Clinical trials: End Stage Lung Disease
Bladder Cancer, Cervical Cancer
Bupropion in Helping Adults Stop Smoking
RATIONALE: Bupropion may help people stop smoking by decreasing the symptoms of nicotine withdrawal. Giving bupropion over a longer period of time may be effective in helping people stop smoking.
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00534001
- Testing
- bupropion hydrochloride
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Roswell Park Cancer Institute
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Chronic Obstructive Pulmonary Disease Severe, Chronic Obstructive Pulmonary Disease End Stage
Effects of a Comprehensive Health Coaching Program in Advanced Chronic Obstructive Pulmonary Disease.
Chronic obstructive pulmonary disease due to incurable and prevalence has increased steadily, chronic respiratory disease is considered hazardous to health and quality of life of the disease.
- Trial name
- NCT03398772
- Testing
- Comprehensive Health Coaching Program
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Taipei Medical University
Cancer
Early Intervention vs. Standard Palliative Care in Improving End-of-Life Care in Advanced Cancer Patients
RATIONALE: Palliative care may help patients with advanced cancer live more comfortably. PURPOSE: This randomized clinical trial is studying an early intervention palliative care program to see how well it works compared to a…
- Trial name
- NCT00253383
- Testing
- counseling intervention, educational intervention, psychosocial assessment and care
- Where
- 2 sites in United States
- Volunteers
- 329 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Lung Cancer, Nonsmall Cell, Stage IIIA, Lung Cancer Non-Small Cell Stage IIIB
Psychosocial eHealth in Advanced Lung Cancer
Being diagnosed with cancer impairs many areas of a person's life. Although efficacious educational, emotional and social interventions exist in this regard, they often reach few survivors and late.
- Conditions
- Lung Cancer, Nonsmall Cell, Stage IIIA, Lung Cancer Non-Small Cell Stage IIIB, Lung Cancer Non-Small Cell Stage III, Lung Cancer Stage IV
- Trial name
- NCT05497973
- Testing
- E-health ecosystem of stepped psychosocial care, Usual psychosocial care
- Where
- Spain
- Volunteers
- 152 people
- Sponsor
- Institut Català d'Oncologia
Cystic Fibrosis
A Study of Ataluren in Pediatric Participants With Cystic Fibrosis
In some participants with cystic fibrosis (CF), the disease is caused by a nonsense mutation (premature stop codon) in the gene that makes the cystic fibrosis transmembrane regulator (CFTR) protein.
- Trial name
- NCT00458341
- Testing
- Ataluren
- Where
- 3 sites in Belgium, France
- Volunteers
- 30 people
- Sponsor
- PTC Therapeutics
End Stage Liver Disease, Lung Cancer
Antinociceptive Modalities on Ischemia Reperfusion Injury
Postoperative pain caused by surgery-associated tissue injury is a major concern for all the clinical practitioners. Because it affects multiple systems and induces physiological, immunological and psychological changes.
- Trial name
- NCT01932918
- Testing
- Patient controlled analgesia
- Where
- Taiwan
- Volunteers
- 142 people
- Sponsor
- National Taiwan University Hospital
End Stage Kidney Disease
Phenotyping Seroconversion Following Vaccination Against COVID-19 in Patients on Haemodialysis Study
Patients on haemodialysis are at higher risk of getting a severe form of COVID-19 if they become infected. Vaccinations are soon to arrive and offer great hope of controlling the current pandemic.
- Trial name
- NCT04815850
- Where
- United Kingdom
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of Leicester
End Stage Renal Disease (ESRD), Chronic Kidney Disease on Hemodialysis
Expanded Hemodialysis Versus High-Volume Online Hemodiafiltration for Uremic Toxin Removal
People with advanced kidney disease need dialysis to remove waste products from the blood. Some of these waste products, called uremic toxins, are small, while others are medium-sized and more difficult to remove.
- Conditions
- End Stage Renal Disease (ESRD), Chronic Kidney Disease on Hemodialysis, Renal Dialysis, Uremia; Chronic
- Trial name
- REMOV-HDx (NCT07348536)
- Testing
- Expanded Hemodialysis With Medium Cut-Off Membrane, High-Volume Online Hemodiafiltration
- Where
- Mexico
- Volunteers
- 15 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Pulmonary Hypertension
Idiopathic Pre-capillary Pulmonary Hypertension in ESKD Patients
This study investigates the prevalence and prognosis of idiopathic pre-capillary pulmonary hypertension (PH) in patients with end-stage kidney disease (ESKD).
- Trial name
- NCT02743091
- Volunteers
- 1,988 people
- Sponsor
- Toujinkai Hospital
Cystic Fibrosis
PTC124 for Cystic Fibrosis
In some patients with cystic fibrosis (CF), the disease is caused by a nonsense mutation (premature stop codon) in the gene that makes the cystic fibrosis transmembrane regulator (CFTR) protein.
- Trial name
- NCT00234663
- Testing
- PTC124
- Where
- 5 sites in United States
- Volunteers
- 24 people
- Sponsor
- PTC Therapeutics
End Stage Renal Disease on Dialysis
Pulmonary Function Tests in Children and Adolescents With End Stage Renal Disease On Regular Hemodialysis
to study pulmonary function tests in children with ESRD on regular HD and its correlation with dialysis duration and other various risk factors
- Trial name
- NCT06106438
- Volunteers
- 40 people
- Sponsor
- Assiut University
COPD
Respiratory Muscles in End-stage Lung Disease: Pathophysiological Processes & Clinical Consequences
Rationale: In patients with chronic lung diseases, the role of respiratory muscle dysfunction has been underestimated. Also, current treatment options, like chronic NIV and lung transplantation (LTx), might also have deleterious…
- Trial name
- Re-MAP (NCT06935825)
- Where
- 4 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen
Cancer, Congestive Heart Failure (CHF)
Outlook Quality of Life Intervention Study
The purpose of this study is to determine whether discussions of life story, forgiveness, and future goals improve quality of life for patients with serious illness.
- Conditions
- Cancer, Congestive Heart Failure (CHF), Chronic Obstructive Pulmonary Disease (COPD), End Stage Renal Disease (ESRD)
- Trial name
- NCT01044290
- Testing
- Life Completion, Attention Control
- Where
- United States
- Volunteers
- 221 people
- Sponsor
- VA Office of Research and Development
Breast Cancer, Lung Cancer
Using an End-of-life Conversation Game to Engage Patients With Cancer in Advance Care Planning
The goal of this clinical trial is to explore feasibility, acceptability, and effectiveness of end-of-life conversation game "Hello" as a tool to help individuals with breast, lung, and/or genito-urinary cancers treated at Penn…
- Conditions
- Breast Cancer, Lung Cancer, Genito Urinary Cancer
- Trial name
- NCT06028152
- Testing
- End-of-life conversation game called "Hello"
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Milton S. Hershey Medical Center
Lung Diseases
Interest of Learning Self-hypnosis for Patients Awaiting Lung Transplantation
Patients benefitting from a lung transplantation are subject to long-lasting and often severe post-operative pain. Self-hypnosis has been proven effective in the management of acute pain.
- Trial name
- AUTOHYPNOSE-TP (NCT02216539)
- Testing
- Self-hypnosis, Lung transplantation, Standard post-operative pain management
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Dyspnea; Uremic, End Stage Renal Disease
Dyspnea Assessment in Hemodialysis Patients
Shortness of breath is very common among patients on dialysis for kidney failure; however, its causes are often not understood. This study will explore the lungs and the heart of these patients to determine the causes of…
- Conditions
- Dyspnea; Uremic, End Stage Renal Disease, Chronic Lung Disease, Chronic Heart Disease
- Trial name
- NCT03773991
- Testing
- Lung MRI, Sodium MRI, Chest CT
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
End Stage Chronic Obstructive Airways Disease
VASCULUX-examination of the Pulmonary VASCUlar Barrier in Patients During LUng Transplantation
Lung transplantation is a well established method for surgical therapy for patients with end stage pulmonary disease. The investigators seek to determine to which extent the pulmonary vascular barrier gets harmed during lung…
- Trial name
- VASCULUX (NCT02225249)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Intradialytic Hypotension, End-Stage Renal Disease Requiring Haemodialysis
Predictive Value of Carotid Ultrasonography for Intradialytic Hypotension
This multicenter, prospective observational study aims to evaluate the predictive value of carotid corrected flow time (FTc) and peak flow velocity variability (PFVV) for hypotension during maintenance hemodialysis.
- Conditions
- Intradialytic Hypotension, End-Stage Renal Disease Requiring Haemodialysis, Uremia; Chronic, Hemodialysis
- Trial name
- CUPID (NCT07033260)
- Testing
- Non-invasive Monitoring
- Where
- China
- Volunteers
- 183 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Emphysema, Alveolitis, Fibrosing
Assessment of Heart and Heart-Lung Transplant Patient Outcomes Following Pulmonary Rehabilitation
At present, a specific community based rehabilitation programme for lung or heart-lung transplant recipients does not exist. 160 hospitals throughout the United Kingdom (UK) offer pulmonary rehabilitation programmes.
- Conditions
- Emphysema, Alveolitis, Fibrosing, Cystic Fibrosis, Bronchiectasis
- Trial name
- NCT00129350
- Testing
- Pulmonary rehabilitation programme
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust