Clinical trials: Endocarditis
Enterococcal Endocarditis
FOUR-SIX TRIAL for the Treatment of Enterococcal Endocarditis
Duration of therapy in severe infections has a high impact in term of compliance, adverse events, and costs but also in term of antibiotic pressure on selection of multidrug-resistant pathogens.
- Trial name
- FOURSIX (NCT05398289)
- Testing
- 4-week duration of antibiotic therapy, 6-week duration of antibiotic therapy
- Volunteers
- 130 people
- Sponsor
- University Magna Graecia
Infective Endocarditis (IE)
Percutaneous AngioVac Vegetation Extraction (PAVE) to Remove Right Heart Vegetations in Patients With Infective Endocarditis
The investigation aims to demonstrate initial safety and efficacy of the AngioVac System for the removal of vegetation in the right heart in patients with infective endocarditis.
- Trial name
- PAVE (NCT07282002)
- Testing
- AngioVac System
- Volunteers
- 30 people
- Sponsor
- Angiodynamics, Inc.
Endocarditis, Bacteremia
Efficacy and Safety of Dalbavancin Compared to Standard of Care Antibiotic Therapy for the Completion of Treatment of Patients With Complicated Bacteremia or Infective Endocarditis
This study will compare dalbavancin to standard of care (SOC) antibiotic therapy for the completion of therapy in patients with complicated bacteremia or infective endocarditis.
- Trial name
- NCT03148756
- Testing
- Dalbavancin, Standard of Care
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- AbbVie
Endocarditis, Bacterial
Daptomycin as an Adjuvant Agent in the Treatment of Enterococcal Native Valve Endocarditis.
The aim of this study is to determine the safety and efficacy of daptomycin when used as an adjuvant agent to standard care in the treatment of proven native valve Enterococcal endocarditis.
- Trial name
- NCT00401960
- Testing
- Daptomycin
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Weill Medical College of Cornell University
Staphylococcus Aureus Endocarditis, Prosthetic Valve Endocarditis
Adjunctive Rifampin for the Treatment of Prosthetic Valve Endocarditis Due to S. Aureus
This is a sub-study of the S. aureus Network Adaptive Platform (SNAP) trial (NCT05137119) wherein we will evaluate whether not giving rifampin in patients with probable or definite prosthetic valve endocarditis due to S.
- Trial name
- RIFA-SNAP (NCT07253688)
- Testing
- Rifampin, No rifampin
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Todd C. Lee MD MPH FIDSA
Infective Endocarditis
Research Interest Antiphospholipid in Predicting Embolic Risk During Infective Endocarditis
EMBOL-EI (Research Interest antiphospholipid antibody for embolic risk prediction in infective endocarditis) is a prospective cohort study with a biological collection.
- Trial name
- EMBOL-EI (NCT02887079)
- Where
- 2 sites in France
- Volunteers
- 186 people
- Sponsor
- Central Hospital, Nancy, France
Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Endocarditis
Direct Lysis of Staph Aureus Resistant Pathogen Trial of Exebacase
The purpose of this superiority study is to evaluate the efficacy and safety of exebacase in addition to standard of care antibiotics (SoCA) compared with SoCA alone for the treatment of patients with Staphylococcus aureus (S.
- Trial name
- DISRUPT (NCT04160468)
- Testing
- Exebacase
- Where
- 55 sites in United States
- Volunteers
- 259 people
- Sponsor
- ContraFect
Infective Endocarditis
The Incidence, Clinical Characteristics and Outcome of Infective Endocarditis Among Intravenous Drug Abusers Versus Non-Drug Abusers.
We aim to describe the incidence of IVDA among patients presented with IE, describe their clinical, psychiatric and microbiological characteristics in comparison to non - IVDA, as well as the rate and types of complications and…
- Trial name
- NCT06194409
- Testing
- Echocardiography, Urine analysis , blood culture
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Assiut University
Infective Endocarditis
Predisposition to Infectious Endocarditis
To evaluate the gender-related elements, a first step will be to analyze the impact of sex ratio on different parameters such as age in endocarditis and the type of underlying valvulopathy and other associated comorbidities.
- Trial name
- NCT03979261
- Testing
- evolution of sex ratio according to age
- Where
- France
- Volunteers
- 450 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Infective Endocarditis (IE)
From Commensalism to Pathogenicity: Exploring the Pathophysiology of Bacteremia to Better Understand Enterococcus Faecalis Infective Endocarditis
Enterococci are pathobionts of the human intestinal microbiota: they colonize the gastrointestinal tract as well as the skin, urine, wounds, bile, the oral cavity and endodontic canal, and medical devices (urinary catheters…
- Trial name
- BAC-ENDO (NCT07313865)
- Testing
- Microbiological sampling (swab collection)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Clermont-Ferrand
Infective Endocarditis
Vancomycin, Gentamycin in Infective Endocarditis
Infective endocarditis is a microbial infection of the endocardial surface of the heart.
- Trial name
- NCT03688659
- Testing
- Vancomycin and gentamycin
- Volunteers
- 30 people
- Sponsor
- Assiut University
Infective Endocarditis
Fosfomycin Plus Imipenem for Treatment of Infective Endocarditis
The study evaluates the efficacy and safety of fosfomycin and imipenem for the treatment of methicillin-resistant staphyloccocus aureus infective endocarditis in comparison to vancomycin, the standard therapy.
- Trial name
- NCT00871104
- Testing
- Fosfomycin and imipenem, Vancomycin
- Where
- 10 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Juan A. Arnaiz
Endocarditis Infective, Endocarditis, Bacterial
Dalbavancin Therapy for Infective Endocarditis
This study compares two treatment strategies for antibiotic therapy in endocarditis. The aim of the study is to determine which treatment is more effective overall and better tolerated by patients.
- Trial name
- EndoDalba (NCT07699211)
- Testing
- Dalbavancin administration, Standard of Care (Investigator Choice)
- Where
- 9 sites in Germany
- Volunteers
- 184 people
- Sponsor
- Stefan Hagel
Infective Endocarditis
CopenHeart IE - Integrated Rehabilitation of Patients Treated for Infective Endocarditis
The aim of the study is to describe the effect and meaning of an integrated rehabilitation programme, consisting of physical training and psycho-educational care, for patients treated for infective endocarditis.
- Trial name
- NCT01512615
- Testing
- Complex Cardiac rehabilitation, Control group
- Where
- Denmark
- Volunteers
- 117 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Bacterial Endocarditis, Bacteremia
Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus
The purpose of this study is to compare the safety and efficacy of daptomycin, an antibiotic, to standard therapy in subjects who have infective endocarditis or bacteremia due to Staphylococcus aureus (S. aureus).
- Trial name
- NCT00093067
- Testing
- daptomycin
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Endocarditis, Bacterial
Bacteriophages in Addition to Antibiotics for the Treatment of Patients With Infective Endocarditis
Infective endocarditis (IE) is an endocardial lesion caused by bacterial and/or fungal infection that most commonly affects the heart valves and/or the endocardium around implanted intracardiac devices.
- Trial name
- PHARAOH (NCT06870409)
- Testing
- Bacteriophage
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- University Clinical Hospital na V.V.Vinogradov (branch of RUDN university na Patrice Lumumba)
Endocarditis
Contribution of 18F-FDG PET-CT in the Diagnosis and the Detection of Peripheral Emboli of Infectious Endocarditis on Native Valves
The diagnosis of infectious endocarditis is not always easy and is based on several clinical and imaging arguments. Positron Emission Tomography - Computed Tomography (PET-CT) has been validated for endocarditis on prosthetic…
- Trial name
- NATIVTEP (NCT03695861)
- Testing
- Whole-body 18F-FDG PET-CT scan
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Bordeaux
Infective Endocarditis (IE), Heart Valve Disease
The Study Tests if Preoperative Dental Screening is Superior to no Preoperative Dental Screening in Improving the Outcome of Patients Undergoing Surgical Cardiac Valve Replacement or Transcatheter Cardiac Valve Implantation.
This randomized, multicenter, open-label trial evaluates whether preoperative dental screening improves outcomes in patients undergoing surgical or transcatheter cardiac valve intervention.
- Trial name
- SMILE (NCT07511673)
- Testing
- Preoperative dental screening, No preoperative dental screening
- Where
- 5 sites in Sweden
- Volunteers
- 1,300 people
- Sponsor
- Region Skane
Infective Endocarditis, Cardiac Sarcoidosis
Evaluation of the Impact of a Patient Education Protocol on the Quality of 18F-FDG PET Imaging Indicated for Investigation of Cardiac Inflammation
The aim of this study is to assess the impact of implementing a patient education and preparation protocol for FDG PET (18F-FDG PET) imaging on the quality of imaging results.
- Trial name
- CARTEP (NCT07029295)
- Testing
- Sending a link to the video, Compliance questionnaire, Determination of beta-hydroxybutyrate (BHB) in capillary blood
- Where
- 2 sites in France
- Volunteers
- 138 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Endocarditis, Endocarditis;Chronic
64Cu-DOTATATE PET-CT-skanning and Infective Endocarditis.
The investigators hypothesize that the 64Cu-DOTATATE will show uptake in the infected vegetations on the prosthetic heart valves and increase the accuracy of the right diagnosis - thus increasing the sensitivity and specificity…
- Conditions
- Endocarditis, Endocarditis;Chronic, Endocarditis Acute
- Trial name
- NCT05432427
- Testing
- 64Cu-DOTATATE and 18F-FDG
- Where
- Denmark
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Emil Loldrup Fosbol