Clinical trials: End of Life Patients
Chronic Heart Failure
Evaluation of NT PRO BNP Guided Therapy on Hospitalization Rate and Mortality in Patients With Chronic HF NYHA II-IY
To use continuous measurement of NT Pro BNP level as guide in therapy patients with CHF.
- Trial name
- NCT00469001
- Testing
- Treatment according NT Pro BNP level
- Where
- Israel
- Volunteers
- 108 people
- Sponsor
- Hillel Yaffe Medical Center
Melanoma Stage Iv
Anti-PD 1 Brain Collaboration + Radiotherapy Extension (ABC-X Study)
This is a phase II, open label, randomised trial of ipilimumab and nivolumab with concurrent intracranial stereotactic radiotherapy versus ipilimumab and nivolumab alone in patients with asymptomatic, untreated melanoma brain…
- Trial name
- ABC-X (NCT03340129)
- Testing
- Ipilimumab, Nivolumab, Stereotactic Radiotherapy
- Where
- 9 sites in Australia, Norway
- Volunteers
- 218 people
- Sponsor
- Melanoma Institute Australia
PD-L1 Gene Mutation, PD-L1 Gene Amplification
Programmed Cell Death Ligand 1 PET/CT in Various PD-L1-Related Disease Patients
To evaluate the potential usefulness of 68Ga/18F-PD-L1 positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various PD-L1-related disease patients
- Conditions
- PD-L1 Gene Mutation, PD-L1 Gene Amplification, PD-L1-related Disease, Positron Emission Tomography
- Trial name
- NCT07618936
- Testing
- Single Group Assignment
- Where
- 3 sites in China
- Volunteers
- 500 people
- Sponsor
- Tianjin Medical University
The Families or Next of Kin of Patients Treated at MSKCC for Non-cutaneous Squamous Cell Carcinomas of the, Upper Aerodigestive Tract
Improving End of Life Care in Head and Neck Cancer
The purpose of this study is to improve the quality of care provided for head and neck cancer patients. By better understanding the end of life experiences of dying patients and their families, the investigators hope to better…
- Trial name
- NCT01632969
- Testing
- The The Family Assessment of Treatment at the End of life (FATE ) survey
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Acute Promyelocytic Leukemia With PML-RARA, t(15;17)
Simplified Patient Care Strategy in Decreasing Early Death in Patients With Acute Promyelocytic Leukemia
This clinical trial studies how well simplified patient care strategy works in decreasing early death in patients with acute promyelocytic leukemia.
- Trial name
- NCT03253848
- Testing
- Simplified Patient Care Strategy, Laboratory Biomarker Analysis
- Where
- 294 sites in United States, Puerto Rico
- Volunteers
- 202 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Pulmonary Disease, Chronic Obstructive
Inhaled Long-acting Bronchodilators With or Without Inhaled Glucocorticosteroids for Preventing Hospitalizations and Death in Elderly Patients With Chronic Obstructive Pulmonary Disease
This will be a phase IV, open label, multicenter, randomized pragmatic study in frail elderly patients with COPD. Participants will be treated with either inhaled LABD alone or LABD combined with inhaled glucocorticosteroids.
- Trial name
- NCT03662711
- Testing
- Bronchodilator Agents
- Where
- 39 sites in Italy
- Volunteers
- 843 people
- Sponsor
- Università degli Studi di Ferrara
Kidney Transplantation in Highly Sensitized Patients
Efficacy and Safety in Imlifidase Desensitized Kidney Tx Patients, Including Two Non-Comparative Reference Cohorts
An open-label post authorization efficacy and safety study evaluating graft failure-free survival at 1-year in highly sensitized end-stage renal disease (ESRD) patients with positive crossmatch (XM) against a deceased donor prior…
- Trial name
- PAES (NCT05369975)
- Testing
- Imlifidase, Normal Transplantation Routine
- Where
- 22 sites in Austria, Belgium and 9 more
- Volunteers
- 113 people
- Sponsor
- Hansa Biopharma AB
Palliative Care, Refractory Pain
Single Arm, Monocentric, Pilot Feasibility Study on an Interactive Virtual Reality Program in 20 Complex In-clinic Palliative Care Patients
Palliative care patients frequently face a "symptom cluster" of pain (up to 96%), fatigue (up to 90%), and anxiety (up to 79%), which severely degrades their quality of life in their final months.The study is built on the concept…
- Conditions
- Palliative Care, Refractory Pain, Anxiety, Depression Disorders
- Trial name
- ZENCTUARY_VR+ (NCT07545928)
- Testing
- ZenctuaryVR+ Interactive Virtual Reality
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
SARS-CoV-2, Covid19
Pathological Findings of Fatal COVID-19
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new coronavirus discovered in December 2019 in Wuhan, China and currently responsible of a worldwide outbreak and the death of more than 55,000 patients in…
- Conditions
- SARS-CoV-2, Covid19, Pathology, Intensive Care Units
- Trial name
- HISTOCOVID (NCT04675281)
- Testing
- 2 post-mortem transcutaneous lung biopsies (1 anterior ; 1 posterior) using anatomical landmarks
- Where
- 44 sites in France
- Volunteers
- 170 people
- Sponsor
- Nantes University Hospital
Comorbidities, Critical Care
Method of Measuring Comorbidity to Predict Outcome After Intensive Care
In this study the investigators will validate the impact of comorbidity on readmission to intensive care unit (ICU) and mortality after ICU and which method of measuring comorbidity that is most predictive.
- Trial name
- AA (NCT04109001)
- Volunteers
- 223,495 people
- Sponsor
- Uppsala University
Sepsis
The Study of Drotrecogin Alfa (Activated) in Adult Patients With Severe Sepsis at a Low Risk of Death
Adult Patients with Severe Sepsis
- Trial name
- NCT00568737
- Testing
- Drotrecogin alfa (activated)
- Where
- 70 sites in Argentina, Australia and 10 more
- Volunteers
- 2,640 people
- Sponsor
- Eli Lilly and Company
Opiate Antagonist Overdose, Opioid-Related Disorders
Naloxone Auto-injector as a Universal Precaution for Patients With Opioid Use Disorder
The purpose of this pilot-study is to to distribute naloxone auto-injector in a "Universal Precaution" manner to patients with opioid substance use disorder.
- Trial name
- NCT02669901
- Testing
- Naloxone Auto-Injector
- Where
- United States
- Volunteers
- 395 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Carcinoma, Squamous Cell
Study of Pembrolizumab as First Line Therapy in Patients With Unresectable Squamous Cell Carcinoma of the Skin
The purpose of this study is to assess the efficacy and safety of pembrolizumab in patient with locally advanced or metastatic squamous cell carcinoma of the skin
- Trial name
- CARSKIN (NCT02883556)
- Testing
- Pembrolizumab
- Where
- France
- Volunteers
- 57 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Palliative Care
Advance Care Planning in Palliative Care
The question of the end of life is a major public health issue. In the field of palliative care, the notion of anticipation is central for people with a serious and progressive illness.
- Trial name
- ANTICIPALL (NCT05662917)
- Testing
- Individual semi-structured interviews
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Hospices Civils de Lyon
Chronic Obstructive Pulmonary Disease, End-of-Life Fear
End-of-Life Fear in Patients With End-Stage Lung Disease (COPD)
The aim of the study is to develop an interview to ask patients with COPD about their fear of death and dying, their needs and wishes at the end-of-life.
- Conditions
- Chronic Obstructive Pulmonary Disease, End-of-Life Fear, Fear About Death and Dying, Depression
- Trial name
- NCT00792974
- Testing
- A brief psycho-educational intervention
- Where
- 2 sites in Germany
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Chronic Obstructive Pulmonary Disease Severe
A Decision Aid on End-of-life Care for Patients With Advanced COPD and Their Family
This study aims to support EOL decision-making in patients with advanced COPD and their family members. A parallel two-arm single-blinded randomised controlled trial will be conducted to evaluate the effects of a specific…
- Trial name
- NCT06008210
- Testing
- Decision Support Intervention, Health Coaching
- Where
- 2 sites in China
- Volunteers
- 226 people
- Sponsor
- Food and Health Bureau, Hong Kong
Lung Cancer
Pembrolizumab Plus Epacadostat vs Pembrolizumab Plus Placebo in Metastatic Non-Small Cell Lung Cancer (KEYNOTE-654-05/ECHO-305-05)
The purpose of this study is to evaluate the efficacy and safety of pembrolizumab plus epacadostat compared to pembrolizumab plus placebo as first-line treatment in participants with metastatic non-small cell lung cancer (NSCLC)…
- Trial name
- NCT03322540
- Testing
- Pembrolizumab, Epacadostat
- Where
- 101 sites in United States, Australia and 16 more
- Volunteers
- 154 people
- Sponsor
- Incyte Corporation
End Stage Renal Disease, Malnutrition
The Effect of Intradialytic Parenteral Nutrition on Nutritional Status and Quality of Life in Hemodialysis Patients
Protein-energy wasting (PEW), a hypercatabolic state characterized by loss of muscle mass and fuel reserves, is highly prevalent in hemodialysis patients.
- Conditions
- End Stage Renal Disease, Malnutrition, Sarcopenia, Hemodialysis Complication
- Trial name
- NCT04094038
- Testing
- Olimel N12, Glucose IV
- Where
- 2 sites in Netherlands
- Volunteers
- 166 people
- Sponsor
- Erasmus Medical Center
Cardiomyopathies, Cardiac Arrest
AI-powered ECG Analysis Using Willem™ Software in High-risk Cardiac Patients (WILLEM)
WILLEM is a multi-center, prospective and retrospective cohort study. The study will assess the performance of a cloud-based and AI-powered ECG analysis platform, named Willem™, developed to detect arrhythmias and other abnormal…
- Conditions
- Cardiomyopathies, Cardiac Arrest, Cardiac Arrhythmias, Sudden Cardiac Death
- Trial name
- WILLEM (NCT05890716)
- Testing
- AI-powered ECG analysis to detect cardiac arrhythmic episodes
- Where
- 13 sites in Netherlands, Spain
- Volunteers
- 5,342 people, healthy volunteers welcome
- Sponsor
- Idoven 1903 S.L.
Opioid Use
Preventing Premature Death in Patients With Serious Opioid-related Infection
The purpose of this study is to test the efficacy of a combination of motivational interventions and a brief therapy session to increase the adherence to medication-assisted treatment (MAT) for opioids.
- Trial name
- NCT03999450
- Testing
- brief motivational intervention (BMI), cognitive behavioral therapy
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Rochester