Clinical trials: Endocrine, Nutritional, Metabolic and Immunity Disorders
Type 1 Diabetes
Artificial Pancreas - Adolescent Physiology & Psychology Longitudinal Evaluation
This study designed to assess changes in control of Type 1 Diabetes in pubertal adolescents over a two year period. There are two arms/substudies, the first being a longitudinal randomized controlled trial and the second an…
- Trial name
- AP APPLE (NCT04510506)
- Testing
- Artificial Pancreas (AP)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 1
Type 1 Diabetes Aerobic and Resistance Exercise (T1-DARE)
This is a randomized controlled trial evaluating different exercise modalities in previously inactive subjects with type 1 diabetes.
- Trial name
- NCT00148538
- Testing
- Resistance and/or Aerobic Exercise
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- Ottawa Hospital Research Institute
Type 1 Diabetes
Efficacy and Safety of an Artificial Intelligence Tool for Carbohydrate Counting (Tiabete) in Children and Adults With Type 1 Diabetes Mellitus
IntroductionType 1 Diabetes Mellitus (T1DM) requires lifelong exogenous insulin therapy, along with self-management strategies, such as carbohydrate counting, to appropriately adjust insulin doses in response to meals.
- Trial name
- Tiabete (NCT07150052)
- Testing
- Artifical intelligence in whatsapp
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo
Type 1 Diabetes
Use of Exenatide and Pramlintide to Decrease Post-prandial Hyperglycemia
The main purpose of the study is to determine the effects of 16 weeks of adjunctive pramlintide or exenatide use on glycemic control in Type 1 Diabetes.
- Trial name
- NCT01269047
- Testing
- Pramlintide, Exenatide, Insulin
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Albert Einstein College of Medicine
Type 1 Diabetes Mellitus
Using Wearable Sensors To Understand Low Blood Sugar in Type 1 Diabetes
This is a single-site study using wearable sensor technology (CGM and smartwatch) to better explain low blood sugars in patients living with type 1 diabetes.
- Trial name
- Wear WOLF (NCT06727071)
- Testing
- Hyperglycemic clamp
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Type I Diabetes
Evaluation of the Function "Stop Before Hypoglycemia" on External Insulin Pump
This study compares the apparition of hypoglycaemia in type I diabetic patients between 2 phases: the one without the use of SmartGuard® function and the one with the use of SmartGuard® function.
- Trial name
- AAHPI (NCT03653533)
- Testing
- MiniMed™ 640G, Captor CGM Enlite®, SmartGuard®
- Where
- France
- Volunteers
- 8 people
- Sponsor
- ARAIR Assistance
Type 1 Diabetes (T1D), Islets of Langerhans Transplantation
Efficacy of Islet Re-transplantation After Failure of Beta-cell Replacement
Islet transplantation and pancreas transplantation are established therapeutic options for selected individuals with type 1 diabetes experiencing severe glycemic instability and recurrent hypoglycemia.
- Trial name
- MULT-ILOT (NCT07666789)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Type 1 Diabetes, Type 1 Diabetes Mellitus
Alleviating Carbohydrate Counting for Patients With Type 1 Diabetes Using a Novel Insulin-plus-pramlintide Artificial Pancreas
One of the main challenges in maintaining tight glucose control in a closed-loop system occurs at meal times. Amylin is a gluco-regulatory beta-cell hormone that is co-secreted with insulin in response to nutrient stimuli, and is…
- Conditions
- Type 1 Diabetes, Type 1 Diabetes Mellitus, Hyperglycemia, Postprandial
- Trial name
- NCT04163874
- Testing
- Fiasp, Pramlintide Acetate, Artificial Pancreas
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- McGill University
Diabetes Mellitus, Type 1
GPR119 Agonist for Hypoglycemia in Type 1 Diabetes
The purpose of this study is to test if a specific research medication could increase the response to low blood glucose in people with type 1 diabetes.
- Trial name
- PHROG (NCT04432090)
- Testing
- Study Medication (MBX-2982), No medication for this group
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Type 1 Diabetes
Study to Compare Efficacy of the MiniMed Paradigm REAL-Time System Vs. MDI in Subjects Naive to Insulin Pump Therapy
Primary Outcomes: Average decrease in A1c from baseline to end of Study Phase (52 weeks) for subjects in the "722 Group" is greater than that for subjects in the "Control (MDI) Group".
- Trial name
- STAR3 (NCT00417989)
- Testing
- MiniMed Paradigm REAL-Time System
- Where
- 30 sites in United States, Canada
- Volunteers
- 485 people
- Sponsor
- Medtronic MiniMed, Inc.
Type 1 Diabetes
Effect of the InsuPatch on Automated Closed-loop Glucose Control in Type 1 Diabetes
This research study designed to look at how well adolescents' and young adults' blood sugars can be controlled with a "closed loop artificial pancreas" using a continuous glucose sensor, an insulin pump, and a computer program…
- Trial name
- IPCL (NCT01787318)
- Testing
- ePID closed loop system, InsuPatch
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Type 1 Diabetes
Milk as Treatment for Hypoglycemia
Test hypothesis that milk can raise blood sugars as well as orange juice or glucose tablets without raising blood sugars too much the way that orange juice or glucose tablets sometimes do.
- Trial name
- NCT00643110
- Testing
- D50 glucose
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Creighton University
Diabetes Mellitus, Type 1
A Study to Compare LY2963016 to Lantus After a Single Dose to Participants With Type 1 Diabetes Mellitus
The study involves a single injection of LY2963016 and a single injection of Lantus, on 2 separate occasions in participants with type I diabetes.
- Trial name
- NCT01600950
- Testing
- LY2963016, Lantus
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Type 1
MELD-ATG: Phase II, Dose Ranging, Efficacy Study of Anti-thymocyte Globulin (ATG) Within 6 Weeks of Diagnosis of Type 1 Diabetes (T1D)
This study has been set up within the framework of the INNODIA network. INNODIA is a global partnership between 31 academic institutions, 6 industrial partners, a small sized enterprise and 2 patient organizations, bringing their…
- Trial name
- Meld-ATG (NCT04509791)
- Testing
- Anti-Human Thymocyte Immunoglobulin, Rabbit
- Where
- 14 sites in Austria, Belgium and 6 more
- Volunteers
- 114 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Type 1 Diabetes Mellitus
Rezpegaldesleukin (NKTR-358) in New Onset Type 1 Diabetes Mellitus
This Phase 2 study is a 2-arm, multi-center, double-masked (masking of the participant, care provider and investigator), placebo-controlled, 2:1 randomized trial design in new onset T1D participants (within 100 days of…
- Trial name
- NCT07142252
- Testing
- Rezpegaldesleukin
- Where
- 15 sites in United States, Canada
- Volunteers
- 66 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes
Non Invasive Breath Based Acetone-meter- Easy Check
Segment 1- this segment will include two main steps: Step 1-Calibration: During this step we plan to collect paired measurements of capillary blood glucose using reference method and data generated by the non invasive study…
- Trial name
- NCT01530347
- Testing
- Easy Check
- Where
- Israel
- Volunteers
- 6 people
- Sponsor
- Rabin Medical Center
Diabetes Mellitus, Type 1
Carbohydrate Content in the Diet in Type 1 Diabetes
The aim of this study is to analyse the effect of a diet with a moderate amount of carbohydrates and compare it with a traditional diabetic diet with a higher content of carbohydrates on mean glucose level, high and low glucose…
- Trial name
- NCT03400618
- Testing
- Moderate carbohydrate diet, Higher carbohydrate diet
- Where
- Sweden
- Volunteers
- 54 people
- Sponsor
- Vastra Gotaland Region
Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis
Prevalence of NAFLD and Advanced Fibrosis in Patients With Type 1 Diabetes
The aim of this study is to assess the prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with type 1 diabetes receiving care at Joslin clinic using noninvasive imaging and serum-based methods with the goal of…
- Conditions
- Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis, Fibrosis, Liver, Type 1 Diabetes
- Trial name
- NCT04595474
- Testing
- Transient Elastography
- Where
- United States
- Volunteers
- 533 people
- Sponsor
- Joslin Diabetes Center
Diabetes Mellitus, Type 1
Can Gluten-free Diet Prevent the Destruction of Beta-cells During Remission?
Type 1 diabetes (T1D) emerge when the auto-immune destruction exceeds the beta cell's regenerative capacity. The patients' beta-cell capacity increases shortly after onset when glucotoxicity decreases after the start of insulin…
- Trial name
- NCT02284815
- Testing
- Glutenfree diet
- Volunteers
- 20 people
- Sponsor
- Herlev Hospital
Type 1 Diabetes
A Comparison of Pharmacodynamics and Pharmacokinetics of Insulin Aspart, Biphasic Insulin Aspart 30, 50 and 70.
The hypothesis is that an optimal formulation of fast acting and intermediary acting insulin analogues will improve post prandial glycaemic control in patients with type 1 diabetes.
- Trial name
- NCT00283218
- Testing
- NovoRapid, NovoMix 30, Bifasisk Insulin Aspart 50, BIAsp70
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- University of Aarhus
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