Clinical trials: Endobronchial Ultrasound, active
Lung Cancer, Non Small Cell Lung Cancer
The Development, Safety, and Feasibility of an Artificial Intelligence-Powered Platform (NodeAI) for Real-Time Prediction of Mediastinal Lymph Node Malignancy During Endobronchial Ultrasound Staging for Lung Cancer
Lung cancer is the leading cause of annual cancer deaths globally, more than breast, prostate, and colon cancers combined. The staging of chest lymph nodes (LNs) is a crucial step in the lung cancer diagnostic pathway because it…
- Trial name
- NodeAI (NCT06540196)
- Testing
- NodeAI, Surgeon
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- McMaster University
Lung Cancer
Prospective Cohort of Diagnostic Bronchoscopy for Peripheral Lung Lesions
The primary objective is To evaluate the usefulness and safety of advanced guided bronchoscopy for histological diagnosis of peripheral pulmonary lesions.
- Trial name
- NCT05804786
- Testing
- Guided bronchoscopy
- Where
- 11 sites in South Korea
- Volunteers
- 1,240 people
- Sponsor
- Seoul National University Bundang Hospital
Lung Cancers, Peripheral Pulmonary Nodules
General Anesthesia vs Conscious Sedation for Radial Endobronchial Ultrasound
The endoscopic investigation of lung lesions is experiencing significant growth with the increasing number of lung cancer screening programs.
- Trial name
- RESSOURCE (NCT06950515)
- Testing
- Peripheral EBUS under Concious sedation, Peripheral EBUS under General Anesthesia
- Where
- Canada
- Volunteers
- 306 people
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Mediastinal Lymphadenopathy
Comparison of Two Needle Agitation Strategies in Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA) for Diagnostic Yield
The goal of this clinical trial is to learn whether the number of needle agitations during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) affects diagnostic yield in patients with enlarged…
- Trial name
- NCT07424807
- Testing
- Needle Agitation Strategy During EBUS-TBNA
- Where
- Vietnam
- Volunteers
- 180 people
- Sponsor
- Phan Quang Hieu
Sarcoidosis Lung, Pulmonary Sarcoidosis
Comparative Diagnostic Yield of Endobronchial Cryo Biopsy vs Forceps Biopsy in Patients With Suspected Sarcoidosis
Sarcoidosis is a multi-systemic granulomatous disease of unknown cause that is characterized by the formation of non-caseous epithelioid cell granulomas.
- Trial name
- CREBS (NCT06853834)
- Testing
- Cryobiopsy with liquid nitrogen, Endobronchial Forceps Biopsy
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Suspected Sarcoidosis
Comparing Menghini-type Needle and Franseen-type Needle in EBUS-TBNA for Sarcoidosis
This randomized pilot clinical trial aims to examine whether sample collection with Franseen-type needles are effective for the diagnosis of sarcoidosis, as defined by improved sample quality for pathological diagnosis compared…
- Trial name
- NCT06220526
- Testing
- endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)
- Where
- Canada
- Volunteers
- 128 people
- Sponsor
- University Health Network, Toronto
Fibrosing Mediastinitis, Pulmonary Hypertension
Study on the Treatment of Nonthrombotic Obstructive Pulmonary Hypertension
Through a randomized controlled trial (RCT) design, this study aiming to evaluated the efficacy and safety of rituximab lymph node injection combined with pulmonary vascular interventional therapy in treating fibrosing…
- Trial name
- ACCT-NOPH (NCT06980584)
- Testing
- Rituximab Lymph Node Injection Combined with Pulmonary Vascular Intervention, Pulmonary Vascular Interventional Therapy
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Beijing Chao Yang Hospital
Pulmonary Nodules
The SEQUENCE Trial
This study will randomize participants undergoing a bronchoscopic biopsy of a peripheral pulmonary nodule for their standard of care to receive robotic-assisted bronchoscopy (RaB) and then staging linear endobronchial ultrasounnd…
- Trial name
- SEQUENCE (NCT06676956)
- Testing
- Linear EBUS first, Robotic-assisted bronchoscopy first
- Where
- 5 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Non Small Cell Lung Cancer, Non Small Cell Lung Cancer (NSCLC)
Liquid Biopsy Assay of EBUS-TBNA Supernatant Fluid for Diagnosing Lung Cancer
Background and aim: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the gold standard of lung cancer staging, yet up to 15% of procedures produce inadequate samples for definite diagnosis or…
- Conditions
- Non Small Cell Lung Cancer, Non Small Cell Lung Cancer (NSCLC), Lung Cancer (NSCLC), Lung Cancer - Non Small Cell
- Trial name
- NCT06889467
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Barzilai Medical Center
Lung Cancer (Locally Advanced or Metastatic)
Evaluation of Endobronchial Ultrasound Needle Cleaning Techniques and Their Impact on Specimen Contamination
Endobronchial ultrasound (EBUS) bronchoscopy is commonly used to sample lymph nodes in patients with suspected or known lung cancer to determine the stage of the disease.
- Trial name
- EBUS (NCT07461662)
- Testing
- Purge cleaning
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- University of Mississippi Medical Center
Mediastinal and Hilar Lymphadenopathy
Diagnostic Value and Safety of Endobronchial Ultrasound-guided Transbronchial Mediastinal Cryobiopsy Versus Transbronchial Needle Aspiration in the Diagnosis of Lymphoma: a Randomized Controlled Trial
The goal of this clinical trial is to learn which of two minimally invasive procedures is better at safely diagnosing lymphoma in the mediastinum (chest) in adults (aged 18 and older) who are suspected to have either a new or a…
- Trial name
- NCT07352267
- Testing
- Endobronchial ultrasound-guided transbronchial needle aspiration, Endobronchial ultrasound-guided tranbronchial mediastinal cryobiopsy
- Volunteers
- 470 people
- Sponsor
- China-Japan Friendship Hospital
Artificial Intelligence, Endobronchial Ultrasound
Augmented Endobronchial Ultrasound (EBUS-TBNA) With Artificial Intelligence
To evaluate the usefulness of Deep neural network (DNN) in the evaluation of mediastinal and hilar lymph nodes with Endobronchial ultrasound (EBUS).
- Conditions
- Artificial Intelligence, Endobronchial Ultrasound, Lung Cancer
- Trial name
- NCT05739331
- Testing
- machine learning algorithm
- Where
- 2 sites in Norway
- Volunteers
- 50 people
- Sponsor
- Norwegian University of Science and Technology
Mediastinal Lymphadenopathy
Confocal Laser Endomicroscopy Assisted Endobronchial Ultrasound-guided- Transbronchial Mediastinal Cryobiopsy Via a Tunnel for Diagnosing Mediastinal Lymphadenopathy
Mediastinal and/or hilar lymphadenopathy (MHL) becoming more and more common in clinical practice with the development of imaging technique.
- Trial name
- NCT06741852
- Testing
- nCLE assisted endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy via a tunnel, Endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy via a tunnel
- Where
- China
- Volunteers
- 98 people
- Sponsor
- China-Japan Friendship Hospital
ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION, Hypoxemia
The Role of Ultrasonographic Tracheal Measurements in Predicting Hypoxemia During Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration
Bronchoscopic procedures performed under endobronchial ultrasound (EBUS) guidance are widely used minimally invasive diagnostic methods for the evaluation of mediastinal lymph nodes.
- Conditions
- ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION, Hypoxemia, Trachea
- Trial name
- NCT07587736
- Testing
- TRACHEAL DIAMETER MEASUREMENT, Hypoxemia
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Non-small Cell Lung Cancer (NSCLC)
ROSE for Improved Molecular Marker Testing Via EBUS
This research study is being done to compare two ways to conduct bronchoscopic biopsy of lymph nodes and other structures in the chest (i.e.
- Trial name
- ROSE/NoROSE (NCT04945317)
- Testing
- ROSE (presence of cytotech) & liquid prep, NO-ROSE (absence of cytotech) & liquid prep, ROSE (presence of cytotech) & tissue clot sample
- Where
- 4 sites in United States
- Volunteers
- 349 people
- Sponsor
- Johns Hopkins University
ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION, Procedural Sedation and Analgesia
Consent Understanding and Propofol Requirement During Endobronchial Ultrasound
The goal of this observational study is to learn whether a participant's understanding of the informed consent information is related to the amount of propofol needed during endobronchial ultrasound (EBUS).
- Conditions
- ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION, Procedural Sedation and Analgesia, Informed Consent
- Trial name
- NCT07677982
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Uludag University
Thoracic Surgery With One-lung Ventilation
Ultrasound vs. Auscultation and Fiberoptic Bronchoscopy for Double-Lumen Tube Placement
One-lung ventilation is frequently required in thoracic surgery and is most commonly achieved using double-lumen endobronchial tubes (DLTs).
- Trial name
- NCT07465510
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Izmir City Hospital
Tuberculosis, Mediastinal and Hilar Lymph Node Enlargement
Diagnostic Performance and Safety of Endobronchial Ultrasound-guided Transbronchial Mediastinal Cryobiopsy in Diagnosing Tuberculous Mediastinal Lymphadenitis: a Randomised Controlled Trial
The goal of this clinical trial is to compare the diagnostic efficacy and safety of Endobronchial Ultrasound-guided Transbronchial Mediastinal Cryobiopsy (EBUS-TBMC) versus standard EBUS-guided Transbronchial Needle Aspiration…
- Trial name
- NCT07459569
- Testing
- EBUS-TBMC, EBUS-TBNA
- Where
- China
- Volunteers
- 108 people
- Sponsor
- China-Japan Friendship Hospital
Acute Pulmonary Embolism
Pilot Study to Evaluate the Role of EBUS in the Diagnosis of Acute PE in Critically Ill Patients
Acute pulmonary embolism (PE) in critically ill patients is common and often life threatening. The diagnosis of acute PE is often entertained in intensive care unit patients who develop unexplained hypotension or hypoxemia.
- Trial name
- VEBUS (NCT04047784)
- Testing
- Endobronchial ultrasound (EBUS)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Lung Cancer Metastatic
Phase 1 Trial of Endobronchial Ultrasound-Guided Transbronchial Needle Injection of Cisplatin for Stage IV Lung Cancer
The goal of the study is to identify the maximum tolerated dose of endobronchial ultrasound-guided transbronchial injection (EBUS-TBNI) of cisplatin for Stage IV lung cancer.
- Trial name
- NCT04311762
- Testing
- cisplatin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Vermont