Clinical trials: End-stage Disease
End Stage Renal Disease
Blood Flow Conditions and Sounds in AVFs
This is a prospective non-pharmacological interventional study aimed at investigating the relationship between the blood flow condition and the arteriovenous fistula (AVF) sound, with the ultimate aim of predicting the AVF…
- Trial name
- APOLLO (NCT06411353)
- Testing
- MRI acquisition, US examination
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
End-Stage Liver Disease, Liver Transplantation
Multidimensional Frailty Assessment and Post-Transplant Outcomes in Liver Transplant Candidates
This study will evaluate frailty, nutrition, sarcopenia, and psychological health in people waiting for a liver transplant. The purpose is to understand how these factors affect outcomes before and after transplantation.
- Conditions
- End-Stage Liver Disease, Liver Transplantation, Cirrhosis
- Trial name
- NCT07414095
- Testing
- Comprehensive Observational Assessment in Liver Transplant Candidates
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Izmir Bakircay University
Leukemia
A Study of Imatinib and Nilotinib in Patients With Chronic Myelogenous Leukemia in Chronic Phase
The extension study followed the core study CAMN107ECN02 (NCT01275196). which is an open-label, two armed study. All patients enrolled in this extension study were able to benefit from the treatment given in CAMN107ECN02 per…
- Trial name
- NCT02272777
- Testing
- Imatinib, Nilotinib
- Where
- 12 sites in China
- Volunteers
- 225 people
- Sponsor
- Novartis Pharmaceuticals
End-stage Renal Disease, Hemodialysis Access Failure
Arteriovenous Fistula Maturation Evaluation Study. FAME Study
Study of the features of hemodynamic and clinical maturation of the native arteriovenous fistula for hemodialysis.
- Conditions
- End-stage Renal Disease, Hemodialysis Access Failure, Vascular Access Maturation, Native Arteriovenous Fistula
- Trial name
- NCT04736875
- Testing
- Doppler ultrasound study
- Where
- Greece
- Volunteers
- 86 people
- Sponsor
- Medifil AE
End-Stage Renal Failure, Functional Iron Deficiency
Mean Reticulated Haemoglobin (Hb) Content (RetHe) Analysis of Renal Patients
Anaemia is a common complication of Chronic Kidney Disease (CKD) the management of which has been aided by the use of synthetic recombinant human erythropoietin therapy (r-HuEPO).
- Trial name
- NCT01126905
- Volunteers
- 250 people
- Sponsor
- University of Ulster
End Stage Liver Disease, Hepatitis C
DAA Treatment in Donor HCV-positive to Recipient HCV-negative Liver Transplant
This is a single center study for the donation of Hepatitis C Virus (HCV)-positive livers to HCV negative recipient patients, with preemptive, interventional treatment to prevent HCV transmission upon transplantation.
- Trial name
- NCT03208127
- Testing
- Treatment with Direct Acting Antiviral tablet
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Massachusetts General Hospital
Vascular Diseases, End Stage Renal Disease on Dialysis
Individual Patient Expanded Access for Acellular Tissue Engineered Vessel (ATEV) for Vascular Disease and Dialysis Access
Individual patient expanded access requests may be considered for patients who have no other treatment options and are not eligible for an ATEV clinical study.
- Trial name
- NCT07141641
- Testing
- Acellular Tissue Engineered Vessel (ATEV)
- Sponsor
- Humacyte, Inc.
Restless Legs Syndrome, End Stage Renal Disease
Exercise Training in Dialysis Patients With Restless Legs Syndrome (RLS)
Uremic etiology Restless legs syndrome (RLS) has been associated with poorer quality of life (QoL) compared to RLS-free counterparts mainly due to sleep deprivation factors.
- Conditions
- Restless Legs Syndrome, End Stage Renal Disease, Hemodialysis, Muscle Cachexia
- Trial name
- HDRLS (NCT00942253)
- Testing
- Dopamine Agonist and Exercise
- Where
- Greece
- Volunteers
- 46 people
- Sponsor
- University of Thessaly
End Stage Renal Disease
Complementary Intradialytic Nutritional Supplementation in Dialysis Patients
In this study, the investigators hypothesize that long-term administration of adequate intradialytic oral nutritional supplementation will increase visceral protein concentrations and somatic protein stores in malnourished…
- Trial name
- NCT00179205
- Testing
- Nepro nutritional supplement
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Vanderbilt University
Delayed Graft Function, End Stage Renal Disease
Norepinephrine Infusion Combined With Goal-directed Fluid Therapy in Patients Undergoing Kidney Transplantations
Delayed graft function (DGF), delineated by the necessity for dialytic intervention within the initial week post-transplantation, afflicts approximately 20%-50% of recipients.
- Conditions
- Delayed Graft Function, End Stage Renal Disease, Kidney Transplantation
- Trial name
- NCT06367205
- Testing
- Goal-Directed Fluid Therapy (GDFT), Regular Fluid Therapy
- Where
- 3 sites in China
- Volunteers
- 380 people
- Sponsor
- RenJi Hospital
Hemodialysis, Probiotics
Effect of Probiotic and Synbiotic Administration on Nutritional Status in Hemodialysis Patients
This study aims to investigate the impact of probiotics and synbiotics on the nutritional status of patients with end-stage kidney disease (ESRD) who are undergoing hemodialysis.
- Conditions
- Hemodialysis, Probiotics, Synbiotics, Nutritional Status
- Trial name
- ProSyn-HD (NCT06891105)
- Testing
- Lactogemikan (Probiotic Supplement), Lactogemikan + Prebiotic Fiber (Synbiotic Supplement)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Bladder Cancer, Cervical Cancer
Bupropion in Helping Adults Stop Smoking
RATIONALE: Bupropion may help people stop smoking by decreasing the symptoms of nicotine withdrawal. Giving bupropion over a longer period of time may be effective in helping people stop smoking.
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00534001
- Testing
- bupropion hydrochloride
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Roswell Park Cancer Institute
End Stage Renal Disease, Hemodialysis Complication
The Feasibility of Propofol TCI in Hemodialysis Patients Undergoing Arteriovenous Shunt Surgery
Written informed consent must be obtained before any study specific procedures are undertaken. Informed consent will be obtained during pre-operative assessment.
- Trial name
- NCT03311581
- Testing
- Propofol, Sevoflurane
- Where
- Taiwan
- Volunteers
- 47 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Infections, Bacterial
Pharmacokinetic Study of Gepotidacin in Subjects With Varying Degrees of Renal Impairment and in Subjects With Normal Renal Function
This study will be conducted to determine if altered renal function affects the plasma pharmacokinetics of gepotidacin, which will inform if dosing recommendations based upon renal impairment are required.
- Trial name
- NCT02729038
- Testing
- Gepotidacin
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Mild Cognitive Impairment (MCI), Early Stages of Cognitive Decline
Mild Cognitive Impairment Community Screening and Early Intervention Via Stem Cell Therapy and Wearable Brain Computer Interface Device.
This study aims to evaluate the efficacy of community-based early detection and targeted interventions, including stem cell therapy and wearable non-invasive brain-computer interface (BCI) devices, for Mild Cognitive Impairment…
- Conditions
- Mild Cognitive Impairment (MCI), Early Stages of Cognitive Decline, Alzheimer's Disease Dementia, Alzheimer's Disease Diagnosis
- Trial name
- MCITestCare (NCT07214974)
- Testing
- Structured wellness care, Wearable brain-computer interface devices, Stem Cell Therapy - Experimental
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Noah Tech, Corp.
End-stage Renal Disease, Kidney Transplantation
Evaluation of Desensitization Protocols in HLA-incompatible Kidney-transplant Candidates
Kidney transplantation is the best renal-replacement in the setting of end-stage renal disease. However, some transplant candidates have developed anti-HLA alloantibodies (human leukocyte antigen).
- Conditions
- End-stage Renal Disease, Kidney Transplantation, Hla-incompatible Kidney Transplant Candidates
- Trial name
- NCT03507348
- Testing
- visits of tocilizumab injection (every 4 weeks, up to 5 visits), Rituximab 375 mg/m2 at Day-30, Rituximab 375 mg/m2 at Day-15 (only for donors living)
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Grenoble
End-Stage Kidney Disease
Transplantation of Uncontrolled DCD Kidneys REconditioned by a Novel Ex-VIVo Perfusion MEthod
Eight patient will be transplanted with kidneys from donors dying after uncontrolled circulatory arrest (uDCD), with prolonged warm ischemia (up to 4,5 hours), preserved by a new method based on removal of fibrinogen/fibrin in…
- Trial name
- REVIVEME (NCT05703633)
- Testing
- uDCD treatment
- Volunteers
- 8 people
- Sponsor
- Sahlgrenska University Hospital
End Stage Renal Disease
Effects of Oral Cholecalciferol (Vitamin D3) on Bone Health, Neuromuscular Function, and Quality of Life in Adults With Chronic Kidney Disease
Will oral vitamin improve strength, bone quality, pain and quality of life. This is a double blind, randomized placebo controlled study using 10,000 IU of cholecalciferol vs placebo.
- Trial name
- Neph (NCT00511225)
- Testing
- cholecalciferol
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Creighton University
End Stage Renal Disease
Transplant Navigator Intervention to Overcome Barriers to Kidney Transplantation
Compared with chronic dialysis treatment, kidney transplantation generally offers a longer life span, a better quality of life, and lower health care costs for the over 500,000 Americans with End Stage Renal Disease.
- Trial name
- NCT00805038
- Testing
- Transplant navigator, Usual care
- Where
- United States
- Volunteers
- 167 people
- Sponsor
- Case Western Reserve University
Hemodialysis
CR845-100303: Study to Assess the Potential of Physical Withdrawal From Intravenous CR845 (Difelikefalin) in Hemodialysis Patients
This is a multicenter, randomized, double-blind, placebo-controlled study to assess the potential of physical withdrawal from CR845 upon treatment discontinuation after 3 weeks of IV administration at a dose of 0.5 mcg/kg in…
- Trial name
- NCT05533008
- Testing
- CR845 0.5 mcg/kg
- Where
- 5 sites in United States
- Volunteers
- 35 people
- Sponsor
- Cara Therapeutics, Inc.