Clinical trials: End of Life Patients
Chagas Cardiomyopathy, Non-sustained Ventricular Tachycardia
Amiodarone Against ICD Therapy in Chagas Cardiomyopathy for Primary Prevention of Death
The primary objective is to compare the efficacy of the treatment using implantable cardioverter defibrillator (ICD) implantation to that of the treatment using amiodarone in the primary prevention of all-cause mortality in…
- Conditions
- Chagas Cardiomyopathy, Non-sustained Ventricular Tachycardia, At Least 10 Points in Rassi Risk Score for Death
- Trial name
- CHAGASICS (NCT01722942)
- Testing
- ICD implantation, amiodarone hydrochloride
- Where
- 20 sites in Brazil
- Volunteers
- 1,100 people
- Sponsor
- InCor Heart Institute
Cardiomyopathy
Quantitive LGE Mass in Prediction of SCD in NICM Patients With Severe Cardiac Dysfunction
The purpose of this study is to establish a quantitative LGE mass based scoring system (including LGE mass on cardiac magnetic resonance , clinical features, specific medical histories, et al) for risk prediction of sudden…
- Trial name
- NCT02757742
- Where
- China
- Volunteers
- 356 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Chronic Kidney Diseases
Competing Risk of Death and ESRD in Incident CKD Patients
Although chronic kidney disease (CKD) affects a growing number of people, epidemiologic data on incident CKD in the general population are scarce. Screening strategies to increase early CKD detection have been developed.
- Trial name
- EPIRAN (NCT03379571)
- Volunteers
- 631 people
- Sponsor
- Central Hospital, Nancy, France
Metastatic Colon Cancer, Solid Tumor
Pembrolizumab + Poly-ICLC in MRP Colon Cancer
The main purpose of this study is to determine the dose of poly-ICLC that is safe and tolerable when it is combined with pembrolizumab in patients with colon cancer.
- Trial name
- NCT02834052
- Testing
- pembrolizumab, Poly-ICLC
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Asha Nayak
Old Age
End-of-Life Patient Identification Assistance in Acute GEriatric Medicine
The main objective of this project is to build a tool, adapted to the French geriatric population, that will predict the risk of death at three months after hospitalization in acute geriatric medicine.
- Trial name
- ARPEGE (NCT03549585)
- Testing
- Criteria for Screening and Triaging to Appropriate aLternative care
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- University Hospital, Toulouse
End of Life Care, Advanced Cancer
Empathetic Communication Facilitation Program for Early Initiation of End-of-life Discussions
Background: The National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology: palliative care recommends discussing advance care planning (ACP) when patients' estimated life expectancy is reduced from a year to…
- Conditions
- End of Life Care, Advanced Cancer, Recurrent Cancer
- Trial name
- NCT05045040
- Testing
- Mobile-based empathetic communication support program to promote ACP discussion
- Where
- Japan
- Volunteers
- 264 people
- Sponsor
- Yosuke Uchitomi
Non-small Cell Lung Cancer
A Trial to Learn How the Combination of Fianlimab With Cemiplimab and Chemotherapy Works Compared With Cemiplimab and Chemotherapy for Treating Adult Patients With Advanced Non-small Cell Lung Cancer
This study is researching an investigational drug called fianlimab (also called REGN3767) with two other medications called cemiplimab and chemotherapy, individually called a "study drug" or collectively called "study drugs".
- Trial name
- NCT05800015
- Testing
- fianlimab, cemiplimab, Pemetrexed
- Where
- 76 sites in United States, Australia and 8 more
- Volunteers
- 160 people
- Sponsor
- Regeneron Pharmaceuticals
Kidney Disease, Chronic, Renal Transplant Failure
The RENAL LIFECYCLE Trial: A RCT to Assess the Effect of Dapagliflozin on Renal and Cardiovascular Outcomes in Patients With Severe CKD
Rationale: Sodium glucose co transporter 2 (SGLT2) inhibitors are a relatively new class of agents, originally developed as oral antihyperglycemic drugs.
- Conditions
- Kidney Disease, Chronic, Renal Transplant Failure, Heart Failure, Kidney Failure
- Trial name
- NCT05374291
- Testing
- Dapagliflozin 10 mg/day (oral)
- Where
- 101 sites in Australia, Belgium and 4 more
- Volunteers
- 1,750 people
- Sponsor
- University Medical Center Groningen
End Stage Renal Disease, Coronary Heart Disease
T Wave Alternans in Hemodialysis
The purpose of this study is to determine if the hemodialysis procedure changes the risk for cardiac arrest in patients.
- Conditions
- End Stage Renal Disease, Coronary Heart Disease, Congestive Heart Failure
- Trial name
- NCT00296543
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Neurological Outcome, Survival From First Diagnosis Metastatic Spinal Cord Compression to Death
Emergency Radiotherapy in Metastatic Spinal Cord Compression of Patients With Non-small Cell Lung Cancer
Acute neurological deficit in metastatic spinal cord compression is an emergency condition in radiation oncology. Despite some reports about the high efficacy of radiation treatment for oncological emergencies, a standard of care…
- Trial name
- CK-INF (NCT02000518)
- Testing
- external beam radiotherapy
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Heidelberg University
SID, Acid-Base Imbalance
Effect of Crystalloids With Different SID on pH, and Urinary Electrolytes During General Anesthesia
The present study will investigate variations in acid base equilibrium caused by the administration of four different crystalloids with increasing strong ion difference (0.9% saline, Ringer's lactate, Ringer's acetate…
- Trial name
- CRYSID (NCT03507062)
- Testing
- 0.9% saline administration, Ringer's lactate administration, Plasmalyte-like solution administration
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Postoperative Complications, Emotion Regulation
The Effect of Emotional Freedom Techniques Application on Patients With Cancer Phobia
The aim is to examine the effect of Emotional Freedom Technique on death anxiety in patients with postoperative cancer phobia. The hypotheses of the study are as follows: H0: Emotional Freedom Technique has no effect on…
- Conditions
- Postoperative Complications, Emotion Regulation, Death Anxiety
- Trial name
- NCT06816576
- Testing
- Emotional Freedom Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bitlis Eren University
Cardiomyopathy
Morphological Predictors of Sudden Cardiac Death in Patients With Known Cardiomyopathies
This is a pilot study to find a correlation between MRI and ICD therapy in patients with known cardiomyopathies, aiming to determine if cardiac scarring identified by MRI correlates with ventricular arrhythmias and the occurrence…
- Trial name
- NCT00312624
- Testing
- contrast-enhanced cardiac MRI
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Pancreatic Cancer
SBRT and Anti-programmed Cell Death Protein 1(Anti-PD-1) in Late Stage or Recurrent Pancreatic Cancer Patients
When gemcitabine based chemo and fluorouracil based chemo regimes are failed in late-stage or recurrent pancreatic cancer patients, there is no alternative options. Anti-PD-1 antibody has became a promising anti-cancer drug.
- Trial name
- CISPD-2 (NCT03716596)
- Testing
- SBRT, anti-PD-1 antibody
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
End-of-life Care
Practice Analysis of Care, Paraclinical Exams and Treatments Received by Geriatric Patients Both During the Last Week and the Last 24 Hours of Their Lives.
End-of-life care is a core topic for geriatricians. One of the key aspects of end-of-life management is deciding when to discontinue active care measures (for example blood pressure monitoring, blood tests and X-rays) in favor of…
- Trial name
- NCT06026241
- Testing
- Collecting data from the medical record
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Myocardial Infarction, Death, Sudden, Cardiac
Assessment of Noninvasive Methods to Identify Patients at Risk of Serious Arrhythmias After a Heart Attack
This study evaluates the usefulness of noninvasive tests of the structure of the heart and the nervous system controlling the heart.
- Conditions
- Myocardial Infarction, Death, Sudden, Cardiac, Death
- Trial name
- NCT00399503
- Testing
- Spectral T Wave Alternans, Modified Moving Average T Wave Alternans, Baroreceptor Sensitivity
- Where
- Canada
- Volunteers
- 350 people
- Sponsor
- University of Calgary
Leukemia
Identifying Risk Factors for Bone Tissue Death in Young Patients With Acute Lymphoblastic Leukemia Treated on Clinical Trial CCG-1882
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to bone tissue death.
- Trial name
- NCT00898469
- Testing
- polymorphism analysis
- Volunteers
- 671 people
- Sponsor
- Children's Oncology Group
Death, Communication, Multidisciplinary
A Multicenter Implementation Study of the 3 Wishes Project
The 3 Wishes Project (3WP) was created to promote the connections between patients, family members, and clinicians that are foundational to empathic end-of-life care.
- Conditions
- Death, Communication, Multidisciplinary, Empathy, Compassion
- Trial name
- 3WP (NCT04147169)
- Testing
- Focused end-of-life conversations to promote connections among patients, family members and clinicians.
- Where
- Canada
- Volunteers
- 730 people
- Sponsor
- McMaster University
Cardiomyopathy, Dilated, Arrhythmia
Mental Stress Reduction in Defibrillator Patients
The purpose of this study is to assess the effectiveness of a 10 week program of Stress Management versus control Patient Education sessions on cardiac responses to mental stress in veterans with Implantable…
- Conditions
- Cardiomyopathy, Dilated, Arrhythmia, Anger, Stress
- Trial name
- NCT00624520
- Testing
- Cognitive Behavioral Stress Management (CBSM), Patient Education
- Where
- 2 sites in United States
- Volunteers
- 129 people
- Sponsor
- US Department of Veterans Affairs
End-stage Liver Disease, Liver Cirrhosis
Nutrition and Exercise Prehabilitation in Patients Awaiting Liver Transplantation
This study aims to evaluate the effects of a diet with even protein distribution plus exercise (Group A) versus a diet with skewed protein distribution plus exercise (Group B) versus standard dietary and physical activity advice…
- Conditions
- End-stage Liver Disease, Liver Cirrhosis, Liver Transplantation, Malnutrition
- Trial name
- POWER-LT (NCT07561138)
- Testing
- Diet with even protein distribution plus exercise program, Diet with skewed protein distribution plus exercise program, Standard dietary and physical activity advice
- Where
- 2 sites in Greece
- Volunteers
- 90 people
- Sponsor
- Kalliopi Anna Poulia