Clinical trials: End-stage Kidney Disease
Hemodialysis, End Stage Renal Disease
The Effectiveness and the Safety of Acupuncture for Symptomatic Care of Hemodialysis Patients: A Case-series
Purpose: Hemodialysis-dependent patients with an end-stage renal disease (ESRD) suffer from a number of distressing symptoms, such as pain, poor mental health, fatigue, sleep disturbance and pruritus.
- Trial name
- NCT00883831
- Testing
- Individualized manual acupuncture
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Korea Institute of Oriental Medicine
End Stage Renal Disease, Gut Microbiome Dysbiosis
Prebiotics in Peritoneal Dialysis
The Prebiotics in Peritoneal Dialysis trial is a non-randomized, open-label, crossover study of p-inulin for patients with end-stage renal disease treated with peritoneal dialysis.
- Trial name
- NCT03265639
- Testing
- P-inulin
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Ali Ramezani
End Stage Renal Disease (ESRD), Chronic Kidney Disease (CKD)
Advancing Renal TRANSplant eFficacy and Safety Outcomes With an eveRolimus-based regiMen (TRANSFORM)
This is a 2-year, randomized, multicenter, open-label, 2-arm study evaluating the graft function of everolimus and reduced CNI versus MPA and standard CNI in adult de novo renal transplant recipients.
- Conditions
- End Stage Renal Disease (ESRD), Chronic Kidney Disease (CKD), Hemodialysis, Renal Replacement Therapy
- Trial name
- TRANSFORM (NCT01950819)
- Testing
- Induction therapy, Corticosteroids, EVR+rCNI
- Where
- 184 sites in United States, Argentina and 40 more
- Volunteers
- 2,037 people
- Sponsor
- Novartis Pharmaceuticals
End Stage Renal Disease
Alterations in Cognitive Function and Cerebral Blood Flow After Conversion From Calcineurin Inhibitors (CNIs) to Everolimus
The purpose of this study is to learn if changing from Tacrolimus to Everolimus will improve cognitive function by having less effect on brain blood flow.
- Trial name
- NCT03413722
- Testing
- Tacrolimus, Everolimus
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Kansas Medical Center
Children on Chronic Peritoneal Dialysis
Comparing Conventional Continuous Ambulatory Peritoneal Dialysis Prescription (C-CAPD) With Modified-CAPD (M-CAPD) Prescription in Children With End-stage Kidney Disease From Low-resource Settings
This study aims to compare modified CAPD (M-CAPD) and conventional CAPD (C-CAPD) in terms of delivering high-quality, goal-directed PD as well as avoiding resource wastage in prevalent ESKD patients aged 2 to ≤18 years using a…
- Trial name
- NCT07134595
- Testing
- C-CAPD Prescription, M-CAPD Prescription
- Where
- Philippines
- Volunteers
- 44 people
- Sponsor
- National University Health System, Singapore
End Stage Renal Disease, Kidney Transplant; Complications
Study Investigating Whether Robot-assisted Surgery Can Reduce Surgical Complications Following Kidney Transplantation
The purpose of this study is to explore whether robot-assisted surgery can reduce 30-day surgical complications compared to open surgery in kidney transplantation. Participants are adult recipients of kidney transplantation.
- Trial name
- ORAKTx (NCT05730257)
- Testing
- Robot-Assisted Kidney Transplantation, Open Kidney Transplantation
- Where
- 2 sites in Denmark
- Volunteers
- 106 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Medication Adherence, End Stage Renal Failure on Dialysis
Prevalence of Non-adherence to Medication Among Patients on Chronic Hemodialysis
Background: Non-adherence to medication among patients on chronic hemodialysis compromises treatment effects and results in increased morbidity, mortality and extensive costs to the healthcare system.
- Trial name
- NCT03897231
- Testing
- questionnaire
- Where
- Denmark
- Volunteers
- 385 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
End Stage Renal Disease, Venous Stenosis
Sirolimus Use in Angioplasty for Vascular Access Extension
Dialysis patients presenting for angioplasty intervention for graft failure will be randomized to receive either Sirolimus or not receive Sirolimus (standard of care) to assess the time from primary failure or angioplasty…
- Trial name
- SAVE (NCT01595841)
- Testing
- Sirolimus
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Type 2 Diabetes Mellitus
Specified Drug-Use Survey of Trelagliptin Tablets "Survey on Long-term Use in Type 2 Diabetes Mellitus Patients With Severe Renal Impairment or End-stage Renal Disease"
The purpose of this study is to evaluate the long-term safety of trelagliptin tablets in patients with type 2 diabetes mellitus complicated by severe renal impairment or end-stage renal failure in the routine clinical setting.
- Trial name
- NCT04285983
- Testing
- Trelagliptin
- Where
- Japan
- Volunteers
- 89 people
- Sponsor
- Takeda
Kidney Failure, Chronic
Intradialytic Inspiratory Muscle Training at Different Intensities and Functional Capacity
Investigate the effects of Inspiratory Muscle Training (IMT) performed during hemodialysis (HD) procedures in patients with end stage kidney disease (ESKD).
- Trial name
- NCT04660383
- Testing
- Inspiratory Muscle Training
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Chronic Kidney Failure
Belatacept as a Replacement for CNIs 3 to 12 Months Post-transplantation in Patients With Early Graft Dysfunction
Calcineurin inhibitors (CNI) remain the standard treatment in renal transplantation to prevent rejection. Currently the main limitation of kidney transplantation is the occurrence of chronic graft dysfunction due to the CNI…
- Trial name
- BELASBRIDGE (NCT05562869)
- Testing
- Belatacept 250 Milligram Intravenous Powder for Solution
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Kidney Disease, Peritoneal Dialysis (PD)
Sensor-based Congestion ALert for Events in Peritoneal Dialysis (SCALE-PD)
To explore the use of the Bodyport Cardiac Scale in predicting worsening of events due to fluid overload in patients with kidney disease on peritoneal dialysis.
- Conditions
- Kidney Disease, Peritoneal Dialysis (PD), End Stage Kidney Disease (ESRD)
- Trial name
- SCALE-PD (NCT07059962)
- Testing
- Bodyport Cardiac Scale
- Where
- 7 sites in United States, Canada
- Volunteers
- 125 people
- Sponsor
- Bodyport Inc.
End Stage Renal Disease (ESRD)
Evaluate the Efficacy and Safety of Amino Acid (15) Peritoneal Dialysis Solution in Peritoneal Dialysis Patients with Malnutrition.
This is a multicenter, randomized, parallel controlled Phase IV clinical study to evaluate the safety and efficacy of amino acid (15) peritoneal dialysis solution in patients undergoing peritoneal dialysis with malnutrition in…
- Trial name
- NCT06597201
- Testing
- amino acid (15) peritoneal dialysis solution, glucose peritoneal dialysis solution
- Where
- 21 sites in China
- Volunteers
- 400 people
- Sponsor
- Chengdu Qingshan Likang Pharmaceutical Co., Ltd
End Stage Renal Failure on Dialysis, Arteriovenous Graft Occlusion
Sirolimus Coated Angioplasty Versus Plain Balloon Angioplasty
A functioning dialysis access is critical to the delivery of hemodialysis therapy in patients with End Stage Renal Disease. Stenosis secondary to neo-intimal hyperplasia frequently occur within the dialysis access, resulting in…
- Trial name
- IMPRESSION (NCT04409912)
- Testing
- Sirolimus coated balloon, Plain balloon
- Where
- 3 sites in Singapore
- Volunteers
- 170 people
- Sponsor
- Singapore General Hospital
Chronic Kidney Disease 5D
Feasibility of a Randomized Cluster Trial for Blood Pressure Targets in In-centre Hemodialysis Units
High blood pressure in people receiving hemodialysis is known to contribute to heart disease and heart-related death from strokes, heart failure, left ventricular hypertrophy (which is a thickening of the heart wall that makes it…
- Trial name
- NCT06695611
- Testing
- Increase systolic blood pressure, Decrease systolic blood pressure
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Manitoba
Chronic Renal Failure
Evaluation of Two New Innovative Haemostasis Tests: Measurement of the Active Form of GTP-bound Rap1b (aRap1b) in Platelets and the Pro and Antithrombotic Balance of Circulating Endothelial Microvesicles (patEMV) (INNOV-CKD Test)
The aim of this PROJECT is to develop two biomarkers to assess the thrombotic and hemorrhagic risk of patients with chronic renal failure (CKD) treated with antiplatelet drugs following the occurrence of an acute coronary…
- Trial name
- INNOV-CKD test (NCT05765630)
- Testing
- BLOOD SAMPLES
- Where
- France
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis
Steroid Impregnated Tape in the Treatment of Over-granulating Peritoneal Dialysis Exit Sites
Kidney failure is a devastating illness requiring treatment with dialysis or transplantation to preserve life. Individuals unable to have transplants are managed by peritoneal dialysis (PD)or haemodialysis (HD).
- Conditions
- Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, End Stage Renal Failure, Chronic Renal Failure
- Trial name
- STOP (NCT01996930)
- Testing
- Haelan tape (steroid impregnated tape), Silver Nitrate
- Where
- 8 sites in United Kingdom
- Volunteers
- 32 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Hyperphosphatemia, End-stage Renal Disease
A Safety and Tolerability Study of Zerenex (Ferric Citrate) in Patients With End-Stage Renal Disease (ESRD)
This study is to evaluates the safety and tolerability of Zerenex™ (ferric citrate) as a treatment for hyperphosphatemia in patients with End-Stage Renal Disease.
- Trial name
- NCT00648167
- Testing
- ferric citrate
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Keryx Biopharmaceuticals
Kidney Disease, Chronic, End Stage Renal Disease
Development and Test of a Communication Skills Training for Transplant Providers - Aims 2 & 3
The goal of this clinical trial is to understand the communication occurring between Black and Caucasian patients and their transplant providers during transplant evaluation consultations and assess relationships between these…
- Conditions
- Kidney Disease, Chronic, End Stage Renal Disease, Kidney Replacement
- Trial name
- EPPComm (NCT06182475)
- Testing
- EPPComm Provider Training
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Temple University
End-Stage Renal Disease
Gum Arabic as Antioxidant and Anti-inflammatory in Hemodialysis Patients
Oxidative processes increased in patients with renal failure and especially patients with end stage renal failure on dialysis. Oxidative stress plays a role in renal damage and also on cardiovascular disease, atherosclerosis…
- Trial name
- GA&CRF (NCT03214692)
- Testing
- Gum Arabic
- Where
- Sudan
- Volunteers
- 50 people
- Sponsor
- Lamis Kaddam
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