Clinical trials: End of Life Patients
Palliative Patients, Surrogate Decision Maker
Multiprofessional Advance Care Planning and Shared Decision Making for End of Life Care
Multiprofessional Advance Care Planning and shared decision making for end of live care for terminal patients and their relatives.
- Trial name
- MAPS (NCT01914848)
- Testing
- Advance Care Planning ACP, Control Group
- Where
- Switzerland
- Volunteers
- 115 people
- Sponsor
- University of Zurich
Arrhythmias, Cardiac, Heart Diseases
Efficacy and Safety Study of Azimilide on the Incidence of Cardiovascular Hospitalizations/Emergency Department Visits or Cardiovascular Death in Patients With an Implantable Cardioverter Defibrillator (ICD) (SHIELD-2)
This study will evaluate the efficacy and safety of Azimilide on the incidence of cardiovascular hospitalizations, cardiovascular emergency department visits or cardiovascular death in patients with Implantable Cardioverter…
- Conditions
- Arrhythmias, Cardiac, Heart Diseases, Cardiovascular Diseases, Implantable Cardioverter Defibrillator
- Trial name
- SHIELD-2 (NCT01464476)
- Testing
- Azimilide Dihydrochloride
- Where
- 138 sites in United States, Belgium and 11 more
- Volunteers
- 240 people
- Sponsor
- Forest Laboratories
Pulmonary Disease, Chronic Obstructive, Lung Transplantation
Evaluating Quality of Life for Patients With Chronic Obstructive Pulmonary Disease Who Are Undergoing Lung Transplantation
Most people undergoing lung transplantation have chronic obstructive pulmonary disease (COPD), a disease in which the lung airways are partly damaged and obstructed, making it difficult to breathe.
- Trial name
- NCT00675376
- Where
- United States
- Volunteers
- 419 people
- Sponsor
- Washington University School of Medicine
Breast Cancer, Triple Negative Breast Cancer
Abraxane With or Without Tigatuzumab in Patients With Metastatic, Triple Negative Breast Cancer
Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer deaths in American women. Metastatic disease including metastatic breast cancer unfortunately remains incurable.
- Conditions
- Breast Cancer, Triple Negative Breast Cancer, Stage IV Breast Cancer, Metastatic Breast Cancer
- Trial name
- NCT01307891
- Testing
- Abraxane alone, Abraxane + Tigatuzumab
- Where
- 10 sites in United States
- Volunteers
- 64 people
- Sponsor
- University of Alabama at Birmingham
Stroke
Extern Validation of a Predictive Score of Brain Death in Severe Stroke (DIAPASON1)
There is currently a shortage of organ in France, for patients with chronic diseases who are on the waiting list for an organ. The first source of organ donor in France is patients with brain death.
- Trial name
- DIAPASON1 (NCT03612141)
- Where
- 25 sites in France
- Volunteers
- 650 people
- Sponsor
- Central Hospital, Nancy, France
Sleep Apnea
Long-Term Follow-up in Patients Included in the Meta-analysis "Sleep Apnea Syndrome and Arterial Stiffness"
The meta-analysis "sleep apnea syndrome and arterial stiffness" includes data from 893 patients initially included in 9 studies conducted by the EFCR Department of the CHUGA between 2006 and 2015, presenting a sleep apnea…
- Trial name
- PWV follow-up (NCT04704401)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 321 people
- Sponsor
- University Hospital, Grenoble
Advanced Solid Tumors
Safety and Efficacy of LCL161 in Patients With Solid Tumors
The study will evaluate the safety of increasing doses of oral LCL161 in patients with solid tumors. It is primarily designed to evaluate the side effects and find the maximum tolerated dose of LCL161.
- Trial name
- NCT01098838
- Testing
- LCL161
- Where
- 3 sites in United States
- Volunteers
- 71 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer, Lung Cancer
Using an End-of-life Conversation Game to Engage Patients With Cancer in Advance Care Planning
The goal of this clinical trial is to explore feasibility, acceptability, and effectiveness of end-of-life conversation game "Hello" as a tool to help individuals with breast, lung, and/or genito-urinary cancers treated at Penn…
- Conditions
- Breast Cancer, Lung Cancer, Genito Urinary Cancer
- Trial name
- NCT06028152
- Testing
- End-of-life conversation game called "Hello"
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Milton S. Hershey Medical Center
Non Small Cell Lung Cancer, Influenza Vaccine
Impact of Inactivated Trivalent Influenza Vaccine on NSCLC Patients Receiving PD-1 / PD-L1 Inhibitors
This project is to assess the immunogenicity, safety and overall survival impact of intramuscular injection of trivalent influenza vaccine in non-small cell lung cancer (NSCLC) patients with PD-1/PD-L1 inhibitor treatment.
- Trial name
- NCT04355806
- Testing
- PD-1/PD-L1 inhibitors, Inactivated trivalent influenza vaccine
- Where
- 2 sites in China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Dementia, Alzheimer, Electronic Health Records, Hospitalizations, Epidemiology, Comorbidity, United Kingdom, Incidence, Mortality, Cause of Death
Natural History and Patient Journey in Dementia: a Nationwide Linked Electronic Health Records Study of 5.6 Million Individuals.
The trajectory of dementia patients within the national health system and their recent temporal trends remains to be fully elucidated.
- Trial name
- NCT04321486
- Testing
- The study does not have an intervention, but observe the dementia incidence of the UK disease-free population.
- Volunteers
- 4,309,481 people, healthy volunteers welcome
- Sponsor
- University College, London
End Stage Renal Disease (ESRD), Kidney Failure, Chronic
Probiotic and Synbiotic Supplements in Hemodialysis Patients
This single-center randomized controlled trial evaluated the effects of natural probiotic and synbiotic supplementation on clinical and biochemical characteristics in adults with end-stage renal disease receiving maintenance…
- Conditions
- End Stage Renal Disease (ESRD), Kidney Failure, Chronic, Hemodialysis
- Trial name
- NCT07531186
- Testing
- Natural Probiotic Supplement, Natural Synbiotic Supplement (Probiotic + Prebiotic Oat Fiber)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
End-stage Renal Disease, Cardiovascular Disease
Effect of Increased Convective Clearance by On-Line Hemodiafiltration on All Cause Mortality in Chronic Hemodialysis Patients
The purpose of this study is to compare the effect of low flux hemodialysis with online hemodiafiltration on all cause mortality and a combination of cardiovascular morbidity and mortality in chronic hemodialysis patients.
- Trial name
- CONTRAST (NCT00205556)
- Testing
- on-line hemodiafiltration, low flux hemodialysis
- Where
- 29 sites in Canada, Netherlands and 1 more
- Volunteers
- 715 people
- Sponsor
- Amsterdam UMC, location VUmc
Renal Insuffiency, Kidney Transplantation
Pre-emptive Kidney Transplantation Quality of Life
The main objective is to assess the psychological impact of pre-emptive kidney transplantation on patients' quality of life taking into account psychological adjustment (response shift), compared to patients who have experienced…
- Trial name
- PreKiTQoL (NCT02154815)
- Testing
- Questionnaires : Patient-Reported Outcomes
- Where
- 5 sites in France
- Volunteers
- 390 people
- Sponsor
- Nantes University Hospital
Sudden Cardiac Death, Ventricular Arrythmias
Effect of Ranolazine on Arrhythmias and Microvolt T- Wave Alternans (MVTWA) Patients With LV Dysfunction
The purpose this investigation is to more thoroughly investigate the effects of ranolazine on arrhythmias and microvolt t-wave alternans in patients who have an automatic implantable cardioverter defibrillator (AICD) implanted…
- Trial name
- NCT00998218
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Aspirus Heart and Vascular Institute-Research and Education
Quality of Life, Mental Health Wellness 1
QOL and Mental Health Using APD With Remote Monitoring System
Although peritoneal dialysis (PD) is a representative renal replacement therapy along with hemodialysis, number of PD patients decreases every year.
- Trial name
- NCT07012499
- Testing
- Automated peritoneal dialysis with Sharesource device, APD without sharesource
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Wonju Severance Christian Hospital
Pulmonary Hypertension
Effects of Inhaled Treprostinil on Exercise Performance in Exercise Induced Pulmonary Hypertension
This study aims to investigate therapies for exercise induced pulmonary hypertension (EiPH). This is a condition that effects the blood vessels in the lungs and causes shortness of breath with activity.
- Trial name
- NCT07116681
- Testing
- Inhaled treprostinil
- Volunteers
- 8 people
- Sponsor
- University of California, San Diego
to Predict an Unfavorable Evolution of Covid-19 at the Hospital Admission of Patients
Prediction of Unfavourable Outcome in Newly Covid-19 Hospitalized Patient
The project is a part of the "Protocol for a multicentre study of nosocomial SARS-CoV2 transmission: The NOSO-COR Project" registered in ClinicalTrials (NCT04290780).
- Trial name
- PredictCovid19 (NCT04412031)
- Testing
- non applicable
- Where
- France
- Volunteers
- 802 people
- Sponsor
- Hospices Civils de Lyon
Kidney Failure, End of Life
Feasibility Testing a shareD dEciSIon Making Intervention for People With Kidney failuRE, Their Relatives, and the Health Professionals in Kidney Services: a Pilot Randomized Controlled Trial Study Protocol
The aim of this research is to test the acceptability and feasibility of a shared decision making intervention and a patient decision aid to support patients with kidney failure, relatives, and health professionals in planning…
- Trial name
- DESIRE (NCT05842772)
- Testing
- Shared decision making intervention for patients with kidney failure when planning end-of-life care
- Where
- Denmark
- Volunteers
- 27 people
- Sponsor
- University of Aarhus
Stable Angina, Myocardial Infarction
Heart Rate and Cardiovascular Diseases Prognosis in People With Stable Coronary Artery Disease
The Cardiovascular disease research using Linked Bespoke studies and Electronic Records (CALIBER) e-health database was the data resource for this study.
- Conditions
- Stable Angina, Myocardial Infarction, Coronary Heart Disease, Heart Failure
- Trial name
- NCT02244853
- Where
- United Kingdom
- Volunteers
- 51,703 people, healthy volunteers welcome
- Sponsor
- University College, London
Myocardial Infarction, Death, Sudden, Cardiac
Effect of High Dose Fish Oil Supplementation After Recent Heart Attack Using Magnetic Resonance Imaging
Doctors use magnetic resonance imaging (MRI) to obtain detailed pictures of the inside of the body. This study will evaluate a new MRI technique in people who have recently had a heart attack.
- Trial name
- OmegaREMODEL (NCT00729430)
- Testing
- Omega-3 Fatty Acids (Fish Oil Supplements)
- Where
- United States
- Volunteers
- 358 people
- Sponsor
- Brigham and Women's Hospital