Clinical trials: End of Life Patients
Sleep Apnea
Long-term Follow-up in Patients Included in the European Sleep Apnea Data Base (ESADA)
The European database ESADA, containing data from more than 30,000 patients with very different severities of obstructive sleep apnea (OSA) syndrome, prospectively collects data from patients referred to academic sleep…
- Trial name
- ESADAfollow-up (NCT04800341)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 233 people
- Sponsor
- University Hospital, Grenoble
Type 2 Diabetes Mellitus
Does Saxagliptin Reduce the Risk of Cardiovascular Events When Used Alone or Added to Other Diabetes Medications
The purpose of this study is to determine whether saxagliptin can reduce the risk of cardiovascular events when used alone or added to other diabetes medications
- Trial name
- SAVOR- TIMI 53 (NCT01107886)
- Testing
- Saxagliptin
- Where
- 536 sites in United States, Argentina and 25 more
- Volunteers
- 18,206 people
- Sponsor
- AstraZeneca
Urachal Cancer, Parathyroid Carcinoma
Agnostic Therapy in Rare Solid Tumors
The ANTARES study is a phase II basket trial designed to evaluate the tissue-agnostic efficacy of the monoclonal anti-PD1 antibody, nivolumab, in patients with advanced or metastatic rare tumors.
- Conditions
- Urachal Cancer, Parathyroid Carcinoma, Fibrolamellar Carcinoma, Angiosarcoma
- Trial name
- ANTARES (NCT06638931)
- Testing
- Nivolumab
- Where
- 5 sites in Brazil
- Volunteers
- 28 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Palliative Care, Decision Making
Feasibility Of An Advanced Care Decision Aid Among Patients And Physicians_Matlock
The investigators propose an evaluation of an end of life patient decision aid (EOL-PtDA) developed by the Foundation for Informed Medical Decision Making using the RE-AIM (Reach Effectiveness, Adoption, Implementation, and…
- Conditions
- Palliative Care, Decision Making, Decision Support Techniques, Decision Support Systems, Clinical
- Trial name
- NCT01190488
- Testing
- End-of-Life / Advanced Care Decision Aid, Active Comparator
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pregnancy, Postpartum
Organ Dysfunction Score for Obstetric Patients
The goal of this observational study is to develop and evaluate an organ dysfunction score adapted to pregnancy and early puerperium (SOFA-OBS) that also incorporates a non-invasive tool to evaluate respiratory function (pulse…
- Conditions
- Pregnancy, Postpartum, Organ Dysfunction, Critical Care, Intensive Care
- Trial name
- SOFA-OBS (NCT07068022)
- Testing
- Organ dysfunction score adjusted to obstetric patients (SOFA-OBS)
- Where
- 18 sites in Argentina, Ecuador and 2 more
- Volunteers
- 130 people
- Sponsor
- Daniela Vasquez
Hospice, End-of-life Decision Making
Pilot Evaluation of Hospice Decision Support Tools
The goal of this project is to determine the feasibility and acceptability of a hospice decision aid among a diverse population of older adults at multiple stages of illness (Aim 1) and to determine the preliminary efficacy of…
- Conditions
- Hospice, End-of-life Decision Making, Hospice Decision Making
- Trial name
- NCT03794700
- Testing
- Hospice Decision Aids
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- University of Colorado, Denver
Death, Sudden, Cardiac, Death, Sudden
Decision Support for Adults Facing Implantable Cardioverter-Defibrillator Pulse Generator Replacement
The implantable-cardioverter defibrillator (ICD) is a small medical device used to treat dangerously fast and potentially life-threatening heart rates.
- Conditions
- Death, Sudden, Cardiac, Death, Sudden, Cardiovascular Diseases
- Trial name
- NCT02668900
- Testing
- Decision Support
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Older Patients Dying in Acute Geriatric Hospital Wards
The Effectiveness of the Care Programme for the Last Days of Life
BACKGROUND Demographic trends coupled with a rise in chronic diseases mean that the population of patients requiring palliative and end-of-life care is ageing.
- Trial name
- PLaDays (NCT01890239)
- Testing
- Care Programme for the Last Days of Life
- Where
- 9 sites in Belgium
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- End-of-Life Research Group
Cardiovascular Disease, Sudden Cardiac Death
Vitamin D and Cardiac Autonomic Tone in Hemodialysis
Despite advances in treatment of conventional cardiovascular risk factors, patients with kidney disease remain at high risk for fatal cardiac events.
- Trial name
- VITAH (NCT01774812)
- Testing
- Alfacalcidol, Ergocalciferol
- Where
- 3 sites in Canada
- Volunteers
- 56 people
- Sponsor
- University of Calgary
Chronic Obstructive Pulmonary Disease
Intrinsic PEEP and Laryngeal Aperture in COPD
In this study the investigators aim to investigate the extent to which in patients with chronic obstructive pulmonary disease narrowing of the vocal cords causes a positive pressure within the airways thus improving airflow and…
- Trial name
- NCT02437630
- Testing
- Oesophageal balloon to measure intra-thoracic pressure, Fibre-optic laryngoscopy, standard lung function tests
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Quality of Life
Comparison of Postoperative Early Period Quality of Life of Patients With Open and Robot Assisted Kidney Transplantation
The investigators aimed to investigate the quality of life in patients with end-stage renal disease who underwent open or robot-assisted renal transplantation.
- Trial name
- NCT04435171
- Testing
- Renal transplantation
- Where
- Turkey (Türkiye)
- Volunteers
- 129 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
High-risk Non-muscle Invasive Bladder Cancer
Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Bacillus Calmette-Guerin (BCG) in High-Risk Non-Muscle Invasive Bladder Cancer (HR NMIBC) (MK-3475-676/KEYNOTE-676)
Researchers are looking for new ways to treat high-risk non muscle invasive bladder cancer (HR NMIBC). NMIBC is cancer in the tissue that lines the inside of the bladder but has not spread to the bladder muscle or outside of the…
- Trial name
- NCT03711032
- Testing
- Pembrolizumab, BCG
- Where
- 209 sites in United States, Australia and 28 more
- Volunteers
- 1,397 people
- Sponsor
- Merck Sharp & Dohme LLC
Asymptomatic Cirrhosis, Clinically Significant Portal Hypertension
Effect of Long-term Carvedilol to Prevent Decompensation or Death in Patients With Asymptomatic Child-Pugh A5 to B8 Cirrhosis and Clinically Significant Portal Hypertension: a Multicenter Double-blind Randomized Control Trial
Decompensation of cirrhosis is a turning point in cirrhosis course, as associated with a marked decrease in life expectancy. Thus, prevention of decompensation is crucial.
- Trial name
- CARVECIR (NCT06263816)
- Testing
- Experimental group: Patients will be treated with carvedilol.
- Where
- 24 sites in France
- Volunteers
- 290 people
- Sponsor
- University Hospital, Tours
Pancreatic Ductal Adenocarcinoma (PDAC)
A Clinical Trial Testing the Safety of Pumitamig (an Investigational Drug) and How Well it Works When Combined With Chemotherapy for People Who Have Not Been Treated Yet for Pancreatic Cancer
This study will enroll adults with confirmed metastatic pancreatic ductal adenocarcinoma (PDAC, systemic PDAC treatment naïve), Eastern Cooperative Oncology Group performance status (ECOG PS) 0-1, and adequate organ function.
- Trial name
- NCT07255404
- Testing
- Pumitamig, Nab-paclitaxel, Gemcitabine
- Where
- 24 sites in Australia, China
- Volunteers
- 105 people
- Sponsor
- BioNTech SE
Known CAD, or Intermediate-high Pretest Likelihood for CAD
Study of Perfusion and Anatomy's Role in Coronary Artery (CAD)
Three main clinical outcomes will be assessed: 1. Post-test resource utilization as assessed by referral rate to catheterization within 90-days of the index study; 2.
- Trial name
- SPARC (NCT00321399)
- Where
- 41 sites in United States, Canada
- Volunteers
- 3,019 people
- Sponsor
- Brigham and Women's Hospital
Sarcoidosis of the Heart, Cardiomyopathy
Implantable Cardiac Defibrillators for the Prevention of Sudden Death in Patients With Cardiac Sarcoidosis
The purpose of this study is to identify patients with cardiac sarcoidosis who may be at risk for sudden death.
- Trial name
- NCT01013311
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Virginia Commonwealth University
Advanced Cancer
Study of Palliative Care Intervention for Advanced Cancer Patients and Their Caregivers -Educate Nurture Advise Before Life Ends (ENABLE III)
ENABLE III is a randomized clinical trial that evaluates a phone-based palliative care intervention designed to improve quality of life, mood, and symptom management for patients with an advanced stage cancer and their…
- Trial name
- ENABLE III (NCT01245621)
- Testing
- Later entry group, Early palliative care intervention
- Where
- 7 sites in United States
- Volunteers
- 360 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Renal Replacement Therapy, Renal Dialysis
A Clinical Trial of IntensiVE Dialysis
This study will assess clinical outcomes of extended weekly hours of haemodialysis (>= 24 hours per week) compared with standard hours of haemodialysis (<=18 hours/week) in people with ESKD.
- Conditions
- Renal Replacement Therapy, Renal Dialysis, End Stage Kidney Disease, End Stage Renal Disease
- Trial name
- ACTIVE (NCT00649298)
- Testing
- haemodialysis
- Where
- 40 sites in Australia, Canada and 2 more
- Volunteers
- 200 people
- Sponsor
- The George Institute
End Stage Renal Disease
Protein Supplementation in Dialysis Patients
Poor nutritional status as evidenced by low body mass index, low muscle mass or low serum albumin is a strong predictor of morbidity and mortality in dialysis patients.
- Trial name
- NCT01855295
- Testing
- Protein Supplement
- Volunteers
- 73 people
- Sponsor
- University of Utah
Metastatic Cervical Cancer, Persistent Cervical Cancer
PD-1 (Programmed Death-1) Versus PD-L1 (Programmed Death-ligand 1) Immune Check Point Inhibitors Combined With Chemotherapy, With or Without Bevacizumab, In Patients With Metastatic, Persistent Or Recurrent Cervical Cancer
This is a randomized trial evaluating the results of using of PD-1 and PD-L1 immune checkpoint inhibitors combined with chemotherapy, with or without bevacizumab, in patients with metastatic, persistent, and recurrent cervical…
- Conditions
- Metastatic Cervical Cancer, Persistent Cervical Cancer, Recurrent Cervical Cancer
- Trial name
- NCT07472153
- Testing
- PD-1 antibody, PD-L1 antibody, Chemotherapy and bevacizumab (CT-BEV)
- Where
- Belarus
- Volunteers
- 120 people
- Sponsor
- N.N. Alexandrov National Cancer Centre