Clinical trials: End of Life Patients
Chronic Kidney Diseases, Atrial Fibrillation
Stroke Prophylaxis With Apixaban in Chronic Kidney Disease Stage 5 Patients With Atrial Fibrillation
Objective: To study the efficacy and safety of apixaban as stroke prophylaxis in patients with chronic kidney disease (CKD) stage 5 and atrial fibrillation (AF) with or without dialysis treatment.
- Conditions
- Chronic Kidney Diseases, Atrial Fibrillation, Stroke, Intracerebral Hemorrhage
- Trial name
- SACK (NCT05679024)
- Testing
- Apixaban 2.5 milligram Oral Tablet
- Where
- 34 sites in Finland, Iceland and 2 more
- Volunteers
- 1,400 people
- Sponsor
- Region Stockholm
Squamous Cell Carcinoma of the Head and Neck
Phase III Open Label Study of MEDI 4736 With/Without Tremelimumab Versus Standard of Care (SOC) in Recurrent/Metastatic Head and Neck Cancer
This is a randomized, open-label, multi-center, 3-arm, global Phase III study to determine the efficacy and safety of MEDI4736 + tremelimumab combination or MEDI4736 monotherapy versus SoC (EXTREME regimen) in the treatment of…
- Trial name
- KESTREL (NCT02551159)
- Testing
- MEDI4736, Tremelimumab, MEDI4736+Tremelimumab
- Where
- 197 sites in United States, Austria and 21 more
- Volunteers
- 823 people
- Sponsor
- AstraZeneca
Cancer
The Effectiveness of the LCP in Improving End of Life Care for Dying Cancer Patients in Hospital.
The purpose of this study is to evaluate the effectiveness of the LCP-I Program in improving the quality of end-of-life care provided to cancer patients who die on hospital medical wards as compared to standard healthcare…
- Trial name
- NCT01081899
- Testing
- The LCP-I Program
- Where
- Italy
- Volunteers
- 308 people
- Sponsor
- Regional Palliative Care Network
Diabetes Mellitus Type 2, End Stage Renal Disease
Surrogate Markers for Sudden Cardiac Death in Patients With Diabetes Mellitus and End Stage Renal Disease
Aim: Patients with type 2 diabetes mellitus (T2DM) and hemodialysis due to diabetic nephropathy exhibit a high risk for sudden cardiac death (SCD).
- Trial name
- NCT02001480
- Testing
- 12 lead Holter, CGM Continuous Glucose Monitoring
- Where
- 3 sites in Germany
- Volunteers
- 60 people
- Sponsor
- RWTH Aachen University
Dementia, Chronic Disease
Project to Improve Communication About Serious Illness--Hospital Study: Comparative Effectiveness Trial (Trial 2)
The objective of this protocol is to test the effectiveness of a Jumpstart intervention on patient-centered outcomes for patients with chronic illness by ensuring that they receive care that is concordant with their goals over…
- Conditions
- Dementia, Chronic Disease, Neoplasm Metastasis, Lung Neoplasms
- Trial name
- PICSI-H (NCT04283994)
- Testing
- Survey-based Patient/Clinician Jumpstart, EHR-based Clinician Jumpstart
- Where
- 3 sites in United States
- Volunteers
- 756 people
- Sponsor
- University of Washington
Cerebrovascular Accident, Cerebrovascular Accident, Acute
Comparison of the Efficacy of Ticagrelor Combined With ASA to ASA Alone in Patients With Stroke
Cerebrovascular disease is the main cause of death and severe long-term disability worldwide. Antiplatelet drugs are the main drugs for ischemic stroke and TIA.
- Trial name
- NCT04962451
- Testing
- ticagrelor + ASA
- Where
- China
- Volunteers
- 13,000 people
- Sponsor
- Peking University Third Hospital
Systolic Heart Failure, Sudden Cardiac Death
A Pilot Trial of Patient Decision Aids for Implantable Cardioverter-Defibrillators (ICDs)
The purpose of this study is to test the acceptability and feasibility of a "toolkit" of patient decision aids (PtDAs) for heart failure patients who are considering an ICD implant.
- Trial name
- NCT02026102
- Testing
- ICD Decision Aid Toolkit
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Colorado, Denver
Brugada Syndrome
Epicardial Ablation in Brugada Syndrome
This prospective study evaluates the methodology and results of epicardial mapping/ablation in a large series of consecutive selected BrS patients and to verify if RFA could normalize the consequences of a genetic disease.
- Trial name
- BRUGADA_I (NCT02641431)
- Testing
- mapping/ablation, Ajmaline, ablation
- Where
- Italy
- Volunteers
- 135 people
- Sponsor
- IRCCS Policlinico S. Donato
Older Patients Dying in Acute Geriatric Hospital Wards
The Effectiveness of the Care Programme for the Last Days of Life
BACKGROUND Demographic trends coupled with a rise in chronic diseases mean that the population of patients requiring palliative and end-of-life care is ageing.
- Trial name
- PLaDays (NCT01890239)
- Testing
- Care Programme for the Last Days of Life
- Where
- 9 sites in Belgium
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- End-of-Life Research Group
Diabetes, Hypoglycaemia
Predicting Hypoglycaemia and Arrhythmias in the Patient With Diabetes and CKD - Validation Study
Patients with insulin-dependent diabetes mellitus (DM) and chronic kidney disease (CKD) exhibit an excessive risk for cardiac arrhythmias, in particular sudden cardiac death (SCD).
- Conditions
- Diabetes, Hypoglycaemia, Chronic Kidney Disease
- Trial name
- HypoArrhythmia (NCT02778269)
- Testing
- 12-lead ECG T-shirt, Dexcom G4-System
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- RWTH Aachen University
Epilepsy
Phenomenological Approach of Epilepsy in Patients With Epilepsy
Rationale : Persons with epilepsy have a greater risk of incurring accidental injury and a higher mortality risk than the general population.
- Trial name
- NCT02952456
- Testing
- interview with a psychologist
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Montpellier
End of Life Care
The Effect of Repetitive Standardized Patient Simulation and End of Life Care Education on Nursing Students' Knowledge Attitudes and Moods
This research is a randomized experimental intervention study designed to examine the effect of repetitive standard patient-based education given to nursing students with end-of-life care education nursing on the level of…
- Trial name
- NCT05596487
- Testing
- repetitive standardized patient simulation
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ankara Yildirim Beyazıt University
Hyperactive Delirium, Delirium of Mixed Origin
Effects of Dexmedetomidine in Patients With Agitated Delirium in Palliative Care
The goal of this multi-centre phase I/II open-label, single-arm study is to determine the feasibility, optimal dose, and preliminary efficacy of dexmedetomidine to manage agitated delirium among patients near the end of life…
- Trial name
- NCT04824144
- Testing
- Dexmedetomidine Hydrochloride
- Where
- 3 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Bruyère Health Research Institute.
Melanoma Stage III, Melanoma (Skin)
A Study of Neoadjuvant Therapy With BCD-217 (Nurulimab + Prolgolimab) in Patients With Resectable Stage III Skin Melanoma
This study is an open-label, randomized, comparative phase III study, which will include subjects with resectable stage III skin melanoma (up to 3 resectable transient metastases are acceptable).
- Trial name
- NEO-MIMAJOR (NCT05751928)
- Testing
- BCD-217, anti-PD1, Excision of the primary lesion
- Where
- 36 sites in Belarus, Russia
- Volunteers
- 411 people
- Sponsor
- Biocad
Emotional Stress, Psychological Distress
Dignity Therapy for Terminally Ill Patients: A Randomized Controlled Trial
We conducted a randomized, controlled trial of dignity therapy for terminally ill patients with the aim of reducing dignity-related distress and demoralization and improving spiritual well-being.
- Conditions
- Emotional Stress, Psychological Distress, Death, Dignity
- Trial name
- NCT04256239
- Testing
- Dignity Therapy
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- European University of Rome
Cancer, Malignancies Multiple
Remote Vital Sign Monitoring in Palliative Care Patients Using a Wearable ECG Monitor
The goal of this study is the assess the use of remote monitoring of vital signs using commercially available medical devices in patients with advanced cancer admitted to a hospice inpatient unit for end-of-life care.
- Conditions
- Cancer, Malignancies Multiple, Terminal Care, Hospice
- Trial name
- VITAL-PC (NCT07512505)
- Where
- Ireland
- Volunteers
- 120 people
- Sponsor
- Our Lady's Hospice and Care Services
Channelopathies, Brugada Syndrome
Safety of Local Dental Anesthesia in Patients With Cardiac Channelopathies
Patients with cardiac channelopathies needing restorative dental treatment will be included in two sessions of the study, using local dental anesthetic: lidocaine 2% with epinephrine and lidocaine 2% without vasoconstrictor.
- Conditions
- Channelopathies, Brugada Syndrome, Long QT Syndrome, Ventricular, Tachycardia
- Trial name
- SLDAPCC (NCT03182777)
- Testing
- Dental restorative procedure
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- University of Sao Paulo General Hospital
Cytomegalovirus Infections, HIV Infections
A Study of Valacyclovir Hydrochloride in the Prevention of Life-Threatening Cytomegalovirus Disease in HIV-Infected Patients
PRIMARY: To evaluate the efficacy of valacyclovir hydrochloride (BW 256U87) in the prevention of cytomegalovirus (CMV) end-organ disease in HIV/CMV co-infected patients with CD4+ lymphocytes < 100 cells/mm3.
- Trial name
- NCT00001038
- Testing
- Valacyclovir hydrochloride, Acyclovir
- Where
- 35 sites in United States, Australia and 8 more
- Volunteers
- 1,200 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Parkinson Disease
Preparing Patient-Caregiver Dyads with Parkinson's Disease for Future Decision Making
Persons with Parkinson's disease and family care partners are often unprepared to make difficult, future medical decisions. Earlier conversations about future medical decisions between persons with Parkinson's disease and family…
- Trial name
- NCT05084209
- Testing
- Parkinson's medical decision making support
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Purdue University
Advanced Cancer, End of Life
Resilience-Building for Advance Care Planning
The aims of this study are to (1) assess the feasibility, acceptability, and usability of the ROCKS intervention among patients with advanced cancer and their family caregivers through a randomized controlled trial in a cancer…
- Trial name
- ROCKS (NCT07428278)
- Testing
- ROCKS, Usual Care
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- University of Illinois Chicago