Clinical trials: End-stage Kidney Disease
End Stage Renal Disease (ESRD), Arteriovenous Fistula Patency
Anesthetic Effect of Ropivacaine on Local Infiltration Anesthesia in Arteriovenous Fistula Surgery
This study compares two local anesthetics, ropivacaine and lidocaine, for patients undergoing arteriovenous fistula surgery. Arteriovenous fistula is the preferred vascular access for end-stage kidney disease patients needing…
- Conditions
- End Stage Renal Disease (ESRD), Arteriovenous Fistula Patency, Chronic Kidney Disease 5D
- Trial name
- NCT07259772
- Testing
- Ropivacaine, Lidocaine
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The First People's Hospital of Lianyungang
CKD Stage 4, CKD Stage 5
The Effects of Application Intervention on the Physiological Indicators and Low Protein Diet Cognition Among the Patients With Chronic Kidney Disease
The effects of Application intervention on the physiological indicators and low protein diet cognition among the patients with chronic kidney disease
- Trial name
- NCT06083545
- Testing
- App
- Where
- Taiwan
- Volunteers
- 184 people
- Sponsor
- yi ting Hsu
Antioxidative Stress, End Stage Renal Disease on Dialysis
A Novel Role of Alpha Lipoic Acid in Comparison With Selenium in Mitochondrial Resuscitation and miRNA-126 Expression in Hemodialysis Patients
An Open labeled, Paralled, Randomized, Prospective, study was conducted on 60 patients who were randomized into 3 groups, 22, 20 and 18 patients in Control, Selenium and, Thiotacid groups respectively.
- Trial name
- NCT05266794
- Testing
- Alpha lipoic acid, Selenium
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Ain Shams University
Renal Insufficiency, Chronic, Kidney Failure, Chronic
Effect of Vitamin D Supplementation on Balance in CKD
Patients with end-stage renal disease on dialysis (ESRD5D) are 4-5x more likely to suffer from a fracture. Fractures can occur spontaneously but typically occur after a fall.
- Trial name
- NCT03710161
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Nebraska
End Stage Renal Disease
Pharmacokinetics of Immunosuppressants in Renal Transplant Candidates Who Have Undergone Laparoscopic Sleeve Gastrectomy
The purpose of this study is to evaluate how quickly and to what extent different immunosuppressants are absorbed into the blood (this is called pharmacokinetics) in renal transplant candidates who have undergone a laparoscopic…
- Trial name
- NCT02221583
- Testing
- Astagraf XL, Prograf, Mycophenolate mofetil
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Cincinnati
Chronic Kidney Disease
Evaluation of the Effect of a Daily Dose of Wakame Seaweed on Reducing Circulating Concentrations of Advanced Glycation End Products in Patients With Stage III Chronic Kidney Disease
Persistent glomerular hyperfiltration is a characteristic feature of the early stages of kidney disease and represents a factor in the progression of chronic kidney disease (CKD).
- Trial name
- Ckd-WEED (NCT07729683)
- Testing
- Consumption of wakame
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Groupe Hospitalier de la Rochelle Ré Aunis
Chronic Kidney Disease Stage 5
Shared Decision Making for Choosing renAl Replacement Therapy in Chronic Kidney Disease Patients
Shared decision making (SDM) is an approach where clinicians and patients make decisions together using the best available evidence.
- Trial name
- SDM-ART (NCT04976166)
- Testing
- Education
- Where
- 19 sites in South Korea
- Volunteers
- 1,194 people
- Sponsor
- Seoul National University Hospital
Anemia, Kidney Failure, Chronic
Study of the Efficacy of Darbepoetin Alfa in the Treatment of Renal Anemia
Anaemia is a common consequence of chronic renal failure. Darbepoetin alfa is a unique erythropoietic protein that stimulates erythropoiesis by the same mechanism as endogenous erythropietin and conventional recombinant human…
- Conditions
- Anemia, Kidney Failure, Chronic, Peritoneal Dialysis, Continuous Ambulatory
- Trial name
- NCT00563446
- Testing
- Darbepoetin alfa
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Hospital Authority, Hong Kong
Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 5
Healthy Diet Rich in Potassium to Chronic Kidney Disease With Sodium Zirconium Cyclosilicate: A Feasibility Study
This is a descriptive single arm open-label interventional trial lasting 6 weeks aiming to test if a low protein healthy K-rich diet with fruits, vegetables, whole grains, and nuts with concomitant use of new potassium binder…
- Conditions
- Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 5, Hyperkalemia
- Trial name
- HELPFUL (NCT04207203)
- Testing
- sodium zirconium cyclosilicate and healthy diet
- Where
- Sweden
- Volunteers
- 26 people
- Sponsor
- Karolinska Institutet
End Stage Renal Disease
Evaluation of STARgraft-3 for Hemodialysis
This study is a single site, prospective, single arm evaluation of the safety and effectiveness of the Healionics STARgraft-3 hemodialysis access graft.
- Trial name
- NCT05729620
- Testing
- Implant of STARgraft-3 shunt in the upper arm and subsequent use for hemodialysis access
- Where
- Paraguay
- Volunteers
- 21 people
- Sponsor
- Healionics Corporation
End Stage Renal Failure
Volume,Sodium and Blood Pressure Management in HD
The purpose of this study to conduct a pilot, randomized trial in stable HD patients to evaluate the effect of gradual, step-wise reduction of post-hemodialysis target weight, combined with diligent dietary sodium restriction and…
- Trial name
- VSBP (NCT01766882)
- Testing
- Lower sodium intervention, Progressive Challenge to Post Dialysis Weight
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan
Kidney Failure, Chronic, End Stage Renal Disease, Requiring Dialysis
FREEDOM: Following Rehabilitation, Economics and Everyday-Dialysis Outcome Measurements Study
Purpose The purpose of this study is to compare the economical impact and clinical parameters of short daily hemodialysis using the NxStage® System One hemodialysis device with thrice-weekly conventional in-center dialysis using…
- Trial name
- NCT00288613
- Where
- 41 sites in United States
- Volunteers
- 501 people
- Sponsor
- NxStage Medical
Kidney Diseases, End Stage Renal Disease
Non- Clinical Coagulation Activation During Hemodialysis
Every patient included in the study will undergo 1 conventional hemodialysis treatment, ie 1 study visit. During the conventional hemodialysis treatment lasting 4 hours, 2 blood samples will be taken at different time points (5…
- Conditions
- Kidney Diseases, End Stage Renal Disease, Hemodialysis Complication
- Trial name
- NC-Coact (NCT04063423)
- Testing
- blood sample
- Where
- Belgium
- Volunteers
- 32 people
- Sponsor
- Universitair Ziekenhuis Brussel
Chronic Kidney Disease Stage 3B, Chronic Kidney Disease stage4
Low-Protein Diet With Low-Protein Foods Versus a LPD Without LP Foods in Patients With Chronic Kidney Disease (CKD)
The KDOQI 2020 - Clinical practice guideline for nutrition in chronic kidney disease (CKD) -recommends protein restriction to reduce the risk of end-stage renal disease/death and improve quality of life, a low protein diet…
- Conditions
- Chronic Kidney Disease Stage 3B, Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 5, Chronic Kidney Disease Stage 3A
- Trial name
- NCT05489120
- Testing
- Consumption of FLAVIS
- Where
- 18 sites in France
- Volunteers
- 210 people
- Sponsor
- Dr. Schär AG / SPA
Renal Disease, End Stage Renal Disease
A Multi-Center, Open-Label Study
This study will be an open-label, single-treatment, single-dose, parallel group study to evaluate the pharmacokinetics (PK) of droxidopa in subjects with mild, moderate, and severe renal dysfunction and End Stage Renal Disease…
- Trial name
- NCT01468259
- Testing
- Droxidopa
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Chelsea Therapeutics
SLE, Lupus Nephritis
Tacrolimus Versus Cyclophosphamide as Treatment for Lupus Nephritis
In this comparative open-label cohort study, the investigators compared the efficacy and safety of tacrolimus (TAC)and cyclophosphamide (CYC) in the treatment of diffuse proliferative and membranous lupus nephritis with severe…
- Conditions
- SLE, Lupus Nephritis, Renal Insufficiency, End-stage Renal Disease
- Trial name
- NCT01207297
- Testing
- Tacrolimus, cyclophosphamide
- Volunteers
- 40 people
- Sponsor
- Zhejiang University
ESRD (End Stage Renal Disease), Dialysis
Laser Acupuncture for Fatigue in Hemodialysis Patients
The goal of this clinical trial is to learn if laser acupuncture (low-level laser therapy) works to treat fatigue and improve quality of life in adults with end-stage renal disease (ESRD) undergoing hemodialysis.
- Conditions
- ESRD (End Stage Renal Disease), Dialysis, Fatigue
- Trial name
- LA-HD-Fatigue (NCT07538310)
- Testing
- Low-Level Laser Acupuncture (LA)
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Taipei City Hospital
Chronic Kidney Failure
CNI Transient Replacement by Belatacept From 3 to 12 Months Post Transplantation in Patients With Early Graft Dysfunction
Calcineurin inhibitors (CNI) remain the standard treatment in renal transplantation to prevent rejection. Currently the main limitation of kidney transplantation is the occurrence of chronic graft dysfunction due to the CNI…
- Trial name
- TRANSIBELA (NCT04013620)
- Testing
- Belatacept 250 Milligram Intravenous Powder for Solution
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Nantes University Hospital
End Stage Renal Disease, Cardiovascular Diseases
Comparison of MCO HD on Markers of Vascular Health Compared With On-Line Haemodiafiltration
The aim of this study is to evaluate haemodialysis treatment using a medium cut-off dialysis membrane (Theranova) compared with on-line haemodiafiltration treatment with respect to markers of endothelial health (plasma…
- Conditions
- End Stage Renal Disease, Cardiovascular Diseases, Inflammation
- Trial name
- MoDal (NCT03510520)
- Testing
- Medium Cut-Off Haemodialysis, On-Line Haemodiafiltration
- Where
- United Kingdom
- Volunteers
- 63 people
- Sponsor
- Manchester University NHS Foundation Trust
End Stage Renal Disease
Icodextrin Effects on Glucose Transporter Activation and Mediators of Fibrosis
The time on peritoneal dialysis may be limited for a significant number of patients that use this modality of renal replacement therapy due to the inability of the peritoneal membrane to clear solutes or achieve adequate…
- Trial name
- NCT02133313
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Alabama at Birmingham
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