Clinical trials: Endocrine, Nutritional, Metabolic and Immunity Disorders
Diabetes Mellitus, Diabetes Mellitus, Type 1
A Novel mHealth Application Guided by an Optimization Algorithm for T1D Sensor-Augmented Insulin Injection Users
The Artificial Pancreas lab at McGill University has developed an optimization algorithm for adults with Type 1 Diabetes (T1D) on Multiple Daily Injection (MDI) therapy with the adjunctive use of glucose sensor technology…
- Trial name
- NCT04123054
- Testing
- Mobile App, Mobile App + Basal-Bolus Optimization Algorithm
- Where
- 2 sites in Canada
- Volunteers
- 84 people
- Sponsor
- McGill University
Type 1 Diabetes Mellitus
Rituximab in New Onset Type 1 Diabetes
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks the insulin-producing beta cells in the pancreas.
- Trial name
- TN05 (NCT00279305)
- Testing
- Anti-CD20 (rituximab)
- Where
- 16 sites in United States, Australia and 2 more
- Volunteers
- 87 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes Mellitus, Type 1
Study to Compare Intraperitoneal Insulin to Subcutaneous Insulin Administration in Type 1 Diabetes Mellitus
The purpose of this study is to compare intraperitoneal (IP) therapy to subcutaneous administration of insulin regarding safety, glycemic control and number of episodes of hypoglycemia in patients with type 1 diabetes mellitus.
- Trial name
- NCT00286962
- Testing
- MIP 2007C implantable insulin pump, continuous subcutaneous insulin infusion (CSII) or MDI
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Medical Research Foundation, The Netherlands
Diabetes Mellitus, Type 1
The PSIQS Study - User Experience With Pro-Set
Open label, randomized 2-period cross-over study comparing two continuous subcutaneous insulin infusion sets ; MiniMed® Pro-set® with BD FlowSmart™ technology and MiniMed® Quick-set®
- Trial name
- NCT03242005
- Testing
- MiniMed® Pro-set®, MiniMed® Quick-set®
- Sponsor
- Becton, Dickinson and Company
Type 1 Diabetes, Adherence, Patient
Diabetes Journey: An Adolescent Adherence Barriers Intervention
The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a web-based intervention addressing adherence barriers in adolescents with T1D.
- Trial name
- NCT04404556
- Testing
- Diabetes Journey, Enhanced Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 195 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Diabetes Complications, type1diabetes
Early Detection of Long-term Diabetic Complications in Children and Adolescents With Type 1 Diabetes
Aims: To investigate early markers of long-term diabetic complications and the association to an extended glucose metabolic profile comprising glucose control (current and past), glucose variability and insulin sensitivity in…
- Conditions
- Diabetes Complications, type1diabetes, Children, Only, Diabetic Neuropathies
- Trial name
- NCT05159856
- Where
- Denmark
- Volunteers
- 400 people
- Sponsor
- Steno Diabetes Center Copenhagen
Diabetes Mellitus, Type 1
Optimizing Closed-Loop Control of Type 1 Diabetes Mellitus in Adolescents
The purpose of this study is to use a closed-loop Control-to-Range (CTR) system in adolescents with type 1 diabetes in an outpatient setting, and to evaluate the CTR system's ability to significantly improve blood glucose levels…
- Trial name
- NCT01890954
- Testing
- Diabetes Assistant (DiAs)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Virginia
Type 1 Diabetes
Additional Insulin for Fat and Protein in Children With Diabetes Study
The aims of the study are to see if additional insulin doses for the fat and protein in a meal, given at different times, improve blood glucose levels and are safe and acceptable to children with Type 1 diabetes using multiple…
- Trial name
- NCT02680054
- Testing
- Insulin, Asp(B28)-
- Where
- 2 sites in United Kingdom
- Volunteers
- 38 people
- Sponsor
- Oxford University Hospitals NHS Trust
Type 1 Diabetes, Hypoglycemia
hOKT3γ1 (Ala-Ala) Combined With Sirolimus and Delayed Tacrolimus in Type 1 Diabetic Islet Allograft Recipients
The collective effects of two-layer pancreas preservation, pretransplant islet culture, day -2 pretransplant immunosuppression, and induction immunosuppression with the FcR-nonbinding anti-CD3 monoclonal antibody hOKT3γ1…
- Trial name
- NCT00285194
- Testing
- Allogeneic Islets of Langerhans, hOKT3γ1 (Ala-Ala)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Diabetes type1, Diabetes Mellitus, Type 1
Pilot of Pragmatic Delivery of Behavioral Approaches to Reduce Diabetes Distress in Adults With Type 1 Diabetes
This study is designed to test the feasibility and acceptability of behavioral approaches to reduce diabetes distress ("the expected burdens, concerns, fears, and threats that arise from the challenges of living with diabetes")…
- Conditions
- Diabetes type1, Diabetes Mellitus, Type 1, Diabetes, Autoimmune, Diabetes Mellitus
- Trial name
- ChargeUp (NCT06405386)
- Testing
- ReCharge, TakeCharge
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of North Carolina, Chapel Hill
Sleep Apnea, Obstructive, Type 1 Diabetes (T1D)
Type 1 Diabetes and Obstructive Sleep Apnea
The purpose of the study is to investigate the role of sleep apnea in glycemic dysregulation in adults with Type 1 diabetes.
- Trial name
- T1D and OSA (NCT06915831)
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Chicago
Type 1 Diabetes
Premixed Glucagon/Insulin Solution for Faster Insulin Absorption in Type 1 Diabetes
We will investigate if Lyumjev premixed with nanogram amounts of glucagon speed up the absorption of insulin and the effect on whole body glucose consumption compared to native lyumjev in patients with type 1 diabetes.
- Trial name
- MicroGlucag2 (NCT06854861)
- Testing
- Lyumjev 100 UNT/ML Injectable Solution, Premixed Lyumjev
- Where
- Norway
- Volunteers
- 9 people
- Sponsor
- St. Olavs Hospital
Diabetes Mellitus, Type 1, Food Habits
High Salt Intake Unrelated to Obesity in Diabetes
People around the world are consuming much more sodium than is physiologically necessary. A number of studies suggest that dietary sodium intake is related to weight gain.
- Trial name
- Diasalt (NCT04256447)
- Testing
- Urinary sodium concentrations
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- University of Campania Luigi Vanvitelli
Diabetes, Diabetes Mellitus, Type 1
Within-subject Variability of Insulin Detemir in Children and Adolescents With Type 1 Diabetes
This trial is conducted in Europe. The aim of this trial is to compare the within-subject variability of the pharmacokinetic profiles of insulin detemir and insulin glargine in children and adolescents with type 1 diabetes.
- Trial name
- NCT01497574
- Testing
- insulin detemir, insulin glargine
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Novo Nordisk A/S
Diabetes, Diabetes Mellitus, Type 1
Comparing Insulin Aspart With Fast-acting Insulin Human in Subjects With Type 1 Diabetes
This trial is conducted in Japan. The aim of the trial is to compare pharmacokinetics (at which rate the body eliminates the substance from the body) of insulin aspart with fast-acting insulin human following intravenous (IV)…
- Trial name
- NCT01269606
- Testing
- insulin aspart, insulin human
- Where
- Japan
- Volunteers
- 13 people
- Sponsor
- Novo Nordisk A/S
Addison Disease, Type 1 Diabetes
Continuous Subcutaneous Hydrocortisone Infusion In Addison's Disease and Type 1 Diabetes
The conventional glucocorticoid replacement therapy in primary adrenal insufficiency (Addison's disease) renders the cortisol levels unphysiological, which may cause symptoms and long-term complications.
- Trial name
- NCT01840189
- Testing
- Cortef, Solu-cortef
- Where
- Norway
- Volunteers
- 4 people
- Sponsor
- Haukeland University Hospital
Type 1 Diabetes
Carbohydrates Under Target for Type 1 Diabetes Management
Recently, there has been an increased interest in limiting carbohydrates (CHO) intakes for improving long-term health. Low CHO (<30% energy from CHO) and very low CHO high fat (VLCHF; 10% CHO, 75% Lipid) diets are being advocated…
- Trial name
- NCT04758858
- Testing
- Insulin treatment optimization with participant's usual diet, Abbott's FreeStyle Libre, Three-day food journal
- Where
- Canada
- Sponsor
- Institut de Recherches Cliniques de Montreal
Diabetes, Diabetes Mellitus, Type 1
GAPP 1 Survey: Global Attitudes of Patients and Physicians in Insulin Therapy for Diabetes Mellitus
This study is conducted in Asia, Europe and in the United States of America. The aim of this study is to examine patient and physician beliefs regarding insulin therapy and the degree to which patients adhere to their insulin…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01950650
- Testing
- No treatment given, survey
- Where
- 10 sites in United States, China and 8 more
- Volunteers
- 1,800 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes Mellitus
Effect of Ethanol Intoxication on the Anti-Hypoglycemic Action of Glucagon
This study will test the hypothesis that a BAC (blood alcohol content) of 0.1% will not significantly alter the anti-hypoglycemic effect of mico-dose glucagon in individuals with type 1 diabetes.
- Trial name
- NCT02516150
- Testing
- Ethanol, Glucagon
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Massachusetts General Hospital
Depression
Ability to Cope With Type 1 Diabetes
The purpose of this study is to learn about the relationship that exists between coping skills and blood glucose control. In addition to this, we will study the effect of Type 1 diabetes on coping skills in different age groups…
- Trial name
- NCT00206349
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Baylor College of Medicine
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