Clinical trials: End-stage Kidney Disease
End Stage Renal Disease
Trial of Hemodialysis Based Exercise for Strength Improvement Study
Study Hypothesis: The combination of aerobic and resistance exercise training will improve walking speed compared to either individual intervention.
- Trial name
- THESIS (NCT01962597)
- Testing
- aerobic exercise, resistance training
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Renal Disease, End Stage, Kidney Disease, End-Stage
Ellipsys Vascular Access System Post Market Surveillance (PS) Study
The proposed clinical study is a prospective, non-randomized, multi-center, single-arm, observational, post-market surveillance (PS) study of the Ellipsys Vascular Access System in subjects eligible for arteriovenous (AV) fistula.
- Conditions
- Renal Disease, End Stage, Kidney Disease, End-Stage, AV Fistula, Fistulas Arteriovenous
- Trial name
- NCT04484220
- Testing
- Ellipsys Vascular Access System
- Where
- 12 sites in United States
- Volunteers
- 142 people
- Sponsor
- Medtronic Endovascular
Kidney Failure, Chronic
Effects of Probiotics on the Patients With End Stage Renal Disease (ESRD)
The purpose of this study is to investigate the effects of oral administration of probiotics on the metabolism of uremic toxins, in the patients with End Stage Renal Disease (ESRD).
- Trial name
- NCT03010735
- Testing
- probiotics
- Where
- 3 sites in China
- Volunteers
- 150 people
- Sponsor
- China Agricultural University
End-Stage Kidney Disease (ESKD), Maintenance Hemodialysis (MHD)
Health Coaching for Self-Management in Maintenance Hemodialysis Patients
This study is a quasi-experimental study designed to evaluate the effects of a health coaching intervention on self-management ability in patients undergoing maintenance hemodialysis.
- Trial name
- NCT07685626
- Testing
- Health Coaching, Routine Care
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Anhui Medical University
End Stage Renal Disease
A Multiple-Dose Study of Oral Oseltamivir in Participants on Hemodialysis (HD) and Continuous Ambulatory Peritoneal Dialysis (CAPD)
This study is designed to assess the pharmacokinetics (PK) and safety of oseltamivir and its metabolite oseltamivir carboxylate in participants undergoing routine HD and CAPD for end-stage renal disease (ESRD).
- Trial name
- NCT02617784
- Testing
- Oseltamivir
- Where
- New Zealand
- Volunteers
- 24 people
- Sponsor
- Hoffmann-La Roche
End Stage Renal Disease
Your Path to Transplant: A Randomized Control Trial of A Tailored Computer Education Intervention for Living Donor Kidney Transplant
Because of the deceased donor organ shortage, more kidney patients are considering whether to receive kidneys from family and friends, a process called living donor kidney transplantation (LDKT).
- Trial name
- NCT02181114
- Testing
- Expert System Coaching
- Where
- 2 sites in United States
- Volunteers
- 815 people
- Sponsor
- The Methodist Hospital Research Institute
End-Stage Kidney Disease (ESKD), Hemodialysis
Effects of Intradialytic Nutrition on Dialysis Adequacy and Fatigue
This randomized, two-period, two-sequence crossover trial aims to evaluate the effects of intradialytic nutrition on dialysis adequacy, intradialytic hemodynamic parameters, and fatigue in adults receiving maintenance…
- Trial name
- NCT07687498
- Testing
- Standardized Intradialytic Nutrition
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Mersin University
Kidney Transplantation, End Stage Kidney Disease (ESRD)
Novel Desensitization Kidney Transplantation
This proposal's objective is to determine whether belatacept, in conjunction with a proteasome inhibitor can be used to safely increase the likelihood of finding an acceptable donor for highly HLA sensitized kidney transplant…
- Trial name
- NCT05345717
- Testing
- Belatacept Injection
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Chicago
End Stage Renal Disease, Antibody Mediated Rejection
Belatacept in Kidney Transplantation of Moderately Sensitized Patients
The purpose of this study is to evaluate the safety and effectiveness of an immunosuppressive medication, Belatacept, as a replacement for a calcineurin inhibitor, in combination with a standard of care regimen of…
- Trial name
- BelatPilot (NCT02130817)
- Testing
- Belatacept, Tacrolimus withdrawal, Plasmapheresis/Intravenous Immunoglobulin G
- Where
- United States
- Sponsor
- University of Wisconsin, Madison
Renal Disease, End-Stage, Renal Insufficiency, Chronic
Bosutinib In Subjects With Renal Impairment
This is a two-staged study of a single dose of 200 mg of bosutinib given to subjects with renal impairment and matching healthy volunteers.
- Conditions
- Renal Disease, End-Stage, Renal Insufficiency, Chronic, Renal Insufficiency, Acute
- Trial name
- NCT01233882
- Testing
- Bosutinib
- Where
- 5 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Pfizer
End-stage Renal Disease, Kidney Transplantation
Evaluation of Desensitization Protocols in HLA-incompatible Kidney-transplant Candidates
Kidney transplantation is the best renal-replacement in the setting of end-stage renal disease. However, some transplant candidates have developed anti-HLA alloantibodies (human leukocyte antigen).
- Conditions
- End-stage Renal Disease, Kidney Transplantation, Hla-incompatible Kidney Transplant Candidates
- Trial name
- NCT03507348
- Testing
- visits of tocilizumab injection (every 4 weeks, up to 5 visits), Rituximab 375 mg/m2 at Day-30, Rituximab 375 mg/m2 at Day-15 (only for donors living)
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Grenoble
Chronic Renal Insufficiency
Very Low Protein Diet and Renal Death in Chronic Kidney Disease (CKD)-ERIKA Study
The purpose of this study is to determine whether the use of a very low protein diet is effective in delaying the start of chronic dialysis treatment in patients affected by chronic kidney disease (CKD).
- Trial name
- NCT00323713
- Testing
- Very low protein diet, Low protein diet
- Where
- 17 sites in Italy
- Volunteers
- 360 people
- Sponsor
- Azienda Sanitaria ASL Avellino 2
Chronic Kidney Disease, Stage 5, Secondary Hyperparathyroidism
A Study of Zemplar® Injection and Hectorol® Injection on Intestinal Absorption of Calcium in Chronic Kidney Disease
The purpose of this study is to evaluate the effects of Zemplar® Injection and Hectorol® Injection on intestinal calcium absorption in Chronic Kidney Disease Stage 5 subjects on hemodialysis.
- Trial name
- NCT00257920
- Testing
- Zemplar® injection, Hectorol® injection
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Abbott
Chronic Kidney Disease, End-Stage Renal Disease
House Calls and Peer Mentorship
Live donor kidney transplantation (LDKT) offers the most optimal survival and quality of life benefit for those with late-stage chronic kidney disease.
- Trial name
- HC+PM (NCT03354910)
- Testing
- House Call, Peer Mentorship
- Where
- 2 sites in United States
- Volunteers
- 320 people
- Sponsor
- Beth Israel Deaconess Medical Center
Anemia in Incident Dialysis Patients
Safety and Efficacy Study of Roxadustat (FG-4592) for the Treatment of Anemia in End-Stage Renal Disease (ESRD) Newly Initiated Dialysis Participants
The purpose of this study is to determine whether roxadustat is safe and effective in the treatment of anemia in participants who have just begun dialysis treatment for ESRD.
- Trial name
- Himalayas (NCT02052310)
- Testing
- Roxadustat, Epoetin Alfa
- Where
- 113 sites in United States, Argentina and 13 more
- Volunteers
- 1,043 people
- Sponsor
- Kyntra Bio
Uremic Pruritus
Efficacy and Safety of MT-9938 for Treatment of Uremic Pruritus in Subjects With End-stage Renal Disease Receiving Hemodialysis
This study is being conducted to investigate the efficacy of MT-9938 compared with placebo after 2 weeks, to continue to evaluate efficacy for an additional 6 weeks, and to explore the effect of a reduction in itching intensity…
- Trial name
- NCT01660243
- Testing
- Nalfurafine hydrochloride(MT-9938) 2.5μg, Nalfurafine hydrochloride(MT-9938) 5μg, Nalfurafine hydrochloride(MT-9938) 10μg
- Where
- 4 sites in United States
- Volunteers
- 45 people
- Sponsor
- Toray Industries, Inc
End Stage Renal Disease, Restless Legs Syndrome
Biotin Deficiency and Restless Legs Syndrome
Restless Leg Syndrome (RLS) is a common neuropathic disorder in patients with end stage renal disease (ESRD). Study Design: Because micronutrient depletion has been associated with RLS in ESRD and because the vitamin biotin is…
- Trial name
- NCT02011191
- Testing
- Biotin Supplementation, Sugar Pill
- Volunteers
- 49 people
- Sponsor
- Heidi Moretti, MS, RD
CKD (Chronic Kidney Disease) Stage 5D
ASPIrin in Reducing Events in Dialysis ( ASPIRED )
People with kidney failure requiring dialysis have a much higher risk of developing cardiovascular (CV) disease compared with the general population.
- Trial name
- NCT04381143
- Testing
- Aspirin 100 mg Oral Tablet
- Where
- 127 sites in China
- Volunteers
- 9,082 people
- Sponsor
- Guangdong Provincial People's Hospital
Kidney Failure, Chronic
Case-Control Study on Analgesics and Nephropathy (SAN)
The objective of the international, multicenter case-control study was to evaluate the association between end-stage renal disease (ESRD) and use of non-phenacetin-containing analgesics with particular emphasis on combined…
- Trial name
- NCT00302835
- Testing
- non-phenacetin containing analgesics
- Where
- Germany
- Volunteers
- 4,200 people
- Sponsor
- Center for Epidemiology and Health Research, Germany
Kidney Failure, Chronic, Malnutrition-Inflammation Syndrome
Roxadustat's Effect on Heart, Nutrition, and Inflammation in Hemodialysis Patients
Patients with kidney failure who require hemodialysis often suffer from anemia (low red blood cell count), heart and blood vessel problems, and a condition involving poor nutrition, inflammation, and hardening of the arteries…
- Conditions
- Kidney Failure, Chronic, Malnutrition-Inflammation Syndrome, Anemia in End Stage Renal Disease, Cardiovascular Diseases (CVD)
- Trial name
- ROXA-HD-MIA (NCT06903559)
- Testing
- Roxadustat, Conventional Anemia Management
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Mansoura University
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