Clinical trials: Endocrine, Nutritional, Metabolic and Immunity Disorders
Type 1 Diabetes Mellitus
Medtronic 670G Insulin Pump and the Impact on Glycemic Control, Quality of Life, and Compliance
Analyze the Medtronic 670g pump on glycemic control
- Trial name
- NCT04329871
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Metabolic Research Institute, Inc.
Diabetes Mellitus, Type 1
Probiotics Supplementation Effect on Glucose Homeostasis in Children With Type 1 Diabetes
Background: Probiotics influence immune homeostasis, through altering gut microbiota. The efficacy of probiotics in diabetes has been shown in preclinical settings as well as in human trials.
- Trial name
- NCT04579341
- Testing
- probiotics
- Where
- 2 sites in Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Type 1 Diabetes
Transdisciplinary Care for Young Adults With Type 1 Diabetes
The incidence of type 1 diabetes (T1D) is increasing globally with the most substantial increases occurring in the youngest age groups.
- Trial name
- TCT (NCT06172166)
- Testing
- Transdisciplinary Care for Transition
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Nemours Children's Clinic
Type 1 Diabetes
The Management of Glucose Control and Hypoglycemic Prevention Using Continuous Glucose Monitoring System in Patients With Type 1 Diabetes
This study was designed to evaluate the glucose control and hypoglycemic prevention effect of using continuous glucose monitoring system(CGMS) in patients with type 1 diabetes.
- Trial name
- NCT04684030
- Testing
- Continuous glucose monitoring system(CGMS), Self-monitoring of blood glucose (conventional fingerpricking method)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Type 1 Diabetes Mellitus
Efficacy and Safety of Insulin Glargine Versus. Neutral Protamine Hagedorn (NPH) Insulin in Children With Type 1 Diabetes Above 6 Years Old.
Primary Objective: 6 To assess the efficacy of insulin glargine given once daily (QD) on glycosylated hemoglobin (HbA1c) levels over a period of 24 weeks in children with type 1 diabetes mellitus (T1DM) aged at least 6 years to…
- Trial name
- Lantus-P-CN (NCT01223131)
- Testing
- Insulin glargine (HOE901), NPH insulin
- Where
- 10 sites in China
- Volunteers
- 162 people
- Sponsor
- Sanofi
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Local Registration Trial in China Humalog Mix 50
The primary objective of this study is to compare the 2-hour PPBG excursion following a standard test meal in insulin-requiring diabetic patients treated twice daily with human insulin mix 50/50, versus the 2-hour PPBG excursion…
- Trial name
- NCT00191581
- Testing
- Humalog Mix 50, Human Insulin Mix 50:50
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Eli Lilly and Company
Contact Dermatitis, Type 1 Diabetes Mellitus
Exploring Skin Barrier Function, Recurrence of Diabetes Device-Related Contact Dermatitis, and Evaluation of Hydrocolloid and Silicone-Based Patches for Its Prevention in Children and Adolescents With Type 1 Diabetes
The goal of this clinical trial is to ensure that contact dermatitis does not prevent any person with diabetes from accessing optimal diabetes treatment.
- Trial name
- StenoAD1 (NCT07767461)
- Testing
- hydrocolloid patch as patch used in the Sandwich method, Silicone-based patch as patch used in the Sandwitch method
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Steno Diabetes Center Copenhagen
Hypertension, Diabetes Mellitus, Type 2
Enhancing Community Health Through Patient Navigation, Advocacy and Social Support
Some patients who have multiple long-term health conditions have significant challenges accessing needed services despite available primary care and social services resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- ENCOMPASS (NCT03077386)
- Testing
- ENCOMPASS Intervention
- Where
- Canada
- Volunteers
- 176 people
- Sponsor
- University of Calgary
Type 1 Diabetes
Effects of Low-calorie Sweetened Beverage Restriction in Youth With Type 1 Diabetes
This study will investigate whether low-calorie sweeteners (LCS) are helpful or harmful for preventing diabetes complications among children with Type 1 Diabetes (T1D).
- Trial name
- NCT04385888
- Testing
- Low-calorie sweetener restriction
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Allison Sylvetsky (Meni)
Diabetes Mellitus, Type 1
Automated Fully Closed-Loop Insulin Delivery in Type 1 Diabetes With Ultra-Rapid Lispro (ACOLYTE Study)
The main objective of the study is to determine whether fully closed-loop insulin delivery using ultra-rapid acting insulin lispro will improve glucose control compared to standard lispro under conditions mimicking missed meal…
- Trial name
- ACOLYTE (NCT05660941)
- Testing
- Lispro
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- Manchester University NHS Foundation Trust
Type 1 Diabetes Mellitus
Physiologic Response to Glucagon at Varying Insulin Levels
The purpose of this research study is to test how different levels of insulin block the effect of glucagon. Insulin is a hormone that lowers blood glucose. Glucagon raises blood glucose.
- Trial name
- NCT01483651
- Testing
- Glucagon, Insulin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Legacy Health System
Kidney Failure, Chronic, Diabetic Nephropathies
Effects of Rituximab and Mycophenolate Mofetil (MMF) on Highly Sensitized Patients Awaiting Renal Transplant
This is a 12-month phase 2, prospective, open label study to evaluate the effect of rituximab with mycophenolate mofetil (MMF)on the PRA of 14 highly sensitized patients who just completed an 8 month trial of MMF treatment alone.
- Conditions
- Kidney Failure, Chronic, Diabetic Nephropathies, Glomerulonephritis, IGA, Hypertension, Renal
- Trial name
- NCT00446251
- Testing
- Rituximab, Mycophenolate mofetil (MMF)
- Volunteers
- 14 people
- Sponsor
- University of Washington
Diabetes Mellitus, Type 1
Telemedicine Program in Type 1 Diabetes and CSII
Diabetes mellitus is a chronic disease of high socio-health relevance for their clinical and economic implications (risk of complications, disability ...) (healthcare costs).
- Trial name
- NCT02790645
- Testing
- Group 2a. Telemedicine program, Group 1a. Control, Group 1b.Telemedicine program
- Volunteers
- 51 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Type 1 Diabetes
Open-label Investigation of the Safety and Effectiveness of DIABECELL® in Patients With Type 1 Diabetes Mellitus
The purpose of this study is to establish the safety and efficacy of xenotransplantation of DIABECELL® in patients with established type 1 diabetes mellitus
- Trial name
- NCT01739829
- Testing
- DIABECELL (R)
- Where
- Argentina
- Volunteers
- 8 people
- Sponsor
- Diatranz Otsuka Limited
Type I Diabetes
Immunosafety Study of Recombinant Human Insulins in Type 1 Diabetics
This is an open label, randomized, parallel group comparison of the immunogenicity safety of Wockhardt's human insulin and isophane insulin compared with the Novo Nordisk's yeast based human insulin products (marketed in USA) in…
- Trial name
- NCT01308437
- Testing
- Wosulin (N or 70/30 with R), Novolin® (N or 70/30 with R)
- Where
- 25 sites in United States, India
- Volunteers
- 134 people
- Sponsor
- Wockhardt
Type 1 Diabetes
Sweetgoals for Type 1 Diabetes
The study will test an app and web-delivered intervention designed to improve glycemic control (HbA1c) among young adults with Type 1 diabetes.
- Trial name
- NCT04646473
- Testing
- Coaching, Incentives, Sweetgoals app
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Trustees of Dartmouth College
Foot Ulcer, Diabetic
Study to Assess the Safety of DERMASEAL for Diabetic Foot Ulcers
The goal of this clinical trial is to determine the safety of DERMASEAL for the treatment of non-healing, neuropathic diabetic foot ulcers. The main outcome measure is safety.
- Trial name
- NCT05586542
- Testing
- DERMASEAL, Plasma Film, Standard of Care
- Where
- 4 sites in United States
- Volunteers
- 26 people
- Sponsor
- Vitruvian Medical Devices, Inc.
Diabetes Mellitus, Type 1
Effect of Medium Chain Fatty Acids on Cognitive Function During Acute Hypoglycemia in Patients With Type 1 Diabetes
At present, there are no therapeutic agents that can minimize severe hypoglycemia (low blood sugar) and its effects on long-term brain function.
- Trial name
- NCT00592072
- Testing
- Medium chain fatty acid (Octanoic and Decanoic acid)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Yale University
Type 1 Diabetes
The Separate and Combined Glucagonotropic Effects of Glucose-dependent Insulinotropic Polypeptide and Alanine in Subjects With and Without Type 1 Diabetes
The hormone glucose-dependent insulinotropic polypeptide (GIP) is naturally produced in the intestine during a meal and stimulates insulin secretion from the pancreas.
- Trial name
- GIPALANIN (NCT06881472)
- Testing
- Glucose-dependent Insulinotropic Polypeptide (GIP), alanine
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Asger Lund, MD
Type 1 Diabetes
Reversal of Type 1 Diabetes in Children by Stem Cell Educator Therapy
Type 1 diabetes (T1D) is an autoimmune disease that usually occurs in children and reduces their pancreatic islet beta cells and thereby limits insulin production.
- Trial name
- NCT01996228
- Testing
- Stem Cell Educator
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Throne Biotechnologies Inc.
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