Clinical trials: Endocrine Disorder
Cardiovascular Diseases, Diabetes Mellitus, Non-insulin Dependent
Epidemiology of Cardiovascular Disease in Diabetes
To locate and identify genes contributing to the genetic component of subclinical cardiovascular disease (CVD) in Type 2 diabetes and to evaluate the impact of lifestyle and environment on the expression of these genetic…
- Conditions
- Cardiovascular Diseases, Diabetes Mellitus, Non-insulin Dependent, Heart Diseases, Atherosclerosis
- Trial name
- NCT00037297
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Diabetes Mellitus, Type 2
A Long-term Study on the Side Effects of TRADIANCE in Japanese Patients With Type 2 Diabetes
Study objectives is to investigate the safety of long-term daily use of TRADIANCE® Combination Tablets AP and BP in Japanese patients with Type 2 Diabetes mellitus (T2DM) used in routine care.
- Trial name
- NCT03761797
- Testing
- TRADIANCE® Combination Tablets AP, TRADIANCE® Combination Tablets BP
- Where
- Japan
- Volunteers
- 1,164 people
- Sponsor
- Boehringer Ingelheim
Polycystic Ovary Syndrome, Obesity
Ovarian Contribution to Androgen Production in Adolescent Girls
Women with polycystic ovary syndrome (PCOS) can have unwanted facial or male-patterned body hair, irregular menstrual periods, or no menstrual periods excess body weight, and infertility.
- Conditions
- Polycystic Ovary Syndrome, Obesity, Hyperandrogenism
- Trial name
- CBS001 (NCT01421810)
- Testing
- Dexamethasone, rhCG
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Breast Cancer
Letrozole in Preventing Cancer in Postmenopausal Women Who Have Received 4-6 Years of Hormone Therapy for Hormone Receptor-Positive, Lymph Node-Positive, Early-Stage Breast Cancer
RATIONALE: Estrogen can cause the growth of breast cancer cells. Letrozole may fight breast cancer by lowering the amount of estrogen the body makes.
- Trial name
- SOLE (NCT00553410)
- Testing
- Letrozole
- Where
- 164 sites in United States, Australia and 18 more
- Volunteers
- 4,884 people
- Sponsor
- ETOP IBCSG Partners Foundation
Cardiovascular Diseases, Hypercholesterolemia
Plant Sterols on Cardiovascular Markers, Microbiota and Sterol Metabolism (Cardiofoodsterol)
Potential cholesterol-lowering effect of a regular intake of a plant sterol (PS)-containing food supplement, in overweight/obese type 1 or 2, normoglycemic/pre-diabetic, with LDL-cholesterol values > 115 mg/dl and not…
- Conditions
- Cardiovascular Diseases, Hypercholesterolemia, Prediabetic State, Overweight and Obesity
- Trial name
- NCT06481020
- Testing
- Plant sterols 2g/day
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- University of Valencia
Neuroendocrine Tumor, Carcinoid Tumor
Sorafenib in Combination With RAD001 in Patients With Advanced Neuroendocrine Tumors
The purpose of this research study is to find out more about the combination of RAD001 and sorafenib such as the safest dose to use, the side effects it may cause, and if the drug is effective for treating neuroendocrine tumors.
- Conditions
- Neuroendocrine Tumor, Carcinoid Tumor, Pancreatic Neuroendocrine Tumor
- Trial name
- NCT00942682
- Testing
- Sorafenib, RAD001
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Dana-Farber Cancer Institute
Primary Aldosteronism, Finerenone
The Clinical Efficacy and Safety of Finerenone in the Treatment of Primary Aldosteronism
The purpose of our research is to clarify the therapeutic efficacy and safety of Finerenone in patients with Primary Aldosteronism and explore the effective clinical predictive indicators of Finerenone in the treatment of Primary…
- Conditions
- Primary Aldosteronism, Finerenone, Mineralocorticoid Receptor Antagonist
- Trial name
- NCT06381323
- Testing
- Finerenone
- Where
- China
- Volunteers
- 55 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Pancreatic Carcinoma
L-CARnitine in the Palliative Treatment of Advanced PANcreatic Cancer (CARPAN)
The study investigated the role of L-Carnitine supplementation on proinflammatory immune response, malnutrition, cancer cachexia and cancer related fatigue in advanced and inoperable pancreatic cancer, UICC Stage IV .
- Trial name
- CARPAN (NCT01330823)
- Testing
- L-Carnitine
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- University Medicine Greifswald
Obesity & Overweight, Diabetes Mellitus Type 2
Pre-Diagnosis GLP-1 Receptor Agonist Use and Post-Cancer Mortality in Adults With Obesity and Type 2 Diabetes
This study will examine whether the type of diabetes treatment used before cancer diagnosis is associated with survival and serious complications after obesity-associated cancer in adults with obesity and type 2 diabetes.
- Conditions
- Obesity & Overweight, Diabetes Mellitus Type 2, Neoplasms
- Trial name
- NCT07513259
- Where
- Taiwan
- Volunteers
- 203,424 people
- Sponsor
- Chung Shan Medical University
Diabetes
Bioequivalence Study
The purpose of this study is to determine if tablets manufactured at different sites have the same bioavailability, that is yield similar blood levels/concentrations of the drugs and are handled by the body similarly
- Trial name
- NCT01874080
- Testing
- Saxagliptin/Metformin
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Type 2 Diabetes Mellitus, Dyslipidemia
Characterization of High Density Lipoprotein (HDL) in Type 2 Diabetes (T2D) After Fenofibrate or Niacin Treatment
The structural and functional alterations of high density lipoproteins (HDL) levels in type 2 diabetes (T2D) patients linked to hypertriglyceridemia, hyperglycemia, insulin resistance, inflammation and oxidation, play a major…
- Trial name
- LOWHDL (NCT02153879)
- Testing
- Fenofibrate, Niacin plus laropiprant
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Type 1 Diabetes (Juvenile Onset), Type 1 Diabetes
Type 1 Diabetes Autonomic and Vascular Function
The goal of this clinical trial is to investigate the autonomic and vascular function in men and women with Type 1 diabetes. The main questions it aims to answer are: 1.
- Conditions
- Type 1 Diabetes (Juvenile Onset), Type 1 Diabetes, Diabetes, Autoimmune
- Trial name
- NCT06786546
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Thyroid Gland Disease, Surgery
TOETVA Feasibility and Complications - Single Center First Experience
All participants who underwent (or will undergo) a transoral endoscopic thyroidectomy via vestibular approach (TOETVA) at the investigators' center are observed for complications and feasibility of this surgery.
- Trial name
- NCT05396703
- Testing
- TOETVA
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Zuyderland Medisch Centrum
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW-III Sweden Satellite Registry
This registry is a clinical post-market evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES).
- Trial name
- NCT01667003
- Where
- 8 sites in Sweden
- Volunteers
- 406 people
- Sponsor
- Biotronik ApS
Diabetic Foot Ulcer Outcome, Quality of Patient Care
The Diabetic Foot Ulcer Registry
This is an observational, longitudinal real world registry of diabetic foot ulcers created from electronic health record data obtained in the course of clinical care.
- Trial name
- DFUR (NCT02813161)
- Testing
- cellular and tissue based therapy, negative pressure wound therapy, debridement
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- U.S. Wound Registry
Primary Aldosteronism, Autonomous Cortisol Secretion
Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent With or Without Autonomous Cortisol Secretion
To evaluate the incidence of adrenal insufficiency after surgery in Primary aldosteronism (PA) patients concurrent with or without autonomous cortisol secretion (ACS).
- Conditions
- Primary Aldosteronism, Autonomous Cortisol Secretion, Adrenal Insufficiency
- Trial name
- NCT06955286
- Testing
- complete ACTH stimulation test the day after surgery and complete ACTH stimulation test 1 or 4 week for patients with Adrenal Insufficiency
- Where
- China
- Volunteers
- 521 people
- Sponsor
- Qifu Li
Thyroid Cancer
Identification of Molecular Biomarkers for Thyroid Cancer
This is a two part study; part A proposes to collect plasma samples to examine how ctDNA (circulating thyroid DNA) markers correlate with detection of recurrent disease, response to therapy, clinical outcome and pathological…
- Trial name
- NCT04133870
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Breast Neoplasms
First-line Palbociclib and Endocrine Therapy for Patients With HR+/HER2- Advanced Breast Cancer in the Real-world Setting.
This is a prospective, single-arm, multi-center observational non-interventional study (NIS) in Germany and Austria.
- Trial name
- PERFORM (NCT04767594)
- Testing
- Palbociclib + endocrine therapy
- Where
- 192 sites in Austria, Germany
- Volunteers
- 1,407 people
- Sponsor
- Pfizer
Type 1 Diabetes Mellitus
Closing the Loop in Adults With Type 1 Diabetes in the Home Setting
The main study objective is to compare real-time continuous subcutaneous glucose monitoring (CGM) combined with overnight automated closed-loop glucose control, and real-time CGM alone in the home setting.
- Trial name
- NCT01440140
- Testing
- Closed-loop, Conventional insulin pump delivery
- Where
- 3 sites in United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Cambridge
Diabetes Complications
Dynamic Parameters of Glucose Control in Relation to Biomarkers in Serum and Intraocular Fluid in Patients With Diabetes
Our project investigates the new characteristics of diabetic retinopathy using liquid eye biopsy in combination with novel parameters of glucose control obtained with continuous glucose monitoring.
- Trial name
- NCT05944640
- Testing
- Intraocular surgery
- Where
- Czechia
- Volunteers
- 213 people
- Sponsor
- Charles University, Czech Republic
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