Clinical trials: Endocrine Disorder
Acute Pancreatitis, Pancreatitis
Study of Copeptin as a Diagnostic Marker for Acute Pancreatitis
The purpose of this study is to investigate if there is an association between copeptin level in serum and the severity of pancreatitis and if copeptin can be used as a predictor for organ failure and pancreatic necrosis with or…
- Trial name
- COPA (NCT01293318)
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University Hospital, Basel, Switzerland
Diabetes Mellitus, Type 2
MARLINA - T2D : Efficacy, Safety & Modification of Albuminuria in Type 2 Diabetes Subjects With Renal Disease With LINAgliptin
Evaluate linagliptin in terms of glycemic control as defined by HbA1c after 24 weeks of treatment and in terms of renal efficacy as defined by changes in albuminuria (UACR) after 24 weeks of treatment.
- Trial name
- NCT01792518
- Testing
- Linagliptin 5mg
- Where
- 74 sites in United States, Canada and 10 more
- Volunteers
- 360 people
- Sponsor
- Boehringer Ingelheim
Secondary Hyperparathyroidism, Chronic Kidney Disease
Study to Evaluate the Effects of Zemplar Injection and Calcijex on Intestinal Absorption of Calcium
A study to investigate the effects of Zemplar and Calcijex on intestinal calcium absorption in hemodialysis subjects.
- Trial name
- NCT00073710
- Testing
- Zemplar, 42 Ca carbonate absorption via single tracer method, Calcijex
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Abbott
Epithelial Ovarian Cancer, Peritoneal Cancer
LCC-CARIS-01: Molecular Profiling in Gynaecological Cancer
This is a pilot feasibility study assessing the use of a commercial molecular profiling service in the UK's National Health Service (NHS).
- Conditions
- Epithelial Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer, Gynaecological Malignancy
- Trial name
- NCT02668913
- Testing
- Diagnostic analysis
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- Geoff Hall
Pancreatic Cancer
Tissue Pharmacokinetics of Intraoperative Gemcitabine in Resectable Adenocarcinoma of the Pancreas
The goal of this clinical research study is to learn if gemcitabine can enter pancreas cancer cells, to measure the amount of it that may enter the cells, and for biomarker testing.
- Trial name
- NCT01276613
- Testing
- Gemcitabine, Losartan
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- M.D. Anderson Cancer Center
Type 1 Diabetes Mellitus
The Effect of a Web-Based Education Program on Eating Habits, Metabolic Control, and Self-Management in Adolescents With Type 1 Diabetes Mellitus and Their Mothers With Irregular Eating Behavior
The study was planned as a randomized controlled experimental study to investigate the effects of a web-based educational program given to adolescents with diabetes mellitus and their mothers on eating habits, metabolic control…
- Trial name
- NCT07355660
- Testing
- Eating habits, Diabetes self-management, Metabolic control
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Insulin Pump Therapy in Treating Diabetic Nephropathy
Effect Insulin Pump Therapy to Patients With Diabetic Nephropathy
The recent study suggested that oxidative stress resulting from increased production of reactive oxygen species (ROS) plays a crucial role in the development of diabetic complications.
- Trial name
- NCT03174821
- Testing
- Insulin pump
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Type 2 Diabetes, Insulin Resistance
Effect of Low-Glycemic Index Mediterranean Diet on AGEs
Advanced glycation end products (AGE) result from a chemical reaction between the carbonyl group of reducing sugar and the nucleophilic NH2 of a free amino acid or a protein; lysine and arginine being the main reactive amino…
- Conditions
- Type 2 Diabetes, Insulin Resistance, Obesity, Cardiovascular Disease
- Trial name
- Nutri_AGEs (NCT02353416)
- Testing
- Low Glycemic Index Mediterranean Diet, INRAM Guidelines' diet
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Pancreas Cancer
Evaluation of Endoscopic Ultrasound Shear Wave Elastography (EUS-SWE) for the Diagnosis of Pancreatic Adenocarcinoma.
To assess the diagnostic accuracy of Shear Wave elastography (SWE) for the diagnosis of pancreatic adenocarcinoma.
- Trial name
- EDEN (NCT04851106)
- Testing
- Endoscopic ultrasound
- Where
- France
- Volunteers
- 130 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Obesity and Overweight, Diabetes Mellitus
FAMily-centered WEight Loss for Black Adults (FAM WEL B-ing)
The goal of this clinical trial is to learn the best combination of family components that yields optimal weight loss among Black adults.
- Conditions
- Obesity and Overweight, Diabetes Mellitus, Weight Loss, Behavior Change
- Trial name
- FAM WEL B-ing (NCT06724406)
- Testing
- Family Skills Training Session Quantity: 5, Family Skills Training Session Mode: In-person, Family Skills Training Content: Communication
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- University of North Carolina, Chapel Hill
Type 2 Diabetes
Meal Timing on Postprandial Glucose, Insulin and GLP-1 in Type 2 Diabetes
Enhanced insulin and GLP-1 postprandial response after morning meal versus evening meal, might be underlying explanation of the beneficial effect of eating breakfast with reduced dinner vs skipping breakfast on glycemic control…
- Trial name
- GLP-1inT2D (NCT01977833)
- Testing
- High Calorie Breakfast (BTdiet), High Caloric Dinner (DTdiet)
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Tel Aviv University
Self Care
Evaluation of the Eversense Continuous Glucose Monitoring System in Type I Diabetic Youth
The purpose of this clinical investigation is to provide pilot clinical data to direct pivotal study development for the pediatric indication of the Senseonics Continuous Glucose Monitoring System (CGM) measurements when compared…
- Trial name
- FNH (NCT03815552)
- Testing
- Eversense Continuous Glucose Monitoring
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Diabetic Polyneuropathy
A Study of CGRP Monoclonal Antibody to Treat Diabetic Neuropathy
The main purpose of this study is to compare the change in pain intensity during treatment with a CGRP monoclonal antibody (eptinezumab) compared with placebo treatment in patients with painful diabetic polyneuropathy (DPN).
- Trial name
- NCT05937152
- Testing
- Eptinezumab
- Where
- 3 sites in United States, Denmark
- Sponsor
- Mayo Clinic
Cushing Disease
Long-Term Follow-Up of Survivors of Pediatric Cushing Disease
Background: The pituitary gland produces hormones. A tumor in this gland can cause it to produce too much of the hormone cortisol. Too much cortisol in the body causes Cushing disease. This disease causes many problems.
- Trial name
- NCT03831958
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Acute and Chronic Wounds, Pressure Ulcers
Clinical Evaluation of the SNaP Wound Care System
The purpose of this study is to assess the efficacy of design improvements of the Spiracur SNaP Wound Care System. This study prospectively evaluates the safety and efficacy of current and new design iterations of components of…
- Conditions
- Acute and Chronic Wounds, Pressure Ulcers, Trauma Wounds, Diabetic Foot Ulcers
- Trial name
- NCT01113658
- Testing
- SNaP Wound Care System
- Where
- 2 sites in United States
- Sponsor
- 3M
Diabetes Mellitus
Efficacy and Safety of Alogliptin in Subjects With Type 2 Diabetes
The purpose of this study is to evaluate the efficacy and safety of alogliptin, once daily (QD), in adults with type 2 diabetes.
- Trial name
- NCT00286455
- Testing
- Alogliptin
- Where
- 67 sites in United States, Argentina and 16 more
- Volunteers
- 329 people
- Sponsor
- Takeda
Diabetic Nephropathies, Hyperhomocysteinemia
The Effect of Folic Acid Administration in the Progression of Microalbuminuria
The development of diabetic nephropathy has been linked to several genetic polymorphisms, including those related with homocysteine metabolism such as the methylenetetrahydrofolate reductase (MTHFR)and the…
- Trial name
- NCT00737126
- Testing
- Folic acid
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Cervical Cancer, Ovarian Clear Cell Carcinoma
Asian Multicenter Prospective Study of ctDNA Sequencing
This study is a genetic analysis of aberrations in circulating tumor DNA (ctDNA) in patients in Asian countries. This study protocol is divided into parts describing several subanalyses that differ in terms of cancer types…
- Conditions
- Cervical Cancer, Ovarian Clear Cell Carcinoma, Nasopharyngeal Carcinoma, Ovarian Cancer
- Trial name
- A-TRAIN (NCT05099978)
- Testing
- NGS analysis of ctDNA
- Where
- 19 sites in Japan, Malaysia and 6 more
- Volunteers
- 506 people
- Sponsor
- National Cancer Center, Japan
Type 1 Diabetes Mellitus
A Phase III Study to Investigate if the Study Drug Diamyd Can Preserve Insulin Production and Improve Glycemic Control in Patients Newly Diagnosed With Type 1 Diabetes
The objective of DIAGNODE-3 is to evaluate the efficacy and safety of three intranodal injections of 4 μg of Diamyd also known as retogatein compared to placebo, along with oral Vitamin D supplementation, to preserve endogenous…
- Trial name
- DIAGNODE-3 (NCT05018585)
- Testing
- Recombinant human glutamic acid decarboxylase (rhGAD65) formulated in Alhydrogel®, Colecalciferol 2000 IU
- Where
- 60 sites in United States, Czechia and 7 more
- Volunteers
- 321 people
- Sponsor
- Diamyd Medical AB
Diabetic Polyneuropathy, Diabetes Mellitus, Type 2
Driving with Neuropathy
This study is a proof-of-concept randomised controlled trial (RCT). The goal of the study is to investigate the effectiveness of a feedback intervention to improve use of the accelerator pedal in patients driving with diabetes…
- Trial name
- NCT06739135
- Testing
- Visual feedback training
- Where
- United Kingdom
- Volunteers
- 115 people
- Sponsor
- Manchester Metropolitan University
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