Clinical trials: End-stage Kidney Disease
End Stage Renal Disease, Dialysis
Peritoneal Membrane Dysfunction in Peritoneal Dialysis Using Metabolomics
Ability and sensitivity of metabolomics analysis to highlight biomarkers or a score of biomarkers that will be able to identify those pediatric patients on peritoneal dialysis at high risk for possible peritoneal dialysis…
- Trial name
- NCT03964701
- Testing
- no intervention
- Where
- Greece
- Volunteers
- 18 people
- Sponsor
- Baxter (Hellas) Ltd
Chronic Kidney Diseases, End Stage Renal Disease on Dialysis
Registry of GORE® ACUSEAL Vascular Graft in Dialysis Access
The goal of this observational study is to evaluate safety and performance of GORE® ACUSEAL Vascular Graft for the treatment of CKD in patients with ESRD in hemodialysis.
- Trial name
- AVG22-09 (NCT05846581)
- Testing
- GORE® ACUSEAL Vascular Graft
- Where
- 4 sites in Germany, Italy and 1 more
- Volunteers
- 72 people
- Sponsor
- W.L.Gore & Associates
Arteriovenous Fistula, Arteriovenous Graft
A Randomised Trial Comparing Supraclavicular Block vs Supraclavicular and Pecs II Block in Arteriovenous Grafting
This study evaluates the addition of Pecs II block to ultrasound-guided supraclavicular brachial plexus block in patients undergoing arteriovenous graft creation surgery.
- Conditions
- Arteriovenous Fistula, Arteriovenous Graft, Kidney Failure, Chronic, Renal Failure, End-stage
- Trial name
- NCT02331030
- Testing
- Supraclavicular, Pecs II block, Ropivacaine 0.5% 20ml
- Where
- Singapore
- Volunteers
- 36 people
- Sponsor
- Changi General Hospital
Anemia of End Stage Renal Disease
TARGTEPO Treatment for Anemia in PD US Trial
The objectives of this study are to assess safety and to evaluate the biologic activity of TARGTEPO treatment in Peritoneal Dialysis patients
- Trial name
- NCT02468414
- Testing
- MDGN201 TARGTEPO
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Aevi Genomic Medicine, LLC, a Cerecor company
Chronic Kidney Disease Stage 5 (Dialysis Dependent)
A Randomized, Comparative, Open-label Study of IV Monofer® Administered as Maintenance Therapy by Single or Repeated Bolus Injections in Comparison With IV Iron Sucrose in Subjects With CKD-5D
The purpose of this study is to compare the efficacy and safety of intravenous iron isomaltoside 1000 with intravenous iron sucrose in patients suffering from Stage 5 Chronic Kidney Disease on Dialysis Therapy (CKD-5D).
- Trial name
- NCT01222884
- Testing
- Monofer, Iron sucrose
- Where
- India
- Volunteers
- 351 people
- Sponsor
- Pharmacosmos A/S
End Stage Renal Failure on Dialysis
Low Molecular Weight Heparin for Hemodialysis Anticoagulation
Low-molecular weight heparins (LMWHs) as well as Unfractionated heparin (UFH) is used as anticoagulation during hemodialysis (HD) therapy.
- Trial name
- NCT01356615
- Testing
- low molecular weight heparin (enoxaparin sodium), standard unfractionated heparin
- Volunteers
- 27 people
- Sponsor
- Tehran University of Medical Sciences
End-stage Renal Disease, Left Ventricular Hypertrophy
Impact of In-centre Nocturnal Hemodialysis on Ventricular Remodeling and Function in End-stage Renal Disease
Background: Recent data indicate that home nocturnal hemodialysis (8 hours of hemodialysis at home for 5-6 nights per week) may have substantial cardiovascular benefits, including regression of left ventricular (LV) hypertrophy…
- Trial name
- NCT00718848
- Testing
- Incentre nocturnal hemodialysis, Remaining on conventional hemodialysis
- Where
- 2 sites in Canada
- Volunteers
- 67 people
- Sponsor
- Unity Health Toronto
Chronic Renal Insufficiency, Peritoneal Dialysis
Apixaban in Subjects With Peritoneal Dialysis
The primary objective of this study is to assess the pharmacokinetics of a single oral dose of apixaban (5mg) in participants with dialysis peritoneal versus participants with normal renal function.
- Trial name
- ApiDP (NCT04006093)
- Testing
- Apixaban single dose 5mg
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Caen
End Stage Renal Disease, Hemolysis
Ventilatory Functions and Physical Intolerance in ESRD Adolescents: Response to Program of Walking With Dogs
adolescents with chronic renal failure going on hemodialysis usually complain many problems including compromised ventilation, early fatigue, early physical intolerance, and bad life quality.
- Trial name
- NCT06861816
- Testing
- incentive spirometer and walking with dog, training by incentive spirometer only
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Infections, Bacterial
Pharmacokinetic Study of Gepotidacin in Subjects With Varying Degrees of Renal Impairment and in Subjects With Normal Renal Function
This study will be conducted to determine if altered renal function affects the plasma pharmacokinetics of gepotidacin, which will inform if dosing recommendations based upon renal impairment are required.
- Trial name
- NCT02729038
- Testing
- Gepotidacin
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
End Stage Renal Failure on Dialysis
A Pilot Trial of Twice-weekly Versus Thrice-weekly Hemodialysis in Patients With Incident End-stage Kidney Disease
The optimal frequency of hemodialysis treatments in patients with incident end-stage kidney disease in not known. This pilot trial will randomize patients with incident end-stage kidney disease due to chronic kidney disease…
- Trial name
- TWOPLUS-HD (NCT03740048)
- Testing
- Hemodialysis, Patiromer Oral Product
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Chronic Renal Failure/ Kidney Disease, Contrast-medium Induced Acute Kidney Injury
Effect of Red Wine, White Wine and Beer on Contrast-Medium Induced Acute Kidney Injury
Patients with impaired renal function are at elevated risk for development of contrast-medium induced acute kidney injury (CI-AKI). CI-AKI is associated with increased risk for cardiovascular morbidity and mortality.
- Trial name
- RenPro-II-WINE (NCT01562925)
- Testing
- Red wine, White wine, Beer
- Where
- Germany
- Volunteers
- 260 people
- Sponsor
- University of Cologne
End Stage Renal Failure
Different Doses of Intravenous Administered Dexamethasone Effecting Brachial Plexus Supraclavicular Block
To compare the analgesic properties of ultrasound guided supraclavicular block using ropivacaine 0.5% in arteriovenous fistula creation when used in combination with intravenous administered dexamethasone at 4mg and 8 mg as an…
- Trial name
- NCT06389617
- Testing
- supraclavicular block with 20mls of Ropivacaine 0.5% and Intravenous administered dexamethasone
- Volunteers
- 50 people
- Sponsor
- Hospital Universiti Sains Malaysia
Chronic Kidney Failure
Developing and Evaluating the Yorkshire Dialysis Decision Aid
The purpose of this research is to develop a patient decision aid in paper and web formats to help patients with chronic kidney disease make informed dialysis treatment decisions.
- Trial name
- YoDDA (NCT01671228)
- Testing
- Decision Aid, Decision aid + patient stories, Decision Aid + values task
- Where
- 6 sites in United Kingdom
- Volunteers
- 488 people
- Sponsor
- University of Leeds
End Stage Renal Disease, Inflammation
Evaluation of Biocompatibility and Performances of 4 Dialyzers in Different Mode Treatments
Prospective multicenter randomized cross-over study Number of patients : 32 (8 patients per group) Obtain objectives data to advise each hemodialyzer according to dialysis treatment and patient profile.
- Trial name
- BIOMODAL (NCT03262272)
- Testing
- VIE A Hemodialyzer, Rexsys 27H hemodialyzer, Leoceed 21HX hemodialyzer
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Hemotech
Blood Pressure, End Stage Renal Disease on Dialysis (Diagnosis)
Blood Pressure Lowering in Dialysis (BOLD) Trial
Blood pressure may be one of the most important modifiable risk factors for cardiovascular disease in patients with end-stage-renal-disease undergoing maintenance hemodialysis.
- Conditions
- Blood Pressure, End Stage Renal Disease on Dialysis (Diagnosis), Chronic Kidney Diseases, Chronic Kidney Disease Stage 5
- Trial name
- BOLD (NCT03459807)
- Testing
- Anti-Hypertensive medications, Dry Weight Adjustment
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
End-stage Renal Disease, Dialysis
Economic Evaluation of an Education Platform for Patients With End-stage Renal Disease
1600 patients with severe, end stage renal disease or post transplant will be randomised 1:1:1 to either standard therapeutic education; or education using a specific app; or the enhanced interactive app using feedback messages.
- Conditions
- End-stage Renal Disease, Dialysis, Kidney Transplantation
- Trial name
- PIC-R (NCT03090828)
- Testing
- app-based therapeutic education, enhanced app-based therapeutic education
- Volunteers
- 1,600 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
End Stage Renal Disease
Association of Middle Molecules Clearance With HDF Volume
HDF is a dialysis technique which involves diffusion and convection. HDF with high convection volume has consistently shown to improve survival in dialysis patients in number of robust RCTs.
- Trial name
- NCT06515899
- Where
- United Kingdom
- Volunteers
- 342 people
- Sponsor
- East and North Hertfordshire NHS Trust
End-stage Renal Disease
Physical Fitness/Training and Inflammatory Immune Responses in Patients With End-stage Renal Disease
The end-stage renal disease (ESRD) leading two causes of death are cardiovascular diseases and sepsis. Exercise improves low physical fitness, available research concerning its effect on the pro-/anti-inflammatory immune response…
- Trial name
- NCT04949919
- Testing
- aerobic training by a cycle ergometer and Biodex system 4 pro
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Chang Gung Memorial Hospital
End-Stage Renal Disease
Study of HemoCare™ Hemodialysis System for Home Nocturnal Dialysis in Patients With ESRD
This prospective multi-center, open-label, single-arm study intends to gather and evaluate safety data for the nocturnal use of the HemoCare™ Hemodialysis System.
- Trial name
- NCT04087213
- Testing
- HemoCare™ Hemodialysis System
- Where
- 8 sites in United States
- Volunteers
- 36 people
- Sponsor
- Deka Research and Development