Clinical trials: End-Stage Kidney Disease
Kidney Failure, Chronic, Olfaction Disorders
Taste And Smell TEsting in End Stage Renal Disease
Malnutrition is an important complication of advanced kidney disease and impairment in smell and taste may affect nutritional status.
- Conditions
- Kidney Failure, Chronic, Olfaction Disorders, Taste Disorders, Malnutrition
- Trial name
- TASTE ESRD (NCT03043144)
- Testing
- Worsening of olfaction from enrollment visit to 6 months, Worsening of taste from enrollment visit to 6 months, Serum Zinc
- Where
- United States
- Sponsor
- Beth Israel Deaconess Medical Center
Type 2 Diabetes, End Stage Renal Disease
Using Sitagliptin as a Treatment to Prevent New Onset Diabetes After Kidney Transplantation
This study is designed to see if the use of the drug Sitagliptin (used to reduce insulin resistance) will delay or prevent kidney transplant patients from getting diabetes.
- Trial name
- NCT00936663
- Testing
- Sitagliptin
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Nebraska
End Stage Kidney Disease, Immunological Tolerance
Immunological Tolerance in Patients With Mismatched Kidney Transplants
This study seeks to determine if administration of the drug belumosudil (KD025) will be safe and improve transplant tolerance in subjects undergoing combined Human Leukocyte Antigen (HLA) single haplotype-matched related or 0-3…
- Conditions
- End Stage Kidney Disease, Immunological Tolerance, Kidney Transplant Failure and Rejection, Chronic Kidney Diseases
- Trial name
- NCT05806749
- Testing
- Donor CD34+, CD3+. and belumosudil
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, Los Angeles
End-stage Renal Disease
Nutrition, Inflammation and Insulin Resistance in End-Stage Renal Disease
By 2030 an estimated 2 million people in the US will need dialysis or transplantation. Insulin resistance and chronic inflammation are common in dialysis patients and have been linked to protein-energy wasting, the most important…
- Trial name
- SummerMRI (NCT04067752)
- Testing
- high dialysate sodium concentration (138 mEq/L), Low dialysate sodium concentration
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- VA Office of Research and Development
End Stage Renal Disease
Protein Supplementation in Dialysis Patients
The mortality rate in chronic hemodialysis (CHD) patients remains excessively high and approaches 21% per year. Among the many factors that adversely affects patient outcome is uremic malnutrition, a unique form of deranged…
- Trial name
- NCT00367198
- Testing
- Pro-Stat
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
End Stage Renal Disease (ESRD)
Product Evaluation for the Effectiveness of the ClearGuard® HD End Cap
To assess blood stream infections in participants using two FDA-cleared devices: ClearGuard HD end caps compared to the Tego® connector with the CurosTM for Tego disinfecting port protector.
- Trial name
- NCT02593149
- Testing
- ClearGuard HD End Cap
- Where
- United States
- Volunteers
- 1,902 people
- Sponsor
- Pursuit Vascular, Inc.
Chronic Kidney Diseases
Determinants of Vascular Calcification in Chronic Renal Failure : Impact of Pyrophosphate Levels After Renal Transplantation
Arterial calcifications (AC) are constant lesions in patients with Chronic Kidney Diseases (CKD). Renal transplantation would reduce their progression compared to dialysis.
- Trial name
- PyroCal-greffe (NCT03462238)
- Testing
- Blood collection for Ppi assay, CT Scan
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
End Stage Renal Disease, Fatigue
Bupropion for Fatigue in End-stage Kidney Disease Patients on Hemodialysis
Fatigue is the most common symptom reported by end-stage kidney disease patients on maintenance hemodialysis. Unfortunately, there currently is no medical management for this overwhelming feeling of tiredness.
- Trial name
- BRISK (NCT06609343)
- Testing
- Bupropion Hydrochloride 150 MG
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Kidney Failure, Chronic
Prehabilitation for Adults With End Stage Renal Disease on the Kidney Transplant Waitlist
This pilot study will be a clinical trial to test the feasibility and effectiveness of a kidney transplant (KT) prehabilitation intervention in adults with end stage renal disease (ESRD) who are within 3-6 months of…
- Trial name
- NCT02895243
- Testing
- Prehabilitation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Kidney Failure, Chronic, Renal Disease, End-Stage
Pharmacokinetics/Pharmacodynamics of Argatroban Injection in End-Stage Renal Disease Patients Undergoing Hemodialysis
The primary goals of this investigation are to provide guidance on how to dose Argatroban in patients undergoing hemodialysis and to assess the safety and tolerability of Argatroban in hemodialysis patients.
- Trial name
- NCT00035178
- Testing
- Argatroban
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Texas Biotechnology Corporation
End Stage Renal Disease (ESRD), Brachiocephalic Fistula (BCF)
Outcome of BCF Access in Hemodialysis Patients
Dialysis access, which is the connection that allows blood to flow in and out of the body during dialysis sessions, is important to remove wastes and excess fluid for patients with end stage renal disease (ESRD).
- Conditions
- End Stage Renal Disease (ESRD), Brachiocephalic Fistula (BCF), Cephalic Arch Stenosis (CAS), Dialysis
- Trial name
- BCF (NCT01693263)
- Testing
- brachiocephalic fistula (BCF)
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Chicago
End Stage Renal Disease on Dialysis
Home-based vs Intradialysis Exercise Guided by Nursing Staff
Participants will be randomized either to home-based exercise or to intradialysis exercise guided by nurses of the renal unit. The programs will last 16 weeks.
- Trial name
- HoBIDnurse (NCT04051515)
- Testing
- Intradialysis exercise training, Home-based exercise training
- Where
- 7 sites in Belgium, Greece and 2 more
- Volunteers
- 70 people
- Sponsor
- Cardenal Herrera University
End Stage Renal Disease, Sexual Dysfunction, Physiological
Pain, Sexual Dysfunction, and Depression in Hemodialysis Patients
This study is seeking to identify the most effective strategy to manage pain, sexual dysfunction, and depression in patients receiving chronic hemodialysis therapy.
- Conditions
- End Stage Renal Disease, Sexual Dysfunction, Physiological, Pain, Depression
- Trial name
- SMILE (NCT00692419)
- Testing
- Symptom management nurse intervention, Feedback intervention
- Where
- United States
- Volunteers
- 315 people
- Sponsor
- US Department of Veterans Affairs
End-stage Renal Disease
Effects of Strict Volume Control in Hypertensive Hemodialysis Patients on Cardiac Structure and Chronic Inflammation
This study aims mainly to investigate the effects of two approaches to control blood pressure in hypertensive hemodialysis patients; using antihypertensive drugs versus strict volume control (by strict dietary salt restriction…
- Trial name
- NCT00307463
- Testing
- strict volume control policy, antihypertensive drugs administration
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 258 people
- Sponsor
- Ege University
Hypoalbuminemia, Protein-energy Malnutrition
Anit-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients
Study of efficiency and safety of oral nutritional supplements with anti-inflammatory and antioxidative properties combined with an appetite stimulant with anti-inflammatory properties (pentoxiphylline) in treatment of…
- Conditions
- Hypoalbuminemia, Protein-energy Malnutrition, Inflammation, Oxidative Stress
- Trial name
- AIONID (NCT00561093)
- Testing
- pentoxiphylline, Nepro, anti-inflammatory module (similar to Oxepa)
- Where
- 2 sites in United States
- Volunteers
- 93 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Chronic Renal Disease
Once-a-day Immunosuppression(CISECON_a_day)
The objective of this study is to assess the efficacy and safety and Immunosuppressant Therapy Barrier Scale (ITBS) of once daily immunosuppressant maintenance therapy in patients who had kidney transplantations earlier.
- Trial name
- CISECON (NCT01964014)
- Testing
- advagrf
- Where
- 7 sites in South Korea
- Volunteers
- 160 people
- Sponsor
- Ajou University School of Medicine
Stage 5 Chronic Kidney Disease (CKD), Secondary Hyperparathyroidism (SHPT)
Four Week, Pharmacodynamic/Pharmacokinetic, Efficacy, and Safety Study of Lunacalcipol (CTA018)
Open-label, pharmacodynamic, safety, pharmacokinetic and efficacy study of Lunacalcipol Injection.
- Conditions
- Stage 5 Chronic Kidney Disease (CKD), Secondary Hyperparathyroidism (SHPT), Hemodialysis (HD)
- Trial name
- 2007 (NCT01453634)
- Testing
- Lunacalcipol 180, Lunicalcipol 270
- Sponsor
- OPKO Health, Inc.
Hepatitis B, ESRD (End Stage Renal Disease)
Comparing Hepatitis B Vaccination Schedules in Patients on Hemodialysis
People with kidney failure who are on dialysis have a weaker immune response to the hepatitis B vaccine than healthy people. Even after vaccination, many dialysis patients do not develop enough protection against hepatitis B…
- Conditions
- Hepatitis B, ESRD (End Stage Renal Disease), Kidney Failure, Chronic
- Trial name
- 3v4-HEP-DOSE (NCT07784452)
- Testing
- Recombinant Hepatitis B Vaccine - 3-Dose Schedule, Recombinant Hepatitis B Vaccine - 4-Dose Schedule
- Where
- Pakistan
- Volunteers
- 104 people
- Sponsor
- Jinnah Hospital
End Stage Renal Disease
High-Intensity Interval Training and Regulatory T Cells
Regulatory T cells (Tregs) are a small population of T cells compromising of 1% to 5% of the total T cells in the body but they are playing a fundamental role in the maintenance of the immune homeostasis.
- Trial name
- NCT04774484
- Testing
- High Intensity Interval Training
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Francesc Marti
Renal Insufficiency, Kidney Diseases
A Study to Evaluate the Pharmacokinetics and Safety of INCB161734 in Participants With Impaired Renal Function and Participants on Hemodialysis
This study is conducted to evaluate the pharmacokinetics and safety of INCB161734 in participants with impaired renal function and participants on hemodialysis.
- Trial name
- NCT07854249
- Testing
- INCB161734
- Volunteers
- 24 people
- Sponsor
- Incyte Corporation
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.