Clinical trials: End of Life Patients
Family of Dying Patient in the ICU
A Communication Strategy for Families of Patients Dying in the ICU
Decisions to limit life sustaining treatments are made for most patients dying in the ICU, usually with input from the family. The well-being of the family may be jeopardized by involvement in the decision-making process and…
- Trial name
- NCT00331877
- Testing
- family conference with bereavement information leaflet
- Volunteers
- 136 people
- Sponsor
- Famirea Study Group
Heart Failure, Sudden Death
MIBG Scintigraphy as a Tool for Selecting Patients Requiring Implantable Cardioverter Defibrillator (ICD)
The aim of the study is to assess the cardiac innervation in patients with heart failure to better select candidates for an implantable cardioverter defibrillator.
- Trial name
- MISTIC (NCT01185756)
- Testing
- MIBG for diagnostic purpose
- Where
- France
- Volunteers
- 330 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infection
Revitalization of Teeth With Necrotic Pulps and Open Apexes Using Platelet-Rich Plasma
When root canals of infected teeth with closed ends are cleaned, disinfected and filled, the results are predictable with excellent outcomes.
- Trial name
- NCT01212939
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Torabinejad, Mahmoud
Arrhythmia
Effects of Docosahexaenoic Acid (DHA) on Heart Rate Variability in Elderly Patients
The purpose of this study is to test the hypothesis that dietary supplementation with an algal source of docosahexaenoic acid (DHA) can improve the heart rate variability in elderly patients.
- Trial name
- NCT00749307
- Testing
- Docosahexaenoic acid (DHA)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Campus Bio-Medico University
End of Life, Pain
Assessment of the Interest of ANI in the Non-communicating Patient in Palliative Care
Comfort evaluation is one of the major challenges in the palliative care setting, particularly when it comes to non-communicative patients.
- Conditions
- End of Life, Pain, Analgesia
- Trial name
- ANI-CARE (NCT05454202)
- Testing
- ANI
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Lille
Terminal Illness, Intensive Care Unit Syndrome
End Of Life in the Critically Ill patiEnt
The purpose of this multicentric study is to evaluate the perception of the quality of the end of life in intensive care units seen from the side of the caregivers, trough the CAESAR scale.
- Trial name
- EOLE (NCT03392857)
- Testing
- Assessment by caregivers of the quality of the end of life in intensive care units
- Where
- 112 sites in France
- Volunteers
- 514 people
- Sponsor
- French Society for Intensive Care
Coronary Artery Disease, Myocardial Ischemia
EXCEL-II Stent Vesus EXCEL Stent to Treat the Patients With de Novo Coronary Artery Lesions.
The purpose of this Randomized Study to evaluate the safety and efficacy of the Excel-II DES compared to the EXCEL DES in the treatment of patients with de novo coronary artery lesions.
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Coronary Disease, Heart Diseases
- Trial name
- CREDIT-II (NCT02057978)
- Testing
- EXCEL DES implatation, EXCEL-II DES implantation
- Where
- China
- Volunteers
- 419 people
- Sponsor
- JW Medical Systems Ltd
Coronary Artery Disease, Myocardial Infarction
Imaging Modalities in Detection of Coronary Artery Disease in End-stage Renal Disease Patients
This study investigates hypothesizes that the combination of dobutamine stress echocardiography with dobutamine stress echocardiography with real time perfusion myocardial contrast echocardiography and coronary computed…
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Stroke, Death
- Trial name
- NCT00726921
- Where
- United States
- Volunteers
- 189 people
- Sponsor
- University of Nebraska
SARS-CoV-2 Acute Respiratory Disease, Covid19
Pandemic Triage Score in Patients With Known or Suspected Severe Acute Respiratory Syndrome (SARS) CoronaVirus (CoV) 2 Infection
During this pandemic period, the goal of the health care system is to optimize the use of intensive care services for patients infected with SARS-CoV-2, given the frequency of complications that can lead to high mortality.
- Trial name
- STC-19 (NCT04371471)
- Testing
- STC-19 score
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Groupe Hospitalier de la Rochelle Ré Aunis
Sudden Cardiac Death
Imaging Techniques for Identifying Factors of Sudden Cardiac Death Risk
Sudden cardiac death is a tragic event that strikes all age groups and is unfortunately increasing in prevalence. Because it is difficult to predict those at highest risk, this study is designed to test the hypothesis that new…
- Trial name
- NCT00181233
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Johns Hopkins University
Neurologic Signs and Symptoms
Incidence, and Survival Medical Expenditure of Patients With Multiple Sclerosis
Multiple sclerosis (MS) is a disease of autoimmune system which attacks the central nervous system and that is one of the most common inflammatory diseases and has caused a heavy disease burden on patients.
- Trial name
- NCT04022564
- Where
- Taiwan
- Volunteers
- 2,000 people
- Sponsor
- Chun-Ming Liao
Chronic Kidney Disease (CKD), Kidney Transplant
Remote vs In-Person Prehabilitation for Kidney Transplant Candidates
Patients with advanced chronic kidney disease awaiting deceased-donor kidney transplantation frequently experience progressive functional decline, frailty, reduced mobility, and poor quality of life while on the transplant…
- Conditions
- Chronic Kidney Disease (CKD), Kidney Transplant, Frailty, Prehabilitation
- Trial name
- KIDFIT (NCT07701382)
- Testing
- In-Person Multimodal Prehabilitation, Remote Multimodal Prehabilitation
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Hospital Clinic of Barcelona
Squamous Cell Carcinoma of the Head and Neck
Phase III Open Label Study of MEDI 4736 With/Without Tremelimumab Versus Standard of Care (SOC) in Recurrent/Metastatic Head and Neck Cancer
This is a randomized, open-label, multi-center, 3-arm, global Phase III study to determine the efficacy and safety of MEDI4736 + tremelimumab combination or MEDI4736 monotherapy versus SoC (EXTREME regimen) in the treatment of…
- Trial name
- KESTREL (NCT02551159)
- Testing
- MEDI4736, Tremelimumab, MEDI4736+Tremelimumab
- Where
- 197 sites in United States, Austria and 21 more
- Volunteers
- 823 people
- Sponsor
- AstraZeneca
Quality of Life, End Stage Renal Disease
Improving Outcomes for Hemodialysis Patients
End stage renal disease (ESRD) affects approximately 700,000 Americans of which approximately 400,000 are on life-saving hemodialysis therapy.
- Trial name
- NCT03395366
- Testing
- Multifaceted Educational / Cognitive Behavioral Intervention
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Columbia University
Chronic Heart Failure With Reduced Ejection Fraction (HFrEF)
Study to Evaluate the Effect of Dapagliflozin on the Incidence of Worsening Heart Failure or Cardiovascular Death in Patients With Chronic Heart Failure
The purpose of this study is to evaluate the effect of dapagliflozin on the incidence of worsening heart failure or cardiovascular death in patients with chronic heart failure with reduced ejection fraction
- Trial name
- DAPA-HF (NCT03036124)
- Testing
- Dapagliflozin
- Where
- 419 sites in United States, Argentina and 18 more
- Volunteers
- 4,744 people
- Sponsor
- AstraZeneca
Critical Illness, Chronic Disease
Improving Communication About Serious Illness
The purpose of this study is to improve care delivered to patients with serious illness by enhancing communication among patients, families, and clinicians in the outpatient setting.
- Conditions
- Critical Illness, Chronic Disease, Terminal Care, Palliative Care
- Trial name
- ICSI (NCT01933789)
- Testing
- Communication Feedback Form for Patients with Serious Illness
- Where
- 6 sites in United States
- Volunteers
- 817 people
- Sponsor
- University of Washington
Rheumatoid Arthritis
Comparison Between Dead Sea Solar and Water Treatment to Sulfur Pool and Medicinal Mud Treatment in Patients With RA
Prospective open label crossover self controlled study. The study population will randomly be divided into two groups. The study will take place in Lot Spa Hotel at the Dead Sea in two cycles (one of 16 participants and one of 14…
- Trial name
- NCT01861782
- Testing
- Dead Sea Solar and Water Treatment, Sulfur Pool & Medicinal Mud
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Soroka University Medical Center
Advance Directives, Resuscitation Orders
Patient Understanding of End of Life Care
This study aims at assessing factors that affect patient choices for end of life care. 300 patients would be assigned either to a control arm (questionnaire alone) or intervention arm (standardized explanation+ questionnaire).
- Trial name
- NCT01683097
- Testing
- Standardized explanation
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Partners in Internal Medicine
Chronic Kidney Diseases, Atrial Fibrillation
Stroke Prophylaxis With Apixaban in Chronic Kidney Disease Stage 5 Patients With Atrial Fibrillation
Objective: To study the efficacy and safety of apixaban as stroke prophylaxis in patients with chronic kidney disease (CKD) stage 5 and atrial fibrillation (AF) with or without dialysis treatment.
- Conditions
- Chronic Kidney Diseases, Atrial Fibrillation, Stroke, Intracerebral Hemorrhage
- Trial name
- SACK (NCT05679024)
- Testing
- Apixaban 2.5 milligram Oral Tablet
- Where
- 34 sites in Finland, Iceland and 2 more
- Volunteers
- 1,400 people
- Sponsor
- Region Stockholm
Obstructive Hypertrophic Cardiomyopathy (oHCM)
Left Ventricular Mass Index Predicts Clinical Outcomes in Patients with Obstructive Hypertrophic Cardiomyopathy Undergoing Septal Myectomy
In this study, we aimed to analyze the association between left ventricular mass index and clinical outcomes to provide the potential indicator for worse survival.
- Trial name
- LVMI and oHCM (NCT06609382)
- Testing
- Patients had a higher left ventricular mass index or not （the exact value is determined by the cut-off value for the clinical outcomes)
- Where
- China
- Volunteers
- 490 people
- Sponsor
- Changrong Nie