Clinical trials: End of Life Patients
Death, Myocardial Infarction
A Trial Evaluating Vitamin D Normalization on Major Adverse Cardiovascular-Related Events Among Myocardial Infarction Patients
This study evaluates whether achieving 25-hydroxyvitamin D (25[OH] Vit D) levels (>40 ng/mL) among myocardial infarction patients will result in a reduction of cardiovascular-related adverse events.
- Conditions
- Death, Myocardial Infarction, Cerebral Vascular Accident, Heart Failure Hospitalization
- Trial name
- TARGET-D (NCT02996721)
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 634 people
- Sponsor
- Intermountain Health Care, Inc.
Chronic Kidney Disease on Hemodialysis, Physical Exercise Behavior (Liking/Aversion)
Physical Exercise in Patients With Chronic Kidney Disease in Hemodialysis (Pehedal-ESKD)
The goal of this clinical trial is to learn whether different types of exercise performed during hemodialysis are safe, well tolerated, and beneficial for adults receiving maintenance hemodialysis.
- Trial name
- Pehedal-ESKD (NCT07820514)
- Testing
- Intradialytic aerobic exercise using a cycle ergometer, Intradialytic elastic-band resistance exercise
- Where
- Italy
- Volunteers
- 312 people
- Sponsor
- Ricerca Nefrocenter
Death, Sudden, Cardiac, Ventricular Fibrillation
DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients.
To prospectively evaluate if the analysis of genetic polymorphisms can be used to identify patients at risk of ventricular tachycardia.
- Conditions
- Death, Sudden, Cardiac, Ventricular Fibrillation, Tachycardia, Atrial Fibrillation
- Trial name
- DISCOVERY (NCT00478933)
- Testing
- Defibrillator, Dual Chamber ; Implantable, Blood sampling
- Volunteers
- 1,223 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Stage IV Lung Cancer
Truthful Information on Chemotherapy and Its Impact on Chemotherapy at the End of Life
Patients with metastatic cancer have a substantial symptom burden and may receive aggressive care at the end of life. There is evidence that the use of chemotherapy near the end of life is not related to its likelihood of…
- Trial name
- HIPPOCRATE (NCT02606149)
- Testing
- Truthful information on chemotherapy risks, Standard of information
- Where
- France
- Volunteers
- 123 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hunter Syndrome
An Observational Study Evaluating Anti-Idursulfase Serum Antibody Response in Hunter Syndrome Patients
The objective of this study is to evaluate the effect of anti-idursulfase antibodies on idursulfase safety (measured by infusion related adverse events) between patients who develop anti-idursulfase antibodies and patients who do…
- Trial name
- NCT00882921
- Testing
- Idursulfase
- Where
- 6 sites in United States, Brazil and 1 more
- Volunteers
- 26 people
- Sponsor
- Shire
Rare Diseases, Fabry Disease
Evaluation of HEArt invoLvement in Patients With FABRY Disease
This study evaluates predictors for the incidence of arrhythmias and sudden cardiac death as well as terminal heart failure in patients with Fabry disease.
- Conditions
- Rare Diseases, Fabry Disease, Fabry Disease, Cardiac Variant, Hypertrophic Cardiomyopathy
- Trial name
- HEAL-FABRY (NCT03362164)
- Where
- Germany
- Volunteers
- 650 people
- Sponsor
- Wuerzburg University Hospital
Ulcerative Colitis (UC), Crohn's Diseases
Cardiovascular Risk in Patients With IBD
In this study the Research Hospital San Donato Policlinic ask the participation with the aim to evaluate the risk of cardiovascular complication (i.e. stroke, myocardial infarction) in patients with inflammatory bowel disease.
- Conditions
- Ulcerative Colitis (UC), Crohn's Diseases, Cardiovascular Risk
- Trial name
- DICOM-IBD (NCT07663201)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Drowning, Drowning; Anoxia
Primary or Secondary Drowning
According to WHO's rules, any death certificate must state the underlying cause of death and contributory causes of death may also be stated.
- Conditions
- Drowning, Drowning; Anoxia, Drowning, Near, Drowning in Swimming Pool
- Trial name
- DROWN_COD (NCT06310499)
- Testing
- Drowning
- Where
- Denmark
- Volunteers
- 700 people
- Sponsor
- Prehospital Center, Region Zealand
Clinical Outcomes
An Observational Study on Patients With NTM Pulmonary Disease
Non-tuberculous mycobacterial (NTM) infection is becoming more and more common, especially causing pulmonary diseases in those elderly or the immunocompromised.
- Trial name
- NCT04463134
- Testing
- NTM drug treatment
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Regular Low-Frequency Hemoperfusion, Medium- to Long-Term Prognosis
Impact of Regular Low-Frequency Hemoperfusion on Medium- to Long-Term Prognosis in Maintenance Dialysis Patients
Objective: To investigate the effect of regular low-frequency hemoperfusion on all-cause mortality and cardiovascular/cerebrovascular mortality risk in maintenance hemodialysis (MHD) patients.
- Conditions
- Regular Low-Frequency Hemoperfusion, Medium- to Long-Term Prognosis, Maintenance Dialysis Patients, Retrospective Study
- Trial name
- NCT07348913
- Where
- China
- Volunteers
- 879 people
- Sponsor
- Yunfeng Xia
Death, Sudden, Cardiac, Arrythmia
Monitoring of Arrhythmias in Patients Treated With Antipsychotics
Antipsychotics may be associated to life-threatening arrhythmias and sudden cardiac death. This is the fist study to estimated the arrhythmic burden using long-term monitoring by implantable loop recorder in patients treated with…
- Conditions
- Death, Sudden, Cardiac, Arrythmia, Antipsychotics and Neuroleptics Toxicity
- Trial name
- MAPP (NCT04575103)
- Testing
- Antipsychotic
- Where
- 18 sites in Denmark
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Herlev and Gentofte Hospital
Hepatitis D
HDV-Europe: Prevalence and Outcome of HDV in HIV/HBV Coinfection
The aim of this project is to set up a cross-sectional cohort study (France, Germany, The Netherlands, Poland, Spain, Switzerland, Italy, United Kingdom and Portugal) to assess the implementation of EACS guidelines for…
- Trial name
- NCT06264583
- Testing
- HDV screening
- Where
- Germany
- Volunteers
- 8,000 people
- Sponsor
- University Hospital, Bonn
Palliative Care, Advanced Cancer
A Feasibility Study of Death Education Intervention for Family Caregivers of Advanced Cancer Patients
Advanced cancer is the leading cause of death in the world and China. Family caregivers, as the closest individuals to advanced cancer patients, suffer from a range of psychological and spiritual issues due to patients' impending…
- Conditions
- Palliative Care, Advanced Cancer, Family Caregivers
- Trial name
- NCT07367984
- Testing
- Death education intervention for family caregivers of advanced cancer patients
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
Pancreatic Cancer
Study of Personalized Tumor Vaccines (PCVs) and a PD-L1 Blocker in Patients With Pancreatic Cancer That Can be Treated With Surgery
The purpose of this study is to evaluate the safety or treating pancreatic cancer with surgery to remove cancerour tissue, followed by atezolizumab, followed by a personalized cancer vaccine (PCV), and then with chemotherapy.
- Trial name
- NCT04161755
- Testing
- Atezolizumab, RO7198457, mFOLFIRINOX
- Where
- 7 sites in United States
- Volunteers
- 29 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Adenocarcinoma of the Lung, Recurrent Non-small Cell Lung Cancer
Low-Dose Acetylsalicylic Acid in Treating Patients With Stage I-III Non-Small Cell Lung Cancer
This pilot clinical trial studies low-dose acetylsalicylic acid in treating patients with stage I-III non-small cell lung cancer.
- Conditions
- Adenocarcinoma of the Lung, Recurrent Non-small Cell Lung Cancer, Stage IA Non-small Cell Lung Cancer, Stage IB Non-small Cell Lung Cancer
- Trial name
- NCT01707823
- Testing
- acetylsalicylic acid, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
End Stage Renal Disease
Impact of Clinical Pharmacy Services on Medication Cost and Hospitalization Rates in Hemodialysis Patients
The purpose of this study is to evaluate the effects of pharmaceutical care interventions in the ambulatory hemodialysis patients over a one-year period.
- Trial name
- NCT05952388
- Testing
- Behavioral Patient care
- Sponsor
- University of New Mexico
Parkinson Disease
Interest of Continuous Subcutaneous Apomorphine in Parkinsonian Patients at the End of Life
Care for Parkinson's patients at the end of life is far from optimal, particularly due to specificities linked to the disease itself, often unknown to non-specialists.
- Trial name
- OPTIDOM (NCT07257861)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Myotonic Dystrophy 1, Sudden Cardiac Death
Sudden Cardiac Death Stratification in Myotonic Dystrophy Type 1 Patients
The aim of the study is to evaluate if the electrophysiological study (EPS) guided therapy, including the prophylactic implantation of implantable cardioverter defibrillator (ICD), in inducible patients, is able to improve…
- Trial name
- ACADEMY 1 (NCT03784586)
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- University of Campania Luigi Vanvitelli
End-of-life Decision-making
End-of-life Decision-making Among Young Patients With Advanced Cancer: a Grounded Theory Approach
The purpose of this qualitative research is to use grounded theory to explore and describe the thoughts of young advanced cancer patients regarding end-of-life care and how these thoughts influence the related decision-making…
- Trial name
- NCT06551831
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Death, Cardiac
Mortality Predictors in Coronary Care in Turkey
This study was undertaken to investigate and document the mortality rates and predictors in coronary care unit (CCU) patients in Turkey. It is designed to be a multicenter, observational, cross-sectional, and descriptive study.
- Trial name
- MORCOR-TURK (NCT05296694)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 2,560 people
- Sponsor
- Afyonkarahisar Health Sciences University