Clinical trials: End of Life
Prostate Cancer, Neuroendocrine Tumors
A Trial of BXCL701 and Pembrolizumab in Patients With mCRPC Either Small Cell Neuroendocrine Prostate Cancer or Adenocarcinoma Phenotype.
An open-label, multicenter, Phase 1b/2 study to identify the recommended Phase 2 dose and assess the efficacy and safety of BXCL701 administered orally, as monotherapy and in combination with PEMBRO, in patients with mCRPC.
- Conditions
- Prostate Cancer, Neuroendocrine Tumors, Small Cell Carcinoma
- Trial name
- NCT03910660
- Testing
- BXCL701 plus Pembrolizumab, BXCL701 monotherapy
- Where
- 12 sites in United States, United Kingdom
- Volunteers
- 98 people
- Sponsor
- BioXcel Therapeutics Inc
Ischemic Cardiomyopathy, Dilated Cardiomyopathy
Inflammation, Cardiac Sympathetic Innervation, and Arrhythmic Sudden Death
Despite pharmacologic advances for the treatment of congestive heart failure (HF), sudden cardiac death (SCD) and pump failure remain the leading causes of mortality in patients with HF.
- Conditions
- Ischemic Cardiomyopathy, Dilated Cardiomyopathy, Inflammation, Sudden Cardiac Death
- Trial name
- NCT01919983
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Johns Hopkins University
Liver Transplantation
The Effects of Glucose/Ischemic Preconditioning on Reperfusion Injury in Deceased-Donor Liver Transplantation
Standard liver retrieval procedures for transplantation from a deceased donor inevitably result in a "reperfusion injury" to the liver tissue.
- Trial name
- NCT00718575
- Testing
- Glucose/Ischemic Preconditioning Pre-treatment
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Low Birth Weight Baby, Small for Gestational Age (SGA)
Biological Impacts of Rising Temperatures on Maternal, Fetal, and Newborn Health: A Cohort Study (BIRTH Cohort)
The goal of this study is to learn how being exposed to high environmental temperatures during pregnancy affects the health of pregnant women and their babies.
- Conditions
- Low Birth Weight Baby, Small for Gestational Age (SGA), Preterm Birth, Pregnancy Complications
- Trial name
- BIRTH (NCT06957769)
- Testing
- heat stress
- Where
- 3 sites in Pakistan
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Mucopolysaccharidosis II
Iduronate-2-sulfatase Enzyme Replacement Therapy in Mucopolysaccharidosis II (MPS II)
The purpose of this study is to determine whether the administration of iduronate-2-sulfatase enzyme in a weekly or every other week therapy frequency is safe and efficacious in patients with MPS II.
- Trial name
- NCT00069641
- Testing
- Iduronate-2-sulfatase enzyme replacement therapy
- Where
- 9 sites in United States, Brazil and 2 more
- Volunteers
- 96 people
- Sponsor
- Shire
Ventricular Arrhythmia, Cardiomyopathies
ElectroPhySiological Characterization Of the Arrhythmia Substrate for Sudden Cardiac Death PrEdiction
EP-SCOPE is a prospective, multicentric, non-randomized pilot study that aims to estimate the risk of life-threatening ventricular arrhythmia through use of advanced electrophysiological studies in patients with ischemic or…
- Conditions
- Ventricular Arrhythmia, Cardiomyopathies, Left Ventricular Ejection Fraction Less Then or Equal to 50percent
- Trial name
- EP-SCOPE (NCT07020702)
- Testing
- Implantation of an ICD
- Where
- 3 sites in France
- Volunteers
- 210 people
- Sponsor
- University Hospital, Bordeaux
Chronic Renal Failure
MSC and Kidney Transplant Tolerance (Phase A)
The general aim of the present study is to test a cell therapy with third-party ex-vivo expanded bone marrow-derived mesenchymal stromal cells (MSCs) as a strategy to induce tolerance in kidney transplant recipients with a…
- Trial name
- NCT02565459
- Testing
- Mesenchymal Stromal Cells
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- Monia Lorini
Advanced/Metastatic Solid Tumors
Study of Selumetinib (MK-5618) in Combination With Pembrolizumab (MK-3475) in Participants With Advanced/Metastatic Solid Tumors (MK-5618-001)
This study will examine the safety, pharmacokinetics, and efficacy of escalating doses of selumetinib (MK-5618) in combination with intravenous (IV) pembrolizumab (MK-3475) for participants with advanced / metastatic solid tumors.
- Trial name
- NCT03833427
- Testing
- Selumetinib, Pembrolizumab
- Where
- 6 sites in United States, Canada
- Volunteers
- 32 people
- Sponsor
- Merck Sharp & Dohme LLC
Death, Pain
Intervention to Improve Care at Life's End
The BEACON trial (Best Practices for End-of-Life Care for Our Nations' Veterans) was a six-site implementation study to evaluate a multi-component, education-based intervention to improve the quality of end-of-life care provided…
- Conditions
- Death, Pain, Dyspnea
- Trial name
- BEACON (NCT00234286)
- Testing
- Comfort care education intervention
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- US Department of Veterans Affairs
Death, Carotid Artery Disease
NOR-SYS: The Norwegian Stroke in the Young Study
NOR-SYS is a clinical research program about young ischemic stroke patients from 15 to 60 years. Patients, partners and the couple´s adult children who are at least 18 years old, are all invited to ultrasound examinations due to…
- Conditions
- Death, Carotid Artery Disease, Cardiovascular Disease, Peripheral Artery Disease
- Trial name
- NOR-SYS (NCT01597453)
- Testing
- Lifestyle counseling
- Where
- Norway
- Volunteers
- 1,062 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Solid Tumors
Study of the Safety and Efficacy of LHC165 Single Agent and in Combination With PDR001 in Patients With Advanced Malignancies
The purpose of this trial was to explore the clinical utility of two investigational agents in patients with advanced cancer. This was a multi-center, open-label Phase I/Ib study.
- Trial name
- NCT03301896
- Testing
- LHC165, PDR001
- Where
- 9 sites in United States, Belgium and 5 more
- Volunteers
- 45 people
- Sponsor
- Novartis Pharmaceuticals
Neoplasms
Evaluation and Implementation Preparation of a Proactive Palliative Care Model (ENABLE-SG)
The current interdisciplinary specialist palliative care model focuses on supporting patients with advanced cancer who have complex problems in the last weeks of life.
- Trial name
- ENABLE-SG (NCT06044441)
- Testing
- ENABLE-SG model, Wait-list control
- Where
- Singapore
- Volunteers
- 715 people, healthy volunteers welcome
- Sponsor
- National Cancer Centre, Singapore
Refractory Metastatic Colorectal Cancer
A Study Evaluating TAS-102 Plus Nivolumab in Patients With MSS CRC
A Phase 2 Study with Safety Lead-in, Evaluating TAS-102 Plus Nivolumab in Participants with Microsatellite Stable Refractory Metastatic Colorectal Cancer
- Trial name
- NCT02860546
- Testing
- TAS-102, nivolumab
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- Taiho Oncology, Inc.
Severe Combined Immunodeficiency (SCID), Immunodeficiency With Predominant T-cell Defect, Unspecified
Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases
The purpose of this study is to determine whether bilateral orthotopic lung transplantation (BOLT) followed by cadaveric partially-matched hematopoietic stem cell transplantation (HSCT) is safe and effective for patients aged…
- Conditions
- Severe Combined Immunodeficiency (SCID), Immunodeficiency With Predominant T-cell Defect, Unspecified, Severe Chronic Neutropenia, Chronic Granulomatous Disease (CGD)
- Trial name
- BOLT+BMT (NCT01852370)
- Testing
- CD3/CD19 negative allogeneic hematopoietic stem cells
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Paul Szabolcs
End of Life Care, Violent Aggressive Behavior
Death, Dying, Violence and Aggression as Shown on Medical Television Series.
Medical TV dramas have become very popular in recent years. These shows are mainly created for entertainment and often do not reflect what really happens in hospitals.
- Conditions
- End of Life Care, Violent Aggressive Behavior, Television Viewing, Media Use
- Trial name
- NCT07416669
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 500 people
- Sponsor
- King's College Hospital NHS Trust
Death, Graft Failure
TransplantLines Insulin Resistance and Inflammation Biobank and Cohort Study
Short-term (1-year) results of renal transplantation are now excellent (over 95%). Long-term (10-year and longer) results are, however, still disappointing.
- Conditions
- Death, Graft Failure, Death, Cardiac, Diabetes
- Trial name
- TxL-IRI (NCT03272854)
- Testing
- No intervention performed, the study is observational
- Volunteers
- 606 people
- Sponsor
- University Medical Center Groningen
Programmed Cell Death 1
Effect of Anesthesia on Expression of Programmed Death-1 and Programmed Death-1 Ligand in Breast Cancer
Surgery is first-line treatment for solid tumors. However, surgical trauma-induced physiologic stress has been demonstrated to facilitate metastasis and recurrence in different types of cancer.
- Trial name
- NCT04657237
- Testing
- Thoracic Paravertebral block
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Pancreatic Cancer
SBRT and Anti-programmed Cell Death Protein 1(Anti-PD-1) in Late Stage or Recurrent Pancreatic Cancer Patients
When gemcitabine based chemo and fluorouracil based chemo regimes are failed in late-stage or recurrent pancreatic cancer patients, there is no alternative options. Anti-PD-1 antibody has became a promising anti-cancer drug.
- Trial name
- CISPD-2 (NCT03716596)
- Testing
- SBRT, anti-PD-1 antibody
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Rectal Cancer, Rectal Neoplasms
Transverse Coloplasty vs. Side-to-end Anastomosis Following Low Anterior Resection (LAR): CSAR Trial
CSAR Trial's aim is to determine whether the transverse coloplasty pouch or the side-to-end anastomosis as rectal reservoir reconstruction offers the best functional results.
- Conditions
- Rectal Cancer, Rectal Neoplasms, Rectal Tumors, Fecal Incontinence
- Trial name
- CSAR (NCT03074461)
- Testing
- Side-to-End Anastomosis, Transverse Coloplasty
- Where
- 3 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Kidney Failure, Chronic
Lung Water by Ultrasound Guided Treatment in Hemodialysis Patients (The Lust Study).
Volume overload is a leading risk factor for death and cardiovascular events in end stage renal disease patients maintained on chronic dialysis, particularly in those with myocardial ischemia and heart failure which represent a…
- Trial name
- LUST (NCT02310061)
- Testing
- Extra-vascular lung water measurements by ultrasound (LW-US), Standard protocol of fluid management in hemodialysis
- Where
- 19 sites in France, Germany and 7 more
- Volunteers
- 383 people
- Sponsor
- Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy