Clinical trials: Endocrine, Nutritional, Metabolic and Immunity Disorders
Type 1 Diabetes
Evaluation of Glycemic Control in Adults With Type 1 Diabetes When Switching to Insulin Degludec
Retrospective multicenter study analyzing data gathered from medical records and diabetes management platforms to assess the effect of using Insulin Degludec (Tresiba®) on measures of diabetes control.
- Trial name
- GLADE (NCT05434559)
- Testing
- Insulin Degludec
- Where
- 2 sites in Belgium
- Volunteers
- 475 people
- Sponsor
- prof dr Pieter Gillard
Type 1 Diabetes
The Importance of Meal Composition on Preventing Exercise-induced Hypoglycemia in People With Type 1 Diabetes.
This study is a clinical, randomized, crossover study. The study investigates the effect of a low-carbohydrate-high-protein pre-exercise meal on preventing exercise-induced hypoglycemia in people with type 1 diabetes.
- Trial name
- NCT04472962
- Testing
- Pre-exercise meal
- Where
- Denmark
- Volunteers
- 14 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type I Diabetes
Epigenetic Modifications of Diabetes Mellitus Type I
This research is being done to find out if significant changes in blood glucose cause bad outcomes in patients with diabetes.
- Trial name
- NCT01623388
- Testing
- Oral glucose tolerance test for Phase I
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Islet Cell Transplantation, Type 1 Diabetes
Pancreatic Islet Cell Transplantation - A Novel Approach to Improve Islet Quality and Engraftment
The purpose of this study is to assess a novel approach to immunosuppression in allogenic pancreatic islet cell transplant recipients.
- Trial name
- NCT00530686
- Testing
- Islet cell transplantation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Baylor Research Institute
Diabetes, Diabetes Mellitus, Type 1
An International Survey on Hypoglycaemia Among Insulin-treated Patients With Diabetes
This study is conducted in Europe. The aim of the study is to gather information about hypoglycaemia (low blood glucose) among patients with Type 1 or Type 2 diabetes mellitus. The study is both retrospective and prospective.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01696266
- Testing
- No treatment given
- Where
- 24 sites in Argentina, Austria and 22 more
- Volunteers
- 29,304 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
Description of Patients With Type 1 Diabetes Treated With Teplizumab
Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease caused by the destruction of pancreatic β cells. T1D pathogenesis progresses through several stages: Stage 1 T1D includes the presence of β cell autoimmunity and thus…
- Trial name
- TEPLI-REAL (NCT06892002)
- Testing
- Teplizumab
- Where
- 27 sites in United States, Israel
- Volunteers
- 110 people
- Sponsor
- Sanofi
Celiac Disease, Diabetes Mellitus, Type 1
Celiac Disease and Diabetes- Dietary Intervention and Evaluation Trial
Currently no consensus exists on the optimal way to manage asymptomatic patients with celiac disease (CD) and Type 1 diabetes (T1D).
- Trial name
- CD-DIET (NCT01566110)
- Testing
- Gluten Free Diet
- Where
- 7 sites in Canada
- Volunteers
- 50 people
- Sponsor
- The Hospital for Sick Children
Type 1 Diabetes (T1D), Islet Transplantation
Extended Follow-Up After Islet Transplantation in T1D
The purpose of this study is to provide patients who have received at least one islet transplant as a previous participant in a Clinical Islet Transplantation Consortium (CIT) clinical trial with maintenance immunosuppressive…
- Trial name
- NCT01369082
- Testing
- Maintenance Immunosuppressive Treatment
- Where
- 8 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 1 Diabetes
ACT Stress Management in Type 1 Diabetes
For many people living with type 1 diabetes it is a challenge to achieve good glucose control. Barely 20% reaches the goal level and many people experience self-care as complex, demanding and stressful.
- Trial name
- NCT02914496
- Testing
- Acceptance and Commitment Therapy (ACT)
- Where
- Sweden
- Volunteers
- 81 people
- Sponsor
- Karolinska Institutet
Diabetes, Diabetes Mellitus, Type 1
A Trial Investigating the Total Exposure of NN5401 (Insulin Degludec/Insulin Aspart) in Children, Adolescents and Adult Subjects With Type 1 Diabetes
This trial was conducted in Europe. The aim of this study was to investigate the total exposure of NN5401 (insulin degludec/insulin aspart) in children, adolescents and adult subjects with type 1 diabetes.
- Trial name
- NCT01138488
- Testing
- insulin degludec/insulin aspart
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
Insulin Bolus Required for High Fat Foods in Type 1 Diabetes
The purpose of this study is to evaluate an insulin bolus for use to cover higher fat meals. Subjects will have several admissions during which the investigators will apply an iterative dose escalation protocol to derive an…
- Trial name
- NCT02248454
- Testing
- Lispro
- Volunteers
- 10 people
- Sponsor
- Joslin Diabetes Center
Diabetes Mellitus, Type 1
Probiotics in Newly Recognized Type 1 Diabetes
They are major genera of bacteria that make up the colon flora in human, constitute intestinal microbial homeostasis, inhibit growth of pathogens, improve the gut mucosal barrier and modulate local and systemic immune responses.
- Trial name
- NCT03032354
- Testing
- Lactobacillus rhamnosus GG and Bifidobacterium lactis BB12
- Volunteers
- 96 people
- Sponsor
- Medical University of Warsaw
Type 1 Diabetes, Insulin Pump Users
Feasibility Study of the Solo™ Insulin Pump
The purpose of this study is to assess the safety and usability of the Solo™ insulin MicroPump in subjects with type 1 diabetes who are pump users.
- Trial name
- NCT01055951
- Testing
- Solo MicroPump
- Where
- 3 sites in Austria, Israel
- Volunteers
- 90 people
- Sponsor
- Medingo Ltd
Diabetes, Diabetes Mellitus, Type 1
A Trial Investigating the Pharmacokinetic and Pharmacodynamic Properties of FIAsp When Administered as a Bolus in a Continuous Subcutaneous Infusion Regimen in Subjects With Type 1 Diabetes
This trial is conducted in Europe. The aim of the trial is to compare the pharmacokinetic (the exposure of the trial drug in the body) and pharmacodynamic (the effect of the investigated drug on the body) properties of FIAsp…
- Trial name
- NCT01992588
- Testing
- Faster-acting insulin aspart, insulin aspart
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes, Adolescent
Roy Adaptation Model in People With Type 1 Diabetes
The study was conducted to determine the effect of Roy adaptation model-based education on disease compliance and metabolic control in adolescents with Type 1 diabetes.
- Trial name
- NCT05336929
- Testing
- Roy adaptation model-based nursing education
- Volunteers
- 60 people
- Sponsor
- Balikesir University
Type 1 Diabetes
Ciclosporin Followed by Low-dose IL-2 in Patients With Recently Diagnosed Type 1 Diabetes
Type 1 diabetes (T1D) is caused by the destruction of insulin-producing cells by effector T cells (Teffs), due to a deficiency of regulatory T cells (Tregs).
- Trial name
- DF-IL2-REP (NCT05153070)
- Testing
- Cyclosporin, ILT101
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus, Type 1, Hyperglycemia, Postprandial
Effect of Protein Intake on Post Prandial Hyperglycemia in Children and Adolescents With Type1 Diabetes Mellitus
In type 1 Diabetes Mellitus, patients receive insulin doses if they consume specific amounts of carbohydrates. Currently, insulin is not being administered for consumption of protein although studies in adults show that consuming…
- Trial name
- NCT04655131
- Testing
- Whey protein isolate
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University Hospitals Cleveland Medical Center
Diabetes Mellitus, Type 1
Safety/Efficacy Study of Subcutaneously Injected Prandial Insulins Compared to Insulin Lispro Alone in Participants With Type 1 Diabetes Mellitus
The purpose of the study is to compare Humalog (Insulin lispro)-recombinant human hyaluronidase (rHuPH20) or Novolog (Insulin aspart)-rHuPH20 to Humalog (Insulin lispro) for the treatment of Type 1 Diabetes Mellitus (T1DM) in…
- Trial name
- NCT01194245
- Testing
- Insulin lispro, recombinant human hyaluronidase PH20, Insulin aspart
- Where
- 19 sites in United States
- Volunteers
- 135 people
- Sponsor
- Halozyme Therapeutics
Type 1 Diabetes
Timing of Pre-meal Insulin Versus Accurate Carbohydrate Counting in Youth With Type 1 Diabetes
The investigators are hoping to figure out how youth with type 1 diabetes can best control their blood glucose levels after meals, by determining whether accurate carbohydrate dosing or the timing of the bolus is more important.
- Trial name
- NCT01209312
- Testing
- Bolus timing and dosing
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes
Gene-virus Interactions Implicated in Type 1 Diabetes
Type 1 diabetes (T1D) is the most common endocrine disorder in children. In France, T1D prevalence is estimated to 12.2 per 100 000. Worldwide T1D incidence increased rapidly in the last decades, around 3% per year.
- Trial name
- GENEVIR (NCT02804165)
- Testing
- Enterovirus vaccination
- Where
- France
- Sponsor
- Hospices Civils de Lyon
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