Clinical trials: End of Life Patients
Depression, Depressive Symptoms
ICU Family Communication Study
The purpose of this study is to improve care in the Intensive Care Unit (ICU) by focusing on communication with family members of patients who are too sick to make decisions about their own care while they are in the ICU.
- Conditions
- Depression, Depressive Symptoms, Anxiety, Stress Disorders, Post-Traumatic
- Trial name
- NCT00720200
- Testing
- Facilitator-Based intervention, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 593 people
- Sponsor
- University of Washington
Ischemic Cardiomyopathy, Nonischemic Cardiomyopathy
Ranolazine Implantable Cardioverter-Defibrillator Trial
The purpose of the study is to see how effective a drug called ranolazine is in reducing the risk of ventricular arrhythmia and death in people with implantable cardioverter-defibrillators (ICDs).
- Conditions
- Ischemic Cardiomyopathy, Nonischemic Cardiomyopathy, Heart Failure
- Trial name
- RAID (NCT01215253)
- Testing
- Ranolazine
- Where
- 90 sites in United States, Canada
- Volunteers
- 1,012 people
- Sponsor
- University of Rochester
Pulmonary Embolism, Lung Cancer
Predictive Value of Epicardial Adipose Tissue for Pulmonary Embolism and Death in Patients With Lung Cancer
The occurrence and progression of lung cancer is related to visceral adipose tissue (VAT). Epicardial adipose tissue (EAT) is a kind of VAT, producing a variety of inflammatory cytokines and adipokines, participating in the…
- Trial name
- NCT06017271
- Testing
- CTPA (computed tomography pulmonary angiography)
- Where
- China
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Kidney Failure Chronic, Arrhythmias Cardiac
Effects of Marine n-3 Fatty Acids on Heart Rate Variability and Arrhythmias in Patients Receiving Chronic Dialysis
Background: End Stage Renal Disease (ESRD) patients have an extremely high mortality and the leading cause of death is cardiovascular disease which accounts for 50% of all deaths.
- Trial name
- NCT02147977
- Testing
- dietary supplement: n-3 PUFA, olive oil
- Where
- Denmark
- Volunteers
- 112 people
- Sponsor
- Aalborg University Hospital
Advanced Cancer
Web-Based Advance Care Planning for Patients With Advanced Cancer
The goal of this clinical trial is to determine whether a web-based advance care planning (ACP) intervention can reduce preferences for aggressive life-sustaining treatments among patients with advanced cancer.
- Trial name
- NCT07712237
- Testing
- Web-Based Advance Care Planning Program, Patient Right to Autonomy Act Leaflet
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Ventilator Associated Pneumonia, Death
Futility of Exhaled Breath Condensate pH Measurements in Ventilated Patients in Intensive Care Unit (ICU)
Measurement of pH in Exhaled breath condensate has been mentioned as a robust variable from lung inflammation. It is non-invasive and reproducible.
- Trial name
- NCT01393431
- Where
- Argentina
- Volunteers
- 34 people
- Sponsor
- Universidad Nacional de Rosario
Brain Death
Implementation of Apnoea Test for Patients With Suspected Brain Death
This study consists of a survey created for intensive care physicians regarding their current practice of the implementation of apnoea test for patients with suspected brain death.
- Trial name
- NCT06359119
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kiskunhalas Semmelweis Hospital the Teaching Hospital of the University of Szeged
Heart Failure
Impact of Advance Care Planning on Care for Patients With Advanced Heart Failure
Aims: Advance care planning (ACP) is considered to be one of the most promising interventions to enable patients with life limiting illnesses to receive treatment at the end of life (EOL) according to their own preferences and to…
- Trial name
- NCT02299180
- Testing
- ACP
- Where
- 2 sites in Singapore
- Volunteers
- 282 people
- Sponsor
- Duke-NUS Graduate Medical School
Constipation, End Stage Renal Disease on Dialysis
Effects of Synbiotics Supplementation on the Uremic Toxin Indoxyl Sulfate Level and Constipation in End-stage Renal Disease Patients Undergoing Hemodialysis
This is a double-blind, placebo-controlled, randomized clinical trial conducted to evaluate the effects of synbiotics supplementation on the level of the uremic toxin indoxyl sulfate, symptoms of constipation, and…
- Trial name
- NCT04527640
- Testing
- Synbiotics containing Lactobacillus acidophilus & Bifidobacterium longum 5x10^9 CFU and FOS 60 mg
- Volunteers
- 60 people
- Sponsor
- Universitas Indonesia
Advanced Cancer
Survival Expectations and Hope Among Cancer Patients at End-of-Life
Literature shows that less than half of advanced cancer patients accurately understand their prognosis, with most being overly optimistic.
- Trial name
- SHAPE (NCT03325218)
- Where
- 2 sites in Singapore
- Volunteers
- 214 people
- Sponsor
- Duke-NUS Graduate Medical School
End-Stage Renal Disease, Hemodialysis
Hemocontrol and Blood Pressure Control in Dialysis Patients
Volume overload contributes significantly to the pathogenesis of hypertension in hemodialysis patients. The Hemocontrol(HC)system (Gambro), which automatically adjusts ultrafiltration rate and dialysate conductivity according to…
- Trial name
- NCT00319774
- Testing
- Hemocontrol Biofeedback System
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Université de Montréal
Cirrhosis of the Liver
HRQoL in the Low MELD Pre-tx Population
The purpose of this study is to describe the HRQoL in those with MELD scores </= 15 in a single center for those who are pre-liver transplant candidates
- Trial name
- LowMELD (NCT01573325)
- Volunteers
- 50 people
- Sponsor
- Northwestern University
Acute Kidney Injury
Acute Kidney Outreach to Reduce Deterioration and Death (AKORDD)
The study pilots an outreach service for Acute kidney injury (AKI) patients, based on electronic alerts. Using the alerts we will contact the primary clinician caring for the patient with AKI in the Intervention group.
- Trial name
- AKORDD (NCT02398682)
- Testing
- Rapid diagnosis of AKI cause, Rapid treatment of AKI cause, Stopping 'nephrotoxic' drugs
- Where
- United Kingdom
- Volunteers
- 1,865 people
- Sponsor
- Heart of England NHS Trust
Myocardial Infarction, Sudden Cardiac Death
Personalised Risk scOre For Implantation of Defibrillators in Patients With Preserved LVEF>35% and a High Risk for Sudden Cardiac Death
The objective of the study is to demonstrate that in post-MI patients with preserved LVEF>35% but high risk for SCD according to a personalised risk score, the implantation of an ICD (index group) is superior to optimal medical…
- Trial name
- NCT04540289
- Testing
- Optimal Medical Therapy (OMT), Implantable cardioverter-defibrillator (ICD)
- Sponsor
- Helios Health Institute GmbH
Hypertrophic Cardiomyopathy
Efficacy of Risk Assessment for Sudden Cardiac Death in Patients With Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is a heart disease characterized by hypertrophy of the left ventricular myocardium and is most often caused by mutations in sarcomere genes.
- Trial name
- NCT04402268
- Testing
- Cardioverter-defibrillator
- Where
- Poland
- Volunteers
- 252 people
- Sponsor
- Poznan University of Medical Sciences
Acute Kidney Failure, Renal Replacement Therapy for Acute Kidney Injury in ICU
Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE)
The STEPCARE-MAKE study is a predefined sub-study of the large Sedation, TEmperature and Pressure after Cardiac Arrest and REsuscitation (STEPCARE) trial, which evaluates the effects of three interventions in comatose adult…
- Conditions
- Acute Kidney Failure, Renal Replacement Therapy for Acute Kidney Injury in ICU, Sedation in Intensive Care Unit Patients, Sedation in the ICU
- Trial name
- STEPCARE-MAKE (NCT07579390)
- Testing
- Feedback-controlled temperature device, High MAP, Deep sedation
- Where
- 52 sites in Australia, Belgium and 12 more
- Volunteers
- 3,500 people
- Sponsor
- Helsinki University Central Hospital
End-of-life Decision-making
End-of-life Decision-making Among Young Patients With Advanced Cancer: a Grounded Theory Approach
The purpose of this qualitative research is to use grounded theory to explore and describe the thoughts of young advanced cancer patients regarding end-of-life care and how these thoughts influence the related decision-making…
- Trial name
- NCT06551831
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Influenza A
Convalescent Plasma Treatment in Severe 2009 H1N1 Infection
Treatment of severe 2009 H1N1 infection with convalescent plasma will reduce mortality.
- Trial name
- NCT01306773
- Testing
- H1N1 convalescent plasma and oseltamivir, Oral Oseltamivir alone
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The University of Hong Kong
Breast Neoplasms
ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer
This is a Phase III trial where participants will be randomized to two treatment groups, which means participants will be assigned by equal chance to a treatment group.
- Trial name
- NCT07173751
- Testing
- Pumitamig, Nab-paclitaxel/Paclitaxel, Gemcitabine
- Where
- 224 sites in United States, Argentina and 17 more
- Volunteers
- 558 people
- Sponsor
- BioNTech SE
Traumatic Brain Injury
TBI-Prognosis Multicenter Prospective Study
Severe traumatic brain injury (TBI) is the leading cause of death and disability among people under 45 years of age and a major public health problem.
- Trial name
- NCT02452541
- Testing
- Prognostic tests
- Where
- 17 sites in Canada
- Volunteers
- 315 people
- Sponsor
- CHU de Quebec-Universite Laval