Clinical trials: Endocrine Disorder
Type 2 Diabetes
Efficacy and Safety of Premixed Insulin Treatment in Patients With Type 2 Diabetes Mellitus
The aim of the study is to investigate the efficacy and safety of premixed insulin treatment in patients With type 2 diabetes mellitus using professional and personal Flash Glucose Mornitoring.
- Trial name
- NCT04847219
- Testing
- Professional flash glucose mornitoring, Personal flash glucose mornitoring
- Where
- China
- Volunteers
- 239 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Non Endometrioid Carcinoma, Endometrioid Carcinoma
Evaluation of Sentinel Node Policy in Early Stage Endometrial Carcinomas at Intermediate and High Risk of Recurrence.
The aim of this trial is to evaluate the sentinel node policy in early stage endometrial carcinomas at intermediate and high risk of recurrence (by comparing the sentinel node policy to current initial staging protocols).
- Trial name
- SENTIRAD (NCT02598219)
- Testing
- Pre-operative SN mapping with radionucleide, Intra-operative SN mapping with patent V blue dye, Intra-operative SN mapping with indocyanin green
- Where
- 16 sites in France
- Volunteers
- 262 people
- Sponsor
- Centre Oscar Lambret
Benign Prostatic Hyperplasia
Efficacy of Prostatic Artery Embolization (PAE) in Patients With Severe Benign Prostatic Hyperplasia (BPH)
Purpose: To evaluate the efficacy of prostatic artery embolization (PAE) in patients with benign prostatic hyperplasia (BPH) and refractory lower urinary tract symptoms (LUTS) in decreasing the volume of the prostate gland.
- Trial name
- NCT02167919
- Testing
- Microspheres
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of North Carolina, Chapel Hill
Diabetes Mellitus, Type 2, Insulin Resistance
Heat Therapy in Patients With Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM) is a significant burden worldwide. In addition to lifestyle intervention, heat therapy has been shown to be effective in improving glycemic control.
- Trial name
- HEATED (NCT05237219)
- Testing
- Passive heating, Thermoneutral
- Where
- Hungary
- Sponsor
- University of Pecs
Polycystic Ovarian Syndrome (PCOS), Reproductive Health
Management of Polycystic Ovarian Syndrome-associated Reproductive Dysfunction Through Kefir Supplementation
Polycystic ovary syndrome (PCOS) affect around 6-12% of women of age 18-25 years. Kefir contains bioactive compounds such as lactic acid bacteria, yeast, peptides, polysaccharides and organic acids and acts as a good probiotic…
- Trial name
- NCT07711782
- Testing
- (C0) Control group, (G1) Experimental group
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- University of Lahore
Diabetes Mellitus, Microbiome
Supplementation of Inulin + L. Acidophilus in Elders With T2DM
This study investigates the effects of a symbotic supplement (Inulin + Lactobacillus acidophilus) on cognitive impairment in older adults with type 2 diabetes mellitus (T2DM).
- Conditions
- Diabetes Mellitus, Microbiome, Cognition Disorders
- Trial name
- NCT06830824
- Testing
- Lactobacillus acidophilus
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Anahuac University
Diabetes
Diabetes Multicenter Observational Study (DIAMOND-1-)
The purpose of this study is to examine whether pump treatment combined with the use of continuous glucose monitoring system is a mena to normalize glycaemic control.
- Trial name
- DIAMOND-1 (NCT01369823)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medtronic Hellas Medical Devices ΑEE
Diabetic Foot Ulcer
High Tone External Muscle Stimulation on Diabetic Foot Ulcer
In this study 80 patients will be randomly assigned into two equal groups (40 patients for each group): 1. Group A: Experimental: (high tone external muscle stimulation for diabetic foot ulcer).
- Trial name
- NCT06664723
- Testing
- high tone external muscle stimulation, Standard medical treatment (SMT)
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Diabetes Mellitus, Normal Glucose Metabolism
Assessment of Non-Fasting vs. Fasting Lipid Measures in Diabetes Patients
This study will examine whether fasting and non-fasting lipid measures can provide similar clinical information in order to guide lipid management by primary physicians. It will compare fasting vs.
- Conditions
- Diabetes Mellitus, Normal Glucose Metabolism, Hyperlipidemia
- Trial name
- NCT00569959
- Testing
- fasting 12+ hours, Non-fasting
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Oral Microbiota, Pancreatitis
The Characteristics of Oral Microbiota in Chronic Pancreatitis and Autoimmune Pancreatitis
There are more than 700 different bacteria colonized in human oral cavity, which are collectively referred to as oral microbiota.
- Conditions
- Oral Microbiota, Pancreatitis, Pancreatic Cancer
- Trial name
- NCT07015580
- Testing
- 16S rRNA sequencing
- Where
- China
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Polycystic Ovary Syndrome (PCOS), Insulin Resistance
Evaluation of Serum Preptin Levels in Patients With Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age and is strongly associated with insulin resistance and metabolic dysfunction.
- Trial name
- PREPTIN-PCOS (NCT07736079)
- Volunteers
- 60 people
- Sponsor
- GÜLDEN ANATACA
Acromegaly
Long Term Use of Somavert (Pegvisomant) For A Regulatory Post Marketing Commitment Plan
The objective of this surveillance is to collect information about 1) adverse drug reaction not expected from the LPD (unknown adverse drug reaction), 2) the incidence of adverse drug reactions in this surveillance, and 3)factors…
- Trial name
- NCT00658879
- Testing
- Somavert (Pegvisomant)
- Volunteers
- 251 people
- Sponsor
- Pfizer
Diabetes Mellitus, Type 2, Hypertension
Evaluation of Blood Pressure Reduction, Safety, and Tolerability of Canagliflozin in Patients With Hypertension and Type 2 Diabetes Mellitus on Stable Doses of Anti-hyperglycemic and Anti-hypertensive Agents
The purpose of this study is to evaluate the effect of canagliflozin (JNJ-28431754) on blood pressure reduction, compared to placebo, in patients with hypertension and type 2 diabetes mellitus and who are on stable doses of…
- Trial name
- NCT01939496
- Testing
- Canagliflozin
- Where
- 57 sites in United States, Puerto Rico
- Volunteers
- 171 people
- Sponsor
- Janssen Scientific Affairs, LLC
Gestational Diabetes, Mobile Application
eHealth in Treatment of Gestational Diabetes (eMOMGDM)
The overall aim of the eMOM GDM-project is to develop and evaluate a novel system to clinical decision making and patient behavior change in treatment of GDM, combining diet, physical activity, sleep, heart rate (e.g.
- Trial name
- eMOMGDM (NCT04714762)
- Testing
- eMOM GDM application
- Where
- Finland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Type 1 Diabetes (T1D)
Circadian Mechanisms, Glucose, and CV Risks in T1D
People with type 1 diabetes are disproportionately affected by cardiovascular disease (CVD). Short and irregular sleep have been associated with cardiovascular risk in this population.
- Trial name
- NCT06624046
- Testing
- Sleep stability intervention
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Illinois Chicago
Type 2 Diabetes Mellitus
Influence of Glucagon Inhibition in Relation to the Anti-Diabetic Effect of Glucagon-Like Peptide-1 (GLP-1) in Patients With Type 2 Diabetes Mellitus
Incretinbased treatment of patients with type 2 diabetes mellitus (T2DM) has increasing interest. The incretin glucagon-like peptide-1 (GLP-1) stimulates beta-cells to increased secretion and production of insulin.
- Trial name
- NCT00655603
- Testing
- Infusion of native hormones from the pancreas and gut (GLP-1)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Pancreatic Cancer
Second-line Irinotecan Liposome Combination Regimen for Irinotecan-treated Pancreatic Cancer
This study is a prospective, single-arm, two-cohort phase II clinical study. It is expected to enroll 48 patients with advanced or metastatic pancreatic cancer who have failed prior treatment with irinotecan-containing regimens…
- Trial name
- NCT06700603
- Testing
- Irinotecan liposome (Nal-IRI) in combination with 5-FU/sodium levofolinate
- Volunteers
- 48 people
- Sponsor
- Rui-hua Xu, MD, PhD
Diabetic Retinopathy, Retinal Detachment
Ranibizumab for Diabetic Traction Retinal Detachment
The purpose of this study was to assess the effect of ranibizumab in reducing intraoperative vitreous haemorrhage during pars plana vitrectomy, thus facilitating surgery and improving its anatomical and functional results in…
- Trial name
- RANITRA (NCT01201161)
- Testing
- Ranibizumab
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- University of Sao Paulo
Obstructive Jaundice, Pancreatic Cancer
Endoscopic Ultrasound-guided Biliary Drainage for Malignant Biliary Obstruction After Failed ERCP
In this study the investigators retrospectively report outcomes of direct transluminal EUS-BD in a series of patients with malignant biliary obstruction after failed ERCP as the experience of a single Italian center
- Trial name
- (EUS-BD) (NCT03510754)
- Testing
- Eus guided biliary drainage
- Volunteers
- 36 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Advanced HR+/HER2- Breast Cancer, Advanced CCNE1-amplified Solid Tumors
Study of ERW316 as a Single Agent or in Combination With Endocrine Therapy in Patients With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors
Phase I: Characterize safety and tolerability of ERW316 as a single agent and in combination with fulvestrant or letrozole. Identify dose range for optimization/recommended dose for further clinical evaluation.
- Conditions
- Advanced HR+/HER2- Breast Cancer, Advanced CCNE1-amplified Solid Tumors, Metastatic Castration-resistant Prostate Cancer (mCRPC)
- Trial name
- NCT07570966
- Testing
- ERW316, Fulvestrant, Letrozole
- Sponsor
- Novartis Pharmaceuticals
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