, Acute-On-Chronic Liver Failure
Role of Bilirubin Molecular Species in Hepatic Encephalopathy and Acute-on-chronic Liver Failure
It has been identified that impaired liver function, as occurs in patients with liver cirrhosis, prevents proper conjugation of glucuronic acid with bilirubin; as a result, unconjugated bilirubin accumulates in the blood, and…
- Trial name
- NCT05566548
- Testing
- Liquid Chromatography-Mass Spectrometry Method to identify bilirubin molecular species
- Where
- Mexico
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medica Sur Clinic & Foundation