Clinical trials: Endocrine, Nutritional, Metabolic and Immunity Disorders
Type 1 Diabetes
Performance Study of the SOLO 2.0 Insulin Pump
The Purpose of the study is to to evaluate the performance of the SOLO (version 2.0) micropump insulin delivery system, in Type 1 diabetic patients who use insulin pumps for their treatment.
- Trial name
- NCT01500928
- Testing
- SOLO insulin pump
- Where
- 2 sites in Israel
- Volunteers
- 40 people
- Sponsor
- Medingo Ltd
Type 1 Diabetes
Closing the Loop in Adults With Type 1 Diabetes - Alcohol Consumption
The main objective is to assess the efficacy and safety of overnight automated closed loop glucose control using a computer-based algorithm compared with conventional insulin pump therapy in adults with type 1 diabetes following…
- Trial name
- ANGELA02 (NCT00944619)
- Testing
- Closed loop, Conventional insulin pump delivery
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Cambridge
Type 1 Diabetes, Cardiovascular Diseases
Repurposing Colchicine for Reduction of Residual Inflammatory Risk in Type 1 Diabetes
The aim of this clinical trial is to evaluate if colchicine in addition to standard of care improves markers of inflammation and cardiovascular disease in persons with type 1 diabetes.
- Conditions
- Type 1 Diabetes, Cardiovascular Diseases, Chronic Inflammation
- Trial name
- REC1TE (NCT05949281)
- Testing
- Colchicine 0.5 MG Oral Tablet
- Where
- Denmark
- Volunteers
- 102 people
- Sponsor
- Asger Lund, MD
Type 1 Diabetes (T1D), Registry
UK Islet Autoantibody Registry
Type 1 diabetes (T1D) is a life-long condition where the immune system destroys part of the body (the pancreas) which makes the chemical, insulin. Insulin is needed to control blood sugar levels.
- Conditions
- Type 1 Diabetes (T1D), Registry, Pre-diabetes, Screening
- Trial name
- UKIAb Registry (NCT07125365)
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- University of Oxford
Diabetes Mellitus, Insulin-Dependent
Comparison of the Ability of Glulisine With Lispro to Control Type 1 Diabetes Mellitus in Children and Adolescents
The purpose of this study is to determine if insulin glulisine (Apidra) is as safe and effective a rapid acting insulin as insulin lispro (Humalog) in children and adolescents with type 1 diabetes mellitus.
- Trial name
- NCT00115570
- Testing
- Insulin glulisine, insulin lispro, insulin glargine
- Where
- United States
- Volunteers
- 572 people
- Sponsor
- Sanofi
Diabetes, Diabetes Mellitus, Type 1
Observational Study of Patients With Diabetes Using Levemir® FlexPen®
This study is conducted in Asia. This study is a prospective, open, uncontrolled, observational surveillance study with Levemir® FlexPen® conducted in Korea.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT00670683
- Testing
- insulin detemir
- Where
- South Korea
- Volunteers
- 797 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
Managing Insulin Pumps for Exercise (Study 2)
People with Type 1 Diabetes Mellitus (T1DM) like to take part in sport and exercise, but problems with metabolism and blood glucose control can make this difficult.
- Trial name
- NCT01398995
- Testing
- Reduction of basal insulin infusion to 50% of normal
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Buckinghamshire Healthcare NHS Trust
Diabetes, Diabetes Mellitus, Type 1
A Trial Investigating the Pharmacokinetic and Pharmacodynamic Properties of FIAsp in Geriatric and Younger Adult Subjects With Type 1 Diabetes
This trial is conducted in Europe. The aim of the trial is to investigate the pharmacokinetic (the exposure of the trial drug in the body) and pharmacodynamic (the effect of the investigated drug on the body)properties of FIAsp…
- Trial name
- NCT02003677
- Testing
- Faster-acting insulin aspart, insulin aspart
- Where
- Germany
- Volunteers
- 67 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes, Pregnancy, High Risk
Intravenous Insulin vs Subcutaneous Insulin Infusion in Intrapartum Management of Type 1 Diabetes Mellitus
The purpose of this study is to perform a randomized trial to investigate if intrapartum insulin delivery mechanisms reduces adverse outcomes associated with type 1 diabetes in pregnancy.
- Trial name
- NCT04599075
- Testing
- Insulin
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Gianna Wilkie
Diabetes Mellitus, Type 1
TRIGR - Primary Prevention Study for Type 1 Diabetes in Children at Risk
The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) is an international effort to conduct a primary prevention nutrition trial for type 1 (insulin-dependent) diabetes.
- Trial name
- TRIGR (NCT00179777)
- Testing
- Hydrolysed infant formula, Nonhydrolysed infant formula
- Where
- 18 sites in United States, Australia and 13 more
- Volunteers
- 5,156 people
- Sponsor
- University of Helsinki
Telemedicine
Telemedicine on Metabolic Control in Type 1 Diabetes Mellitus Andalusian Patients (PLATEDIAN)
To assess the effect of a 6-month telemedicine program (DiabeTIC) in patients with type 1 diabetes mellitus (DM1) and regular metabolic control (HbA1c <8%) in multi-dose insulin treatment (MDI) measured HbA1c vs.
- Trial name
- PLATEDIAN (NCT03332472)
- Testing
- Telemedicine group, Conventional group
- Where
- Spain
- Volunteers
- 334 people
- Sponsor
- Sociedad Andaluza de Endocrinología, Diabetes y Nutrición
Diabetes, Diabetes Mellitus, Type 1
Comparison of Human Insulin to Insulin Inhalation Solution in Children With Type 1 Diabetes
This trial is conducted in Europe. The aim of this trial is to compare the pharmacokinetic profile of two different methods of insulin administration in children with type 1 diabetes.
- Trial name
- NCT00567775
- Testing
- human insulin, inhaled human insulin
- Where
- Denmark
- Volunteers
- 27 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
Closing the Loop for 36 Hours in Adolescents With Type 1 Diabetes
High variability of blood sugar levels and high incidence of night-time hypoglycaemia (low blood sugar) in young people with type 1 diabetes (T1D) make achieving the treatment goals in this population extremely challenging.
- Trial name
- NCT01074801
- Testing
- Closed-loop insulin delivery, Standard insulin pump treatment
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Cambridge
Diabetes
Automated Insulin Delivery Amongst Pregnant Women With Type 1 Diabetes
Evaluation of the biomedical and psychosocial impact of automated Closed-Loop (Artificial Pancreas) insulin delivery in women with type 1 diabetes during pregnancy
- Trial name
- AiDAPT (NCT04938557)
- Testing
- Automated closed-loop insulin delivery (AiD), A standard insulin delivery system
- Where
- United Kingdom
- Volunteers
- 124 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Type 1 Diabetes
Long-Term Outcomes of Teplizumab in Routine Clinical Care
This is an observational, prospective cohort study designed to evaluate the outcomes after teplizumab treatment in participants with Stage 2 Type 1 Diabetes (T1D) for delaying the onset of Stage 3 T1D.
- Trial name
- AL1GN (NCT07360080)
- Testing
- Teplizumab
- Where
- 10 sites in United States, Israel and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Sanofi
Type 1 Diabetes
The Importance of Meal Composition on Preventing Exercise-induced Hypoglycemia in People With Type 1 Diabetes.
This study is a clinical, randomized, crossover study. The study investigates the effect of a low-carbohydrate-high-protein pre-exercise meal on preventing exercise-induced hypoglycemia in people with type 1 diabetes.
- Trial name
- NCT04472962
- Testing
- Pre-exercise meal
- Where
- Denmark
- Volunteers
- 14 people
- Sponsor
- Steno Diabetes Center Copenhagen
Asthma, Diabete Type 2
Bronchial Asthma and Diabetes: Impact on Bronchial Inflammation and Exercise Capacity
Type 2 diabetes is the most common form of diabetes and according to several studies, even lung can represent another target of the diabetic disease.
- Trial name
- NCT04448262
- Testing
- data collection
- Where
- Italy
- Volunteers
- 39 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Type 1 Diabetes
Non-inferiority Study to Compare the Efficacy and Safety of Mylan's Insulin Glargine With Lantus® in Type 1 Diabetes Mellitus Patients (INSTRIDE 1)
To test whether Mylan's insulin glargine once daily is non-inferior to Lantus® once daily (based on change in HbA1c from baseline to 24 weeks) when administered in combination with mealtime insulin lispro.
- Trial name
- INSTRIDE 1 (NCT02227862)
- Testing
- Mylan's insulin glargine, Lantus®
- Where
- 162 sites in United States, Canada and 9 more
- Volunteers
- 558 people
- Sponsor
- Mylan Inc.
Macular Edema, Diabetes Mellitus
Laser and Antioxidant Treatment of Diabetic Macular Edema
This study will compare the side effects of two laser treatments for diabetic macular edema, a common condition in patients with diabetes.
- Trial name
- NCT00055042
- Testing
- Vitamin E
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Eye Institute (NEI)
Diabetes Mellitus, Type I
Assessing Detection Algorithms for Insulin Pump Malfunctions in Type 1 Diabetes
The goal of this clinical trial is to test the effectiveness of fault-detection algorithms in detecting malfunctioning of the insulin infusion system in an artificial pancreas (also known as Automated Insulin Delivery system) for…
- Trial name
- NCT06147583
- Testing
- Simulation of an insulin pump failure
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Padova
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