Clinical trials: Endocrine Disruptors, active
Chronic Kidney Disease (CKD)
Do Endocrine Disruptors Accumulate in Children Undergoing Paediatric Dialysis?
The impact of the environment on health is becoming an increasingly important issue in public health policies. Endocrine disruptors (EDs) are substances or mixtures of substances found in many everyday products that interact with…
- Trial name
- PedDIA-TOX (NCT07763483)
- Testing
- Blood samples collection
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Hospices Civils de Lyon
Puberty, Precocious, Breast
Early Breast Growth in Girls Aged 6 to 8 Years in the Current Environmental Context
Various studies show an increase in the number of cases of early puberty in girls with breast development with a variable clinical presentation and evolution. This increasing phenomenon concerns girls between 6 and 8 years old.
- Conditions
- Puberty, Precocious, Breast, Environmental Exposure
- Trial name
- PENELOPE (NCT06083415)
- Testing
- Environmental health measures
- Where
- 2 sites in France
- Volunteers
- 62 people
- Sponsor
- Lille Catholic University
Obesity &Amp;Amp;Amp; Overweight, Environmental Exposure
Weight Loss and Endocrine Disrupting Chemicals (EDCs): Lifestyle Interventions to Lose Weight and Reduce EDC Exposure in Individuals With Overweight/Obesity
The goal of this study is to examine the relationship in individuals with overweight/obesity and endocrine disrupting chemical (EDC) exposure through a two-armed, randomized clinical trial.
- Conditions
- Obesity &Amp;Amp;Amp; Overweight, Environmental Exposure, Overweight (BMI > 25)
- Trial name
- LiveWell (NCT07560579)
- Testing
- Educational curriculum, Weight loss Application, Urinary EDC metabolite testing
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- Million Marker Wellness, Inc.
Fertility, Male Fertility
Sperm, Exposure and Endocrine Disruptors
The proposed research aims to 1) measure male participants' urinary levels of EDCs and sperm quality before and after report-back and EDC reduction intervention and assess changes, 2) assess the extent to which MM's program…
- Conditions
- Fertility, Male Fertility, Sperm Count, Low, Sperm Quality
- Trial name
- SEED (NCT07703046)
- Testing
- EDC Education Intervention
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Million Marker Wellness, Inc.
Breast Cancer, Endocrine Disruptors
Confirmation of the Link Between Endocrine Disruptors Exposure and Breast Cancer and Identification of Biological Response Biomarkers
A wide variety of chemicals are constantly being introduced in our environment. The toxicological consequences related to the exposure to these compounds and their impact on public health ar of growing concern.
- Conditions
- Breast Cancer, Endocrine Disruptors, Metabolomics, Breast Lesions
- Trial name
- EXPOSAL (NCT07411651)
- Testing
- Collection of biological and clinical data
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Poitiers University Hospital
Breast Cancer
Everyday Exposures: How Chemicals and Weight Impact Breast Cancer Risk
To learn about breast cancer survivors' and their family members' knowledge of and interest in learning about environmental exposures related to personal care products.
- Trial name
- NCT07137468
- Testing
- Surveys, Video
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Cryptorchidism
Role of the Environment and Endocrine Disruptors in Child Cryptorchidism
Cryptorchidism is the most frequent congenital defect of the male newborn. It requires surgery in childhood, increases the risk of fertility disorders and cancer.
- Trial name
- CRYPTENV (NCT04342026)
- Testing
- Measure of the exposure of parent of male with /without cryptorchidism to endocrine disruptors
- Where
- France
- Volunteers
- 1,452 people
- Sponsor
- University Hospital, Montpellier
Pregnancy, Children
Effectiveness of a multicOmpoNent Behavioural intervenTion to Reduce endocrINe disrUptor Exposure During pErinatal Period (CONTINUE)
The general objective of HYPIEND is to understand the effects of chemical substances called "endocrine disruptors" (EDCs) during the perinatal and pre-pubertal stages.
- Trial name
- CONTINUE (NCT07142447)
- Testing
- Multi-Component Behavioral intervention, Control group
- Where
- Spain
- Volunteers
- 810 people
- Sponsor
- Fundació Institut Germans Trias i Pujol
Testicular Cancer
Endocrine Disrupting Chemical Exposure and Testicular Cancer
DISRUPT is a Danish nested case-control study that is currently being conducted to explore the impact of prenatal exposure to endocrine disrupting chemicals on testicular cancer risk (including histological sub-groups) with…
- Trial name
- DISRUPT (NCT04848545)
- Testing
- Observational
- Where
- 2 sites in Denmark
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Prenatal Exposure, Postnatal Exposure
Exposure to Organochlorine Pollutants and Impact on Development in the Peripubertal Age in Guadeloupe
In the context of environmental pollution of the French West Indies by chlordecone and questions about health consequences, monitoring at the peripubertal age of children born alive in the TIMOUN cohort is justified in several…
- Trial name
- TIMOUNPUBERTY (NCT06653660)
- Testing
- Clinical examination
- Where
- Guadeloupe
- Volunteers
- 650 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Childhood Obesity, Life Style
LIMIT Early Adiposity Rebound in Children
Childhood obesity is a strong predictor of adult obesity with health and economic consequences for the individual and society. Adiposity rebound (AR) is a rise in the Body Mass Index occurring between 3-7 years.
- Conditions
- Childhood Obesity, Life Style, Intestinal Microbiome
- Trial name
- LIMIT (NCT04960670)
- Testing
- Evaluation of microbiome and maternal/infant lifestyle
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Endocrine Disruptors in Newborns and Infants
Impact of Parental Training in Endocrine Disruptors on the Excretion of Urinary Biomarkers in Newborns
The impact of the environment on health, responsible for a quarter of all deaths worldwide and costing more than €160 billion a year, is difficult to assess because of the complexity of exposure and interactions.
- Trial name
- FLOCON (NCT07349927)
- Testing
- Training, Questionnaires, Urinary dosage
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Women Who Are Aged 18-49 Years, Able to Read, Write
Reducing Endocrine-Disrupting Chemical Exposure in Reproductive-Age Women: A Pender Model-Based RCT
Abstract Background: Endocrine-disrupting chemicals (EDCs) are widely encountered in daily life and may adversely affect reproductive health.
- Conditions
- Women Who Are Aged 18-49 Years, Able to Read, Write, Voluntarily Agree to Participate in the Study
- Trial name
- NCT07773233
- Testing
- Intervention Group
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Harran University
Metabolic Dysfunction-associated Liver Disease
Effect of Plant-based Diets on Liver Biomarkers, Cardiometabolic Health, and Exposure to Environmental Contaminants and Endocrine Disruptors in Patients With Metabolic Liver Disease.
Plant-based diets have gained increasing recognition for their sustainability and their benefits on cardiometabolic and liver health.
- Trial name
- ESTEATOVEG (NCT07503431)
- Testing
- Traditional Mediterranean diet, Vegan Mediterranean diet
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Miguel López Moreno
Endometriosis
Pilot Study to Characterize the Endometriosis Steroidome and Its Link to Endocrine Disruptors and Vaginal Dysbiosis
Endometriosis is a systemic, steroid-dependent, inflammatory disease characterized by the growth of endometrial-like tissue outside the uterus, affecting approximately 10 % of women of childbearing age.
- Trial name
- STERONLINE (NCT06820450)
- Testing
- Blood test, urine sample, vaginal sample
- Where
- France
- Volunteers
- 135 people
- Sponsor
- Nantes University Hospital
Colorectal Cancer (CRC), Endocrine Disruptors
Effects of Endocrine Disruptors on the Gut Microbiota and Assessment of Their Impact on Colorectal Cancer Development (PERMICA)
Colorectal cancer is the third most common cancer worldwide, yet it was the second leading cause of cancer-related deaths in 2020. The average French population faces a colorectal cancer risk partly linked to lifestyle factors.
- Conditions
- Colorectal Cancer (CRC), Endocrine Disruptors, Microbiota, Dysbiosis
- Trial name
- PERMICA (NCT06809660)
- Testing
- Collection of biological samples and clinical data
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Low-Risk Pregnant Women at Full-Term Gestation, Healthy Fetal Population
Advancing Early Bone Health: New Frontiers for Osteoporosis Prevention
All factors that influence the peak bone mass achieved at skeletal maturity are important in determining an individual's risk of developing osteoporosis later in life.
- Conditions
- Low-Risk Pregnant Women at Full-Term Gestation, Healthy Fetal Population, Healthy Neonatal Population
- Trial name
- REMS-BONE (NCT06750523)
- Testing
- Cord blood sampling, urine sampling, Life style questionnaire
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- University of Parma
Hypospadias
A Multimodal Study of the Relationship Between Exposure to Endocrine Disruptors and Occurrence of Hypospadias - HYPOLLUT
This study aims to demonstrate the impact of Endocrine-Disrupting Chemicals (EDCs) on the risk of hypospadias incidence. It is a multicenter comparative case-control study, involving two groups.
- Trial name
- HYPOLLUT (NCT06628375)
- Testing
- Consultation visit (Visit 1)
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Precocious Puberty, Central, Executive Dysfunction
Hypiend - Multicomponent Behavioral Intervention in Pre-puberal Children (Hypiend-PPC)
This study is part of the European Hypiend project, which aims to explore the effects of co-exposure to endocrine-disrupting chemicals (EDCs) on the function and epigenetic programming of the hypothalamic-pituitary-adrenal (HPA)…
- Trial name
- Hypiend-PPC (NCT07411001)
- Testing
- Multi-Component Behavioral intervention, Information
- Where
- Belgium
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Sciensano
Infertility (IVF Patients)
Plastic Detox During IVF Treatment
Environmental pollutants are present in many aspects of everyday life. Exposures to common household products, such as food packaging and cookware, may affect reproductive health.
- Trial name
- NCT07802691
- Testing
- Environmental Pollutant Detox
- Volunteers
- 60 people
- Sponsor
- Abigail Mancuso