Clinical trials: End of Life Patients
Metastatic Cancer, Solid Tumors
Arginase Inhibitor INCB001158 as a Single Agent and in Combination With Immune Checkpoint Therapy in Patients With Advanced/Metastatic Solid Tumors
This study is an open-label Phase 1/Phase 2 evaluation of INCB001158 as a single agent and in combination with immune checkpoint therapy in patients with advanced/metastatic solid tumors.
- Conditions
- Metastatic Cancer, Solid Tumors, Colorectal Cancer (CRC), Gastric Cancer
- Trial name
- NCT02903914
- Testing
- INCB001158, Pembrolizumab
- Where
- 20 sites in United States, Italy and 2 more
- Volunteers
- 260 people
- Sponsor
- Incyte Corporation
End-Stage Renal Disease
Decreasing Depression and Anxiety and Their Effect on QoL of ESRD Patients (End-Stage Renal Disease)
This study evaluates the effect of a single cognitive-behavioral intervention (CBI) in a control group against the same CBI plus the strengthening of resiliency skills in an experimental group, on ESRD patients.
- Trial name
- ESRD (NCT03330938)
- Testing
- CBI and Resilience, Cognitive-behavioral Intervention
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Hospital Civil de Guadalajara
Brain Death
The Anticipated Organ Donation Approach
The purpose of this study is to make a paramedical evaluation of a selection procedure of serious brain-injured patient in therapeutic abstention to a brain death state within 48 hours.
- Trial name
- PREMORENCE (NCT03765814)
- Where
- 4 sites in France
- Volunteers
- 83 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
End Stage Renal Disease
Preference of Life-Sustaining Treatment Among Patients With End Stage Renal Disease
Although patients with kidney disease can rely on dialysis to prolong their lives, the complexity of the disease, the variability of the course of the disease, and the uncertainty of the prognosis often delay the discussion of…
- Trial name
- NCT05878171
- Where
- 2 sites in Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Chronic Renal Failure
Cost Utility Analysis of Erythropoietin for Anemia Treatment in Hemodialysis Patients
To study the cost utility analysis of Erythropoietin (EPO) for maintaining the different hemoglobin (Hb) target levels in anemic hemodialysis patient in routine clinical practice.
- Trial name
- CUAEPO (NCT01049711)
- Testing
- erythropoietin
- Where
- Thailand
- Volunteers
- 152 people
- Sponsor
- Mahidol University
Type 2 Diabetes Mellitus
The Effects of Immersion in Dead Sea Water on Glucose Levels in Type 2 Diabetes Mellitus Patients
BACKGROUND: Bathing in sweet or mineral water can induce significant physiological changes in several body systems including the endocrine system.
- Trial name
- NCT01580852
- Testing
- Dead Sea water, Pool water
- Where
- Israel
- Volunteers
- 35 people
- Sponsor
- Victor Novack
Influenza A
Convalescent Plasma Treatment in Severe 2009 H1N1 Infection
Treatment of severe 2009 H1N1 infection with convalescent plasma will reduce mortality.
- Trial name
- NCT01306773
- Testing
- H1N1 convalescent plasma and oseltamivir, Oral Oseltamivir alone
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The University of Hong Kong
to Predict an Unfavorable Evolution of Covid-19 at the Hospital Admission of Patients
Prediction of Unfavourable Outcome in Newly Covid-19 Hospitalized Patient
The project is a part of the "Protocol for a multicentre study of nosocomial SARS-CoV2 transmission: The NOSO-COR Project" registered in ClinicalTrials (NCT04290780).
- Trial name
- PredictCovid19 (NCT04412031)
- Testing
- non applicable
- Where
- France
- Volunteers
- 802 people
- Sponsor
- Hospices Civils de Lyon
Pancreatic Cancer Non-resectable, Pancreatic Cancer Metastatic
INCMGA00012 in Patients With Previously Treated Unresectable or Metastatic Adenosquamous Pancreatic or Ampullary Cancer
Phase 2 study to evaluate the clinical activity of INCMGA00012 in patients with Unresectable or metastatic Adenosquamous Pancreatic or Ampullary Cancer.
- Trial name
- NCT04116073
- Testing
- INCMGA00012 (PD-1 antibody)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
End Stage Renal Disease and Kidney Transplantation
Communicating About Choices in Transplantation
The purpose of this study is to test the impact of a newly developed educational program on kidney transplant candidates' communication about living and deceased donor kidney transplantation.
- Trial name
- COACH (NCT01853007)
- Testing
- COACH Program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Commonwealth University
Intervention Compliance, Usability
CSDM: A Trial to Improve Communication and Shared Decision Making Using a Web-Based Tool
The goal is to develop a pragmatic, scalable intervention to overcome problems with surrogate decision making in ICUs. The aim is to conduct a pilot study among surrogates and clinicians of 50 incapacitated patients at high risk…
- Conditions
- Intervention Compliance, Usability, Acceptability
- Trial name
- CSDM Pilot (NCT02955563)
- Testing
- CSDM Web-Based Tool Intervention
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Myocardial Infarction
OMEGA-Study: Effect of Omega 3-Fatty Acids on the Reduction of Sudden Cardiac Death After Myocardial Infarction
Cardiovascular disease (CVD) is the leading cause of death in North America and Europe. The major cause of CVD is atherosclerosis like coronary artery disease (CAD).
- Trial name
- OMEGA (NCT00251134)
- Testing
- Zodin (drug)
- Where
- 10 sites in Germany
- Volunteers
- 3,800 people
- Sponsor
- Stiftung Institut fuer Herzinfarktforschung
Neurologic Signs and Symptoms
Incidence, and Survival Medical Expenditure of Patients With Multiple Sclerosis
Multiple sclerosis (MS) is a disease of autoimmune system which attacks the central nervous system and that is one of the most common inflammatory diseases and has caused a heavy disease burden on patients.
- Trial name
- NCT04022564
- Where
- Taiwan
- Volunteers
- 2,000 people
- Sponsor
- Chun-Ming Liao
Cancer, End-of-Life
Coaches Activating Reaching and Engaging Patients
The purpose of the Team Based Advance Care Planning CAREPLAN program is to understand if a trained lay navigator who engages with patients with advanced stages of cancer can help patients in advance care planning, improve patient…
- Trial name
- CAREPlan (NCT03856463)
- Testing
- Lay Navigator Intervention, Usual Care
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Stanford University
Heart Failure, Sudden Cardiac Death
Evolution of Management Strategies of Heart Failure Patients With Implantable Defibrillators
The EVOLVO study is designed to compare the remote defibrillator management to the current standard of care, to assess its ability to treat and triage patients more effectively.
- Conditions
- Heart Failure, Sudden Cardiac Death, Implantable Defibrillator
- Trial name
- EVOLVO (NCT00873899)
- Testing
- The Medtronic CareLink system (Minneapolis, MN, USA).
- Where
- 6 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Regione Lombardia
End of Life, Cancer
Enhancing Community Capacity to Improve Cancer Care Delivery
Undertreated patient symptoms and resulting acute care use require approaches that improve symptom-burden. Previously a a lay health worker (LHW)-led symptom screening intervention was developed for patients with advanced cancer.
- Trial name
- NCT04107116
- Testing
- Program participants, Usual Care
- Where
- United States
- Volunteers
- 832 people
- Sponsor
- Stanford University
Heart Failure With Reduced Ejection Fraction (HFrEF), Sudden Cardiac Death
Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator
This prospective, multicenter, open-label, randomized comparative effectiveness trial, titled CARVTOP-ICD, evaluates the impact of carvedilol versus metoprolol succinate in patients with heart failure with reduced ejection…
- Conditions
- Heart Failure With Reduced Ejection Fraction (HFrEF), Sudden Cardiac Death, Ventricular Arrhythmia, Implantable Cardioverter Defibrillator (ICD)
- Trial name
- CARVTOP-ICD (NCT06964464)
- Testing
- Metoprolol Succinate, Carvedilol
- Where
- 13 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- University of Rochester
Hunter Syndrome, Mucopolysaccharidosis II (MPS II)
Extension of Study TKT024 Evaluating Long-Term Safety and Clinical Outcomes in MPS II Patients Receiving Idursulfase
Study TKT024EXT was a long-term, single-arm, open-label extension of Study TKT024, a one year Phase 2/Phase 3 registration study.
- Trial name
- NCT00630747
- Testing
- Idursulfase
- Where
- 52 sites in United States, Brazil and 8 more
- Volunteers
- 94 people
- Sponsor
- Shire
Major Cardiovascular Event, Established Atherosclerotic Cardiovascular Disease
A Study Assessing Repatha® in Combination With Standard of Care (SOC) Compared With SOC on Major Cardiovascular Events in Chinese Participants With Atherosclerotic Cardiovascular Disease
The primary objective of the study is to evaluate real-world effectiveness of treatment with Repatha® in combination with SOC, compared with SOC alone, on the risk for cardiovascular (CV) death, myocardial infarction (MI)…
- Trial name
- NCT06295679
- Where
- 90 sites in China
- Volunteers
- 7,000 people
- Sponsor
- Amgen
COVID
Predicting Death and ICU Admission in COVID-19 Patients in ED
INTRODUCTION. The novel coronavirus designated SARS-CoV-2, has determined an international outbreak of respiratory illness named Covid-19. Patients with Covid-19 present primarily with fever, myalgia or fatigue, and dry cough.
- Trial name
- NCT04371562
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS