Clinical trials: Endocrine, Nutritional, Metabolic and Immunity Disorders
Type 1 Diabetes
Dual-wave Boluses in Children With Type 1 Diabetes Insulin Boluses in Children With Type 1 Diabetes
To analyze with the aid of CGM the blood sugar profiles of children receiving dual-wave versus standard bolus for dinner.
- Trial name
- NCT04668612
- Testing
- Dual-bolus, Standard bolus
- Where
- Estonia
- Volunteers
- 30 people
- Sponsor
- Tartu University Hospital
Non-Proliferative Diabetic Retinopathy, Cataract
Nepafenac Once Daily for Macular Edema - Study 1
The purpose of this study is to demonstrate superiority of Nepafenac Ophthalmic Suspension, 0.3% dosed once daily relative to Nepafenac Vehicle based upon clinical outcomes among diabetic subjects following cataract surgery.
- Trial name
- NCT01853072
- Testing
- Nepafenac Ophthalmic Suspension, 0.3%, Nepafenac vehicle, Prednisolone acetate
- Volunteers
- 881 people
- Sponsor
- Alcon Research
Type 1 Diabetes
Very-Low-Density-Lipoprotein-Triglyceride(VLDL-TG) Metabolism During Acute Hyperglycemia
The purpose of this study is to estimate the acute effect of hyperglycemia on Very-Low-Density-Lipoprotein-triglyceride(VLDL-TG) secretion.
- Trial name
- NCT01178957
- Testing
- Hyperglycemia
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- University of Aarhus
Diabetic Retinopathy
Pediatric Type 1 Diabetes and Retinopathy
Diabetic retinopathy (DR) causes more new cases of blindness among young adults than any other disease. More than 90% of individuals with type 1 diabetes (T1D) will have some form of DR by 20 years after their diagnosis.
- Trial name
- NCT02691312
- Testing
- Digital Retinography System
- Where
- 3 sites in United States
- Volunteers
- 500 people
- Sponsor
- University of Florida
Type 1 Diabetes
Timing of Pre-meal Insulin Versus Accurate Carbohydrate Counting in Youth With Type 1 Diabetes
The investigators are hoping to figure out how youth with type 1 diabetes can best control their blood glucose levels after meals, by determining whether accurate carbohydrate dosing or the timing of the bolus is more important.
- Trial name
- NCT01209312
- Testing
- Bolus timing and dosing
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes Mellitus
A Study of an Automated Insulin Delivery System in Adult Participants With Type 1 Diabetes Mellitus
The purpose of this study is to evaluate whether an Automated Insulin Delivery (AID) System is safe to use and functions as intended with personalized basal insulin rates and when basal insulin rates are increased.
- Trial name
- NCT03849612
- Testing
- AID System, Insulin Lispro
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus Type 1
ZP4207(Dasiglucagon) Administered to T1D Patients to Assess the PK and PD Compared to Marketed Glucagon
The trial is a single-centre, randomised, sequential, cross-over trial assessing pharmacokinetic and pharmacodynamic responses after micro-doses of ZP4207 (dasiglucagon*) administered subcutaneously to patients with type 1…
- Trial name
- NCT02916251
- Testing
- ZP4207(dasiglucagon) glucagon analogue, Glucagon (Native glucagon)
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- Zealand Pharma
Hypoglycemia, Type 1 Diabetes
Effect of C-peptide on Hypoglycemic Counterregulation
Iatrogenic hypoglycemia is the most prominent barrier to the safe, effective management of blood sugar in people with type 1 diabetes due to periodic over-insulinization.
- Trial name
- NCT06470295
- Testing
- Saline, C-peptide
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Type 1 Diabetes, Adolescent Development
Emoticare: Serious Game for the Adaptation to the Disease of Adolescents With Type 1 Diabetes Mellitus.
The intervention program targets adolescents with chronic Type 1 Diabetes Mellitus. Given the critical developmental stage and life transitions, necessitating robust personal resources, psychological support becomes imperative.
- Trial name
- NCT06331429
- Testing
- EmoTiCare
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- University of Valencia
Diabetes, Diabetes Mellitus, Type 1
Frequency of Hypoglycaemic Episodes During Treatment With Insulin Detemir in Well Controlled Subjects With Type 1 Diabetes
This trial is conducted in Africa, Europe and Oceania. The aim of this trial is to investigate whether insulin detemir combined with insulin aspart compared to NPH insulin combined with insulin aspart could reduce the frequency…
- Trial name
- NCT01697657
- Testing
- insulin detemir, insulin NPH, insulin aspart
- Where
- 11 sites in Australia, Croatia and 4 more
- Volunteers
- 131 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1
Achieving Rapid, Safe and Sustained Glucose Control in Adolescents With Suboptimally Controlled Type 1 Diabetes Using Advanced Hybrid Closed Loop Systems
The rational of this study is to assess if AHCL systems are able to achieve a better metabolic control (better glucometric data) after 2 weeks, 1 months.
- Trial name
- NCT06305377
- Testing
- Tandem Control IQ
- Volunteers
- 20 people
- Sponsor
- Giulio Frontino
Diabetes Mellitus, Type 1
A Study to See the Effect of NNC0194-0499 Alone or in Combination With Semaglutide on Blood Sugar Control in People Living With Type 1 Diabetes
This study is testing the effect of a new study medicine NNC0194-0499 in type 1 diabetes. The purpose of the study is to compare the effect of NNC0194-0499 on the blood sugar levels of participants with type 1 diabetes when taken…
- Trial name
- NCT07087795
- Testing
- NNC0194-0499, Semaglutide
- Where
- Germany
- Volunteers
- 96 people
- Sponsor
- Novo Nordisk A/S
Diabetes Type 1, Diabetes Distress
Diabetes Distress and Quality of Life in University Students With Type 1 DM
This study aims to encourage and support Sohag University Students with type 1 Diabetes Mellitus (T1DM). It will discover students with poor glycemic control, diabetic retinopathy, and renal complications.
- Trial name
- NCT07110974
- Testing
- Diabetes Distress scale 17 and Quality Of Life Instrument
- Volunteers
- 200 people
- Sponsor
- Sohag University
Type 1 Diabetes
A Longitudinal, Observational Study Comparing Real-World Experiences of Teplizumab-Treated and Untreated Participants With Stage 2 Type 1 Diabetes in the United States
This study is an observational, longitudinal, non-interventional real-world study in the United States. The study is meant to describe the experience of participants with a history of stage 2 type 1 diabetes who have been infused…
- Trial name
- TEPLI-QUEST (NCT07260110)
- Testing
- Teplizumab
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- Sanofi
Diabetes Mellitus, Type 1
Metabolic Effects of Accurate Blood Sugar Results and Education in Type 1 Diabetes
A randomized controlled trial in patients with type 1 diabetes, assessing the metabolic effects of accurate blood sugar results and education.
- Trial name
- NCT00284232
- Testing
- Use and interpretation of blood glucose results, Insulin dosing based on SMBG chart and education
- Where
- Norway
- Volunteers
- 140 people
- Sponsor
- Helse Stavanger HF
Diabetes Mellitus, Type 1
Strengths-Based Behavioral mHealth App for Parents of Adolescents With Type 1 Diabetes-Pilot Study
Type 1 diabetes (T1D) management is particularly challenging during adolescence as responsibility for management begins to shift from parents to youth, and positive family teamwork is critical to achieving optimal diabetes…
- Trial name
- T1DoingWell (NCT02877680)
- Testing
- T1Doing Well
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Baylor College of Medicine
Diabetes Mellitus, Type 1
A Novel Carbohydrate Counting Smartphone App for Youth With Type 1 Diabetes
Type 1 Diabetes Mellitus (T1DM) is a common chronic disease of childhood. T1DM has substantial impact on quality of life (QOL), including burdensome dietary restrictions and the need to count carbohydrates in foods to safely dose…
- Trial name
- NCT04354142
- Testing
- iSpy
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- The Hospital for Sick Children
Type 1 Diabetes
A Study of Autologous Induced Islet Body With Type 1 Diabetes
This is a single centre、single arm、open-label study，to investigate the safety and efficacy of Autologous induced islet body With Type 1 diabetes
- Trial name
- NCT03728296
- Testing
- islet body
- Volunteers
- 20 people
- Sponsor
- Allife Medical Science and Technology Co., Ltd.
Type 1 Diabetes
Investigation of Hyposafe H02 Device in Patients With Type 1 Diabetes
This clinical study is designed to collect data for further development of a hypoglycaemia notification algorithm. In addition, information regarding safety will be collected and analysed.
- Trial name
- NCT05495386
- Testing
- Hyposafe hypoglycaemia notification device (H02)
- Sponsor
- UNEEG Medical A/S
Type 1 Diabetes
Metformin Therapy for Overweight Adolescents With Type 1 Diabetes
The objective of the proposed research is to evaluate the efficacy and safety of the use of metformin in addition to standard insulin therapy in overweight and obese children and adolescents, age 12-<20 years, with type 1…
- Trial name
- NCT01881828
- Testing
- Metformin (glucophage)
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Jaeb Center for Health Research
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