Clinical trials: Endocrine Malignancy
Breast Carcinoma, Cervical Carcinoma
Bupropion Hydrochloride in Improving Sexual Desire in Women With Breast or Gynecologic Cancer
This phase II randomized trial studies how well bupropion hydrochloride works in improving sexual desire in women with breast or gynecological cancer.
- Conditions
- Breast Carcinoma, Cervical Carcinoma, Ovarian Carcinoma, Postmenopausal
- Trial name
- NCT03180294
- Testing
- Bupropion 150 mg XL
- Where
- 362 sites in United States
- Volunteers
- 230 people
- Sponsor
- NRG Oncology
Ovarian Cancer, Colorectal Cancer
EMD 273066 in Patients With Recurrent EpCAM Positive Ovarian, Prostate, Colorectal or Non-small Cell Lung Cancers When First Given Cyclophosphamide
This study is looking at the safety and tolerability of the experimental biological drug EMD 273066 when given with low dose cyclophosphamide to patients with recurring EpCAM positive ovarian, prostate, colorectal or non-small…
- Conditions
- Ovarian Cancer, Colorectal Cancer, Carcinoma, Non-small-cell Lung, Prostate Cancer
- Trial name
- NCT00132522
- Testing
- EMD 273066
- Where
- 5 sites in United States, Switzerland
- Volunteers
- 45 people
- Sponsor
- EMD Serono
Polycystic Ovary Syndrome (PCOS)
App Impact on Quality of Life and Symptoms in PCOS
This study investigates the influence of a PCOS app on the quality of life and symptoms of individuals with polycystic ovary syndrome (PCOS).
- Trial name
- NCT06912594
- Testing
- PCOS-App
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- Endo Health GmbH
Ovarian Cancer, Advanced Epithelial Ovarian Cancer
A Phase 1 Study of Cellgram-DC in Patients With Advanced or Recurrent Epithelial Ovarian Cancer
The goal of this clinical trial was to evaluate the safety of Cellgram-DC, an autologous dendritic cell-based cancer immunotherapy, in patients with advanced or recurrent epithelial ovarian cancer.
- Conditions
- Ovarian Cancer, Advanced Epithelial Ovarian Cancer, Recurrent Epithelial Cancer of Ovary
- Trial name
- NCT04614051
- Testing
- Cellgram-DC
- Where
- South Korea
- Volunteers
- 2 people
- Sponsor
- Pharmicell Co., Ltd.
Ovarian Cancer
Adjuvant Whole Abdominal Intensity Modulated Radiotherapy (IMRT) for High Risk Stage FIGO III Patients With Ovarian Cancer
The prognosis for patients with advanced epithelial ovarian cancer remains poor despite aggressive surgical resection and platinum-based chemotherapy.
- Trial name
- OVAR-IMRT-01 (NCT00527631)
- Testing
- whole abdomen irradiation using IMRT
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- Heidelberg University
Extragonadal Germ Cell Tumor, Testicular Germ Cell Tumor
Combination Chemotherapy With Bone Marrow Transplantation in Treating Men With Germ Cell Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not known whether combining chemotherapy with bone marrow transplantation is a more effective treatment…
- Trial name
- NCT00002566
- Testing
- carboplatin, cisplatin, cyclophosphamide
- Where
- France
- Volunteers
- 280 people
- Sponsor
- UNICANCER
Ovarian Cancer, Sexual Function
Advanced Ovarian Cancer and Sexuality Phase 1
Women with Advanced Ovarian Cancer (AOC) suffer from severe sexual side effects from treatment. The prevalence of the sexual issues is not known.
- Trial name
- ANOVA1 (NCT00488202)
- Where
- 2 sites in Canada
- Volunteers
- 26 people
- Sponsor
- University of British Columbia
Ovarian Cysts
Ovarian Reserve After Ovarian Hemostasis by Floseal Matrix
Laparoscopy has become the gold standard for the surgical treatment of benign ovarian cysts and is usually performed by stripping the ovarian cyst wall, followed by bleeding control of the ovarian wound ground using bipolar…
- Trial name
- NCT01857466
- Testing
- Floseal, Bipolar coagulation
- Where
- 3 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- CHA University
Non-Small Cell Lung Cancer, Renal Cell Cancer
CPI-006 Alone and in Combination With Ciforadenant and With Pembrolizumab for Patients With Advanced Cancers
This is a Phase 1/1b open-label, dose escalation and dose expansion study of CPI-006, a humanized monoclonal antibody (mAb) targeting the CD73 cell-surface ectonucleotidase in adult subjects with select advanced cancers.
- Conditions
- Non-Small Cell Lung Cancer, Renal Cell Cancer, Colorectal Cancer, Triple Negative Breast Cancer
- Trial name
- NCT03454451
- Testing
- CPI-006, CPI-006 + ciforadenant, CPI-006 + pembrolizumab
- Where
- 27 sites in United States, Australia
- Volunteers
- 117 people
- Sponsor
- Corvus Pharmaceuticals, Inc.
PCOS- Polycystic Ovary Syndrome
The Synbiotics Effects in Polycystic Ovary Syndrome: A Randomized Controlled Trial
The goal of this clinical trial is to compare the effect of synbiotics and placebo in Thai women with polycystic ovary syndrome.
- Trial name
- PCOS (NCT06169566)
- Testing
- synbiotics
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maharaj Nakorn Chiang Mai Hospital
Pancreatic Neoplasms, Pancreatic Cancer
On-site Cytopathology EUS-FNA
This study is a multicenter prospective randomized controlled trial. Potential participants in this study include patients referred for Endoscopic Ultrasound-guided fine needle aspiration (EUS-FNA) of a solid pancreatic lesion at…
- Trial name
- NCT01386931
- Testing
- EUS-guided FNA performed with on-site Cytopathologist, EUS-guided FNA performed without on-site Cytopathologist
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- University of Colorado, Denver
Behavioral Economics, Primary Health Care
Primary Care Clinical Excellence Incentive Study
As part of UCLA Health's commitment to developing a premier integrated health system built on a foundation of physician-led, team-based primary care, the Department of Medicine (DOM) recently implemented a new performance based…
- Conditions
- Behavioral Economics, Primary Health Care, Health Maintenance, Diabetes
- Trial name
- PCCE (NCT04237883)
- Testing
- Standard communication email, Social comparison Intervention, Leadership Training
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Fallopian Tube Cancer, Ovarian Cancer
TRINOVA-3: A Study of AMG 386 or AMG 386 Placebo in Combination With Paclitaxel and Carboplatin to Treat Ovarian Cancer
The purpose of this study is to determine whether AMG 386 or AMG 386 Placebo in combination with Paclitaxel and Carboplatin are effective in the treatment of ovarian cancer.
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Peritoneal Cancer
- Trial name
- NCT01493505
- Testing
- AMG 386, Paclitaxel, Carboplatin
- Where
- 310 sites in United States, Austria and 12 more
- Volunteers
- 1,015 people
- Sponsor
- Amgen
Biliary Obstruction, Pancreas Neoplasm
EUS-guided Choledochoduodenostomy for Primary Drainage of Malignant Distal Biliary Obstruction
A prospective single-centre pilot study investigating the feasibility and safety of EUS-guided choledochostomy as primary drainage strategy in patients with distal malignant biliary obstruction using a FCSEMS through LAMS to…
- Conditions
- Biliary Obstruction, Pancreas Neoplasm, Distal Cholangiocarcinoma
- Trial name
- SCORPION-II-p (NCT05595122)
- Testing
- EUS-CDS
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Polycystic Ovary Syndrome
The Effects of Fish Oils on Blood Pressure, Heart Rate Variability and Liver Fat in the Polycystic Ovary Syndrome
We hypothesise that fish oils will have a beneficial effect on cardiometabolic parameters in women with PCOS. The purpose of this study therefore is to examine the effects of fish oils on blood pressure, heart rate variability…
- Trial name
- fops (NCT00620529)
- Testing
- Ocean Nutrition 2050, Olive oil capsules
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Keogh Institute for Medical Research
Autoimmune Pancreatitis, IgG4-Related Diseases
Validation of the Odesa Criteria 2026 for Autoimmune Pancreatitis
This ambispective observational study aims to validate the Odesa Criteria 2026 (OC26), a flexible domain-based point scoring system for diagnosing autoimmune pancreatitis.
- Conditions
- Autoimmune Pancreatitis, IgG4-Related Diseases, Pancreatic Cancer, Chronic Pancreatitis
- Trial name
- ОС26 (NCT07536841)
- Testing
- No intervention (observational study)
- Where
- 2 sites in Ukraine
- Volunteers
- 82 people
- Sponsor
- Military Medical Clinical Center of the Southern Region, Ukraine
Prolactinoma
Dopamine D2 Receptors(D2R) Imaging in Prolactinomas
To study the in vivo expression of dopamine D2 receptors in prolactinoma and the predictive role of dopamine D2 receptors PET-MR imaging in the therapeutic effect of dopamine agonists.
- Trial name
- NCT03717454
- Testing
- Surgery, Drug treatment
- Volunteers
- 50 people
- Sponsor
- Zhebao Wu
Resectable Pancreatic Adenocarcinoma, Pancreatic Cancer
Administration as a Biological Adjuvant in Clinically-Staged, Resectable Pancreatic Adenocarcinoma
The application of immunotherapeutic strategies that target the most potent antigen presenting cell, the dendritic cell (DC), are likely to substantially increase the magnitude of the anti-tumor immune response.
- Trial name
- NCT00600002
- Testing
- GM-CSF
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Edward Nelson
Metastatic Pancreatic Adenocarcinoma, Stage IV Pancreatic Cancer AJCC v8
Binimetinib and Hydroxychloroquine in Treating Patients With KRAS Mutant Metastatic Pancreatic Cancer
This phase I trial studies the best dose of hydroxychloroquine when given together with binimetinib in treating patients with KRAS gene mutated pancreatic cancer that has spread to other places in the body (metastatic).
- Trial name
- NCT04132505
- Testing
- Binimetinib, Hydroxychloroquine
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- M.D. Anderson Cancer Center
Hypoxia, Oxygen Deficiency
Investigation of Hemoglobin Oxygenation With Third Harmonic Generation Microscopy
The specific aims of the project are performing a pre-clinical study on a human model and evaluating the oxygenation and other status of human erythrocytes by spectrally-resolved third harmonic generation (srTHG) microscopy .
- Conditions
- Hypoxia, Oxygen Deficiency, Tumor, Diabetes
- Trial name
- NCT03619356
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital