Clinical trials: End Stage Lung Disease
Lung Cancer
Diagnosis and Treatment Planning in Patients Suspected of Having Lung Cancer
RATIONALE: Diagnostic procedures and treatment-planning systems may affect outcome in patients suspected of having lung cancer. PURPOSE: Randomized diagnostic trial to compare the effectiveness of two types of diagnostic and…
- Trial name
- NCT00005071
- Testing
- biopsy, bronchoscopy, computed tomography
- Where
- United Kingdom
- Sponsor
- Royal Marsden NHS Foundation Trust
Cardiac Ischemia, Thoracic Cancer
Perioperative Troponin I and NT Pro-BNP in Lung Resection
After lung resection, troponin elevation may be regulated by mechanisms other than myocardial ischemia. Perioperative natriuretic peptides measurement may help identify changes in ventricular function during thoracic surgery.
- Conditions
- Cardiac Ischemia, Thoracic Cancer, Complication,Postoperative
- Trial name
- NCT04749212
- Testing
- serum high-sensitivity Troponin I (TnI) and NT-Pro-Brain Natriuretic Peptide (NT-proBNP)
- Where
- Spain
- Volunteers
- 475 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Lung Diseases
Study to Evaluate the Value of the Follow-up of CALCIneurin Activity to MOdulate Calcineurin Inhibitors-induced Immunosuppression in Lung Transplantation
The study is an interventional, multicentre, prospective, randomized, controlled, single-blind, comparative trial of two processes for adjusting the inhibitor of calcineurin (CNI) dosage in lung transplant recipients.
- Trial name
- CalciMo-TP (NCT02897895)
- Testing
- levels of CNI in whole blood, Calcineurin activity (CN-a) in peripheral blood mononuclear cells (PBMCs)
- Where
- France
- Volunteers
- 134 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
End-stage Lung Disease
Perioperative Recovery Outcomes With a Spontaneous Breathing Strategy in Severely Underweight Lung Transplant Recipients
The goal of this prospective, multicenter, single-arm clinical study is to learn whether a spontaneous breathing-preserving perioperative management strategy can improve recovery and is safe in lung transplant recipients with…
- Trial name
- NCT07384572
- Testing
- Lung transplantation that preserves spontaneous breathing function
- Volunteers
- 56 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Bladder Cancer, Breast Cancer
Physician-Initiated Stop-Smoking Program for Patients Receiving Treatment for Early-Stage Cancer
RATIONALE: Physician-initiated smoking cessation strategies may be effective in getting early-stage cancer patients to quit smoking.
- Conditions
- Bladder Cancer, Breast Cancer, Colorectal Cancer, Head and Neck Cancer
- Trial name
- NCT00002520
- Testing
- nicotine, Usual Care
- Where
- United States
- Volunteers
- 434 people
- Sponsor
- Eastern Cooperative Oncology Group
Critical Illness, Chronic Disease
Improving Communication About Serious Illness
The purpose of this study is to improve care delivered to patients with serious illness by enhancing communication among patients, families, and clinicians in the outpatient setting.
- Conditions
- Critical Illness, Chronic Disease, Terminal Care, Palliative Care
- Trial name
- ICSI (NCT01933789)
- Testing
- Communication Feedback Form for Patients with Serious Illness
- Where
- 6 sites in United States
- Volunteers
- 817 people
- Sponsor
- University of Washington
Diabetes Mellitus Type 2, Kidney Disease, Chronic
A Study of Alegitazar in Patients With Type 2 Diabetes And Chronic Kidney Disease (Alerenal Study)
This randomized, double-blind, placebo-controlled study will evaluate the potential of aleglitazar to reduce the risk of end stage renal disease and cardiovascular mortality in patients with type 2 diabetes mellitus and chronic…
- Trial name
- NCT01893242
- Testing
- Aleglitazar
- Sponsor
- Hoffmann-La Roche
Pneumonia, Childhood Pneumonia
Online Learning Portal on Under Five Pneumonia
Despite the availability of standard pneumonia management guidelines and multiple global efforts, pneumonia continues to be the leading killer of children under five, accounting to around 17% of the total under five deaths…
- Conditions
- Pneumonia, Childhood Pneumonia, Infectious Disease, Acute Respiratory Infection
- Trial name
- NCT04495361
- Testing
- E-learning portal
- Where
- Pakistan
- Volunteers
- 600 people
- Sponsor
- University of Edinburgh
Solid Tumors
Open-Label Safety and Tolerability Study of INCB057643 in Subjects With Advanced Malignancies
The purpose of the Study is to select a dose and assess the safety and tolerability of INCB057643 as a monotherapy (Part 1 and Part 2) and in combination with standard-of-care (SOC) agents (Part 3 and Part 4) for subjects with…
- Trial name
- NCT02711137
- Testing
- INCB057643, Gemcitabine, Paclitaxel
- Where
- 18 sites in United States, Belgium and 1 more
- Volunteers
- 137 people
- Sponsor
- Incyte Corporation
Pulmonary Arterial Hypertension
The Combination Ambrisentan Plus Spironolactone in Pulmonary Arterial Hypertension Study
The purpose of this study is to find out if spironolactone added to ambrisentan for Pulmonary Arterial Hypertension (PAH) will increase exercise capacity.
- Trial name
- NCT02253394
- Testing
- Ambrisentan plus Spironolactone
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Brigham and Women's Hospital
Dyspnea, Lung Neoplasms
"Red Morphine Drops" for Symptomatic Treatment of Dyspnoea in Lung Cancer
The purpose of this study is to test whether "red morphine drops" applied in the mouth are superior to an equivalent amount of morphine applied as subcutaneous injection for the relief of breathlessness in terminal patients…
- Trial name
- NCT00338481
- Testing
- Morphine p.o., Morphine s.c.
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Sankt Lukas Hospice
Pulmonary Disease, Chronic Obstructive, Lung Transplantation
Evaluating Quality of Life for Patients With Chronic Obstructive Pulmonary Disease Who Are Undergoing Lung Transplantation
Most people undergoing lung transplantation have chronic obstructive pulmonary disease (COPD), a disease in which the lung airways are partly damaged and obstructed, making it difficult to breathe.
- Trial name
- NCT00675376
- Where
- United States
- Volunteers
- 419 people
- Sponsor
- Washington University School of Medicine
Disorder Related to Lung Transplantation, Chronic Lung Allograft Dysfunction
Studying the Treatment Effect of Pirfenidone in Chronic Lung Allograft Dysfunction (STOP-CLAD)
Greater than 50% of lung transplant recipients show signs of chronic lung allograft dysfunction (CLAD) by 5 years post-transplantation.Therapies to prevent or slow CLAD are lacking.
- Trial name
- NCT03473340
- Testing
- Pirfenidone Capsule
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Michigan
Lung Transplant Rejection
Study of Transbronchial Cryobiopsy in Monitoring Complications of Lung Transplantation
The goal of this randomized controlled trial is to compare the diagnostic efficacy and safety of transbronchial cryobiopsy (TBCB) and traditional transbronchial lung biopsy for diagnosing the lung transplantation rejection , so…
- Trial name
- NCT05792384
- Testing
- transbronchial lung cryobiopsy with a 1.1 mm flexible cryoprobe, transbronchial lung biopsy with biopsy forceps
- Volunteers
- 120 people
- Sponsor
- China-Japan Friendship Hospital
Kidney Diseases, Chronic Renal Insufficiency
Study to Compare Sevelamer Carbonate Powder to Sevelamer Hydrochloride Tablets in Patients With CKD on Hemodialysis
Approximately 207 patients with chronic kidney disease (CKD) on hemodialysis will be entered into this study at approximately 26 centers in the United States.
- Conditions
- Kidney Diseases, Chronic Renal Insufficiency, End-Stage Renal Disease
- Trial name
- NCT00268957
- Testing
- Sevelamer carbonate (Renvela®), Sevelamer hydrochloride (Renagel®)
- Where
- 29 sites in United States
- Volunteers
- 217 people
- Sponsor
- Genzyme, a Sanofi Company
Pulmonary Disease, Chronic Obstructive, Pulmonary Disease, Obstructive
Mortality and Symptom Burden Post Hospitalisation With COPD
Chronic Obstructive Pulmonary Disease (COPD) is a common progressive lung disease which causes breathlessness and frequent exacerbations, with patients often requiring hospitalisation.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Pulmonary Disease, Obstructive, Emphysema, Chronic Bronchitis
- Trial name
- MoSHCOPD (NCT03657121)
- Where
- 2 sites in United Kingdom
- Volunteers
- 447 people
- Sponsor
- Northumbria Healthcare NHS Foundation Trust
Cystic Fibrosis, Diabetes Related Cystic Fibrosis
Metabolic Efficiency of Combined Pancreatic Islet and Lung Transplant for the Treatment of End-Stage Cystic Fibrosis
Patients with end-stage cystic fibrosis (CF) and severe CF-related diabetes (CFRD) may benefit from combined lung-pancreatic islet transplantation.
- Conditions
- Cystic Fibrosis, Diabetes Related Cystic Fibrosis, Insulin-dependent Diabetes
- Trial name
- PIM (NCT01548729)
- Testing
- Combined pancreatic islet and lung transplantation
- Where
- 28 sites in France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Strasbourg, France
Acute Kidney Injury (AKI), Chronic Kidney Disease (CKD)
Assessment of Plasma and NGAL for the Early Prediction of Acute Kidney Injury After Cardiac Surgery in Adults Study
The study aims to recruit 156 (54 Acute Kidney Injury (AKI);102 non-AKI) patients undergoing Cardio pulmonary bypass (CPB) surgery, including those with Chronic Kidney Disease (CKD) and multiple co-morbidities.
- Conditions
- Acute Kidney Injury (AKI), Chronic Kidney Disease (CKD), End Stage Renal Disease (ESRD), Estimated Glomerular Filtration Rate (eGFR)
- Trial name
- NGAL (NCT02733328)
- Testing
- CPB Surgery
- Where
- United Kingdom
- Volunteers
- 405 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Malignant Neoplasm, Leukemia, Lymphocytic, Chronic, B-Cell
Project to Improve Communication About Serious Illness - Pilot Study
This two-year pilot study will test whether a one-page "Jumpstart Form" will affect goals-of-care discussions in the hospital. This form will be provided to clinicians and will include patient-specific information about…
- Conditions
- Malignant Neoplasm, Leukemia, Lymphocytic, Chronic, B-Cell, Lung Disease Chronic, Congestive Heart Failure
- Trial name
- PICSI-P (NCT03746392)
- Testing
- Jumpstart Intervention
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Washington
Primary Immunodeficiency, PID
Bilateral Orthotopic Lung Transplant - Bone Marrow Transplant
The purpose of this study is to determine whether bilateral orthotopic lung transplantation (BOLT) followed by cadaveric partially-matched CD3+/CD19+ depleted bone marrow transplant (BMT) is safe and effective for individuals…
- Trial name
- BOLT-BMT (NCT03330795)
- Testing
- CD3/CD19 neg allogeneic BMT
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)