Clinical trials: Endocrine, Nutritional, Metabolic and Immunity Disorders
Diabetes Mellitus, Type 1
baSal BoluS Therapy in patIenTs With TypE 1 Diabetes Mellitus
Primary Objective: To evaluate the efficacy of the association Lantus (once-a-day, od) Apidra (thrice-a-day, tid) in terms of change HbA1c from baseline to end of study (week 24), in patients with Type 1 Diabetes Mellitus (T1DM).
- Trial name
- SUBSTITUTE (NCT01204593)
- Testing
- INSULIN GLARGINE, INSULIN GLULISINE
- Where
- 43 sites in Algeria, Argentina and 7 more
- Volunteers
- 206 people
- Sponsor
- Sanofi
Diabetes Mellitus, Type I
Study to Determine the Relationship Between Exercise and Hypoglycemia in Children With Type 1 Diabetes
The main purpose of this study is to find out how often low blood sugar (hypoglycemia) happens during the night after exercise in the late afternoon.
- Trial name
- NCT00109434
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- Jaeb Center for Health Research
Diabetes, Diabetes Mellitus, Type 1
Comparison of NN1250 With Insulin Glargine in Type 1 Diabetes
This trial is conducted in Europe and in the United States of America (USA). The aim of this trial is to investigate the efficacy and safety of NN1250 (insulin degludec) in subjects with type 1 diabetes.
- Trial name
- BEGIN™ (NCT01079234)
- Testing
- insulin degludec, insulin glargine, insulin aspart
- Where
- 82 sites in United States, Belgium and 5 more
- Volunteers
- 493 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1
Protective Effects of Saxagliptin (And Vitamin D3) on β Cell Function in Adult-onset Latent Autoimmune Diabetes
The main purpose of this study is to evaluate whether saxagliptin or (and vitamin D3) with metformin (and insulin) therapy can better protect islet β cell function than metformin(and insulin) .
- Trial name
- NCT02407899
- Testing
- Saxagliptin, Vitamin D3, Insulin
- Where
- 39 sites in China
- Volunteers
- 300 people
- Sponsor
- Second Xiangya Hospital of Central South University
Diabetes, Diabetes Mellitus, Type 1
Efficacy and the Safety of Insulin Detemir in Subjects With Insulin Requiring Diabetes
This trial is conducted in Japan. The aim of this trial is to investigate the efficacy of insulin detemir on blood glucose control in subjects with insulin requiring diabetes.
- Trial name
- NCT00604344
- Testing
- insulin detemir, insulin NPH
- Where
- Japan
- Volunteers
- 401 people
- Sponsor
- Novo Nordisk A/S
Endocrine, Nutritional, Metabolic and Immunity Disorders
Wheat Bioactives and Immune Function
The purpose of this research was to understand the effects of bioactive compounds found in wheat cereal on human immunity. Subjects came in for a baseline blood draw, consumed whole wheat bran cereal daily for 21 days, and…
- Trial name
- NCT02210234
- Testing
- 50 grams of whole wheat bran cereal, 100 grams of whole wheat bran cereal
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Florida
Diabete Type 1, Diabetes in Children
Buzzy and TickleFlex in Reducing Insulin Injection Pain and Fear
This interventional randomized controlled clinical trial aims to evaluate the effectiveness of two nonpharmacological devices, Buzzy and TickleFlex, in reducing pain and fear associated with insulin injections among children with…
- Trial name
- NCT07239700
- Testing
- Buzzy, TickleFlex, None (Routine Care)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hakkari Universitesi
Type 1 Diabetes Mellitus
Feasibility Study Using Zone-MPC Controller, HMS and Technosphere® Insulin Inhalation System From MannnKind Corp
This clinical trial is a feasibility study to assess the performance of an Artificial Pancreas (AP) device using the Artificial Pancreas System (APS©) platform for subjects with type 1 diabetes using rapid-acting insulin as well…
- Trial name
- NCT01874392
- Testing
- Investigational inhaled insulin (Technosphere), Artificial Pancreas (AP) device (APS©)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Sansum Diabetes Research Institute
Type 1 Diabetes
Four Way Crossover Closed Loop With Exercise Detection
Closed-loop systems are an emerging technology that automate hormone delivery. They are quickly paving the way to revolutionize the treatment of type 1 diabetes.
- Trial name
- NCT02862730
- Testing
- Artificial Pancreas Controller in Dual Hormone Mode, Subject's insulin pump, Artificial Pancreas Controller in Single Hormone Mode
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Oregon Health and Science University
Coronary Disease, Myocardial Infarction
Chronical Illness-related Limitations of the Ability to Cope With Rising Temperatures, Third Wave
The CLIMATE-III Observational Study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific health behavior, somatosensory amplification, risk and…
- Conditions
- Coronary Disease, Myocardial Infarction, Heart Failure, Arrhythmias, Cardiac
- Trial name
- CLIMATE-III (NCT06890208)
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 176 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Type 1 Diabetes
Diabetes Closed-Loop Project 6 (DCLP6): Fully Automated Closed-Loop Control in Type 1 Diabetes Using Meal Anticipation
The purpose of this study is to test the meal anticipation module on a closed loop algorithm, assessing efficacy and safety.
- Trial name
- NCT04877730
- Testing
- Fully Closed Loop (FCL), Fully Closed Loop with meal anticipation module (FCL+), Hybrid Closed Loop (HCL)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
Diabetes Mellitus Type 1
Blood Glucose Control With BioChaperone Insulin Lispro Compared to Insulin Lispro (Humalog®) After Ingestion of a Standardized Meal
The addition of BioChaperone to already marketed prandial insulin analogue accelerates the onset and shorten the duration of action of insulin lispro due to facilitation of the absorption of the insulin after subcutaneous…
- Trial name
- NCT02344992
- Testing
- BioChaperone insulin lispro, Humalog®
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- Adocia
Type 1 Diabetes Mellitus
A Study of LY900014 in Participants With Type 1 Diabetes Mellitus
The purpose of this study is to compare LY900014 with insulin lispro (Humalog) in participants with type 1 diabetes mellitus. There are 2 parts to this study.
- Trial name
- NCT03465878
- Testing
- LY900014, Insulin Lispro
- Where
- 2 sites in Canada, Germany
- Volunteers
- 56 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes Mellitus
B-Lymphocyte Immunotherapy in Islet Transplantation for Initial Islet Graft Failure
Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT01049633
- Testing
- Allogeneic Pancreatic Islet Cells, Sirolimus, Basiliximab
- Where
- United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 1 Diabetes, Pregnancy
Single Arm Intervention Trial of DEKA TWIIST TM Insulin Pump Utilizing Tidepool Loop Algorithm in Pregnant People With Pre-existing Type 1 Diabetes
Suboptimal glycemic control during pregnancy contributes to adverse maternal and fetal health outcomes and previous automated insulin delivery (AID) studies have demonstrated improvement in glucose control across all ages and…
- Trial name
- NCT07808385
- Testing
- Automated Insulin Delivery (AID)
- Where
- 4 sites in United States
- Volunteers
- 32 people
- Sponsor
- Mayo Clinic
Type 1 Diabetes Mellitus, Adolescent
Effect of High Fat High Protein Meal in Type 1 Diabetes
Aim: Despite optimal glycemic control in individuals with type 1 diabetes, post-meal hyperglycemia remains a clinical challenge, and it has been identified as an independent risk factor for the development of long-term…
- Trial name
- T1DM-HFHP (NCT07158385)
- Testing
- Standard test meal (SM), High fat high protein meal-carbohydrate counting (HFHP), High fat high protein meal-fat counting (HFHP-a)
- Where
- Turkey (Türkiye)
- Volunteers
- 11 people
- Sponsor
- Cumhuriyet University
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Hypo-METRICS: Hypoglycaemia - Measurement, ThResholds and ImpaCtS
Hypoglycaemia or low blood glucose, and its fear are major barriers to achieving optimal glucose control. New technology, such as continuous glucose monitors (CGM), help to better identify hypoglycaemia and develop strategies to…
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Hypoglycemia, Hypoglycemia Unawareness
- Trial name
- Hypo-METRICS (NCT04304963)
- Testing
- NO intervention - observational study
- Where
- United Kingdom
- Volunteers
- 602 people
- Sponsor
- King's College London
Diabetic Kidney Disease
Phase 2 Study of INV-202 in Patients With Diabetic Kidney Disease
The study is designed to assess the efficacy, safety, tolerability, and transformation within the human body of INV-202 investigational drug in the treatment of adult participants with a diagnosis of Diabetic Kidney Disease due…
- Trial name
- NCT05514548
- Testing
- INV-202
- Where
- 72 sites in United States, Canada and 5 more
- Volunteers
- 265 people
- Sponsor
- Inversago Pharma Inc.
Diabetes Type 1
National Epidemiological Study of the Possible Impact of Stress on Glycaemic Control in Patients With Type 1 Diabetes
The EPISTRESS2 study is a one-off cross-sectional epidemiological survey, carried out via an online form in patients with type 1 diabetes followed up by participating investigating centres.
- Trial name
- EPISTRESS2 (NCT06365255)
- Testing
- questionnaires
- Where
- 11 sites in France
- Volunteers
- 1,344 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Type 1 Diabetes Mellitus
Improving Self-Efficacy, Quality of Life and Glycemic Control in Adolescents With Type 1 Diabetes
Empowerment in healthcare, particularly in the context of chronic illness management such as diabetes, entails equipping patients with knowledge, expertise, and self-assurance to proactively oversee their health and make…
- Trial name
- NCT06694467
- Testing
- Education program
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Near East University, Turkey
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